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Mycoprotein ingestion stimulates protein synthesis rates to a greater extent than milk protein in rested and exercised skeletal muscle of healthy young men: a randomized controlled trial

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Monteyne, Alistair J, Coelho, Mariana OC, Porter, Craig, Abdelrahman, Doaa R, Jameson, Thomas SO, Jackman, Sarah R, Blackwell, Jamie R, Finnigan, Tim JA, Stephens, Francis B, Dirks, Marlou L, Wall, Benjamin T·2020·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/nqaa092

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Abstract

Background Mycoprotein is a fungal-derived sustainable protein-rich food source, and its ingestion results in systemic amino acid and leucine concentrations similar to that following milk protein ingestion.Objective We assessed the mixed skeletal muscle protein synthetic response to the ingestion of a single bolus of mycoprotein compared with a leucine-matched bolus of milk protein, in rested and exercised muscle of resistance-trained young men.Methods Twenty resistance-trained healthy young males (age: 22 ± 1 y, body mass: 82 ± 2 kg, BMI: 25 ± 1 kg·m-2) took part in a randomized, double-blind, parallel-group study. Participants received primed, continuous infusions of L-[ring-2H5]phenylalanine and ingested either 31 g (26.2 g protein: 2.5 g leucine) milk protein (MILK) or 70 g (31.5 g protein: 2.5 g leucine) mycoprotein (MYCO) following a bout of unilateral resistance-type exercise (contralateral leg acting as resting control). Blood and m. vastus lateralis muscle samples were collected before exercise and protein ingestion, and following a 4-h postprandial period to assess mixed muscle fractional protein synthetic rates (FSRs) and myocellular signaling in response to the protein beverages in resting and exercised muscle.Results Mixed muscle FSRs increased following MILK ingestion (from 0.036 ± 0.008 to 0.052 ± 0.006%·h-1 in rested, and 0.035 ± 0.008 to 0.056 ± 0.005%·h-1 in exercised muscle; P <0.01) but to a greater extent following MYCO ingestion (from 0.025 ± 0.006 to 0.057 ± 0.004%·h-1 in rested, and 0.024 ± 0.007 to 0.072 ± 0.005%·h-1 in exercised muscle; P <0.0001) (treatment × time interaction effect; P <0.05). Postprandial FSRs trended to be greater in MYCO compared with MILK (0.065 ± 0.004 compared with 0.054 ± 0.004%·h-1, respectively; P = 0.093) and the postprandial rise in FSRs was greater in MYCO compared with MILK (Delta 0.040 ± 0.006 compared with Delta 0.018 ± 0.005%·h-1, respectively; P <0.01).Conclusions The ingestion of a single bolus of mycoprotein stimulates resting and postexercise muscle protein synthesis rates, and to a greater extent than a leucine-matched bolus of milk protein, in resistance-trained young men. This trial was registered at clinicaltrials.gov as 660065600.

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Strategies to Prevent Sarcopenia in the Aging Process: Role of Protein Intake and Exercise
Rogeri, P. S., Zanella, R., Martins, G. L., Garcia, M. D. A., Leite, G., Lugaresi, R., Gasparini, S. O., Sperandio, G. A., Ferreira, L. H. B., Souza-Junior, T. P., et al. (2021) · Nutrients · doi:10.3390/nu14010052 · Cited by 181
A review on mycoprotein: History, nutritional composition, production methods, and health benefits
Ahmad, M. I., Farooq, S., Alhamoud, Y., Li, C., & Zhang, H. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.01.027 · Cited by 152
The anabolic response to plant-based protein ingestion
Pinckaers, P. J. M., Trommelen, J., Snijders, T., & van Loon, L. J. C. (2021) · Sports Medicine · doi:10.1007/s40279-021-01540-8 · Cited by 170
Fungi for future foods
Barzee, T., Cao, L., Pan, Z., & Zhang, R.-H. (2021) · Journal of Future Foods · doi:10.1016/j.jfutfo.2021.09.002 · Cited by 116
Fungal Protein – What Is It and What Is the Health Evidence? A Systematic Review Focusing on Mycoprotein
Derbyshire, E. J., & Delange, J. (2021) · Frontiers in Sustainable Food Systems · doi:10.3389/fsufs.2021.581682 · Cited by 115

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Authors: Monteyne, A. J., Coelho, M. O., Porter, C., Abdelrahman, D. R., Jameson, T. S., Jackman, S. R., Blackwell, J. R., Finnigan, T. J., Stephens, F. B., Dirks, M. L., & Wall, B. T.
Affiliations: University of Exeter (GB)
Shriners Hospitals for Children - Galveston (US)
Quorn (United Kingdom) (GB)
Corresponding author: Wall, Benjamin T
ORCID: Monteyne, Alistair J
Porter, Craig
Abdelrahman, Doaa R
Jackman, Sarah R
Blackwell, Jamie R
Finnigan, Tim JA
Stephens, Francis B
Dirks, Marlou L
Wall, Benjamin T
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2020-08
Volume: 112
Issue: 2
Pages: 318-333
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/nqaa092
OpenAlex: W3026952517
Cited by: 110
References: 69
Citations by year: 2026: 17 · 2025: 20 · 2024: 18 · 2023: 16 · 2022: 23 · 2021: 11 · 2020: 5
FWCI: 6.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 912 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Open Research Exeter (University of Exeter) (acceptedVersion)
Figshare (submittedVersion)
Socio-Environmental Systems Modeling (submittedVersion)
Funders: Shriners Hospitals for Children (#84090)
University of Exeter
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
Keywords: mycoprotein, milk protein, skeletal muscle protein synthesis, resistance training, protein intake, leucine, vastus lateralis, resistance-trained men, amino acid infusion, sustainable protein sources, mTOR signaling, MAPK signaling
MeSH terms: Adult, Amino Acids, Double-Blind Method, Fungal Proteins, Humans, Male, Milk Proteins, Muscle Proteins, Exercise, Muscle, Skeletal, Resistance Training, Young Adult

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Mycoprotein ingestion stimulates protein synthesis rates to a greater extent than milk protein in rested and exercised skeletal muscle of healthy young men: a randomized controlled trial

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