The DOI matches its Crossref record.
Signals from the reproductive system regulate the lifespan of C. elegans
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739
Self-citationThe plasticity of aging: insights from long-lived mutants
Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338
Self-citationStochastic and genetic factors influence tissue-specific decline in ageing C. elegans
Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214
The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity
Durieux, J., Wolff, S., & Dillin, A. (2011) · Cell · doi:10.1016/j.cell.2010.12.016 · Cited by 1,059
“These include alteration of signals from the somatic germline which control the aging of nonmitotic tissues (Arantes-Oliveira et al., 2002; Hsin and Kenyon, 1999); restoration or reduction of insulin/IGF-1 signaling (IIS) in neuronal or fat tissues (Broughton et al.”
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
Tullet, J. M. A., Hertweck, M., An, J. H., Baker, J., Hwang, J. Y., Liu, S., Oliveira, R. P., Baumeister, R., & Blackwell, T. K. (2008) · Cell · doi:10.1016/j.cell.2008.01.030 · Cited by 923
Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan
Libina, N., Berman, J. R., & Kenyon, C. (2003) · Cell · doi:10.1016/s0092-8674(03)00889-4 · Cited by 820
Self-citationGarigan, D., Hsu, A.-L., Fraser, A. G., Kamath, R. S., Ahringer, J., & Kenyon, C. (2002) · Genetics · doi:10.1093/genetics/161.3.1101 · Cited by 803
Self-citationLifespan extension by conditions that inhibit translation in Caenorhabditis elegans
Hansen, M., Taubert, S., Crawford, D., Libina, N., Lee, S., & Kenyon, C. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2006.00267.x · Cited by 803
Self-citationToussaint, O., Medrano, E. E., & von Zglinicki, T. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00180-7 · Cited by 713
Apfeld, J., O'Connor, G., McDonagh, T., DiStefano, P. S., & Curtis, R. (2004) · Genes & Development · doi:10.1101/gad.1255404 · Cited by 643
Regulation of lifespan by sensory perception in Caenorhabditis elegans
Apfeld, J., & Kenyon, C. (1999) · Nature · doi:10.1038/45544 · Cited by 573
Self-citationBooth, L. N., & Brunet, A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.013 · Cited by 499
Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
Van Raamsdonk, J. M., & Hekimi, S. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000361 · Cited by 511
Genetics of longevity in model organisms: debates and paradigm shifts
Gems, D., & Partridge, L. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183712 · Cited by 499
McCarroll, S. A., Murphy, C. T., Zou, S., Pletcher, S. D., Chin, C.-S., Jan, Y. N., Kenyon, C., Bargmann, C. I., & Li, H. (2004) · Nature Genetics · doi:10.1038/ng1291 · Cited by 454
Self-citationGenetics and the Specificity of the Aging Process
Hekimi, S., & Guarente, L. (2003) · Science · doi:10.1126/science.1082358 · Cited by 434
RPN-6 determines C. elegans longevity under proteotoxic stress conditions
Vilchez, D., Morantte, I., Liu, Z., Douglas, P. M., Merkwirth, C., Rodrigues, A. P. C., Manning, G., & Dillin, A. (2012) · Nature · doi:10.1038/nature11315 · Cited by 413
Sex and Death: What Is the Connection?
Partridge, L., Gems, D., & Withers, D. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.026 · Cited by 402
Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons
Alcedo, J., & Kenyon, C. (2004) · Neuron · doi:10.1016/s0896-6273(03)00816-x · Cited by 388
Self-citationTwo conserved histone demethylases regulate mitochondrial stress-induced longevity
Merkwirth, C., Jovaisaite, V., Durieux, J., Matilainen, O., Jordan, S. D., Quiros, P. M., Steffen, K. K., Williams, E. G., Mouchiroud, L., Tronnes, S. U., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.012 · Cited by 363
“The 1,405 overlapping genes were subjected to gene ontology (GO) analysis using the DAVID database (Huang et al., 2009).”
Genetics of healthy aging and longevity
Brooks-Wilson, A. R. (2013) · Human Genetics · doi:10.1007/s00439-013-1342-z · Cited by 380
Endocrine regulation of ageing
Russell, S. J., & Kahn, C. R. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2234 · Cited by 356
Liu, X., Jiang, N., Hughes, B., Bigras, E., Shoubridge, E., & Hekimi, S. (2005) · Genes & Development · doi:10.1101/gad.1352905 · Cited by 345
Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans
Lapierre, L. R., Gelino, S., Meléndez, A., & Hansen, M. (2011) · Current Biology · doi:10.1016/j.cub.2011.07.042 · Cited by 343
Lessons from C. elegans: signaling pathways for longevity
Lapierre, L. R., & Hansen, M. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.07.007 · Cited by 331
The effects of aging on gene expression in the hypothalamus and cortex of mice
Jiang, C. H., Tsien, J. Z., Schultz, P. G., & Hu, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1930 · Cited by 318
Dietary deprivation extends lifespan in Caenorhabditis elegans
Lee, G. D., Wilson, M. A., Zhu, M., Wolkow, C. A., De Cabo, R., Ingram, D. K., & Zou, S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00241.x · Cited by 307
DNA replication stress, genome instability and aging
Burhans, W. C., & Weinberger, M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1059 · Cited by 279
Maures, T. J., Greer, E. L., Hauswirth, A. G., & Brunet, A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00738.x · Cited by 256
Emerging models and paradigms for stem cell ageing
Jones, D. L., & Rando, T. A. (2011) · Nature Cell Biology · doi:10.1038/ncb0511-506 · Cited by 256
Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans
McColl, G., Killilea, D. W., Hubbard, A. E., Vantipalli, M. C., Melov, S., & Lithgow, G. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705028200 · Cited by 202
Boulias, K., & Horvitz, H. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.014 · Cited by 184
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex
Ghazi, A., Henis-Korenblit, S., & Kenyon, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700638104 · Cited by 134
Self-citationThe role of estrogen deficiency in skin ageing and wound healing
Emmerson, E., & Hardman, M. J. (2012) · Biogerontology · doi:10.1007/s10522-011-9322-y · Cited by 118
A steroid receptor-microRNA switch regulates life span in response to signals from the gonad
Shen, Y., Wollam, J., Magner, D., Karalay, O., & Antebi, A. (2012) · Science · doi:10.1126/science.1228967 · Cited by 102
Cell non-autonomous regulation of health and longevity
Miller, H. A., Dean, E. S., Pletcher, S. D., & Leiser, S. F. (2020) · eLife · doi:10.7554/elife.62659 · Cited by 102
Proteostasis and longevity: when does aging really begin?
Labbadia, J., & Morimoto, R. I. (2014) · F1000Prime Reports · doi:10.12703/p6-07 · Cited by 100
Yang, C. C., Chen, D., Lee, S. S., & Walter, L. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00711.x · Cited by 61
Aging of the brain, neurotrophin signaling, and Alzheimer's disease: Is IGF1-R the common culprit?
Puglielli, L. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.01.010 · Cited by 61
ETS-4 Is a Transcriptional Regulator of Life Span in Caenorhabditis elegans
Thyagarajan, B., Blaszczak, A. G., Chandler, K. J., Watts, J. L., Johnson, W. E., & Graves, B. J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001125 · Cited by 51
Kennerdell, J. R., Liu, N., & Bonini, N. M. (2018) · Nature Communications · doi:10.1038/s41467-018-06592-5 · Cited by 56
Metadata
- Authors
- Hsin, H., & Kenyon, C.
- Venue
- Nature
- Published
- 1999-05
- Volume
- 399
- Issue
- 6734
- Pages
- 362-366
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1619158228
- Cited by
- 1,006
- References
- 0
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.