Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,251

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Leptin regulates proinflammatory immune responses

Loffreda, S., Yang, S. Q., Lin, H. Z., Karp, C. L., Brengman, M. L., Wang, D. J., Klein, A. S., Bulkley, G. B., Bao, C., Noble, P. W., Lane, M. D., Diehl, A. M.·1998·The FASEB Journal
DOI 10.1096/fasebj.12.1.57
Open this paper in CoChat — free account

Abstract

Obesity is associated with an increased incidence of infection, diabetes, and cardiovascular disease, which together account for most obesity-related morbidity and mortality. Decreased expression of leptin or of functional leptin receptors results in hyperphagia, decreased energy expenditure, and obesity. It is unclear, however, whether defective leptin-dependent signal transduction directly promotes any of the conditions that frequently complicate obesity. Abnormalities in tumor necrosis factor alpha expression have been noted in each of the above comorbid conditions, so leptin deficiency could promote these complications if leptin had immunoregulatory activity. Studies of rodents with genetic abnormalities in leptin or leptin receptors revealed obesity-related deficits in macrophage phagocytosis and the expression of proinflammatory cytokines both in vivo and in vitro. Exogenous leptin up-regulated both phagocytosis and the production of proinflammatory cytokines. These results identify an important and novel function for leptin: up-regulation of inflammatory immune responses, which may provide a common pathogenetic mechanism that contributes to several of the major complications of obesity.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1096/fasebj.12.1.57

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 5 references

Research works printed but not linked: 31

  1. Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. I., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., and Friedman, J. M. 1995 Weight-reducing effects of the plasma protein encoded by the obese gene.Science269,544–546 · DOI · Paper page
  2. Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., and Collins, F. 1995 Effects of the obese gene product on body weight regulation in ob/ob mice.Science269,540–543 · DOI · Paper page
  3. Yamakawa, T., Tanaka, S., Yamakawa, Y., Kiuchi, Y., Isoda, F., Kawamoto, S., Okuda, K., and Sekihara, H. 1995 Augmented production of tumor necrosis factor-alpha in obese mice.Immunol. Immunopathol.75,51–56 · DOI
  4. Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., and Spiegelman, B. M. 1996 Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.Science274,1377–1379 · DOI · Paper page
  5. Jouislahti, P., Tuomilehto, J., Vartiainen, E., Pekkanen, J., and Puska, P. 1996 Body weight, cardiovascular risk factors, and coronary mortality. 15-year follow-up of middle-aged men and women in eastern Finland.Circulation93,1372–1397 · DOI · Paper page
  6. Gorsky, R. D., Pamuk, E., Williamson, D. F., Shaffer, P. A., and Koplan, J. P. 1996 The 25-year health care costs of women who remain overweight after 40 years of age.Am. J. Prev. Med.12,388–394 · DOI
  7. Seidell, J. C., Verschuren, W. M., van Leer, E. M., and Kromhout, D. 1996 Overweight, underweight, and mortality. A prospective study of 48,287 men and women.Arch. Int. Med.156,958–963 · DOI · Paper page
  8. Yang, S. Q., Lin, H. Z., Lane, M. D., Clemens, M., and Diehl, A. M. 1997 Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis.Proc. Natl. Acad. Sci. USA94,2557–2562 · DOI · Paper page
  9. Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., and Spiegelman, B. M. 1996 IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance.Science271,665–668 · DOI · Paper page
  10. Tracey, K. J., and Cerami, A. 1993 Tumor necrosis factor, other cytokines and disease.Annu. Rev. Cell Biol.9,317–343 · DOI · Paper page
  11. Vassalli, P. 1992 The pathophysiology of tumor necrosis factor.Annu. Rev. Immunol.10,411–452 · DOI · Paper page
  12. Nathan, C. F., Murray, H. W., and Cohen, Z. A. 1980 Current concepts. The macrophage as an effector cell.N. Engl. J. Med.303,622–626 · DOI · Paper page
  13. Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., Moore, K. J., Breitbart, R. E., Duyk, G. M., Tepper, R. I., and Morgenstern, J. P. 1996 Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.Cell84,491–495 · DOI · Paper page
  14. Caput, D., Beutler, B., Hartog, K., Thayer, R., Brown-Shimer, S., and Cerami, A. 1986 Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators.Proc. Natl. Acad. Sci. USA83,1670–1674 · DOI · Paper page
  15. Wysocka, M., Kubin, M., Vieira, L. Q., Ozmen, L., Garotta, G., Scott, P., and Trinchieri, G. 1995 Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice.Eur. J. Immunol.25,672–676 · DOI · Paper page
  16. Noble, P. W., Lake, F. R., Henson, P. M., and Riches, D. W. H. 1993 Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a TNF-alpha dependent mechanism in murine macrophages.J. Clin. Invest.91,2368–2377 · DOI · Paper page
  17. Takao, S., Smith, E. H., Wang, D., Chan, C. K., Bulkley, G. B., and Klein, A. S. 1996 Role of reactive oxygen metabolites in murine peritoneal macrophage phagocytosis and phagocytic killing.Am. J. Physiol.271,C1278–C1285 · DOI
  18. Klein, A., Zhadkewich, Margolick, J., Winkelstin, J., and Bulkley, G. 1994 Quantitative discrimination of hepatic reticuloendothelial clearance and phagocytic killing.J. Leukoc. Biol.55,248–252 · DOI
  19. Chomczynski, P., and Sacchi, N. 1987 Single step method for RNA isolation by acid guanidine thiocyanate-phenol-chloroform extraction.Anal. Biochem.162,156–161 · DOI · Paper page
  20. Gainsford, T., Willson, T. A., Metcalf, D., Handman, E., McFarlane, C., Ng, A., Nicola, N. A., Alexander, W. S., and Hilton, D. J. 1996 Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells.Proc. Natl. Acad. Sci. USA93,14564–14568 · DOI · Paper page
  21. Phillips, M. S., Liu, Q., Hammond, H. A., Dugan, V., Hey, P. J., Caskey, C. J ., and Hess, J. F. 1996 Leptin receptor missense mutation in the fatty Zucker rat.Nat. Genet.13,18–19 · DOI · Paper page
  22. Chua, S. C., Jr., Chung, W. K., Wu-Peng, X. S., Zhang, Y., Liu, S. M., Tartaglia, L., and Leibel, R. L. 1996 Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor.Science271,994–996 · DOI · Paper page
  23. Ahima, R. S., Dushay, J., Flier, S. N., Prabakaran, D., and Flier, J. S. 1997 Leptin accelerates the onset of puberty in normal female mice.J. Clin. Invest.99,391–395 · DOI · Paper page
  24. Chehab, F. F., Mounzih, K., Lu, R., and Lim, M. E. 1997 Early onset of reproductive function in normal female mice treated with leptin.Science275,88–90 · DOI · Paper page
  25. Ware, C. F., Van Arsdale, T. L., Crowe, P. D., and Browning, J. L. 1995 The ligands and receptors of the lymphotoxin system.Curr. Top. Immunol.198,175–218 · DOI
  26. Trienchieri, G. 1995 Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.Annu. Rev. Immunol.13,251–276 · DOI · Paper page
  27. Dalton, D. K., Pitts-Meek, S., Keshav, S., Figari, I. S., Bradley, A., and Stewart, T. A. 1993 Multiple defects of immune cell fucntion in mice with disrupted interferon-gamma genes.Science259,1739–1742 · DOI · Paper page
  28. Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., and Deeds, J. 1995 Identification and expression cloning of a leptin receptor, OB-R.Cell83,1263–1271 · DOI · Paper page
  29. Ghilardi, N., Ziegler, S., Wiestner, A., Stoffel, R., Heim, M. H., and Skoda, R. C. 1996 Defective STAT signaling by the leptin receptor in diabetic mice.Proc. Natl. Acad. Sci. USA93,6231–6235 · DOI · Paper page
  30. Plotkin, B. J., Paulson, D., Chelich, A., Jurak, D., Cole, J., Kasimos, J., Burdick, J. R., and Casteel, N. 1996 Immune responsiveness in a rat model for type II diabetes (Zucker rat, fa/fa): susceptibility toCandida albicansinfection and leucocyte function.J. Med. Microbiol.44,277–283 · DOI
  31. Solbach, W. H., and Rollinghoff, M. 1991 Lymphocytes play the music but macrophages call the tune.Immunol. Today12,4–6 · DOI

Cited by

Metadata

Authors
Loffreda, S., Yang, S. Q., Lin, H. Z., Karp, C. L., Brengman, M. L., Wang, D. J., Klein, A. S., Bulkley, G. B., Bao, C., Noble, P. W., Lane, M. D., & Diehl, A. M.
Venue
The FASEB Journal
Publisher
Wiley
Published
1998-01
Volume
12
Issue
1
Pages
57-65
ISSN
  • 0892-6638 (ISSN-L)
  • 1530-6860
DOI
10.1096/fasebj.12.1.57
OpenAlex
W2142431039
Cited by
1,251
References
5
FWCI
31.51
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.