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The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Dendritic spine changes associated with hippocampal long-term synaptic plasticity

Engert, Florian, Bonhoeffer, Tobias·1999·Nature
DOI 10.1038/19978
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Abstract

Long-term enhancement of synaptic efficacy in the hippocampus is an important model for studying the cellular mechanisms of neuronal plasticity, circuit reorganization, and even learning and memory. Although these long-lasting functional changes are easy to induce, it has been very difficult to demonstrate that they are accompanied or even caused by morphological changes on the subcellular level. Here we combined a local superfusion technique with two-photon imaging, which allowed us to scrutinize specific regions of the postsynaptic dendrite where we knew that the synaptic changes had to occur. We show that after induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrite or in slices where long-term potentiation was blocked, no significant spine growth occurred.

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Research works printed but not linked: 17

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Metadata

Authors
Engert, F., & Bonhoeffer, T.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1999-05
Volume
399
Issue
6731
Pages
66-70
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/19978
Cited by
1,412
References
6
Language
en
Licence
www.springer.com/tdm (unspecified)

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