MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

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Shimazu, Rintaro, Akashi, Sachiko, Ogata, Hirotaka, Nagai, Yoshinori, Fukudome, Kenji, Miyake, Kensuke, Kimoto, Masao·1999·The Journal of Experimental Medicine

DOI 10.1084/jem.189.11.1777

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Abstract

Toll-like receptor 4 (TLR4) is a mammalian homologue of Drosophila Toll, a leucine-rich repeat molecule that can trigger innate responses against pathogens. The TLR4 gene has recently been shown to be mutated in C3H/HeJ and C57BL/10ScCr mice, both of which are low responders to lipopolysaccharide (LPS). TLR4 may be a long-sought receptor for LPS. However, transfection of TLR4 does not confer LPS responsiveness on a recipient cell line, suggesting a requirement for an additional molecule. Here, we report that a novel molecule, MD-2, is requisite for LPS signaling of TLR4. MD-2 is physically associated with TLR4 on the cell surface and confers responsiveness to LPS. MD-2 is thus a link between TLR4 and LPS signaling. Identification of this new receptor complex has potential implications for understanding host defense, as well as pathophysiologic, mechanisms.

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“Interestingly, the protein product for LY96 is myeloid differentiation 2 (MD2), which is required for TLR4 ligand-induced activation at the cell surface 50,51 .”

Authors: Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K., & Kimoto, M.
Venue: The Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 1999-06-07
Volume: 189
Issue: 11
Pages: 1777-1782
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.189.11.1777
OpenAlex: W2095833996
Cited by: 2,185
References: 0
FWCI: 33.43
Type: journal article
Language: en
Open access: bronze

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MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

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