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Metal–Organic Frameworks for Drug Delivery: A Design Perspective

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Lawson, Harrison D., Walton, S. Patrick, Chan, Christina·2021·ACS Applied Materials & Interfaces

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Abstract

The use of metal-organic frameworks (MOFs) in biomedical applications has greatly expanded over the past decade due to the precision tunability, high surface areas, and high loading capacities of MOFs. Specifically, MOFs are being explored for a wide variety of drug delivery applications. Initially, MOFs were used for delivery of small-molecule pharmaceuticals; however, more recent work has focused on macromolecular cargos, such as proteins and nucleic acids. Here, we review the historical application of MOFs for drug delivery, with a specific focus on the available options for designing MOFs for specific drug delivery applications. These options include choices of MOF structure, synthetic method, and drug loading. Further considerations include tuning, modifications, biocompatibility, cellular targeting, and uptake. Altogether, this Review aims to guide MOF design for novel biomedical applications.

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See all 916

Authors: Lawson, H. D., Walton, S. P., & Chan, C.
Venue: ACS Applied Materials & Interfaces
Publisher: American Chemical Society (ACS)
Published: 2021-02-07
Volume: 13
Issue: 6
Pages: 7004-7020
ISSN: 1944-8244 (ISSN-L)
1944-8252
DOI: 10.1021/acsami.1c01089
OpenAlex: W3127881081
Cited by: 916
References: 132
FWCI: 46.56
Type: journal article
Language: en
Open access: green

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Metal–Organic Frameworks for Drug Delivery: A Design Perspective

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