Mechanisms of Hepatic Fibrogenesis

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842

Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.

Valencia-Sanchez, M. A., Liu, J., Hannon, G. J., & Parker, R. (2006) · Genes & Development · doi:10.1101/gad.1399806 · Cited by 2,060

Senescence of Activated Stellate Cells Limits Liver Fibrosis

Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.09.015 · Cited by 2,027

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

Duffield, J. S., Forbes, S. J., Constandinou, C. M., Clay, S., Partolina, M., Vuthoori, S., Wu, S., Lang, R., & Iredale, J. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522675 · Cited by 1,649

Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ

Iredale, J. P. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30542 · Cited by 866

History, Heterogeneity, Developmental Biology, and Functions of Quiescent Hepatic Stellate Cells

Geerts, A. (2001) · Seminars in Liver Disease · doi:10.1055/s-2001-17550 · Cited by 740

Natural Killer Cells Ameliorate Liver Fibrosis by Killing Activated Stellate Cells in NKG2D-Dependent and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Dependent Manners

Radaeva, S., Sun, R., Jaruga, B., Nguyen, V. T., Tian, Z., & Gao, B. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.10.055 · Cited by 610

Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis

Georges, P. C., Hui, J.-J., Gombos, Z., McCormick, M. E., Wang, A. Y., Uemura, M., Mick, R., Janmey, P. A., Furth, E. E., & Wells, R. G. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00032.2007 · Cited by 577

Inhibition of Apoptosis of Activated Hepatic Stellate Cells by Tissue Inhibitor of Metalloproteinase-1 Is Mediated via Effects on Matrix Metalloproteinase Inhibition

Murphy, F. R., Issa, R., Zhou, X., Ratnarajah, S., Arthur, M. J. P., Benyon, C., Iredale, J. P., & Nagase, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111490200 · Cited by 432

CCR1 and CCR5 promote hepatic fibrosis in mice

Seki, E., De Minicis, S., Gwak, G.-Y., Kluwe, J., Inokuchi, S., Bursill, C. A., Llovet, J. M., Brenner, D. A., & Schwabe, R. F. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37444 · Cited by 431

Molecular and cellular mechanisms of liver fibrosis and its regression

Kisseleva, T., & Brenner, D. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00372-7 · Cited by 2,024

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

Gao, B., & Bataller, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.09.002 · Cited by 1,963

Pathogenesis of Liver Fibrosis

Hernandez-Gea, V., & Friedman, S. L. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130246 · Cited by 1,809

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443

Macrophages: master regulators of inflammation and fibrosis

Wynn, T., & Barron, L. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1255354 · Cited by 1,392

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

Roehlen, N., Crouchet, E., & Baumert, T. F. (2020) · Cells · doi:10.3390/cells9040875 · Cited by 1,237

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

Miura, K., Kodama, Y., Inokuchi, S., Schnabl, B., Aoyama, T., Ohnishi, H., Olefsky, J. M., Brenner, D. A., & Seki, E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.052 · Cited by 741

TGF-β in progression of liver disease

Dooley, S., & ten Dijke, P. (2012) · Cell and Tissue Research · doi:10.1007/s00441-011-1246-y · Cited by 718

Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues

Hernández–Gea, V., Ghiassi–Nejad, Z., Rozenfeld, R., Gordon, R., Fiel, M. I., Yue, Z., Czaja, M. J., & Friedman, S. L. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.12.044 · Cited by 654

Therapy for Fibrotic Diseases: Nearing the Starting Line

Friedman, S. L., Sheppard, D., Duffield, J. S., & Violette, S. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004700 · Cited by 655

Kupffer cells in the liver

Dixon, L. J., Barnes, M., Tang, H., Pritchard, M. T., & Nagy, L. E. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c120026 · Cited by 628

Pathogenesis of alcoholic liver disease: Role of oxidative metabolism

Ceni, E., Mello, T., & Galli, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17756 · Cited by 521

Autophagy in the liver: functions in health and disease

Ueno, T., & Komatsu, M. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.185 · Cited by 500

Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis

Mchedlidze, T., Waldner, M., Zopf, S., Walker, J., Rankin, A. L., Schuchmann, M., Voehringer, D., McKenzie, A. N. J., Neurath, M. F., Pflanz, S., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.018 · Cited by 502

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

Kong, X., Feng, D., Wang, H., Hong, F., Bertola, A., Wang, F.-S., & Gao, B. (2012) · Hepatology · doi:10.1002/hep.25744 · Cited by 448

Antifibrotic activities of pirfenidone in animal models

Schaefer, C. J., Ruhrmund, D. W., Pan, L., Seiwert, S. D., & Kossen, K. (2011) · European Respiratory Review · doi:10.1183/09059180.00001111 · Cited by 454

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

Wang, X., Zheng, Z., Caviglia, J. M., Corey, K. E., Herfel, T. M., Cai, B., Masia, R., Chung, R. T., Lefkowitch, J. H., Schwabe, R. F., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.016 · Cited by 413

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

Aoyama, T., Paik, Y.-H., Watanabe, S., Laleu, B., Gaggini, F., Fioraso-Cartier, L., Molango, S., Heitz, F., Merlot, C., Szyndralewiez, C., et al. (2012) · Hepatology · doi:10.1002/hep.25938 · Cited by 336

Multigenerational epigenetic adaptation of the hepatic wound-healing response

Zeybel, M., Hardy, T., Wong, Y. K., Mathers, J. C., Fox, C. R., Gackowska, A., Oakley, F., Burt, A. D., Wilson, C. L., Anstee, Q. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2893 · Cited by 279

NLRP3 inflammasome driven liver injury and fibrosis: roles of IL-17 and TNF in mice

Wree, A., McGeough, M. D., Inzaugarat, M. E., Eguchi, A., Schuster, S., Johnson, C. D., Peña, C. A., Geisler, L. J., Papouchado, B. G., Hoffman, H. M., et al. (2018) · Hepatology · doi:10.1002/hep.29523 · Cited by 266

Radiation-induced liver disease: current understanding and future perspectives

Kim, J., & Jung, Y. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.85 · Cited by 260

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

Jiang, J. X., Chen, X., Serizawa, N., Szyndralewiez, C., Page, P., Schröder, K., Brandes, R. P., Devaraj, S., & Török, N. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.007 · Cited by 251

A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells

Teratani, T., Tomita, K., Suzuki, T., Oshikawa, T., Yokoyama, H., Shimamura, K., Tominaga, S., Hiroi, S., Irie, R., Okada, Y., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.09.049 · Cited by 241

Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy

Hernández-Gea, V., Hilscher, M., Rozenfeld, R., Lim, M. P., Nieto, N., Werner, S., Devi, L. A., & Friedman, S. L. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.02.016 · Cited by 236

Epithelial-mesenchymal transition: From molecular mechanisms, redox regulation to implications in human health and disease

Cannito, S., Novo, E., di Bonzo, L. V., Busletta, C., Colombatto, S., & Parola, M. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2737 · Cited by 239

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

Verbeke, L., Mannaerts, I., Schierwagen, R., Govaere, O., Klein, S., Vander Elst, I., Windmolders, P., Farre, R., Wenes, M., Mazzone, M., et al. (2016) · Scientific Reports · doi:10.1038/srep33453 · Cited by 236

The HLF/IL-6/STAT3 feedforward circuit drives hepatic stellate cell activation to promote liver fibrosis

Xiang, D.-M., Sun, W., Ning, B.-F., Zhou, T.-F., Li, X.-F., Zhong, W., Cheng, Z., Xia, M.-Y., Wang, X., Deng, X., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313392 · Cited by 229

Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice

Liu, S. B., Ikenaga, N., Peng, Z., Sverdlov, D. Y., Greenstein, A., Smith, V., Schuppan, D., & Popov, Y. (2016) · The FASEB Journal · doi:10.1096/fj.14-268425 · Cited by 224

Lipid-Induced Hepatocyte-Derived Extracellular Vesicles Regulate Hepatic Stellate Cells via MicroRNA Targeting Peroxisome Proliferator-Activated Receptor-γ

Povero, D., Panera, N., Eguchi, A., Johnson, C. D., Papouchado, B. G., de Araujo Horcel, L., Pinatel, E. M., Alisi, A., Nobili, V., & Feldstein, A. E. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.07.007 · Cited by 221

Modulation of Hepatic Fibrosis by c-Jun-N-Terminal Kinase Inhibition

Kluwe, J., Pradere, J., Gwak, G., Mencin, A., De Minicis, S., Österreicher, C. H., Colmenero, J., Bataller, R., & Schwabe, R. F. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.09.015 · Cited by 217

CX3CL1-CX3CR1 Interaction Prevents Carbon Tetrachloride-Induced Liver Inflammation and Fibrosis in Mice

Aoyama, T., Inokuchi, S., Brenner, D. A., & Seki, E. (2010) · Hepatology · doi:10.1002/hep.23795 · Cited by 211

Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride #

Park, O., Jeong, W.-I., Wang, L., Wang, H., Lian, Z.-X., Gershwin, E. M., & Gao, B. (2009) · Hepatology · doi:10.1002/hep.22813 · Cited by 189

Telomerase gene mutations are associated with cirrhosis formation

Hartmann, D., Srivastava, U., Thaler, M., Kleinhans, K. N., N'Kontchou, G., Scheffold, A., Bauer, K., Kratzer, R. F., Kloos, N., Katz, S.-F., et al. (2011) · Hepatology · doi:10.1002/hep.24217 · Cited by 173

Pharmacological inhibition of integrin αvβ3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis #

Patsenker, E., Popov, Y., Stickel, F., Schneider, V., Ledermann, M., Sägesser, H., Niedobitek, G., Goodman, S. L., & Schuppan, D. (2009) · Hepatology · doi:10.1002/hep.23144 · Cited by 174

The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice

Li, X., Jin, Q., Yao, Q., Xu, B., Li, L., Zhang, S., & Tu, C. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00072 · Cited by 171

Role of cAMP and phosphodiesterase signaling in liver health and disease

Wahlang, B., McClain, C., Barve, S., & Gobejishvili, L. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.06.005 · Cited by 168

Pathogenesis of alcohol‐induced liver disease: Classical concepts and recent advances

Seth, D., Haber, P. S., Syn, W., Diehl, A. M., & Day, C. P. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06756.x · Cited by 166

Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats

Liu, C., Tao, Q., Sun, M., Wu, J. Z., Yang, W., Jian, P., Peng, J., Hu, Y., Liu, C., & Liu, P. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.123 · Cited by 166

Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-β-dependent mechanisms

Copple, B. L. (2010) · Liver International · doi:10.1111/j.1478-3231.2010.02205.x · Cited by 164

Extrahepatic platelet-derived growth factor-β, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice

Yoshida, S., Ikenaga, N., Liu, S. B., Peng, Z.-W., Chung, J., Sverdlov, D. Y., Miyamoto, M., Kim, Y. O., Ogawa, S., Arch, R. H., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.08.038 · Cited by 164

Dendritic Cell Regulation of Carbon Tetrachloride–Induced Murine Liver Fibrosis Regression

Jiao, J., Sastre, D., Fiel, M. I., Lee, U. E., Ghiassi–Nejad, Z., Ginhoux, F., Vivier, E., Friedman, S. L., Merad, M., & Aloman, C. (2012) · Hepatology · doi:10.1002/hep.24621 · Cited by 154

In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis

Rezvani, M., Español-Suñer, R., Malato, Y., Dumont, L., Grimm, A. A., Kienle, E., Bindman, J. G., Wiedtke, E., Hsu, B. Y., Naqvi, S. J., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.05.005 · Cited by 150

Sphingosine kinase 1 promotes liver fibrosis by preventing miR‐19b‐3p‐mediated inhibition of CCR2

Lan, T., Li, C., Yang, G., Sun, Y., Zhuang, L., Ou, Y., Li, H., Wang, G., Kisseleva, T., Brenner, D., et al. (2018) · Hepatology · doi:10.1002/hep.29885 · Cited by 153

Engineered FGF19 eliminates bile acid toxicity and lipotoxicity leading to resolution of steatohepatitis and fibrosis in mice

Zhou, M., Learned, R. M., Rossi, S. J., DePaoli, A. M., Tian, H., & Ling, L. (2017) · Hepatology Communications · doi:10.1002/hep4.1108 · Cited by 152

IL-17A enhances the expression of profibrotic genes through upregulation of the TGF-β receptor on hepatic stellate cells in a JNK-dependent manner

Fabre, T., Kared, H., Friedman, S. L., & Shoukry, N. H. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400861 · Cited by 150

Intestinal decontamination inhibits TLR4 dependent fibronectin-mediated cross-talk between stellate cells and endothelial cells in liver fibrosis in mice

Zhu, Q., Zou, L., Jagavelu, K., Simonetto, D. A., Huebert, R. C., Jiang, Z.-D., DuPont, H. L., & Shah, V. H. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.11.013 · Cited by 144

Suppression of innate immunity (natural killer cell/interferon-γ) in the advanced stages of liver fibrosis in mice

Jeong, W.-I., Park, O., Suh, Y.-G., Byun, J.-S., Park, S.-Y., Choi, E., Kim, J.-K., Ko, H., Wang, H., Miller, A. M., et al. (2011) · Hepatology · doi:10.1002/hep.24190 · Cited by 142

Hepatocellular carcinoma in nonalcoholic fatty liver: role of environmental and genetic factors

Dongiovanni, P. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i36.12945 · Cited by 145

Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease

Jump, D. B., Lytle, K. A., Depner, C. M., & Tripathy, S. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.07.007 · Cited by 142

Intravenous injection of mesenchymal stem cells is effective in treating liver fibrosis

Zhao, W. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i10.1048 · Cited by 140

Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis

Tarrats, N., Moles, A., Morales, A., García-Ruiz, C., Fernández-Checa, J. C., & Marí, M. (2011) · Hepatology · doi:10.1002/hep.24388 · Cited by 128

Transcriptional regulation of hepatic stellate cells

Mann, J., & Mann, D. A. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.011 · Cited by 119

Fatty Acids - Induced Lipotoxicity and Inflammation

Savary, S., Trompier, D., Andreoletti, P., Le Borgne, F., Demarquoy, J., & Lizard, G. (2012) · Current Drug Metabolism · doi:10.2174/138920012803762729 · Cited by 111

Functional role of chemokines in liver disease models

Sahin, H., Trautwein, C., & Wasmuth, H. E. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.168 · Cited by 107

The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis

Bansal, R., van Baarlen, J., Storm, G., & Prakash, J. (2015) · Scientific Reports · doi:10.1038/srep18272 · Cited by 107

HCC Development Is Associated to Peripheral Insulin Resistance in a Mouse Model of NASH

De Minicis, S., Agostinelli, L., Rychlicki, C., Sorice, G. P., Saccomanno, S., Candelaresi, C., Giaccari, A., Trozzi, L., Pierantonelli, I., Mingarelli, E., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097136 · Cited by 97

Ligand Activation of Peroxisome Proliferator–Activated Receptor β/δ (PPARβ/δ) Attenuates Carbon Tetrachloride Hepatotoxicity by Downregulating Proinflammatory Gene Expression

Shan, W., Palkar, P. S., Murray, I. A., McDevitt, E. I., Kennett, M. J., Kang, B. H., Isom, H. C., Perdew, G. H., Gonzalez, F. J., & Peters, J. M. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn142 · Cited by 97

Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases

Bansal, R., Nakagawa, S., Yazdani, S., van Baarlen, J., Venkatesh, A., Koh, A. P., Song, W.-M., Goossens, N., Watanabe, H., Beasley, M. B., et al. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.213 · Cited by 96

Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways

Xu, P., Zhang, Y., Liu, Y., Yuan, Q., Song, L., Liu, M., Liu, Z., Yang, Y., Li, J., Li, D., et al. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.11.012 · Cited by 97

Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism

Schildberg, F. A., Wojtalla, A., Siegmund, S. V., Endl, E., Diehl, L., Abdullah, Z., Kurts, C., & Knolle, P. A. (2011) · Hepatology · doi:10.1002/hep.24352 · Cited by 90

Hepatic Stellate Cells and Liver Fibrosis

Puche, J. E., Saiman, Y., & Friedman, S. L. (2013) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2013.tb00529.x · Cited by 89

Resveratrol Induces Pro-Oxidant Effects and Time-Dependent Resistance to Cytotoxicity in Activated Hepatic Stellate Cells

Martins, L. A. M., Coelho, B. P., Behr, G., Pettenuzzo, L. F., Souza, I. C. C., Moreira, J. C. F., Borojevic, R., Gottfried, C., & Guma, F. C. R. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9703-8 · Cited by 82

Epithelial-mesenchymal transition in chronic liver disease: fibrogenesis or escape from death?

Pinzani, M. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.02.001 · Cited by 86

Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells

Chen, L., Li, L., Chen, J., Li, L., Zheng, Z., Ren, J., & Qiu, Y. (2015) · Oncotarget · doi:10.18632/oncotarget.6466 · Cited by 83

IL‐20 and IL‐20R1 antibodies protect against liver fibrosis

Chiu, Y.-S., Wei, C.-C., Lin, Y.-J., Hsu, Y.-H., & Chang, M.-S. (2014) · Hepatology · doi:10.1002/hep.27189 · Cited by 77

Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential

Liu, P., Mao, Y., Xie, Y., Wei, J., & Yao, J. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03041-5 · Cited by 82

Review article: the reversibility of cirrhosis

Sohrabpour, A. A., Mohamadnejad, M., & Malekzadeh, R. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12044 · Cited by 80

Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition

Su, T.-H., Shiau, C.-W., Jao, P., Liu, C.-H., Liu, C.-J., Tai, W.-T., Jeng, Y.-M., Yang, H.-C., Tseng, T.-C., Huang, H.-P., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507499112 · Cited by 78

Integrins as a drug target in liver fibrosis

Rahman, S. R., Roper, J. A., Grove, J. I., Aithal, G. P., Pun, K. T., & Bennett, A. J. (2022) · Liver International · doi:10.1111/liv.15157 · Cited by 74

Decellularized hepatic extracellular matrix hydrogel attenuates hepatic stellate cell activation and liver fibrosis

Hussein, K. H., Park, K.-M., Yu, L., Kwak, H.-H., & Woo, H.-M. (2020) · Materials Science and Engineering: C · doi:10.1016/j.msec.2020.111160 · Cited by 75

PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis

Yang, Y., Wu, X.-Q., Li, W.-X., Huang, H.-M., Li, H.-D., Pan, X.-Y., Li, X.-F., Huang, C., Meng, X.-M., Zhang, L., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0383-0 · Cited by 72

Molecular pathways: hepatitis C virus, CXCL10, and the inflammatory road to liver cancer

Brownell, J., & Polyak, S. J. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0928 · Cited by 70

Inhibition of endothelin-1-mediated contraction of hepatic stellate cells by FXR ligand

Li, J., Kuruba, R., Wilson, A., Gao, X., Zhang, Y., & Li, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013955 · Cited by 66

A small population of liver endothelial cells undergoes endothelial-to-mesenchymal transition in response to chronic liver injury

Ribera, J., Pauta, M., Melgar-Lesmes, P., Córdoba, B., Bosch, A., Calvo, M., Rodrigo-Torres, D., Sancho-Bru, P., Mira, A., Jiménez, W., et al. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00428.2016 · Cited by 64

Nerve growth factor-mediated paracrine regulation of hepatic stellate cells by multipotent mesenchymal stromal cells

Lin, N., Hu, K., Chen, S., Xie, S., Tang, Z., Lin, J., & Xu, R. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.06.007 · Cited by 61

Succinate induces hepatic fibrogenesis by promoting activation, proliferation, and migration, and inhibiting apoptosis of hepatic stellate cells

Park, S. Y., Le, C. T., Sung, K. Y., Choi, D. H., & Cho, E.-H. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.01.106 · Cited by 58

Myeloid‐specific disruption of recombination signal binding protein Jκ ameliorates hepatic fibrosis by attenuating inflammation through cylindromatosis in mice

He, F., Guo, F., Li, Z., Yu, H., Ma, P., Zhao, J., Feng, L., Li, W., Liu, X., Qin, H., et al. (2015) · Hepatology · doi:10.1002/hep.27394 · Cited by 54

The role of hepatic stellate cells in the regulation of T-cell function and the promotion of hepatocellular carcinoma

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Liver cirrhosis: An overview of experimental models in rodents

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