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Molecular mechanisms of dendrite stability

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Koleske, Anthony J.·2013·Nature Reviews Neuroscience
DOI 10.1038/nrn3486
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Abstract

In the developing brain, dendrite branches and dendritic spines form and turn over dynamically. By contrast, most dendrite arbors and dendritic spines in the adult brain are stable for months, years and possibly even decades. Emerging evidence reveals that dendritic spine and dendrite arbor stability have crucial roles in the correct functioning of the adult brain and that loss of stability is associated with psychiatric disorders and neurodegenerative diseases. Recent findings have provided insights into the molecular mechanisms that underlie long-term dendrite stabilization, how these mechanisms differ from those used to mediate structural plasticity and how they are disrupted in disease.

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Metadata

Authors
Koleske, A. J.
Venue
Nature Reviews Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2013-07-10
Volume
14
Issue
8
Pages
536-550
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
DOI
10.1038/nrn3486
OpenAlex
W1969693529
Cited by
351
References
45
FWCI
2.21
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

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