The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Free Radical Lipid Peroxidation: Mechanisms and Analysis
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTFree Radical Lipid Peroxidation: Mechanisms and AnalysisHuiyong Yin†‡, Libin Xu†, and Ned A. Porter*†View Author Information† Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States‡ Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, Vanderbilt School of Medicine, Nashville, Tennessee 37232, United StatesE-mail: [email protected]Cite this: Chem. Rev. 2011, 111, 10, 5944–5972Publication Date (Web):August 23, 2011Publication History Received18 March 2011Published online23 August 2011Published inissue 12 October 2011https://pubs.acs.org/doi/10.1021/cr200084zhttps://doi.org/10.1021/cr200084zreview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views20137Altmetric-Citations1255LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Free radicals,Lipids,Oxidation,Oxides,Oxygen Get e-Alerts
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
Funk, C. D. (2001) · Science · doi:10.1126/science.294.5548.1871 · Cited by 3,817
Oxidative Stress in Neurodegenerative Diseases
Simonian, N. A., & Coyle, J. T. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.000503 · Cited by 1,377
Imai, Y., Kuba, K., Neely, G. G., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, Y. H. C., Wang, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.043 · Cited by 1,356
Lipidomics reveals a remarkable diversity of lipids in human plasma
Quehenberger, O., Armando, A. M., Brown, A. H., Milne, S. B., Myers, D. S., Merrill, A. H., Bandyopadhyay, S., Jones, K. N., Kelly, S., Shaner, R. L., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m009449 · Cited by 1,341
Mechanisms of free radical oxidation of unsaturated lipids
Porter, N. A., Caldwell, S. E., & Mills, K. A. (1995) · Lipids · doi:10.1007/bf02536034 · Cited by 1,208
Self-citationBenedetti, A., Comporti, M., & Esterbauer, H. (1980) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(80)90209-x · Cited by 1,085
Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome
Tint, G. S., Irons, M., Elias, E. R., Batta, A. K., Frieden, R., Chen, T. S., & Salen, G. (1994) · New England Journal of Medicine · doi:10.1056/nejm199401133300205 · Cited by 798
Autoxidation of biological molecules. 4. Maximizing the antioxidant activity of phenols
Burton, G. W., Doba, T., Gabe, E., Hughes, L., Lee, F. L., Prasad, L., & Ingold, K. U. (1985) · Journal of the American Chemical Society · doi:10.1021/ja00310a049 · Cited by 779
Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype
Podrez, E. A., Byzova, T. V., Febbraio, M., Salomon, R. G., Ma, Y., Valiyaveettil, M., Poliakov, E., Sun, M., Finton, P. J., Curtis, B. R., et al. (2007) · Nature Medicine · doi:10.1038/nm1626 · Cited by 513
Malformation syndromes caused by disorders of cholesterol synthesis
Porter, F. D., & Herman, G. E. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r009548 · Cited by 473
Cited by
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293
NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
Dodson, M., Castro-Portuguez, R., & Zhang, D. D. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101107 · Cited by 2,435
Lipid peroxidation and ferroptosis: The role of GSH and GPx4
Ursini, F., & Maiorino, M. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.027 · Cited by 1,954
Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo
Murphy, M. P., Bayir, H., Belousov, V., Chang, C. J., Davies, K. J. A., Davies, M. J., Dick, T. P., Finkel, T., Forman, H. J., Janssen-Heininger, Y., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00591-z · Cited by 1,514
Self-citationFerroptosis: Mechanisms and links with diseases
Yan, H.-F., Zou, T., Tuo, Q.-Z., Xu, S., Li, H., Belaidi, A. A., & Lei, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00428-9 · Cited by 1,471
GPX4 at the crossroads of lipid homeostasis and ferroptosis
Forcina, G. C., & Dixon, S. J. (2019) · PROTEOMICS · doi:10.1002/pmic.201800311 · Cited by 1,025
Free radicals and antioxidants: updating a personal view
Halliwell, B. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00476.x · Cited by 912
Insight into the mechanism of ferroptosis inhibition by ferrostatin-1
Miotto, G., Rossetto, M., Di Paolo, M. L., Orian, L., Venerando, R., Roveri, A., Vučković, A.-M., Bosello Travain, V., Zaccarin, M., Zennaro, L., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2019.101328 · Cited by 906
Applications of Deuterium in Medicinal Chemistry
Pirali, T., Serafini, M., Cargnin, S., & Genazzani, A. A. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01808 · Cited by 855
Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis
Shah, R., Shchepinov, M. S., & Pratt, D. A. (2018) · ACS Central Science · doi:10.1021/acscentsci.7b00589 · Cited by 782
Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
Feng, H., & Stockwell, B. R. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2006203 · Cited by 759
Lipid metabolism in cancer: New perspectives and emerging mechanisms
Broadfield, L. A., Pane, A. A., Talebi, A., Swinnen, J. V., & Fendt, S.-M. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.04.013 · Cited by 758
Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis
Zou, Y., Li, H., Graham, E. T., Deik, A. A., Eaton, J. K., Wang, W., Sandoval-Gomez, G., Clish, C. B., Doench, J. G., & Schreiber, S. L. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0472-6 · Cited by 734
Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers
Soula, M., Weber, R. A., Zilka, O., Alwaseem, H., La, K., Yen, F., Molina, H., Garcia-Bermudez, J., Pratt, D. A., & Birsoy, K. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0613-y · Cited by 732
Ferroptosis in cancer and cancer immunotherapy
Zhao, L., Zhou, X., Xie, F., Zhang, L., Yan, H., Huang, J., Zhang, C., Zhou, F., Chen, J., & Zhang, L. (2022) · Cancer Communications · doi:10.1002/cac2.12250 · Cited by 684
Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins
Di Mascio, P., Martinez, G. R., Miyamoto, S., Ronsein, G. E., Medeiros, M. H. G., & Cadet, J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00554 · Cited by 659
Aldehyde dehydrogenases in cellular responses to oxidative/electrophilicstress
Singh, S., Brocker, C., Koppaka, V., Chen, Y., Jackson, B. C., Matsumoto, A., Thompson, D. C., & Vasiliou, V. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.010 · Cited by 601
Mitochondrial regulation of ferroptosis
Gan, B. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202105043 · Cited by 601
Ferroptosis Inhibition: Mechanisms and Opportunities
Angeli, J. P. F., Shah, R., Pratt, D. A., & Conrad, M. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.02.005 · Cited by 563
Biomarkers of Oxidative Stress and Antioxidant Defense
Demirci-Çekiç, S., Özkan, G., Avan, A. N., Uzunboy, S., Çapanoğlu, E., & Apak, R. (2022) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.114477 · Cited by 587
Ageing, age-related diseases and oxidative stress: What to do next?
Luo, J., Mills, K., le Cessie, S., Noordam, R., & van Heemst, D. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100982 · Cited by 581
“arachidonic acid and linoleate, are highly susceptible to ROS and free radicals, known as autocatalytic chain reaction (Yin et al., 2011).”
BackgroundRole of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria
Zhong, H., & Yin, H. (2015) · Redox Biology · doi:10.1016/j.redox.2014.12.011 · Cited by 536
Self-citationLipids and Alzheimer’s Disease
Kao, Y.-C., Ho, P.-C., Tu, Y.-K., Jou, I.-M., & Tsai, K.-J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041505 · Cited by 485
Antioxidant chemistry of graphene-based materials and its role in oxidation protection technology
Qiu, Y., Wang, Z., Owens, A. C. E., Kulaots, I., Chen, Y., Kane, A. B., & Hurt, R. H. (2014) · Nanoscale · doi:10.1039/c4nr03275f · Cited by 481
Griendling, K. K., Touyz, R. M., Zweier, J. L., Dikalov, S., Chilian, W., Chen, Y.-R., Harrison, D. G., & Bhatnagar, A. (2016) · Circulation Research · doi:10.1161/res.0000000000000110 · Cited by 444
Degradation during application of ultrasound in food processing: A review
Pingret, D., Fabiano-Tixier, A.-S., & Chemat, F. (2013) · Food Control · doi:10.1016/j.foodcont.2012.11.039 · Cited by 419
Antioxidants: a comprehensive review
Gulcin, İ. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-03997-2 · Cited by 386
Lipid Metabolism and Ferroptosis
Lee, J.-Y., Kim, W. K., Bae, K.-H., Lee, S. C., & Lee, E.-W. (2021) · Biology · doi:10.3390/biology10030184 · Cited by 374
7-Dehydrocholesterol dictates ferroptosis sensitivity
Li, Y., Ran, Q., Duan, Q., Jin, J., Wang, Y., Yu, L., Wang, C., Zhu, Z., Chen, X., Weng, L., et al. (2024) · Nature · doi:10.1038/s41586-023-06983-9 · Cited by 367
Self-citationRedox Signaling by Reactive Electrophiles and Oxidants
Parvez, S., Long, M. J. C., Poganik, J. R., & Aye, Y. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00698 · Cited by 359
Oxidative Stress: Signaling Pathways, Biological Functions, and Disease
Liu, S., Liu, J., Wang, Y., Deng, F., & Deng, Z. (2025) · MedComm · doi:10.1002/mco2.70268 · Cited by 359
Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection
Galano, A., & Reiter, R. J. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12514 · Cited by 353
Emerging mechanisms and targeted therapy of ferroptosis in cancer
Wang, H., Cheng, Y., Mao, C., Liu, S., Xiao, D., Huang, J., & Tao, Y. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.03.022 · Cited by 312
Antioxidant Capacity Determination in Plants and Plant‐Derived Products: A Review
Pisoschi, A. M., Pop, A., Cimpeanu, C., & Predoi, G. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9130976 · Cited by 304
ROS from Physical Plasmas: Redox Chemistry for Biomedical Therapy
Privat-Maldonado, A., Schmidt, A., Lin, A., Weltmann, K.-D., Wende, K., Bogaerts, A., & Bekeschus, S. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9062098 · Cited by 304
Danylchuk, D. I., Jouard, P.-H., & Klymchenko, A. S. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.0c10972 · Cited by 298
Biomarkers of lipid peroxidation in clinical material
Niki, E. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.03.020 · Cited by 297
Activation of lysosomal iron triggers ferroptosis in cancer
Cañeque, T., Baron, L., Müller, S., Carmona, A., Colombeau, L., Versini, A., Solier, S., Gaillet, C., Sindikubwabo, F., Sampaio, J. L., et al. (2025) · Nature · doi:10.1038/s41586-025-08974-4 · Cited by 287
Involvement of free radicals and oxidative stress in NAFLD/NASH
Sumida, Y., Niki, E., Naito, Y., & Yoshikawa, T. (2013) · Free Radical Research · doi:10.3109/10715762.2013.837577 · Cited by 280
Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement
Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00531 · Cited by 276
Mitochondrial DNA damage and its consequences for mitochondrial gene expression
Cline, S. D. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.06.002 · Cited by 203
Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?
Ademowo, O. S., Dias, H. K. I., Burton, D. G. A., & Griffiths, H. R. (2017) · Biogerontology · doi:10.1007/s10522-017-9710-z · Cited by 184
Chemistry and analysis of HNE and other prominent carbonyl-containing lipid oxidation compounds
Sousa, B. C., Pitt, A. R., & Spickett, C. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.003 · Cited by 172
Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain
Dassati, S., Waldner, A., & Schweigreiter, R. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.148 · Cited by 163
van't Erve, T. J., Lih, F. B., Jelsema, C., Deterding, L. J., Eling, T. E., Mason, R. P., & Kadiiska, M. B. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.03.001 · Cited by 81
Oxidative Stress-Related Mechanisms in Melanoma and in the Acquired Resistance to Targeted Therapies
Pizzimenti, S., Ribero, S., Cucci, M. A., Grattarola, M., Monge, C., Dianzani, C., Barrera, G., & Muzio, G. (2021) · Antioxidants · doi:10.3390/antiox10121942 · Cited by 79
Alkhalifa, A. E., Alkhalifa, O., Durdanovic, I., Ibrahim, D. R., & Maragkou, S. (2025) · Journal of Dementia and Alzheimer's Disease · doi:10.3390/jdad2020017 · Cited by 66
Kim, H.-Y. H., Korade, Z., Tallman, K. A., Liu, W., Weaver, C. D., Mirnics, K., & Porter, N. A. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00054 · Cited by 53
Self-citationZoppi, N., Chiarelli, N., Cinquina, V., Ritelli, M., & Colombi, M. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv382 · Cited by 50
“such as 4-hydroxy-2-nonenal (4-HNE), which is considered a major bioactive marker of LPO (37).”
Vitlov Uljević, M., Starčević, K., Mašek, T., Bočina, I., Restović, I., Kević, N., Racetin, A., Kretzschmar, G., Grobe, M., Vukojević, K., et al. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-03058-y · Cited by 40
Desmosterolosis and desmosterol homeostasis in the developing mouse brain
Allen, L. B., Genaro‐Mattos, T. C., Porter, N. A., Mirnics, K., & Korade, Z. (2019) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12088 · Cited by 31
Self-citationPhoto-induced protein oxidation: mechanisms, consequences and medical applications
Fuentes-Lemus, E., & López-Alarcón, C. (2020) · Essays in Biochemistry · doi:10.1042/ebc20190044 · Cited by 29
Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila
Lee, T., Chen, P., Su, M. P., Li, J., Chang, Y., Liu, R., Juan, H., Yang, J., Chan, S., Tsai, Y., et al. (2021) · Aging Cell · doi:10.1111/acel.13379 · Cited by 27
Ten “Cheat Codes” for Measuring Oxidative Stress in Humans
Cobley, J. N., Margaritelis, N. V., Chatzinikolaou, P. N., Nikolaidis, M. G., & Davison, G. W. (2024) · Antioxidants · doi:10.3390/antiox13070877 · Cited by 17
Metadata
- Authors
- Yin, H., Xu, L., & Porter, N. A.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-08-23
- Volume
- 111
- Issue
- 10
- Pages
- 5944-5972
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2060035882
- Cited by
- 1,937
- References
- 18
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.