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General Anesthesia, Sleep, and Coma
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This review discusses the clinical and neurophysiological features of general anesthesia and their relationships to sleep and coma, focusing on the neural mechanisms of unconsciousness induced by selected intravenous anesthetic drugs.
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Cites
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804
The minimally conscious state: Definition and diagnostic criteria
Giacino, J. T., Ashwal, S., Childs, N., Cranford, R., Jennett, B., Katz, D. I., Kelly, J. P., Rosenberg, J. H., Whyte, J., Zafonte, R. D., et al. (2002) · Neurology · doi:10.1212/wnl.58.3.349 · Cited by 2,422
Steriade, M., Nunez, A., & Amzica, F. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03252.1993 · Cited by 1,903
General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal
Franks, N. P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2372 · Cited by 1,295
Behavioural improvements with thalamic stimulation after severe traumatic brain injury
Schiff, N. D., Giacino, J. T., Kalmar, K., Victor, J. D., Baker, K., Gerber, M., Fritz, B., Eisenberg, B., O’Connor, J., Kobylarz, E. J., et al. (2007) · Nature · doi:10.1038/nature06041 · Cited by 1,051
Self-citationNMDA receptor hypofunction model of schizophrenia
Olney, J. W., Newcomer, J. W., & Farber, N. B. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00029-1 · Cited by 1,020
The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway
Nelson, L. E., Guo, T. Z., Lu, J., Saper, C. B., Franks, N. P., & Maze, M. (2002) · Nature Neuroscience · doi:10.1038/nn913 · Cited by 568
Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness
Ferrarelli, F., Massimini, M., Sarasso, S., Casali, A., Riedner, B. A., Angelini, G., Tononi, G., & Pearce, R. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913008107 · Cited by 554
Neuroanatomical correlates of brainstem coma
Parvizi, J. (2003) · Brain · doi:10.1093/brain/awg166 · Cited by 400
An essential role for orexins in emergence from general anesthesia
Kelz, M. B., Sun, Y., Chen, J., Cheng Meng, Q., Moore, J. T., Veasey, S. C., Dixon, S., Thornton, M., Funato, H., & Yanagisawa, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707146105 · Cited by 341
Cited by
Neural correlates of consciousness: progress and problems
Koch, C., Massimini, M., Boly, M., & Tononi, G. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.22 · Cited by 1,600
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
Electroencephalogram signatures of loss and recovery of consciousness from propofol
Purdon, P. L., Pierce, E. T., Mukamel, E. A., Prerau, M. J., Walsh, J. L., Wong, K. F. K., Salazar-Gomez, A. F., Harrell, P. G., Sampson, A. L., Cimenser, A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221180110 · Cited by 854
Self-citationClinical pharmacokinetics and pharmacodynamics of propofol
Sahinovic, M. M., Struys, M. M. R. F., & Absalom, A. R. (2018) · Clinical Pharmacokinetics · doi:10.1007/s40262-018-0672-3 · Cited by 809
Boly, M., Massimini, M., Tsuchiya, N., Postle, B. R., Koch, C., & Tononi, G. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3218-16.2017 · Cited by 557
Edlow, B. L., Takahashi, E., Wu, O., Benner, T., Dai, G., Bu, L., Grant, P. E., Greer, D. M., Greenberg, S. M., Kinney, H. C., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182588293 · Cited by 497
Are there levels of consciousness?
Bayne, T., Hohwy, J., & Owen, A. M. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2016.03.009 · Cited by 438
Coma and consciousness: paradigms (re)framed by neuroimaging
Laureys, S., & Schiff, N. D. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.041 · Cited by 397
Self-citationvan den Boogaard, M., Schoonhoven, L., Evers, A. W. M., van der Hoeven, J. G., van Achterberg, T., & Pickkers, P. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e31822e9fc9 · Cited by 361
Taylor, N. E., Van Dort, C. J., Kenny, J. D., Pei, J., Guidera, J. A., Vlasov, K. Y., Lee, J. T., Boyden, E. S., Brown, E. N., & Solt, K. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614340113 · Cited by 269
Self-citationVazey, E. M., & Aston-Jones, G. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310025111 · Cited by 279
The Edge of Sentience: Risk and Precaution in Humans, Other Animals, and AI
Birch, J. (2024) · doi:10.1093/9780191966729.001.0001 · Cited by 236
Returning from oblivion: imaging the neural core of consciousness
Långsjö, J. W., Alkire, M. T., Kaskinoro, K., Hayama, H., Maksimow, A., Kaisti, K. K., Aalto, S., Aantaa, R., Jääskeläinen, S. K., Revonsuo, A., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4962-11.2012 · Cited by 205
Akeju, O., & Brown, E. N. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.04.011 · Cited by 200
Self-citationNeural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation
Bastos, A. M., Donoghue, J. A., Brincat, S. L., Mahnke, M., Yanar, J., Correa, J., Waite, A. S., Lundqvist, M., Roy, J., Brown, E. N., et al. (2021) · eLife · doi:10.7554/elife.60824 · Cited by 166
Self-citationJordan, D., Ilg, R., Riedl, V., Schorer, A., Grimberg, S., Neufang, S., Omerovic, A., Berger, S., Untergehrer, G., Preibisch, C., et al. (2013) · Anesthesiology · doi:10.1097/aln.0b013e3182a7ca92 · Cited by 180
Recovery of consciousness is mediated by a network of discrete metastable activity states
Hudson, A. E., Calderon, D. P., Pfaff, D. W., & Proekt, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408296111 · Cited by 178
A common neuroendocrine substrate for diverse general anesthetics and sleep
Jiang-Xie, L.-F., Yin, L., Zhao, S., Prevosto, V., Han, B.-X., Dzirasa, K., & Wang, F. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.033 · Cited by 173
Sundaram, S., Hughes, R. L., Peterson, E., Müller-Oehring, E. M., Brontë-Stewart, H. M., Poston, K. L., Faerman, A., Bhowmick, C., & Schulte, T. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.016 · Cited by 152
Large-scale brain dynamics in disorders of consciousness
Schiff, N. D., Nauvel, T., & Victor, J. D. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.10.007 · Cited by 148
Self-citationFridman, E. A., Beattie, B. J., Broft, A., Laureys, S., & Schiff, N. D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320969111 · Cited by 147
Self-citationEvolution of consciousness: Phylogeny, ontogeny, and emergence from general anesthesia
Mashour, G. A., & Alkire, M. T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301188110 · Cited by 144
Harmonic brain modes: a unifying framework for linking space and time in brain dynamics
Atasoy, S., Deco, G., Kringelbach, M. L., & Pearson, J. (2018) · The Neuroscientist · doi:10.1177/1073858417728032 · Cited by 124
Brain areas that influence general anesthesia
Leung, L. S., Luo, T., Ma, J., & Herrick, I. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.08.001 · Cited by 126
Disconnecting Consciousness: Is There a Common Anesthetic End Point?
Hudetz, A. G., & Mashour, G. A. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001353 · Cited by 121
Anesthesia and the neurobiology of consciousness
Mashour, G. A. (2024) · Neuron · doi:10.1016/j.neuron.2024.03.002 · Cited by 127
Sleep and the functional connectome
Picchioni, D., Duyn, J. H., & Horovitz, S. G. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.067 · Cited by 115
Endogenous opioids mediate left dorsolateral prefrontal cortex rTMS-induced analgesia
Taylor, J. J., Borckardt, J. J., & George, M. S. (2012) · Pain · doi:10.1016/j.pain.2012.02.030 · Cited by 112
State-dependent and reflex drives to the upper airway: basic physiology with clinical implications
Horner, R. L., Hughes, S. W., & Malhotra, A. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00531.2013 · Cited by 104
Thalamic contributions to the state and contents of consciousness
Whyte, C. J., Redinbaugh, M. J., Shine, J. M., & Saalmann, Y. B. (2024) · Neuron · doi:10.1016/j.neuron.2024.04.019 · Cited by 105
Functional geometry of the cortex encodes dimensions of consciousness
Huang, Z., Mashour, G. A., & Hudetz, A. G. (2023) · Nature Communications · doi:10.1038/s41467-022-35764-7 · Cited by 101
Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I
Quintana, A., Morgan, P. G., Kruse, S. E., Palmiter, R. D., & Sedensky, M. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042904 · Cited by 86
“Ketamine anesthetic action may be unique, as it has been suggested to involve increased activation and cortical synchronization rather than neuronal inactivation [32].”
BackgroundPal, D., Li, D., Dean, J. G., Brito, M. A., Liu, T., Fryzel, A. M., Hudetz, A. G., & Mashour, G. A. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1910-19.2019 · Cited by 80
Bettinardi, R. G., Tort-Colet, N., Ruiz-Mejias, M., Sanchez-Vives, M. V., & Deco, G. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.03.037 · Cited by 68
Functional diversity of brain networks supports consciousness and verbal intelligence
Naci, L., Haugg, A., MacDonald, A., Anello, M., Houldin, E., Naqshbandi, S., Gonzalez-Lara, L. E., Arango, M., Harle, C., Cusack, R., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-31525-z · Cited by 66
Arena, A., Comolatti, R., Thon, S., Casali, A. G., & Storm, J. F. (2021) · eneuro · doi:10.1523/eneuro.0343-20.2021 · Cited by 66
Location of the mesopontine neurons responsible for maintenance of anesthetic loss of consciousness
Minert, A., Yatziv, S.-L., & Devor, M. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.0544-17.2017 · Cited by 58
“Network actions Observations, mostly based on noninvasive imaging in humans, have highlighted large-scale network connectivity and top-down processing as central factors in conscious awareness, with thalamocortical interactions taking center stage (Brown et al., 2010; Bonhomme et al., 2012; Vijayan et al., 2013; Hudet…”
BackgroundInfluentialCurrent status of EEG-based depth-of-consciousness monitoring during general anesthesia
Musialowicz, T., & Lahtinen, P. (2014) · Current Anesthesiology Reports · doi:10.1007/s40140-014-0061-x · Cited by 33
Leveraging Nonhuman Primate Multisensory Neurons and Circuits in Assessing Consciousness Theory
Noel, J.-P., Ishizawa, Y., Patel, S. R., Eskandar, E. N., & Wallace, M. T. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0934-19.2019 · Cited by 30
Bola, M., Barrett, A. B., Pigorini, A., Nobili, L., Seth, A. K., & Marchewka, A. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.11.030 · Cited by 27
Modes and models in disorders of consciousness science.
(2012) · PubMed · doi:10.4449/aib.v150i2.1372 · Cited by 22
Lanir-Azaria, S., Meiri, G., Avigdor, T., Minert, A., & Devor, M. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.035 · Cited by 20
Troup, M., Zalucki, O. H., Kottler, B. D., Karunanithi, S., Anggono, V., & van Swinderen, B. (2019) · Anesthesiology · doi:10.1097/aln.0000000000002850 · Cited by 21
Reduced Nav1.6 sodium channel activity in mice increases in vivo sensitivity to volatile anesthetics
Pal, D., Jones, J. M., Wisidagamage, S., Meisler, M. H., & Mashour, G. A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0134960 · Cited by 17
Neural signatures of loss of consciousness and its recovery by thalamic stimulation
Donoghue, J. A., Bastos, A. M., Yanar, J., Kornblith, S., Mahnke, M., Brown, E. N., & Miller, E. K. (2019) · doi:10.1101/806687 · Cited by 5
Self-citationBirch, J. (2024) · The Edge of Sentience · doi:10.1093/9780191966729.003.0003 · Cited by 1
Metadata
- Authors
- Brown, E. N., Lydic, R., & Schiff, N. D.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2010-12-30
- Volume
- 363
- Issue
- 27
- Pages
- 2638-2650
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1988881714
- Cited by
- 1,350
- References
- 10
- FWCI
- 55.88
- Type
- journal article
- Language
- en
- Open access
- green
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