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Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

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Papadopoulos, Vassilios, Baraldi, Mario, Guilarte, Tomás R., Knudsen, Thomas B., Lacapère, Jean-Jacques, Lindemann, Peter, Norenberg, Michael D., Nutt, David, Weizman, Abraham, Zhang, Ming-Rong, Gavish, Moshe·2006·Trends in Pharmacological Sciences
DOI 10.1016/j.tips.2006.06.005
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Abstract

The peripheral-type benzodiazepine receptor or recognition site (PBR) is a widely distributed transmembrane protein that is located mainly in the outer mitochondrial membrane. The PBR binds to high-affinity drug ligands and cholesterol. Many functions are associated directly or indirectly with the PBR, including the regulation of cholesterol transport and the synthesis of steroid hormones, porphyrin transport and heme synthesis, apoptosis, cell proliferation, anion transport, regulation of mitochondrial functions and immunomodulation. Based on these functions, there are many potential clinical applications of PBR modulation, such as in oncologic, endocrine, neuropsychiatric and neurodegenerative diseases. Although "PBR" is a widely used and accepted name in the scientific community, recent data regarding the structure and molecular function of this protein increasingly support renaming it to represent more accurately its subcellular role (or roles) and putative tissue-specific function (or functions). Translocator protein (18kDa) is proposed as a new name, regardless of the subcellular localization of the protein.

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Cited by

Metadata

Authors
Papadopoulos, V., Baraldi, M., Guilarte, T. R., Knudsen, T. B., Lacapère, J.-J., Lindemann, P., Norenberg, M. D., Nutt, D., Weizman, A., Zhang, M.-R., & Gavish, M.
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2006-08
Volume
27
Issue
8
Pages
402-409
ISSN
0165-6147 (ISSN-L)
DOI
10.1016/j.tips.2006.06.005
OpenAlex
W2034450620
Cited by
1,389
References
6
FWCI
3.30
Type
journal article
Language
en
Open access
green
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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