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Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells

Strioga, Marius, Viswanathan, Sowmya, Darinskas, Adas, Slaby, Ondrej, Michalek, Jaroslav·2012·Stem Cells and Development
DOI 10.1089/scd.2011.0722
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Abstract

Mesenchymal stem/stromal cells (MSCs) comprise a heterogeneous population of cells with multilineage differentiation potential, the ability to modulate oxidative stress, and secrete various cytokines and growth factors that can have immunomodulatory, angiogenic, anti-inflammatory and anti-apoptotic effects. Recent data indicate that these paracrine factors may play a key role in MSC-mediated effects in modulating various acute and chronic pathological conditions. MSCs are found in virtually all organs of the body. Bone marrow-derived MSCs (BM-MSCs) were discovered first, and the bone marrow was considered the main source of MSCs for clinical application. Subsequently, MSCs have been isolated from various other sources with the adipose tissue, serving as one of the alternatives to bone marrow. Adipose tissue-derived MSCs (ASCs) can be more easily isolated; this approach is safer, and also, considerably larger amounts of ASCs can be obtained compared with the bone marrow. ASCs and BM-MSCs share many biological characteristics; however, there are some differences in their immunophenotype, differentiation potential, transcriptome, proteome, and immunomodulatory activity. Some of these differences may represent specific features of BM-MSCs and ASCs, while others are suggestive of the inherent heterogeneity of both BM-MSC and ASC populations. Still other differences may simply be related to different isolation and culture protocols. Most importantly, despite the minor differences between these MSC populations, ASCs seem to be as effective as BM-MSCs in clinical application, and, in some cases, may be better suited than BM-MSCs. In this review, we will examine in detail the ontology, biology, preclinical, and clinical application of BM-MSCs versus ASCs.

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Research works printed but not linked: 276

  1. 10.1097/00007890-196803000-00009 · DOI · Paper page
  2. Friedenstein AJ, , Chailakhjan RK, , Lalykina KS. 1970. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet, 3:393–403.
  3. Friedenstein AJ, , Deriglasova UF, , Kulagina NN, , Panasuk AF, , Rudakowa SF, , Luriá EA, , Ruadkow IA. 1974. Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method. Exp Hematol, 2:83–92.
  4. 10.1002/jor.1100090504 · DOI · Paper page
  5. 10.1016/j.stem.2008.03.002 · DOI · Paper page
  6. 10.1016/j.cell.2007.08.025 · DOI · Paper page
  7. 10.1080/14653240500319234 · DOI · Paper page
  8. 10.1038/mt.2009.62 · DOI · Paper page
  9. 10.1242/jcs.02932 · DOI · Paper page
  10. 10.1089/107632701300062859 · DOI · Paper page
  11. 10.1089/scd.2010.0140 · DOI · Paper page
  12. 10.1046/j.1365-2141.2000.01986.x · DOI · Paper page
  13. 10.1634/stemcells.2007-0439 · DOI · Paper page
  14. 10.1080/14653240902974024 · DOI
  15. 10.1111/j.1365-2184.2008.00553.x · DOI
  16. 10.1182/blood.V98.8.2396 · DOI · Paper page
  17. In ’t Anker PS, , Noort WA, , Scherjon SA, , Kleijburg-van der Keur C, , Kruisselbrink AB, , van Bezooijen RL, , Beekhuizen W, , Willemze R, , Kanhai HH, , Fibbe WE. 2003. Mesenchymal stem cells in human second-trimester bone marrow, liver, lung, and spleen exhibit a similar immunophenotype but a heterogeneous multilineage differentiation potential. Haematologica, 88:845–852.
  18. 10.3727/000000005783983070 · doi:10.3727/000000005783983070
  19. 10.1634/stemcells.2007-0637 · DOI · Paper page
  20. 10.2478/v10042-008-0046-z · doi:10.2478/v10042-008-0046-z
  21. 10.3324/haematol.2009.015065 · DOI · Paper page
  22. 10.1016/S0301-472X(03)00110-3 · DOI · Paper page
  23. 10.1634/stemcells.2005-0403 · DOI · Paper page
  24. 10.3109/14653249.2010.507330 · DOI · Paper page
  25. 10.1182/blood-2009-05-219907 · DOI · Paper page
  26. 10.1158/0008-5472.CAN-06-4690 · DOI · Paper page
  27. 10.1634/stemcells.2007-1122 · DOI · Paper page
  28. 10.1016/j.cytogfr.2009.10.014 · DOI · Paper page
  29. 10.1002/path.2469 · DOI · Paper page
  30. 10.1016/j.stem.2011.06.008 · DOI · Paper page
  31. 10.1146/annurev-pathol-011110-130230 · DOI · Paper page
  32. 10.1038/ijo.2010.269 · DOI · Paper page
  33. 10.1002/jcp.21210 · DOI · Paper page
  34. 10.1161/ATVBAHA.109.191643 · DOI · Paper page
  35. 10.1126/science.1110364 · DOI · Paper page
  36. 10.1089/ten.tea.2006.0415 · DOI · Paper page
  37. 10.1016/j.bbrc.2004.09.087 · DOI · Paper page
  38. 10.1242/jcs.03281 · DOI · Paper page
  39. 10.1634/stemcells.22-3-377 · DOI · Paper page
  40. 10.1016/j.bone.2006.09.006 · DOI · Paper page
  41. 10.1111/j.1582-4934.2007.00041.x · DOI · Paper page
  42. 10.1016/j.bbrc.2006.01.072 · DOI · Paper page
  43. 10.1182/blood-2005-02-0572 · DOI · Paper page
  44. 10.1136/gut.2008.154880 · DOI · Paper page
  45. 10.1371/journal.pone.0019569 · DOI
  46. 10.1093/eurheartj/ehp568 · doi:10.1093/eurheartj/ehp568
  47. 10.1002/stem.632 · DOI · Paper page
  48. 10.1016/S0006-291X(02)00469-2 · DOI · Paper page
  49. 10.2217/17460751.3.5.731 · doi:10.2217/17460751.3.5.731
  50. 10.1371/journal.pone.0019025 · DOI
  51. 10.1002/term.165 · DOI
  52. 10.1038/nature00870 · DOI · Paper page
  53. 10.1016/S0301-472X(02)00869-X · DOI · Paper page
  54. 10.1016/B978-0-12-374729-7.00028-7 · DOI
  55. 10.1016/j.beha.2011.01.006 · DOI
  56. Ji KH, , Xiong J, , Fan LX, , Hu KM, , Liu HQ. 2009. Multilineage differentiation capability comparison between mesenchymal stem cells and multipotent adult progenitor cells. Adv Stud Biol, 1:25–35.
  57. 10.1007/s00277-008-0470-3 · doi:10.1007/s00277-008-0470-3
  58. 10.1126/science.315.5813.760 · doi:10.1126/science.315.5813.760
  59. 10.1182/blood-2006-06-030551 · DOI · Paper page
  60. 10.1016/j.exphem.2006.07.016 · doi:10.1016/j.exphem.2006.07.016
  61. 10.1038/sj.leu.2404171 · DOI · Paper page
  62. 10.1002/ibd.22875 · DOI
  63. 10.1016/j.biocel.2003.11.001 · DOI · Paper page
  64. 10.2217/rme.10.72 · DOI · Paper page
  65. 10.1002/art.11365 · DOI · Paper page
  66. 10.2174/1381612053507495 · DOI · Paper page
  67. 10.1161/CIRCULATIONAHA.104.527937 · DOI · Paper page
  68. 10.1073/pnas.1432929100 · DOI · Paper page
  69. 10.1152/ajprenal.00007.2005 · DOI · Paper page
  70. 10.1073/pnas.132252399 · DOI · Paper page
  71. 10.4049/jimmunol.179.3.1855 · DOI · Paper page
  72. 10.1016/j.bbrc.2007.01.045 · DOI · Paper page
  73. 10.1016/j.ymthe.2006.05.016 · DOI · Paper page
  74. 10.1161/01.RES.0000118601.37875.AC · DOI · Paper page
  75. 10.1089/scd.2010.0093 · DOI · Paper page
  76. 10.1634/stemcells.19-5-408 · DOI · Paper page
  77. 10.1634/stemcells.2004-0236 · DOI
  78. 10.1016/j.stem.2009.05.003 · DOI · Paper page
  79. 10.1161/01.CIR.0000084828.50310.6A · DOI · Paper page
  80. 10.1016/j.transproceed.2006.12.019 · DOI · Paper page
  81. 10.1111/j.1365-2141.2005.05409.x · DOI · Paper page
  82. 10.1089/scd.2009.0345 · DOI
  83. 10.4252/wjsc.v2.i3.50 · DOI
  84. 10.1007/978-1-61779-322-6_4 · DOI
  85. 10.1007/s12015-009-9076-y · DOI
  86. 10.1016/j.exphem.2008.06.008 · DOI
  87. 10.1182/blood-2009-02-207795 · DOI
  88. 10.1182/blood-2006-01-0057 · DOI · Paper page
  89. Krampera M. 2011. Mesenchymal stromal cell ‘licensing’: a multistep process. Leukemia, 27:1–7.
  90. 10.1186/scrt34 · DOI
  91. 10.1136/ard.2008.094003 · DOI
  92. 10.1182/blood-2004-04-1488 · DOI · Paper page
  93. 10.1161/hc0102.101442 · DOI · Paper page
  94. 10.1016/S0014-4827(03)00132-0 · DOI · Paper page
  95. Herrera MB, , Bussolati B, , Bruno S, , Fonsato V, , Romanazzi GM, , Camussi G. 2004. Mesenchymal stem cells contribute to the renal repair of acute tubular epithelial injury. Int J Mol Med, 14:1035–1041.
  96. 10.1038/nbt958 · DOI · Paper page
  97. 10.1016/j.transproceed.2010.01.058 · DOI
  98. 10.1161/CIRCULATIONAHA.104.500447 · DOI · Paper page
  99. 10.1016/j.ijcard.2005.05.072 · doi:10.1016/j.ijcard.2005.05.072
  100. 10.1089/tea.2007.0137 · DOI
  101. 10.1073/pnas.042678299 · DOI · Paper page
  102. 10.1634/stemcells.2008-0329 · DOI · Paper page
  103. 10.1080/14653240802419302 · DOI
  104. 10.1002/jcp.1138 · DOI · Paper page
  105. 10.1007/s00418-005-0014-z · DOI
  106. 10.1177/154405910208100806 · DOI · Paper page
  107. 10.1634/stemcells.2004-0024 · DOI · Paper page
  108. 10.1186/1479-5876-7-29 · DOI · Paper page
  109. 10.1016/j.jacc.2009.06.055 · DOI · Paper page
  110. 10.1016/j.bbmt.2008.03.012 · DOI · Paper page
  111. 10.1016/j.transproceed.2007.08.103 · DOI · Paper page
  112. 10.4061/2010/582382 · DOI
  113. 10.2106/00004623-200310000-00010 · DOI · Paper page
  114. 10.1227/01.NEU.0000079333.61863.AA · DOI · Paper page
  115. 10.1016/j.brainres.2007.09.005 · DOI · Paper page
  116. 10.1182/blood-2005-03-1004 · DOI · Paper page
  117. 10.1016/j.jtcvs.2003.07.037 · DOI · Paper page
  118. 10.1172/JCI108516 · DOI · Paper page
  119. 10.1161/01.RES.0000265074.83288.09 · DOI · Paper page
  120. 10.1007/s12015-010-9193-7 · DOI · Paper page
  121. 10.1097/PRS.0b013e31817742ed · DOI
  122. 10.1097/PRS.0b013e3181b5a3f1 · DOI · Paper page
  123. 10.1002/jcp.20636 · DOI · Paper page
  124. 10.1002/jcb.20904 · DOI · Paper page
  125. 10.1089/scd.2011.0044 · DOI
  126. 10.1111/j.1749-6632.2009.04607.x · DOI · Paper page
  127. 10.1186/1478-811X-9-12 · DOI · Paper page
  128. 10.1016/j.tibtech.2006.01.010 · DOI · Paper page
  129. 10.1016/j.mad.2007.12.002 · DOI · Paper page
  130. 10.2217/17460751.4.2.265 · DOI · Paper page
  131. 10.1007/s00266-007-9019-4 · DOI · Paper page
  132. 10.1007/s00384-008-0559-0 · DOI
  133. 10.1091/mbc.e02-02-0105 · DOI · Paper page
  134. 10.1161/CIRCRESAHA.107.159475 · DOI · Paper page
  135. 10.1634/stemcells.2005-0234 · DOI · Paper page
  136. 10.1016/S0165-2478(03)00108-1 · DOI · Paper page
  137. 10.1634/stemcells.2006-0228 · DOI · Paper page
  138. 10.1002/jcp.22408 · DOI · Paper page
  139. 10.1634/stemcells.2004-0021 · DOI · Paper page
  140. 10.1007/s12015-010-9147-0 · DOI
  141. 10.1080/14653240802217011 · DOI · Paper page
  142. 10.1002/art.21212 · DOI · Paper page
  143. 10.1016/j.cellbi.2007.12.007 · DOI
  144. 10.32725/jab.2007.019 · doi:10.32725/jab.2007.019
  145. 10.1002/art.10767 · DOI · Paper page
  146. 10.1016/j.orthres.2005.03.008.1100230621 · DOI · Paper page
  147. 10.1002/jor.20766 · DOI
  148. 10.1002/art.21779 · DOI · Paper page
  149. 10.1080/14653240802716590 · DOI
  150. 10.1002/jcb.22088 · DOI
  151. 10.1016/j.exphem.2005.07.003 · DOI · Paper page
  152. 10.1016/j.imlet.2009.07.010 · DOI · Paper page
  153. 10.1186/scrt19 · DOI · Paper page
  154. 10.4049/jimmunol.176.12.7761 · DOI · Paper page
  155. 10.1002/eji.200738129 · DOI · Paper page
  156. 10.1016/j.clim.2008.02.003 · DOI
  157. 10.3109/14653240903350265 · doi:10.3109/14653240903350265
  158. 10.1159/000317322 · doi:10.1159/000317322
  159. 10.1111/j.1743-6109.2008.01190.x · DOI
  160. 10.1152/ajpheart.00685.2006 · DOI
  161. Yoshimura K, , Sato K, , Aoi N, , Kurita M, , Inoue K, , Suga H, , Eto H, , Kato H, , Hirohi T, , Harii K. 2008. Cell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells. Dermatol Surg, 34:1178–1185.
  162. 10.1111/j.1524-4741.2009.00873.x · DOI · Paper page
  163. 10.1089/ten.2006.12.3375 · DOI · Paper page
  164. 10.1007/978-3-642-00473-5_34 · DOI
  165. 10.1177/1090820X10362730 · DOI
  166. 10.1002/term.158 · DOI
  167. 10.1089/ten.2006.0278 · DOI · Paper page
  168. 10.1097/01.prs.0000299922.96006.24 · DOI · Paper page
  169. 10.1097/SAP.0b013e3181e6d06c · DOI
  170. 10.2174/157488810791268690 · DOI
  171. 10.1097/01.prs.0000256047.47909.71 · DOI · Paper page
  172. 10.1016/j.joca.2006.08.008 · DOI · Paper page
  173. 10.1053/joca.2001.0504 · DOI · Paper page
  174. 10.3727/000000004783983747 · DOI · Paper page
  175. 10.1002/term.8 · DOI · Paper page
  176. 10.1089/ten.2006.0271 · DOI · Paper page
  177. 10.1016/j.ijom.2009.01.001 · DOI · Paper page
  178. 10.4061/2010/215625 · DOI
  179. 10.1016/j.amjcard.2004.03.034 · DOI · Paper page
  180. Mohyeddin-Bonab M, , Mohamad-Hassani MR, , Alimoghaddam K, , Sanatkar M, , Gasemi M, , Mirkhani H, , Radmehr H, , Salehi M, , Eslami M et al. 2007. Autologous in vitro expanded mesenchymal stem cell therapy for human old myocardial infarction. Arch Iran Med, 10:467–473.
  181. Duckers HJ, , Houtgraaf J, , van Geuns RJ, , van Dalen BD, , Regar E, , van der Giessen W, , de Jaegere P, , Schultz C, , Martin M et al. 2010. First-in-man experience with intracoronary infu-sion of adipose-derived regenerative cells in the treatment of patients with ST-elevation myocardial infarction: The Apollo trial. Circulation, 2010,122:A12225(abstr.).
  182. 10.1007/s12013-011-9323-0 · DOI
  183. 10.1089/scd.2009.0465 · DOI
  184. 10.4414/smw.2011.13209 · DOI
  185. 10.1089/hum.2010.211 · DOI
  186. 10.1016/S0140-6736(08)60690-X · DOI · Paper page
  187. 10.1038/sj.bmt.1703032 · doi:10.1038/sj.bmt.1703032
  188. 10.1097/01.tp.0000214462.63943.14 · DOI · Paper page
  189. 10.1038/bmt.2008.316 · DOI · Paper page
  190. 10.1007/s12185-010-0606-9 · doi:10.1007/s12185-010-0606-9
  191. 10.1016/j.bbmt.2010.04.014 · DOI · Paper page
  192. 10.1016/j.bbmt.2009.11.006 · DOI
  193. 10.3324/haematol.2010.038356 · DOI
  194. 10.1038/bmt.2010.195 · DOI · Paper page
  195. 10.1111/j.1399-3046.2007.00780.x · doi:10.1111/j.1399-3046.2007.00780.x
  196. 10.3960/jslrt.50.79 · DOI
  197. 10.3109/14653249.2010.549688 · DOI
  198. 10.1186/1755-7682-4-27 · DOI
  199. 10.1136/gut.2010.214841 · DOI · Paper page
  200. Jonken J, , Gallup D, , Hanson J, , Pandak M, , Custer L. Duke Clinical Research Institute (Durham, NC), Osiris Therapeutics (Baltimore, MD). Successful Outpatient Treatment of Refractory Crohn's Disease Using Adult Mesenchymal Stem Cells. Data presented at the October 2006 American College of Gastroenterology conference www.osiris.com/pdf/Crohn's_Ph_II_Handout.pdf

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Metadata

Authors
Strioga, M., Viswanathan, S., Darinskas, A., Slaby, O., & Michalek, J.
Venue
Stem Cells and Development
Publisher
SAGE Publications
Published
2012-09-20
Volume
21
Issue
14
Pages
2724-2752
ISSN
  • 1525-8165 (ISSN-L)
  • 1547-3287
  • 1557-8534
DOI
10.1089/scd.2011.0722
OpenAlex
W2085582924
Cited by
825
References
16
FWCI
23.04
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)

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Strioga, M., Viswanathan, S., Darinskas, A., Slaby, O., & Michalek, J. (2012). Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells. Stem Cells and Development. https://doi.org/10.1089/scd.2011.0722

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