The DOI matches its Crossref record; 332 of the 350 references it cites were found in a registry or an index; 1 of the 182 sources its claims cite were checked for support.
Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior
Open accessAbstract
The neuropeptides vasopressin (VP) and oxytocin (OT) and their receptors in the brain are involved in the regulation of various social behaviors and have emerged as drug targets for the treatment of social dysfunction in several sex-biased neuropsychiatric disorders. Sex differences in the VP and OT systems may therefore be implicated in sex-specific regulation of healthy as well as impaired social behaviors. We begin this review by highlighting the sex differences, or lack of sex differences, in VP and OT synthesis in the brain. We then discuss the evidence showing the presence or absence of sex differences in VP and OT receptors in rodents and humans, as well as showing new data of sexually dimorphic V1a receptor binding in the rat brain. Importantly, we find that there is lack of comprehensive analysis of sex differences in these systems in common laboratory species, and we find that, when sex differences are present, they are highly brain region- and species- specific. Interestingly, VP system parameters (VP and V1aR) are typically higher in males, while sex differences in the OT system are not always in the same direction, often showing higher OT expression in females, but higher OT receptor expression in males. Furthermore, VP and OT receptor systems show distinct and largely non-overlapping expression in the rodent brain, which may cause these receptors to have either complementary or opposing functional roles in the sex-specific regulation of social behavior. Though still in need of further research, we close by discussing how manipulations of the VP and OT systems have given important insights into the involvement of these neuropeptide systems in the sex-specific regulation of social behavior in rodents and humans.
Overview
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Written from the paper’s full text.
TL;DR
This review synthesizes evidence that brain vasopressin (VP) and oxytocin (OT) systems differ by sex in region- and species-specific ways, with VP/V1aR often higher in males and OT synthesis often higher in females but OTR often higher in males. It also presents new rat data showing male-biased V1aR binding in 8 of 21 forebrain regions and argues these systems regulate social behavior sex-specifically.
Key findings
- VP synthesis, fiber projections, and V1aR binding are generally higher in males across species; new Wistar rat data show males had higher V1aR binding in 8/21 forebrain regions: SSc (p<0.01), PC (p<0.001), BNSTmp (p<0.01), LOT (p<0.001), AVthal (p<0.001), tubLH (p=0.001), StigH (p<0.01), and DG (p<0.001), with no sex differences in the remaining 13 regions.
- OT synthesis shows fewer sex differences than VP; when present, OT-immunoreactivity is typically higher in females, whereas OTR binding is often higher in males. In Wistar rats, males had higher OTR binding in 9/15 forebrain regions, with the largest difference in posterior BNST (almost three times higher than females); deer mice showed male-biased OTR binding in 8/20 regions except CA1.
- VP and OT receptor distributions are distinct and largely non-overlapping in rodent brain, suggesting complementary or opposing functional roles in sex-specific social behavior.
- Sex-specific behavioral effects are reported for VP in partner preference, social recognition, social play, and aggression, and for OT in social avoidance, social recognition, partner preference, social play, and social interest; human intranasal VP/OT and AVPR1A/OXTR variants also show sex-specific associations.
Methods
- Narrative review of rodent and human literature on VP and OT synthesis, receptors, and social behavior, including tables summarizing sex differences across species.
- New data: V1aR autoradiography in Wistar rats using a 125I linear V1aR antagonist, comparing males and females across 21 forebrain regions; additional comparisons examined non-estrus vs. estrus females and nulliparous vs. primiparous females at three weeks post-weaning.
- Main analysis: statistical comparisons of receptor binding densities, with reported p-values; OTR findings draw on prior specific-ligand autoradiography in rats and deer mice.
Limitations
- Stated: comprehensive analysis of sex differences in VP/OT systems is lacking in common laboratory species; many studies analyzed only a few brain regions, used too few animals per sex, or used nonselective ligands; human and non-human primate data are limited; functional significance of sex differences remains largely unknown; no studies directly compared brain VP or OT release between males and females; plasma OT measurement methods need improvement.
- Evident from the text: many behavioral conclusions rely on separate studies in males or females rather than within-sex comparisons; the new rat V1aR data are from one strain/species and cannot establish causality; prior V1aR sex-comparison studies often did not report female estrus phase.
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114 Not checked yet · 49 Own interpretation · 32 No basis given · 7 Own result · 1 Partly supported · accuracy not yet measured
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In the paper
“other rodent studies that did not find sex differences in OTR binding analyzed only a few brain regions”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
What the sources say
- Partly supportedcites Smeltzer et al., 2006 sourceExperimental — accuracy not yet measured
The methods discussion (p. 2) says earlier vole studies examined OT receptor binding in selected brain regions, supporting the limited-regions part of the claim. It does not say those studies found no sex differences in OT receptor binding; this paper instead reports a sex difference in the mPFC (p. 2). (LLM, conf=0.78)
- Not checked yetcites Tribollet et al., 2002 source
- Not checked yetcites Beery et al., 2008 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“This is in contrast with VP synthesis in the brain, where VP-immunoreactivity is consistently higher in males compared to females”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 2. Sex differences in vasopressin and oxytocin synthesis and projections in the brain > 2.b. Oxytocin
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Overall, we can conclude that there is a lack of sex differences in OT synthesis in the brain in most species analyzed.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 2. Sex differences in vasopressin and oxytocin synthesis and projections in the brain > 2.b. Oxytocin
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In the paper
“VP within the BNST/MeA is modulated by gonadal hormones”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 2. Sex differences in vasopressin and oxytocin synthesis and projections in the brain > 2.a. Vasopressin
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In the paper
“when sex differences are present, they are highly brain region- and species- specific.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > Abstract
plaincorrelational- Asserted: passes — The authors put it forward as true.
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The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“VP system parameters (VP and V1aR) are typically higher in males”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > Abstract
plaincorrelational- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“among 21 forebrain regions analyzed primiparous females had higher V1aR binding in the SSc (p<0.01) and medial posterior BNST (p<0.01) compared to nulliparous females (Table 8).”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 3. Sex differences in vasopressin and oxytocin receptors in the brain > 3.a. VP receptors
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“evidence of the presence of V2R in the brain is largely lacking.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 3. Sex differences in vasopressin and oxytocin receptors in the brain > 3.a. VP receptors
plain- Asserted: passes — The authors put it forward as true.
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The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Taken together, across vertebrate species, VP synthesis and projections in the brain are often sexually dimorphic”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 2. Sex differences in vasopressin and oxytocin synthesis and projections in the brain > 2.a. Vasopressin
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“We generally find that, while there are robust sex differences in VP synthesis in conserved brain regions across species”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 1. Introduction
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- Probably not a substantial claim. 8
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In the paper
“Comparative analysis of V1aR binding between males and females of other rodent species is very limited”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 3. Sex differences in vasopressin and oxytocin receptors in the brain > 3.a. VP receptors
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“VP synthesis, VP innervation in the brain, and VP plasma concentrations generally seem to be higher in males than in females.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 2. Sex differences in vasopressin and oxytocin synthesis and projections in the brain > 2.a. Vasopressin
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“ICV administration of the specific V1aR antagonist d(CH2)5[Tyr(Me)2]AVP) reduced social play behavior in male juveniles, while increasing social play behavior in female juveniles (Veenema et al., 2013).”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.a. VP system
What the sources say
- Not checked yetcites Veenema et al., 2013 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“OT administered into the LS decreased social play behavior in females, but not in males (Bredewold et. al, 2014).”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
- Not checked yetcites Bredewold et. al, 2014
plaindirect- Asserted: passes — The authors put it forward as true.
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The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Given the robust and well-known sex differences in VP synthesis, it is surprising that there are only a few comparative studies investigating the behavioral effects of VP in males and females.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
boosted- Asserted: passes — The authors put it forward as true.
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In the paper
“In contrast, there are fewer and inconsistent sex differences in OT synthesis, yet there are several studies comparing the effects of OT on social behavior in males and females.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“we showed that V1aR blockade in the LS increased social investigation of a familiar over a novel stimulus rat in both male and female juvenile rats, but with a stronger effect in males (Veenema et al., 2012).”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
What the sources say
- Not checked yetcites Veenema et al., 2012 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“V1aR has been implicated in pair bonding, maternal care, aggression, social recognition, and social play”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 3. Sex differences in vasopressin and oxytocin receptors in the brain > 3.a. VP receptors
What the sources say
plaincorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
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In the paper
“VP and OT have been implicated in the etiology of psychiatric disorders, such as schizophrenia (Jobst et al., 2014), autism (Yang et al., 2010; Xu et al., 2013; LoParo and Waldman, 2014), depression (Yuen et al., 2014), and borderline personality disorder (Bertsch et al., 2013), disorders which show sex biases in prevalence, symptom severity, and treatment responses.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 1. Introduction
What the sources say
- Not checked yetcites Jobst et al., 2014 source
- Not matchedcites Yang et al., 2010; Xu et al., 2013; LoParo and Waldman, 2014
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites Yuen et al., 2014
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“male Siberian hamsters had higher V1R binding in the ventromedial, medial tuberal, and ventral premammillary hypothalamic nuclei when on a long photoperiod light cycle, and in the ventral premammillary hypothalamus when on a short photoperiod light cycle, compared to females”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 3. Sex differences in vasopressin and oxytocin receptors in the brain > 3.a. VP receptors
What the sources say
- Not checked yetcites Dubois-Dauphlin et al., 1991
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“V1aR and V1bR are both expressed in the brain and are the most well-known mediators of the effects of VP in the brain on social behavior.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 3. Sex differences in vasopressin and oxytocin receptors in the brain > 3.a. VP receptors
What the sources say
boosteddirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“It has been proposed that these consistent sex differences in VP could have a dual function, namely contributing to sex differences in some behaviors while preventing sex differences in other behaviors”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 2. Sex differences in vasopressin and oxytocin synthesis and projections in the brain > 2.a. Vasopressin
What the sources say
- Not checked yetcites De Vries & Boyle, 1998
- Not checked yetcites De Vries, 2004 source
hedgedconditional- Asserted: fails — The authors may not put it forward as true.
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Probably not a substantial claim. The authors may not put it forward as true. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“while there was no effect in DupB−/− carriers, males with the DupB+/− allele had lower dominance and higher conscientiousness scores than females with the DupB+/−”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.a. VP system
What the sources say
- Not checked yetcites Hopkins et al., 2012 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Similar to the VP receptor, sex differences in OTR binding are both brain region- and species-specific (Tables 5–7).”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 3. Sex differences in vasopressin and oxytocin receptors in the brain > 3.b. OT receptor
plaincorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Taken together, the VP system has been shown to regulate social behaviors in both rodents and humans often in sex-specific ways.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.a. VP system
boosteddirect- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“a single neonatal intraperitoneal (i.p.) injection of OT on postnatal day 1 facilitated partner preference in both male and female adult prairie voles, but required a high (12μg) or low (3μg) dose in males and an intermediate dose (6μ) in females”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
- Not checked yetcites Bales & Carter, 2003a
- Not checked yetcites Bales et al. 2007b
plaindirect- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Prepulse inhibition may therefore be a reflection of not only attention and memory, but also social cognition, which may be partially regulated by AVP1A gene variants.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.a. VP system
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“intracerebroventricular (ICV) V1aR antagonist impaired partner preference formation in males (Winslow et al., 1993), but there was no effect in females (Insel & Hulihan, 1995).”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.a. VP system
What the sources say
- Not checked yetcites Winslow et al., 1993 source
- Not checked yetcites Insel & Hulihan, 1995
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“neonatal OT increased V1aR binding in the ventral pallidum and cingulate cortex of adult males, but decreased V1aR binding in the same regions of adult females”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
- Not checked yetcites Bales et al., 2007a
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“while there was no effect in females, males with the DupB−/− allele (which is the shorter bp version and lacks RS3) needed more social cues to elicit an orienting response than males with the DupB+/−”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.a. VP system
What the sources say
- Not checked yetcites Hopkins et al., 2014
plaincorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“The first studies to report intranasal OT effects in humans were done in males only, showing a role for OT in trust and in the processing of socially relevant information”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“the effects of OT on partner preference in females could be located in the nucleus accumbens and in the prefrontal cortex, but these studies did not include males”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Together, these studies suggest a role of OT in social recognition in both sexes, but also suggest that there might be sex differences in the sensitivity to exogenous OT, with a lack of an effect in females.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“facilitated kinship recognition in women, but not men (Fischer-Shofty et al., 2013)”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
- Not checked yetcites Fischer-Shofty et al., 2013 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“OT impaired accurate emotion perception ability in women, but not men (Lynn et al., 2014)”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
- Not checked yetcites Lynn et al., 2014
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“ICV OT administration facilitated partner preference formation in female (Williams et al., 1994; Insel and Hulihan, 1995), but not in male (Winslow et al., 1993) prairie voles.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Initial work in prairie voles indicated a sex-specific role of the OT system in partner preference formation, suggesting that the OT system may be more important for partner preference in females compared to males.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“It is therefore likely that the endogenous OT system plays a similar role in social recognition in both sexes, but that males may be more sensitive to the enhancing effects of exogenous OT, while females have perhaps reached a ceiling effect.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“ICV OT reversed social defeat-induced social avoidance in male (Lukas et al., 2011b), but not in female (Lukas and Neumann, 2014) rats.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
- Not checked yetcites Lukas et al., 2011b
- Not checked yetcites Lukas and Neumann, 2014
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These findings suggest that the OT system is involved in partner preference in both sexes, but that females may be more sensitive to exogenous OT.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These results may suggest that the OT system is involved in modulating the salience and/or valence of social stimuli differently in males and females, possibly via the activation of different neural circuits.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This underscores not only the complexity of the function of the OTR but may also provide a mechanism to explain how the OTR can be involved in such different social behaviors, namely by inducing brain region-specific effects.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“These findings were a bit surprising, given the typically pro-social behavior effects of OT, although recent studies suggest a role for the OTR in the LS in reducing pro-social behaviors and enhancing anxiety in rodents”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These studies highlight the importance of emotional valence in the role of OT in perception and recognition of social stimuli, and how this may differ in men and women.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“ICV OT improved social recognition in male (Benelli et al., 1995), but not in female (Engelmann et al., 1998) rats.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“whereas reduced positive affect (Lucht et al., 2009) and reward dependence (Tost et al., 2010) were found in men only.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one. The quote only partly states this claim.
None of the sources cited for this claim have been checked yet.
In the paper
“Genetic studies of single nucleotide polymorphisms (SNPs) in the OTR gene provide evidence for the involvement of the OTR in various social behaviors in humans (for reviews see Meyer-Lindenberg et al., 2011; Ebstein et al., 2012), and potential sex-specific effects on human social behavior.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Sex differences in VP neurons and plasma VP concentrations have also been found in humans”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
What the sources say
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“a meta-analysis of the most commonly studied SNPs rs53576 and rs2254298 did not reveal any sex effects or any general effects in the social behavior domain (Bakermans-Kranenburg and van IJzerdoorn, 2014)”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
- Not checked yetcites Bakermans-Kranenburg and van IJzerdoorn, 2014
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Intranasal OT increased the caudate/putamen response in males, whereas it decreased this response in females (Rilling et al., 2014).”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
- Not checked yetcites Rilling et al., 2014 source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“these studies overall suggest a correlation between OTR SNPs and differences in social processing, social behaviors, and social functioning in both sexes, with some important sex differences”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Although not statistically significant in a comparison between sex, OT lowered rates of cooperation with computer partners following defection in women only (Rilling et al., 2012; 2014).”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
What the sources say
- Not checked yetcites Rilling et al., 2012 source
- Not checked yetcites [2014]
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“For these species, studies only analyzed a few brain regions or had only a few subjects per sex, which might explain the limited brain regions in which sex differences in V1aR binding were found”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
What the sources say
- Not checked yetcites Dubois Dauphin et al., 1996 source
- Not checked yetcites Dubois-Dauphlin et al., 1991
- Not checked yetcites Delville & Ferris, 1995
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The latter could be due to the lack of comprehensive analysis of sex differences in the OT system across species.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. The paper may give no reason why it holds.
In the paper
“Because some of these sex-specific effects were dose-dependent and required a higher dose in one sex (i.e., role of VP on partner preference in prairie voles with higher doses required in females; Cho et al., 1999), this further suggests that such sex-specific effects may be the result of sex differences in sensitivity to VP or OT systems.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
What the sources say
- Not checked yetcites Cho et al., 1999 source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“in most cases discussed, VP and OT systems seem to modulate several social behaviors in a similar direction (i.e., VP and OT systems both facilitate social recognition, pair bonding, and aspects of social cognition), but they may do so by acting at distinct brain regions.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Yet, this generated different social behaviors and different effects of manipulation of the VP system.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
plaindirectn = 2- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“partner preference formation in prairie voles is modulated by the VP system acting in the LS and ventral pallidum (Liu et al., 2001; Pitkow et al., 2001; Lim & Young, 2004) and by the OT system acting in the NAc and prefrontal cortex (Young et al., 2001; Liu and Wang, 2003).”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
What the sources say
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the direction of sex-specific behavioral actions of the VP and OT systems can be variable, may be specific to a certain aspect of social behavior, and may depend on the species.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“We have recently suggested that this may depend on species-specific social organizations (Dumais & Veenema, 2015).”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
What the sources say
- Not checked yetcites Dumais & Veenema, 2015
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This could imply that VP and OT systems may modulate social behaviors in a similar way by activating distinct neural circuits.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
hedgedconditional- Asserted: fails — The authors may not put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The authors may not put it forward as true. The paper’s conclusions may not depend on it.
In the paper
“This suggests that social behaviors may be regulated by a synchrony of activity of OT and VP acting at distinct brain regions, and that a balance of OT and VP activity is necessary for the modulation of a wide range of social behaviors (Neumann & Landgraf, 2012).”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
What the sources say
- Not checked yetcites Neumann & Landgraf, 2012
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These sex differences were highly species-specific, suggesting a role for species-specific sex differences in social organization.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: unclear — It is unclear why the paper says it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We conclude that the functional significance of sex differences in VP and OT systems is still largely unknown, and in need of further research.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence. It may state two separate claims as one.
The paper relies on this without support.
VP and OT do not pass the blood brain barrier.
“Although VP and OT do not pass the blood brain barrier”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“extracellular OT release in the pBNST was higher in adult male rats compared to adult female rats when exposed to a juvenile conspecific (Dumais et al., 2016)”
From Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network (2017) · cites this paper as Dumais et al., 2016
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Sex differences in the OXTR system are documented,11, 12, 13 suggesting that findings in males may not generalize to females.”
From Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women (2017) · cites this paper as [11]
The cited source says what the claim attributes to it.
In the citing paper
“Sex differences in the vasopressin system also have their origins in development and are androgen-dependent (De Vries & Panzica, 2006; Dumais & Veenema, 2016).”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as Dumais & Veenema, 2016
In the citing paper
“In mammalian brain OTRs and V1aRs are robustly expressed in many regions but their distributions often differ [9; 21; 22] (Figure 3).”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [9]
In the citing paper
“The behavioral effects of AVP are mediated primarily by V1aR (or Avpr1a) and V1bR (16,37,38,49,68), while AVP acts on V2 to regulate fluid homeostasis in the kidney (69).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [49]
In the citing paper
“Some reports have shown that AVP messenger RNA (mRNA) density measurements in the SON of rats are greater in males (50), while, in mice, OXT production is greater in females (51); however, other studies have shown a similar amount of OXT and AVP in both sexes in the PVN/SON of various rodent species, nonhuman primates, and humans (49,52).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [49]
In the citing paper
“There is also a sex-specific role of AVP in the regulation of social play behavior in juvenile rats, as blocking V1aR in the LS increases social play behavior in males and decreases it in females (49).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [49]
In the citing paper
“V1a receptor mRNA has been reported throughout cortex60”
From Insular cortex mediates approach and avoidance responses to social affective stimuli (2018) · cites this paper as [60]
In the citing paper
“Oxytocin (OT) is an evolutionary conserved neuropeptide that is a key regulator of social and emotional behaviors (1–4).”
From Oxytocin receptors in the anteromedial bed nucleus of the stria terminalis promote stress-induced social avoidance in female California mice (2018) · cites this paper as [1]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 3. Sex differences in vasopressin and oxytocin receptors in the brain > 3.b. OT receptor
“Unlike the V1R, the OTR is modulated by gonadal hormones, which may help to explain the mechanisms underlying the sex differences in OTR.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 3. Sex differences in vasopressin and oxytocin receptors in the brain > 3.a. VP receptors
“Like VP neurons and fiber projections, V1R binding has also been found to be dependent on gonadal hormones in various species.”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 4. Implications for sex-specific regulation of social behavior by the VP and OT systems > 4.b. OT system
“we found that males have higher OTR binding densities than females (Dumais et al., 2013) in various brain regions implicated in social behavior, such as the olfactory bulb, LS, and MPOA.”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 3. Sex differences in vasopressin and oxytocin receptors in the brain > 3.b. OT receptor
“Specifically, we found that males had higher OTR binding densities than females in 9 out of 15 forebrain regions analyzed. These brain regions included the NAc, dorsal caudate putamen, intermediate LS, posterior BNST, MPOA, agranular insular cortex, hippocampal CA1 region, MeA, and VMH (Dumais et al., 2013).”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 5. General Discussion
“In contrast, other rodent studies that did not find sex differences in OTR binding analyzed only a few brain regions (mandarin voles: Smeltzer et al., 2006; Cao et al, 2013, ICR mice: Tribollet et al., 2002; singing mice: Campbell et al., 2009; tuco-tuco: Beery et al., 2008).”
§ Vasopressin and oxytocin receptor systems in the brain: sex differences and sex-specific regulation of social behavior > 3. Sex differences in vasopressin and oxytocin receptors in the brain > 3.b. OT receptor
“It was also found that male ICR mice had lower OTR binding in the VMH than female ICR mice (Tribollet et al., 2002). Male S. xerampelinus singing mice had higher OTR binding in the MeA and hippocampal CA1 compared to females (Campbell et al., 2009). Tuco-tuco (Ctenomys sociabilis) males had higher OTR binding than did females in the MPOA and VMH (Beery et al., 2008).”
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · cited 1×
“The right column depicts representative rat brain images adapted from The Rat Brain Atlas (Paxinos & Watson, 1998).”
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · cited 2×
“The first studies to report intranasal OT effects in humans were done in males only, showing a role for OT in trust and in the processing of socially relevant information (Kosfeld et al., 2005; Zak et al., 2007; Domes et al., 2007; Guastella et al., 2008a; Guastella et al., 2008b; Di Simplicio et al., 2009).”
BackgroundThe oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · cited 6×
“…neurons in the PVN, SON, and accessory nucleus of the hypothalamus (Ross et al., 2009, Knobloch et al., 2012) project centrally, where OT can modulate the activity of many brain regions via binding to the widely distributed OT receptor (OTR; Jard et al., 1987; Gimpl and Fahrenholz, 2001).”
BackgroundInfluentialHypothalamic integration: organization of the paraventricular and supraoptic nuclei
Swanson, L. W., & Sawchenko, P. E. (1983) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.06.030183.001413 · Cited by 1,991 · cited 2×
“…Fliers et al., 1985; Weirda et al., 1991; Meynen et al., 2007) or LH, AH, and MPOA (hamsters, gerbils, voles, naked mole rats: Brownstein et al., 1980; Dierickx, 1980; Rhodes et al., 1981; Swanson and Sawchenko, 1983; Wang et al., 1996; Rosen et al., 2008; Xu et al., 2010; Wang et al., 2013).”
BackgroundPolicy: NIH to balance sex in cell and animal studies
Clayton, J. A., & Collins, F. S. (2014) · Nature · doi:10.1038/509282a · Cited by 1,816 · cited 3×
“…potential of the OT system to restore social dysfunction in sex-biased psychiatric disorders (Guastella et al., 2010a; Meyer-Lindenberg et al., 2011; Cochran et al., 2013), and recent initiatives from the NIH requiring the inclusion of both sexes in preclinical research (Clayton & Collins, 2014).”
BackgroundOxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · cited 5×
“This may further gain momentum because of the potential of the OT system to restore social dysfunction in sex-biased psychiatric disorders (Guastella et al., 2010a; Meyer-Lindenberg et al., 2011; Cochran et al., 2013), and recent initiatives from the NIH requiring the inclusion of both sexes in preclinical research (C…”
BackgroundInfluentialSniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356 · cited 1×
“Furthermore, intranasal VP administration in humans was associated with an increase in VP concentration in cerebrospinal fluid (Born et al., 2002).”
BackgroundOxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · cited 1×
“…studies to report intranasal OT effects in humans were done in males only, showing a role for OT in trust and in the processing of socially relevant information (Kosfeld et al., 2005; Zak et al., 2007; Domes et al., 2007; Guastella et al., 2008a; Guastella et al., 2008b; Di Simplicio et al., 2009).”
BackgroundSocial amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130 · cited 2×
“Here, impaired social recognition was found in male OTR KO mice (Takayanagi et al., 2005; Lee et al., 2008; Macbeth et al., 2009), male OT KO mice (Ferguson et al., 2000; Macbeth et al., 2009), and female OT KO mice (Choleris et al., 2003; Choleris et al, 2006).”
BackgroundEvoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049 · cited 2×
“Moreover, OT synthesized in parvocellular neurons of the PVN (Buijs, 1978; Buijs and Swaab, 1979; Sofroniew, 1980; Sofroniew, 1983) and magnocellular neurons in the PVN, SON, and accessory nucleus of the hypothalamus (Ross et al., 2009; Knobloch et al., 2012) project centrally,where OT canmodulate the activity ofmany…”
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Items 201–300 of 539
Solomon‐Lane, T. K., Butler, R. M., & Hofmann, H. A. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105238 · Cited by 15
“Social dominance is most often studied in adults, in part, because one of the most important benefits of dominance is access to reproductive opportunities (Ellis, 1995).”
BackgroundGimsa, U., Brückmann, R., Tuchscherer, A., Tuchscherer, M., & Kanitz, E. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.980350 · Cited by 18
“These were CRHR1 in the hypothalamus; MR in the amygdala, and MR, GR, CRHR1, and OXTR in the PFC. Interestingly, these sex differences disappeared under stress and were no longer present in DA and DG piglets.”
BackgroundInfluentialThe Role of Androgens and Estrogens in Social Interactions and Social Cognition
Aspesi, D., Bass, N., Kavaliers, M., & Choleris, E. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.03.028 · Cited by 20
Feng, T., An, S., Kinden, R., Zhang, X., Jia, R., & Tai, F. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.038 · Cited by 18
“In addition, sex differences in OXT system parameters have been reported, though these appear to be species-specific [100].”
Sex‐linked roles of the CRF 1 and the CRF 2 receptor in social behavior
Piccin, A., & Contarino, A. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24629 · Cited by 22
“Nevertheless, CRF-mediated activity of oxytocin or vasopressin systems in brain regions other than the SON or the PVN might underlie the sex-linked sociability effects of CRF2 receptor deficiency or pharmacological CRF receptor antagonism observed herein (Dumais & Veenema, 2016).”
BackgroundTowner, T. T., Papastrat, K. M., SPEAR, L. P., Varlinskaya, E. I., & Werner, D. F. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14847 · Cited by 14
Effects of alcohol and psychostimulants on the vasopressin system: Behavioural implications
Godino, A., & Renard, G. M. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12611 · Cited by 17
Oxytocin Attenuates Expression, but Not Acquisition, of Sucrose Conditioned Place Preference in Rats
Patel, D., Sundar, M., Lorenz, E., & Leong, K.-C. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.603232 · Cited by 15
“, 2016) and that oxytocin receptor expression in the brain show sex-specific differences (Dumais and Veenema, 2016).”
BackgroundCardiovascular Neuroendocrinology: Emerging Role for Neurohypophyseal Hormones in Pathophysiology
Aikins, A. O., Nguyen, D. H., Paundralingga, O. T. K., Farmer, G. E., Shimoura, C. G., Brock, C., & Cunningham, J. T. (2021) · Endocrinology · doi:10.1210/endocr/bqab082 · Cited by 17
The Biology of BDSM: A Systematic Review
Wuyts, E., & Morrens, M. (2021) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2021.11.002 · Cited by 18
Sex differences in the brain–an interplay of sex steroid hormones and sex chromosomes
Grgurevič, N., & Majdič, G. (2016) · Clinical Science · doi:10.1042/cs20160299 · Cited by 17
Boulet, N. P., Cloutier, C. J., Ossenkopp, K., & Kavaliers, M. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000271 · Cited by 17
“Finally, as higher levels and effects of OT are found in females than males (Dumais and Veenema, 2015), and because the prevalence of AN in females is higher than in males (Boakes et al.”
BackgroundBozorgmehr, A., Alizadeh, F., Sadeghi, B., Shahbazi, A., Ofogh, S. N., Joghataei, M. T., Razian, S., Heydari, F., & Ghadirivasfi, M. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134328 · Cited by 18
Kania, A., Sambak, P., Guguła, A., Szlaga, A., Sołtys, Z., Błasiak, T., Hess, G., Rajfur, Z., & Błasiak, A. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01989-4 · Cited by 17
Fang, A., Jacoby, R. J., Beatty, C. C., Germine, L. T., Plessow, F., Wilhelm, S., & Lawson, E. A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104541 · Cited by 18
“Linear regression models were used to examine group di ff erences, as well as main e ff ects of sex and group by sex interactions, given reported e ff ects of sex in oxytocin (Dumais and Veenema, 2016).”
MethodWhylings, J., Rigney, N., Vries, G. J. D., & Petrulis, A. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2021.104997 · Cited by 16
H2S and Oxytocin Systems in Early Life Stress and Cardiovascular Disease
McCook, O., Denoix, N., Radermacher, P., Waller, C., & Merz, T. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10163484 · Cited by 16
“OTR is known to be modulated by gonadal hormones [80], and, in addition, both endogenous and exogenous steroids (e.”
BackgroundInfluentialThe Role of OXT, OXTR, AVP, and AVPR1a Gene Expression in the Course of Schizophrenia
Broniarczyk-Czarniak, M., Szemraj, J., Śmigielski, J., & Gałecki, P. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44010025 · Cited by 16
“Oxytocin is released centrally in response to various social and emotional stimuli and modifies human behavior [23,24].”
BackgroundEmotion recognition associated with polymorphism in oxytocinergic pathway gene ARNT2
Hovey, D., Henningsson, S., Cortes, D. S., Bänziger, T., Zettergren, A., Melke, J., Fischer, H., Laukka, P., & Westberg, L. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx141 · Cited by 17
“…in the cerebral expression pattern of ARNT2 before gonadal formation (Dewing et al., 2003) and sexual dimorphism is an established fact when it comes to the OXT and vasopressin systems (Westberg and Walum, 2013; Dumais and Veenema, 2016), both of which are modulated by ARNT2 (Michaud et al., 2000).”
BackgroundHe, F., Wang, Z., & Guo, G. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13788 · Cited by 18
“OT is typically higher in females compared with males (Dumais & Veenema, 2016), and OT impairs emotion perception in women but not men (Lynn et al., 2014).”
ResultMaddahi, A., Edvinsson, L. I., & Warfvinge, K. (2022) · The Journal of Headache and Pain · doi:10.1186/s10194-022-01524-7 · Cited by 16
“OT and AVP often regulate social behaviours in sex-specific ways in adult rats [24, 25].”
BackgroundSex matters: The impact of oxytocin on healthy conditions and psychiatric disorders
Marazziti, D., Carter, C. S., Carmassi, C., Vecchia, A. D., Mucci, F., Pagni, G., Carbone, M. G., Baroni, S., Giannaccini, G., Palego, L., et al. (2022) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2022.100165 · Cited by 18
“In contrast, endogenous AVP synthesis and AVP receptors, especially of the V1a type, tend to be androgen-dependent, especially in brain areas related to social behavior and aggression [29,30].”
BackgroundLoiseau, C., Cayetanot, F., Joubert, F., Perrin‐Terrin, A., Cardot, P., Fiamma, M., Frugière, A., Straus, C., & Bodineau, L. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170719104605 · Cited by 18
“These regulatory mechanisms of progesterone shown in peripheral tissues probably occur in the CNS, where the oxytocin receptor is expressed [165, 166].”
BackgroundVoluntary alcohol consumption is increased in female, but not male, oxytocin receptor knockout mice
Rodriguez, K. M., Smith, B. L., & Caldwell, H. K. (2020) · Brain and Behavior · doi:10.1002/brb3.1749 · Cited by 13
“As previous studies have suggested, it may be that sex differences in Oxt are directly regulating sex-specific behaviors [for review see Caldwell (2018), Dumais and Veenema (2016)], in this case alcohol consumption.”
BackgroundMeyer, M. A. A., Anstötz, M., Ren, L. Y., Fiske, M. P., Guedea, A. L., Grayson, V. S., Schroth, S. L., Cicvaric, A., Nishimori, K., Maccaferri, G., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01091-y · Cited by 19
Marazziti, D., Diep, P.-T., Carter, C. S., & Carbone, M. G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220727120646 · Cited by 16
Imaging neuropeptide effects on human brain function
Lefèvre, A., Hurlemann, R., & Grinevich, V. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2899-6 · Cited by 16
Childhood stress impairs social function through AVP-dependent mechanisms
Brydges, N. M., Hall, J., Best, C., Rule, L., Watkin, H., Drake, A. J., Lewis, C., Thomas, K. L., & Hall, J. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0678-0 · Cited by 18
Effects of oxytocin administration on salivary sex hormone levels in autistic and neurotypical women
Procyshyn, T. L., Lombardo, M. V., Lai, M., Bonnie Auyeung, B., Crockford, S. K., Deakin, J., Soubramanian, S., Sule, A., Baron‐Cohen, S., & Bethlehem, R. A. I. (2020) · Molecular Autism · doi:10.1186/s13229-020-00326-5 · Cited by 16
Taylor, J. H., McCann, K. E., Ross, A. P., & Albers, H. E. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12882 · Cited by 18
Pharmacological Treatment for Social Cognition: Current Evidence
Riccardi, C., Montemagni, C., Favero, E. D., Bellino, S., Brasso, C., & Rocca, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147457 · Cited by 16
“It is also interesting to note that the receptor distribution is different between males and females in montane voles [119].”
BackgroundThe vasotocinergic system and its role in the regulation of stress in birds
Kuenzel, W. J., Kang, S. W., & Jurkevich, A. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.10.004 · Cited by 12
Selective sub-nucleus effects of intra-amygdala oxytocin on fear extinction
Gunduz‐Cinar, O., Brockway, E. T., Castillo, L. I., Pollack, G. A., Erguven, T., & Holmes, A. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112798 · Cited by 14
Sex differences of oxytocin and vasopressin in social behaviors
Lu, Q., & Hu, S. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820107-7.00005-7 · Cited by 19
Blending oxytocin and dopamine with everyday creativity
Chong, A., Tolomeo, S., Yue, X., Angeles, D. C., Cheung, M. W. ‐., Becker, B., Lai, P. S., Lei, Z., Malavasi, F., Tang, Q., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-95724-x · Cited by 16
Oxytocin reduces the link between neural and affective responses after social exclusion
Petereit, P., Rinn, C., Stemmler, G., & Mueller, E. M. (2019) · Biological Psychology · doi:10.1016/j.biopsycho.2019.05.002 · Cited by 15
Social affective behaviors among female rats involve the basolateral amygdala and insular cortex
Djerdjaj, A., Rieger, N. S., Brady, B. H., Carey, B. N., Ng, A. J., & Christianson, J. P. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281794 · Cited by 14
“Given known sex differences in oxytocin receptor expression [56, 58, 64], we next sought to test whether oxytocin would alter social interactions in females.”
BackgroundHippocampus Oxytocin Signaling Promotes Prosocial Eating in Rats
Rea, J. J., Liu, C. M., Hayes, A., Bashaw, A. G., Schwartz, G. M., Ohan, R., Décarie-Spain, L., Kao, A. E., Klug, M. E., Phung, K. J., et al. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.07.014 · Cited by 13
Cingulate to septal circuitry facilitates the preference to affiliate with large peer groups
Fricker, B. A., Murugan, M., Seifert, A. W., & Kelly, A. M. (2024) · Current Biology · doi:10.1016/j.cub.2024.08.019 · Cited by 12
Subtle sex differences in vasopressin mRNA expression in the embryonic mouse brain
Aulino, E. A., & Caldwell, H. K. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12835 · Cited by 15
Oxytocin Signaling as a Target to Block Social Defeat-Induced Increases in Drug Abuse Reward
Perez, C. F., Reguilón, M. D., Miñarro, J., & Rodríguez‐Arias, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052372 · Cited by 15
“such as the mesolimbic circuit (including the PFC), NAc, and ventral tegmental area (VTA), among others [2,3].”
BackgroundXie, S., Hu, Y., Fang, L., Chen, S., Botchway, B. O. A., Tan, X., Fang, M., & Hu, Z. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0128 · Cited by 14
Sex-Related Predisposition to Post-Traumatic Stress Disorder Development—The Role of Neuropeptides
Lehner, M., Skórzewska, A., & Wisłowska-Stanek, A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19010314 · Cited by 15
“, forebrain and hypothalamus) between males and females [74,75].”
BackgroundTowner, T. T., Applegate, D. T., Varlinskaya, E. I., & Werner, D. F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.841657 · Cited by 13
“For example, the LS receives greater AVP innervation from the bed nucleus of the stria terminalis (BNST) (De Vries et al., 1981; De Vries and Buijs, 1983) and HYPO (Qiao et al., 2014) in male than in female rodents.”
BackgroundDhungel, S., Rai, D., Terada, M., Orikasa, C., Nishimori, K., Sakuma, Y., & Kondo, Y. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.11.008 · Cited by 15
Paraventricular Nucleus of the Hypothalamus Oxytocin and Incubation of Heroin Seeking
Carter, J. S., Wood, S. K., Kearns, A., Hopkins, J. L., & Reichel, C. M. (2023) · Neuroendocrinology · doi:10.1159/000529358 · Cited by 15
“Furthermore, males and females had similar levels of endogenous oxytocin release in the CeA (in vivo micro-dialysis) at baseline and during a social interest task [61].”
BackgroundThe use of intranasal oxytocin in the treatment of eating disorders
Malewska-Kasprzak, M., Jowik, K., & Tyszkiewicz‐Nwafor, M. (2023) · Neuropeptides · doi:10.1016/j.npep.2023.102387 · Cited by 13
“In addition, it is one of the primary biological determinants of social behavior related to the formation of attachment, such as between mother and child, and during pairing (Liu et al., 2022; Dumais and Veenema, 2016).”
InfluentialTalpo, F., Spaiardi, P., Castagno, A. N., Maniezzi, C., Raffin, F., Terribile, G., Sancini, G., Pisani, A., & Biella, G. R. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1082010 · Cited by 15
“However, OT also acts as a neuromodulator in the central nervous system controlling various social and emotional forms of behavior such as attachment, social exploration, social recognition, aggression, anxiety, fear conditioning, and fear extinction (Donaldson and Young, 2008; Heinrichs et al., 2009; Matsuzaki et al.…”
BackgroundHaram, M., Bettella, F., Brandt, C. L., Quintana, D. S., Nerhus, M., Bjella, T., Djurovic, S., Westlye, L. T., Andreassen, O. A., Melle, I., et al. (2016) · BJPsych Open · doi:10.1192/bjpo.bp.116.003376 · Cited by 13
“45 The expression of central oxytocin is steroid-SCZ dependent, 46 the central regulation differs between men and women, 47 and men and women respond differently to exogenous oxytocin.”
Effects of exogenous oxytocin and atosiban antagonist on GABA in different region of brain
Thakur, P., Shrivastava, R., & Shrivastava, V. K. (2019) · IBRO Reports · doi:10.1016/j.ibror.2019.04.001 · Cited by 14
Chen, X., Xu, Y., Li, B., Wu, X., Li, T., Wang, L., Zhang, Y., Lin, W., Qu, C., & Feng, C. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108561 · Cited by 13
Polk, R. J., Horta, M., Lin, T., Porges, E. C., Ojeda, M., Nazarloo, H. P., Carter, C. S., & Ebner, N. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0048 · Cited by 12
Bredewold, R., Washington, C., & Veenema, A. H. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-024-01987-z · Cited by 13
“There is strong evidence that AVP facilitates social and cognitive abilities across a wide variety of species, including humans, and is often doing so in sex-speci fi c ways [25, 26].”
Self-citationFunctions of habenula in reproduction and socio-reproductive behaviours
Ogawa, S., & Parhar, I. S. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100964 · Cited by 10
Tsingotjidou, A. (2022) · Biomolecules · doi:10.3390/biom12111603 · Cited by 18
“In addition to the two major areas of production, oxytocin is also synthesized in some species in additional sites, including the bed nucleus of the stria terminalis (BNST), the medial preoptic area (MPOA), the lateral hypothalamus (LH) and the medial amygdala (MeA) [21,22].”
BackgroundSuprachiasmatic nucleus promotes hyperglycemia induced by sleep delay
Hurtado‐Alvarado, G., Soto‐Tinoco, E., Santacruz-Martínez, E., Prager‐Khoutorsky, M., Escobar, C., & Buijs, R. M. (2023) · Current Biology · doi:10.1016/j.cub.2023.08.071 · Cited by 14
“6,17,18 Thus, we hypothesized that the decreased SCN VP neuronal activity during SD caused hyperglycemia due to decreased VP release onto ARC tanycytes.”
Kavaliers, M., Colwell, D. D., Wah, D. T. O., Bishnoi, I. R., Ossenkopp, K., & Choleris, E. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.04.016 · Cited by 11
The supraoptic and paraventricular nuclei in healthy aging and neurodegeneration
Stewart, C. A., & Finger, E. C. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820107-7.00007-0 · Cited by 11
Emerging roles for microglia and microbiota in the development of social circuits
Smith, C. J. W. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100296 · Cited by 11
“…as the oxytocin and vasopressin systems are potent regulators of social behavior within these networks and their receptors and synaptic connections change with sex, age, and developmental exposure to immune challenges and stress (Smith et al., 2019; Dumais and Veenema, 2016; Raam and Hong, 2021).”
McCormick, C. M. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2021_245 · Cited by 14
Li, L., Li, P., Guo, J., Wu, Y., Zeng, Q., Li, N., Huang, X., He, Y., Ai, W., Sun, W., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16042 · Cited by 12
“Accumulating evidence suggests that OXT and OXTR exert an antinociceptive action in the brain (Dumais & Veenema, 2016; Etehadi Moghadam et al., 2018).”
BackgroundThe Potential Role of Gut Peptide Hormones in Autism Spectrum Disorder
Qi, X., & Zhang, L. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00073 · Cited by 12
“, 2009) which can regulate social behaviors (Dumais and Veenema, 2016).”
BackgroundQuintana, D. S. (2018) · OSF Preprints (OSF Preprints) · Cited by 12
Duque‐Wilckens, N., Trainor, B. C., & Marler, C. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.90064-5 · Cited by 14
Oxytocin signaling regulates maternally directed behavior during early life
Zelmanoff, D. D., Bornstein, R., Kaufman, M., Dine, J., Wietek, J., Litvin, A., Abraham, S., Cohen, S., Atzmon, A., Porat, I., et al. (2025) · Science · doi:10.1126/science.ado5609 · Cited by 13
Kunitake, Y., Mizoguchi, Y., Imamura, Y., Kunitake, H., Orihashi, R., Matsushima, J., Tateishi, H., Murakawa‐Hirachi, T., Yamada, S., & Monji, A. (2022) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2022.100166 · Cited by 11
“These discrepancies may be because of differences in the commercially available methods for quantifying plasma OT concentrations used between studies [48].”
MethodProsocial Helping Behavior: Conceptual Issues and Neural Mechanisms
Rigney, N., & Hong, W. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.03.003 · Cited by 32
Paternally expressed gene 3 (Pw1/Peg3) promotes sexual dimorphism in metabolism and behavior
Tanaka, K., Besson, V., Rivagorda, M., Oury, F., Marazzi, G., & Sassoon, D. A. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010003 · Cited by 13
“These regions are primary sites of AVP production and vasopressinergic neuronal projections [50,55].”
BackgroundProcyshyn, T. L., Hurd, P. L., & Crespi, B. J. (2016) · Autism Research · doi:10.1002/aur.1716 · Cited by 13
“Furthermore, AVPR1a receptor distribution and binding affinity have been shown to differ in the brains of male versus female rodents [Dumais & Veenema, 2016].”
BackgroundRegion‐specific sex modulation of central oxytocin receptor by gut microbiota: An ontogenic study
Effah, F., Silva, N. K. D. G. T., Camarini, R., Joly, F., Rabot, S., Bombail, V., & Bailey, A. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22805 · Cited by 11
“…in the effects of OT on several social behaviors including social avoidance, social recognition, partner preference, social play, and social interest in males and females have been consistently reported across several species indicating a profound sexual dimorphism effect (Dumais & Veenema, 2016).”
BackgroundMethodInfluentialConformational selection of vasopressin upon V 1a receptor binding
Che, K., Muttenthaler, M., & Kurzbach, D. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.10.024 · Cited by 11
Nazzari, S., Grumi, S., Villa, M., Mambretti, F., Biasucci, G., Decembrino, L., Giacchero, R., Magnani, M. L., Nacinovich, R., Prefumo, F., et al. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105920 · Cited by 12
Quantitative Cellular-Resolution Map of the Oxytocin Receptor in Postnatally Developing Mouse BrainsPreprint
Newmaster, K. T., Nolan, Z. T., Chon, U., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/719229 · Cited by 11
Whylings, J., Rigney, N., Vries, G. J. D., & Petrulis, A. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12915 · Cited by 10
Raymond, J. S., Rehn, S., James, M. H., Everett, N. A., & Bowen, M. T. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00612-4 · Cited by 14
“…several key parameters (and their interactions) on social motivation remain to be systematically investigated—biological sex, housing conditions, time-of-day (ToD), and the sex of the social stimuli—all of which have been shown to influence social behaviours assessed using other paradigms [52–55].”
MethodResultVagal oxytocin receptors are necessary for esophageal motility and function
Asker, M., Krieger, J.-P., Marić, I., Bedel, E., van der Steen, J. T., Börchers, S., Wen, Y., Longo, F., Aronsson, P., Winder, M., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.190108 · Cited by 12
“Experiments were conducted in male and female rats, as most previous studies overlooked assessing the role or presence of OTR in female vagus nerve (11, 22, 26, 31, 32), and sex differences are known to exist in the central and peripheral oxytocin systems (54).”
Peripheral Oxytocin Predicts Higher-Level Social Cognition in Men Regardless of Empathy Quotient
Deuse, L., Wudarczyk, O. A., Rademacher, L., Kaleta, P., Karges, W., Kacheva, S., Gründer, G., & Lammertz, S. E. (2018) · Pharmacopsychiatry · doi:10.1055/a-0590-4850 · Cited by 11
“Second, only men were included, as OT is known to regulate social behavior differentially in men and women [68].”
BackgroundReddon, A. R., Aubin‐Horth, N., & Reader, S. M. (2021) · Journal of Zoology · doi:10.1111/jzo.12937 · Cited by 9
Sex differences in serotonergic control of rat social behaviour
Poceviciute, I., Kasperaviciute, K., Buišas, R., Rukšėnas, O., & Vengeliene, V. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173533 · Cited by 11
Wasilewski, M. A., Grisanti, L. A., Song, J., et al. (2016) · Clinical Science · doi:10.1042/cs20160363 · Cited by 10
OXTR polymorphism in depression and completed suicide—A study on a large population sample
Wasilewska, K., Pawlak, A., Kostrzewa, G., Sobczyk‐Kopcioł, A., Kaczorowska, A., Badowski, J., Brzozowska, M., Drygas, W., Piwoński, J., Bielecki, W., et al. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.12.003 · Cited by 10
Freeman, A. R., Hare, J. F., & Caldwell, H. K. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24400 · Cited by 10
Perkins, A. E., Varlinskaya, E. I., & Terrence Deak, B. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.05.005 · Cited by 10
“However, the previously observed sex differences in the BNST OXT system and the lack of these differences in the present study are not surprising, given that sex differences in OXTR system are both brain region- and strain-specific [74].”
BackgroundPflimlin, E., Zhou, Z., Amso, Z., Fu, Q., Lee, C., Muppidi, A., Joseph, S. B., Nguyen-Tran, V. T. B., & Shen, W. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01862 · Cited by 9
Hou, W., Ma, H., Xun, Y., Zhang, X., Cai, W., Huang, S., He, Z., Tai, F., & Jia, R. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.625116 · Cited by 10
“OT and AVP are evolutionarily conserved and are involved in the regulation of mood and diverse social behaviors in a sex-dependent manner (Dumais and Veenema, 2016; Li et al., 2016).”
BackgroundDumais, K. M., & Veenema, A. H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802114-9.00011-1 · Cited by 11
Self-citationDevelopment of a radioligand for imaging V 1a vasopressin receptors with PET
Naik, R., Valentine, H., Hall, A., Mathews, W. B., Harris, J. C., Carter, C. S., Dannals, R. F., Wong, D. F., & Horti, A. G. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.08.037 · Cited by 9
Sivukhina, E. V., & Jirikowski, G. F. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101882 · Cited by 9
A Glimpse Into the Sexual Dimorphisms in Major Depressive Disorder Through Epigenetic Studies
Cahill, B., Poelker-Wells, S., Prather, J. F., & Li, Y. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.768571 · Cited by 11
“In addition, it has also been suggested that genetic, epigenetic and environmental factors all have impacts on sex differences in social behavior (Manuck et al., 2000; Hammock and Young, 2004; Shepard et al., 2009; Aspe-Sanchez et al., 2015; Dumais and Veenema, 2016).”
BackgroundBonaldo, B., Casile, A., Bettarelli, M., Gotti, S., Panzica, G., & Marraudino, M. (2021) · European Journal of Histochemistry · doi:10.4081/ejh.2021.3272 · Cited by 9
Modelling sexual violence in male rats: the sexual aggression test (SxAT)
Oliveira, V. E. D. M., A, T. R. D. J., & Neumann, I. D. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01973-3 · Cited by 10
“Based on their proven capacity to promote sexual behavior (OXT [19, 24]) and to differentially modulate territorial aggression (OXT and AVP [19, 25, 26, 30–33, 52]), and other relevant social behaviors [18, 19, 53, 54], the OXT and AVP systems were first selected as targets.”
BackgroundBAXTER, A. B., Karaskiewicz, C. L., Campbell, L. A., Kinnally, E. L., Ferrer, E. E., Seelke, A. M. H., Freeman, S. M., & Bales, K. L. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13304 · Cited by 10
Klauß, H., Kunkel, A., Müßgens, D., Haaker, J., & Bingel, U. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1293975 · Cited by 12
“For placebo analgesia, different underlying psychophysiological mechanisms in women versus men are being discussed (Dumais and Veenema, 2016; Zhang et al., 2021; Shafir et al., 2022) and symptom reports seem to vary depending on gender (Shafir et al., 2022).”
BackgroundYang, X., Tang, Y., Wei, Q., Lang, B., Tao, H., Zhang, X., Liu, Y., & Tang, A. (2017) · Oncotarget · doi:10.18632/oncotarget.20252 · Cited by 9
“Besides, the AVP level was reported typically higher in males than females in a recent review [38] and Sacher et al.”
ResultSepp, K., Molnár, Z., László, A., Alapi, T., Tóth, L., Serester, A., Valkusz, Z., Gálfi, M., & Radács, M. (2019) · International Journal of Endocrinology · doi:10.1155/2019/1546131 · Cited by 9
Early Environments Shape Neuropeptide Function: The Case of Oxytocin and Vasopressin
Perry‐Paldi, A., Hirschberger, G., Feldman, R., Zagoory‐Sharon, O., Bazak, S. B., & Ein‐Dor, T. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00581 · Cited by 9
Wang, J., Jin, S., Fu, W., Liang, Y., Yang, Y., & Xu, X. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112843 · Cited by 9
Rohr, K. E., Inda, T., & Evans, J. A. (2021) · Neuroendocrinology · doi:10.1159/000521286 · Cited by 9
Dzirbíková, Z., Talarovičová, A., Štefánik, P., Olexová, L., & Kršková, L. (2018) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2018-024 · Cited by 9
“It is therefore possible that a sex difference observed in be‑ havior is a result of an interaction between sex‑specif‑ ic receptor density in the brain (Dumais and Veenema 2016) and a possible compensatory mechanism of ele‑ vated AVP expression acting via OT receptors.”
Worley, N. B., Dumais, K. M., Yuan, J. C., Newman, L. E., Alonso, A. G., Gillespie, T. C., Hobbs, N. J., Breedlove, S. M., Jordan, C. L., Bredewold, R., et al. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12760 · Cited by 9
Self-citation
Metadata
- Authors
- Dumais, K. M., & Veenema, A. H.
- Affiliations
- Boston College (US)
- Corresponding author
- Dumais, Kelly M.
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 40
- Pages
- 1-23
- ISSN
- 0091-3022 (ISSN-L)
- PMC
- PMC4633405
- OpenAlex
- W318497691
- Semantic Scholar
- 574d709e73a149f815895751a2ba2c3bda879881
- Cited by
- 520
- References
- 350
- Citations by year
- 2026: 41 · 2025: 54 · 2024: 41 · 2023: 37 · 2022: 42 · 2021: 72 · 2020: 43 · 2019: 53 · 2018: 61 · 2017: 43 · 2016: 26
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 428 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Frontiers in Neuroendocrinology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIMH (F31MH100891, R15MH102807, R01MH102456)
- NSF IOS (1253386)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- vasopressin, oxytocin, vasopressin V1a receptor, oxytocin receptor, sex differences, social behavior, neuropeptides, sexually dimorphic gene expression, brain region-specific expression, rodent models, neuropsychiatric disorders, social dysfunction
- MeSH terms
- Animals, Arginine Vasopressin, Humans, Oxytocin, Sex Characteristics, Social Behavior, Vasopressins, Receptors, Oxytocin
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