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Supplemental Protein in Support of Muscle Mass and Health: Advantage Whey
Abstract
Skeletal muscle is an integral body tissue playing key roles in strength, performance, physical function, and metabolic regulation. It is essential for athletes to ensure that they have optimal amounts of muscle mass to ensure peak performance in their given sport. However, the role of maintaining muscle mass during weight loss and as we age is an emerging concept, having implications in chronic disease prevention, functional capacity, and quality of life. Higher‐protein diets have been shown to: (1) promote gains in muscle mass, especially when paired with resistance training; (2) spare muscle mass loss during caloric restriction; and (3) attenuate the natural loss of muscle mass that accompanies aging. Protein quality is important to the gain and maintenance of muscle mass. Protein quality is a function of protein digestibility, amino acid content, and the resulting amino acid availability to support metabolic function. Whey protein is one of the highest‐quality proteins given its amino acid content (high essential, branched‐chain, and leucine amino acid content) and rapid digestibility. Consumption of whey protein has a robust ability to stimulate muscle protein synthesis. In fact, whey protein has been found to stimulate muscle protein synthesis to a greater degree than other proteins such as casein and soy. This review examines the existing data supporting the role for protein consumption, with an emphasis on whey protein, in the regulation of muscle mass and body composition in response to resistance training, caloric restriction, and aging.
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Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553
Self-citationDeutz, N. E. P., Bauer, J. M., Barazzoni, R., Biolo, G., Boirie, Y., Bosy-Westphal, A., Cederholm, T., Cruz-Jentoft, A., Krznariç, Z., Nair, K. S., et al. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.04.007 · Cited by 1,738
Slow and fast dietary proteins differently modulate postprandial protein accretion
Boirie, Y., Dangin, M., Gachon, P., Vasson, M.-P., Maubois, J.-L., & Beaufrère, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14930 · Cited by 1,453
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211
Mixed muscle protein synthesis and breakdown after resistance exercise in humans
Phillips, S. M., Tipton, K. D., Aarsland, A., Wolf, S. E., & Wolfe, R. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e99 · Cited by 1,132
Self-citationTang, J. E., Moore, D. R., Kujbida, G. W., Tarnopolsky, M. A., & Phillips, S. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00076.2009 · Cited by 998
Self-citationMoore, D. R., Robinson, M. J., Fry, J. L., Tang, J. E., Glover, E. I., Wilkinson, S. B., Prior, T., Tarnopolsky, M. A., & Phillips, S. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26401 · Cited by 973
Self-citationSarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study
Landi, F., Liperoti, R., Russo, A., Giovannini, S., Tosato, M., Capoluongo, E., Bernabei, R., & Onder, G. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.02.007 · Cited by 938
Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923
Cermak, N. M., Res, P. T., de Groot, L. C., Saris, W. H., & van Loon, L. J. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.037556 · Cited by 827
Skov, A., Toubro, S., Rønn, B., Holm, L., & Astrup, A. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800867 · Cited by 743
Wycherley, T. P., Moran, L. J., Clifton, P. M., Noakes, M., & Brinkworth, G. D. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.044321 · Cited by 606
Tieland, M., Dirks, M. L., van der Zwaluw, N., Verdijk, L. B., van de Rest, O., de Groot, L. C. P. G. M., & van Loon, L. J. C. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.05.020 · Cited by 556
Witard, O. C., Jackman, S. R., Breen, L., Smith, K., Selby, A., & Tipton, K. D. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.055517 · Cited by 517
Yang, Y., Breen, L., Burd, N. A., Hector, A. J., Churchward-Venne, T. A., Josse, A. R., Tarnopolsky, M. A., & Phillips, S. M. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511007422 · Cited by 480
Self-citationKrieger, J. W., Sitren, H. S., Daniels, M. J., & Langkamp-Henken, B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.260 · Cited by 466
Volpi, E., Mittendorfer, B., Rasmussen, B. B., & Wolfe, R. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7021 · Cited by 464
Dreyer, H. C., Drummond, M. J., Pennings, B., Fujita, S., Glynn, E. L., Chinkes, D. L., Dhanani, S., Volpi, E., & Rasmussen, B. B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00582.2007 · Cited by 447
Tieland, M., van de Rest, O., Dirks, M. L., van der Zwaluw, N., Mensink, M., van Loon, L. J. C., & de Groot, L. C. P. G. M. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.07.005 · Cited by 446
Anthony, J. C., Anthony, T. G., Kimball, S. R., & Jefferson, L. S. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.3.856s · Cited by 434
Fulgoni, V. L. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1554s · Cited by 369
Pennings, B., Groen, B., de Lange, A., Gijsen, A. P., Zorenc, A. H., Senden, J. M. G., & van Loon, L. J. C. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00517.2011 · Cited by 326
Stimulation of net muscle protein synthesis by whey protein ingestion before and after exercise
Tipton, K. D., Elliott, T. A., Cree, M. G., Aarsland, A. A., Sanford, A. P., & Wolfe, R. R. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00166.2006 · Cited by 307
Churchward-Venne, T. A., Breen, L., Di Donato, D. M., Hector, A. J., Mitchell, C. J., Moore, D. R., Stellingwerff, T., Breuille, D., Offord, E. A., Baker, S. K., et al. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.068775 · Cited by 290
Yang, Y., Churchward-Venne, T. A., Burd, N. A., Breen, L., Tarnopolsky, M. A., & Phillips, S. M. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-57 · Cited by 286
Self-citationBurd, N. A., Yang, Y., Moore, D. R., Tang, J. E., Tarnopolsky, M. A., & Phillips, S. M. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511006271 · Cited by 276
Self-citationAbargouei, A. S., Janghorbani, M., Salehi-Marzijarani, M., & Esmaillzadeh, A. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.269 · Cited by 238
Andersen, L. L., Tufekovic, G., Zebis, M. K., Crameri, R. M., Verlaan, G., Kjær, M., Suetta, C., Magnusson, P., & Aagaard, P. (2005) · Metabolism · doi:10.1016/j.metabol.2004.07.012 · Cited by 228
Areta, J. L., Burke, L. M., Camera, D. M., West, D. W. D., Crawshay, S., Moore, D. R., Stellingwerff, T., Phillips, S. M., Hawley, J. A., & Coffey, V. G. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00590.2013 · Cited by 227
Self-citationThe effect of protein timing on muscle strength and hypertrophy: a meta-analysis
Schoenfeld, B. J., Aragon, A. A., & Krieger, J. W. (2013) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-10-53 · Cited by 201
Hulmi, J. J., Kovanen, V., Selänne, H., Kraemer, W. J., Häkkinen, K., & Mero, A. A. (2009) · Amino Acids · doi:10.1007/s00726-008-0150-6 · Cited by 189
Whey protein supplementation during resistance training augments lean body mass
Volek, J. S., Volk, B. M., Gómez, A. L., Kunces, L. J., Kupchak, B. R., Freidenreich, D. J., Aristizabal, J. C., Saenz, C., Dunn-Lewis, C., Ballard, K. D., et al. (2013) · Journal of the American College of Nutrition · doi:10.1080/07315724.2013.793580 · Cited by 181
Effect of Whey and Soy Protein Supplementation Combined with Resistance Training in Young Adults
Candow, D. G., Burke, N. C., Smith-Palmer, T., & Burke, D. G. (2006) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.16.3.233 · Cited by 180
Joy, J. M., Lowery, R. P., Wilson, J. M., Purpura, M., De Souza, E. O., Wilson, S. M., Kalman, D. S., Dudeck, J. E., & Jäger, R. (2013) · Nutrition Journal · doi:10.1186/1475-2891-12-86 · Cited by 179
Maximizing muscle protein anabolism: the role of protein quality
Tang, J. E., & Phillips, S. M. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831cef75 · Cited by 178
Self-citationCribb, P. J., Williams, A. D., Carey, M. F., & Hayes, A. (2006) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.16.5.494 · Cited by 177
Pasiakos, S. M., Vislocky, L. M., Carbone, J. W., Altieri, N., Konopelski, K., Freake, H. C., Anderson, J. M., Ferrando, A. A., Wolfe, R. R., & Rodriguez, N. R. (2010) · The Journal of Nutrition · doi:10.3945/jn.109.118372 · Cited by 176
Hoffman, J. R., Ratamess, N. A., Tranchina, C. P., Rashti, S. L., Kang, J., & Faigenbaum, A. D. (2009) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.19.2.172 · Cited by 123
Miller, P. E., Alexander, D. D., & Perez, V. (2014) · Journal of the American College of Nutrition · doi:10.1080/07315724.2013.875365 · Cited by 122
Influence of Nutrition on Responses to Resistance Training
VOLEK, J. S. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000121944.19275.c4 · Cited by 93
Coker, R. H., Miller, S., Schutzler, S., Deutz, N., & Wolfe, R. R. (2012) · Nutrition Journal · doi:10.1186/1475-2891-11-105 · Cited by 92
Research works printed but not linked: 55
- 10.1093/jn/130.10.2413 · DOI · Paper page
- 10.3945/jn.111.139840 · DOI · Paper page
- 10.1016/j.jand.2013.01.014 · DOI · Paper page
- 10.1152/ajpendo.1997.273.1.E122 · DOI · Paper page
- 10.1007/s00421-005-0127-z · DOI · Paper page
- 10.1093/jn/133.5.1308 · DOI · Paper page
- 10.3945/ajcn.112.037119 · DOI · Paper page
- 10.1038/ijo.2008.278 · DOI · Paper page
- Coburn JW, 2006, Effects of leucine and whey protein supplementation during eight weeks of unilateral resistance training, J Strength Cond Res, 20, 284
- 10.1093/jn/135.3.376 · DOI · Paper page
- 10.1007/s12603-014-0465-9 · DOI
- 10.2337/diacare.15.3.318 · DOI · Paper page
- 10.1186/1550-2783-6-8 · DOI · Paper page
- 10.1152/ajpendo.00402.2005 · DOI
- 10.1111/j.1469-7793.2001.00301.x · DOI · Paper page
- 10.1093/jn/132.1.125 · DOI
- 10.1152/ajpregu.00281.2009 · DOI
- 10.1186/1743-7075-5-8 · DOI
- 10.1016/j.nutres.2013.05.014 · DOI
- 10.3945/jn.113.184705 · DOI
- 10.1093/ajcn/86.2.373 · DOI · Paper page
- 10.1093/ajcn/87.1.150 · DOI · Paper page
- 10.1038/ejcn.2013.52 · DOI
- 10.3945/jn.111.141028 · DOI · Paper page
- 10.1249/01.mss.0000175865.17614.74 · DOI · Paper page
- 10.1016/j.biocel.2010.05.013 · DOI
- 10.1152/ajpendo.00413.2004 · DOI · Paper page
- 10.1038/ejcn.2011.221 · DOI
- 10.1093/jn/135.5.1080 · DOI
- 10.1161/CIRCULATIONAHA.107.716159 · DOI · Paper page
- 10.1093/gerona/glr120 · DOI
- 10.1093/gerona/glu103 · DOI · Paper page
- 10.1093/ajcn/66.4.760 · DOI · Paper page
- 10.1093/ajcn/77.6.1417 · DOI · Paper page
- 10.1097/MCO.0b013e32831cef8b · DOI · Paper page
- 10.1017/S0007114510001911 · DOI
- 10.3945/ajcn.110.008102 · DOI · Paper page
- 10.1001/jama.287.16.2081 · DOI · Paper page
- 10.1139/H09-042 · DOI
- 10.1007/s40279-014-0152-3 · DOI · Paper page
- 10.1136/bmj.a439 · DOI · Paper page
- 10.1007/s00198-013-2431-5 · DOI
- 10.1186/1550-2783-9-54 · DOI
- Stookey J, 2005, Do protein and energy intakes explain long‐term changes in body composition, J Nutr Health Aging, 9, 5
- 10.1249/01.MSS.0000147582.99810.C5 · DOI · Paper page
- Velazquez Alva Mdel C, 2013, The relationship between sarcopenia, undernutrition, physical mobility and basic activities of daily living in a group of elderly women of Mexico City, Nutr Hosp, 28, 514
- 10.3945/ajcn.2008.26626 · DOI · Paper page
- 10.1210/jc.85.12.4481 · DOI · Paper page
- 10.1093/gerona/gls229 · DOI · Paper page
- 10.3945/ajcn.111.013722 · DOI · Paper page
- 10.1146/annurev-nutr-080508-141056 · DOI · Paper page
- 10.1093/ajcn/85.4.1031 · DOI · Paper page
- 10.1093/ajcn/84.3.475 · DOI · Paper page
- 10.1016/j.clnu.2008.06.008 · DOI · Paper page
- 10.1111/j.1463-1326.2010.01307.x · DOI
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Metadata
- Authors
- Devries, M. C., & Phillips, S. M.
- Venue
- Journal of Food Science
- Publisher
- Wiley
- Published
- 2015-03
- Volume
- 80
- Issue
- S1
- Pages
- A8-A15
- ISSN
- 0022-1147 (ISSN-L)
- 1750-3841
- OpenAlex
- W1731095862
- Cited by
- 330
- References
- 41
- Type
- supplementary materials
- Language
- en
- Open access
- closed
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