Transient receptor potential (TRP) channels: a clinical perspective

Calcium's Role in Mechanotransduction during Muscle Development

Benavides Damm, T., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,502

The capsaicin receptor: a heat-activated ion channel in the pain pathway

Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. (1997) · Nature · doi:10.1038/39807 · Cited by 9,107

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Hery-Arnaud, G., Le Berre, R., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 4,992

Impaired nociception and pain sensation in mice lacking the capsaicin receptor

Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Basbaum, A. I., & Julius, D. (2000) · Science · doi:10.1126/science.288.5464.306 · Cited by 3,544

TRP channels as cellular sensors

Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

McKemy, D. D., Neuhausser, W. M., & Julius, D. (2002) · Nature · doi:10.1038/nature719 · Cited by 2,709

ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures

Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T. R., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00158-2 · Cited by 2,486

A TRP Channel that Senses Cold Stimuli and Menthol

Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00652-9 · Cited by 2,355

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057

TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents

Bautista, D. M., Jordt, S.-E., Nikai, T., Tsuruda, P. R., Read, A. J., Poblete, J., Yamoah, E. N., Basbaum, A. I., & Julius, D. (2006) · Cell · doi:10.1016/j.cell.2006.02.023 · Cited by 1,932

Vanilloid (Capsaicin) Receptors and Mechanisms

Szallasi, A., & Blumberg, P. M. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01403-0 · Cited by 1,903

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

Jordt, S.-E., Bautista, D. M., Chuang, H.-H., McKemy, D. D., Zygmunt, P. M., Högestätt, E. D., Meng, I. D., & Julius, D. (2004) · Nature · doi:10.1038/nature02282 · Cited by 1,899

Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin

Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., & Patapoutian, A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00150-3 · Cited by 1,827

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

Davis, J. B., Gray, J., Gunthorpe, M. J., Hatcher, J. P., Davey, P. T., Overend, P., Harries, M. H., Latcham, J., Clapham, C., Atkinson, K., et al. (2000) · Nature · doi:10.1038/35012076 · Cited by 1,760

PKD2 , a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein

Mochizuki, T., Wu, G., Hayashi, T., Xenophontos, S. L., Veldhuisen, B., Saris, J. J., Reynolds, D. M., Cai, Y., Gabow, P. A., Pierides, A., et al. (1996) · Science · doi:10.1126/science.272.5266.1339 · Cited by 1,406

The menthol receptor TRPM8 is the principal detector of environmental cold

Bautista, D. M., Siemens, J., Glazer, J. M., Tsuruda, P. R., Basbaum, A. I., Stucky, C. L., Jordt, S.-E., & Julius, D. (2007) · Nature · doi:10.1038/nature05910 · Cited by 1,387

Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide

Bisogno, T., Hanuš, L., De Petrocellis, L., Tchilibon, S., Ponde, D. E., Brandi, I., Moriello, A. S., Davis, J. B., Mechoulam, R., & Di Marzo, V. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704327 · Cited by 1,311

TRPA1 mediates formalin-induced pain

McNamara, C. R., Mandel-Brehm, J., Bautista, D. M., Siemens, J., Deranian, K. L., Zhao, M., Hayward, N. J., Chong, J. A., Julius, D., Moran, M. M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705924104 · Cited by 1,263

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

Chuang, H.-H., Prescott, E. D., Kong, H., Shields, S., Jordt, S.-E., Basbaum, A. I., Chao, M. V., & Julius, D. (2001) · Nature · doi:10.1038/35082088 · Cited by 1,258

The trp ion channel family

Clapham, D. E., Runnels, L. W., & Strübing, C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077544 · Cited by 1,153

Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction

Montell, C., & Rubin, G. M. (1989) · Neuron · doi:10.1016/0896-6273(89)90069-x · Cited by 1,135

A Mutation in the TRPC6 Cation Channel Causes Familial Focal Segmental Glomerulosclerosis

Winn, M. P., Conlon, P. J., Lynn, K. L., Farrington, M. K., Creazzo, T., Hawkins, A. F., Daskalakis, N., Kwan, S. Y., Ebersviller, S., Burchette, J. L., et al. (2005) · Science · doi:10.1126/science.1106215 · Cited by 1,104

Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances

Hwang, S. W., Cho, H., Kwak, J., Lee, S.-Y., Kang, C.-J., Jung, J., Cho, S., Min, K. H., Suh, Y.-G., Kim, D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.6155 · Cited by 1,048

Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels

Watanabe, H., Vriens, J., Prenen, J., Droogmans, G., Voets, T., & Nilius, B. (2003) · Nature · doi:10.1038/nature01807 · Cited by 1,027

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

Huh, D., Leslie, D. C., Matthews, B. D., Fraser, J. P., Jurek, S., Hamilton, G. A., Thorneloe, K. S., McAlexander, M. A., & Ingber, D. E. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004249 · Cited by 993

A Heat-Sensitive TRP Channel Expressed in Keratinocytes

Peier, A. M., Reeve, A. J., Andersson, D. A., Moqrich, A., Earley, T. J., Hergarden, A. C., Story, G. M., Colley, S., Hogenesch, J. B., McIntyre, P., et al. (2002) · Science · doi:10.1126/science.1073140 · Cited by 970

An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors

Huang, S. M., Bisogno, T., Trevisani, M., Al-Hayani, A., De Petrocellis, L., Fezza, F., Tognetto, M., Petros, T. J., Krey, J. F., Chu, C. J., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122196999 · Cited by 964

Effects of cannabinoids and cannabinoid‐enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes

De Petrocellis, L., Ligresti, A., Moriello, A. S., Allarà, M., Bisogno, T., Petrosino, S., Stott, C. G., & Di Marzo, V. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01166.x · Cited by 946

TRPV3 is a calcium-permeable temperature-sensitive cation channel

Xu, H., Ramsey, I. S., Kotecha, S. A., Moran, M. M., Chong, J. A., Lawson, D., Ge, P., Lilly, J., Silos-Santiago, I., Xie, Y., et al. (2002) · Nature · doi:10.1038/nature00882 · Cited by 920

The transient receptor potential family of ion channels

Nilius, B., & Owsianik, G. (2011) · Genome Biology · doi:10.1186/gb-2011-12-3-218 · Cited by 919

The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

Szallasi, A., Cortright, D. N., Blum, C. A., & Eid, S. R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2280 · Cited by 879

TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function

Reiser, J., Polu, K. R., Möller, C. C., Kenlan, P., Altintas, M. M., Wei, C., Faul, C., Herbert, S., Villegas, I., Avila-Casado, C., et al. (2005) · Nature Genetics · doi:10.1038/ng1592 · Cited by 863

Pungent products from garlic activate the sensory ion channel TRPA1

Bautista, D. M., Movahed, P., Hinman, A., Axelsson, H. E., Sterner, O., Högestätt, E. D., Julius, D., Jordt, S.-E., & Zygmunt, P. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505356102 · Cited by 860

LTRPC2 Ca2+-Permeable Channel Activated by Changes in Redox Status Confers Susceptibility to Cell Death

Hara, Y., Wakamori, M., Ishii, M., Maeno, E., Nishida, M., Yoshida, T., Yamada, H., Shimizu, S., Mori, E., Kudoh, J., et al. (2002) · Molecular Cell · doi:10.1016/s1097-2765(01)00438-5 · Cited by 824

Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin

Moqrich, A., Hwang, S. W., Earley, T. J., Petrus, M. J., Murray, A. N., Spencer, K. S. R., Andahazy, M., Story, G. M., & Patapoutian, A. (2005) · Science · doi:10.1126/science.1108609 · Cited by 800

Attenuated Cold Sensitivity in TRPM8 Null Mice

Colburn, R. W., Lubin, M. L., Stone, D. J., Wang, Y., Lawrence, D., D'Andrea, M. R., Brandt, M. R., Liu, Y., Flores, C. M., & Qin, N. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.017 · Cited by 771

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

Trevisani, M., Siemens, J., Materazzi, S., Bautista, D. M., Nassini, R., Campi, B., Imamachi, N., Andrè, E., Patacchini, R., Cottrell, G. S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705923104 · Cited by 770

Impaired Pressure Sensation in Mice Lacking TRPV4

Suzuki, M., Mizuno, A., Kodaira, K., & Imai, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302561200 · Cited by 747

Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c‐fibers and colocalization with trk receptors

Kobayashi, K., Fukuoka, T., Obata, K., Yamanaka, H., Dai, Y., Tokunaga, A., & Noguchi, K. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20794 · Cited by 729

Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1

Birder, L. A., Nakamura, Y., Kiss, S., Nealen, M. L., Barrick, S., Kanai, A. J., Wang, E., Ruiz, G., de Groat, W. C., Apodaca, G., et al. (2002) · Nature Neuroscience · doi:10.1038/nn902 · Cited by 703

Abnormal Electroretinogram from a Drosophila Mutant

COSENS, D. J., & MANNING, A. (1969) · Nature · doi:10.1038/224285a0 · Cited by 696

Transient receptor potential channels: targeting pain at the source

Patapoutian, A., Tate, S., & Woolf, C. J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2757 · Cited by 646

Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels

Xu, H., Delling, M., Jun, J. C., & Clapham, D. E. (2006) · Nature Neuroscience · doi:10.1038/nn1692 · Cited by 644

TRPC1, a human homolog of a Drosophila store-operated channel.

Wes, P. D., Chevesich, J., Jeromin, A., Rosenberg, C., Stetten, G., & Montell, C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9652 · Cited by 632

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels

Alexander, S. P. H., Mathie, A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14749 · Cited by 606

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

Wu, L.-J., Sweet, T.-B., & Clapham, D. E. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002725 · Cited by 602

TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch

Wilson, S. R., Gerhold, K. A., Bifolck-Fisher, A., Liu, Q., Patel, K. N., Dong, X., & Bautista, D. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2789 · Cited by 599

Genetics and Pathogenesis of Polycystic Kidney Disease

Igarashi, P., & Somlo, S. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000028643.17901.42 · Cited by 593

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

Vriens, J., Owsianik, G., Hofmann, T., Philipp, S. E., Stab, J., Chen, X., Benoit, M., Xue, F., Janssens, A., Kerselaers, S., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.051 · Cited by 583

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

Dong, X.-P., Cheng, X., Mills, E., Delling, M., Wang, F., Kurz, T., & Xu, H. (2008) · Nature · doi:10.1038/nature07311 · Cited by 581

Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with Aδ/C-fibers and colocalization with Trk receptors

小林, 希. (2007) · Medical Entomology and Zoology · Cited by 575

TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling

Kuwahara, K., Wang, Y., McAnally, J., Richardson, J. A., Bassel-Duby, R., Hill, J. A., & Olson, E. N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27702 · Cited by 561

Transient receptor potential channels as therapeutic targets

Moran, M. M., McAlexander, M. A., Bíró, T., & Szallasi, A. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3456 · Cited by 550

Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells

Cavanaugh, D. J., Chesler, A. T., Jackson, A. C., Sigal, Y. M., Yamanaka, H., Grant, R., O'Donnell, D., Nicoll, R. A., Shah, N. M., Julius, D., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6451-10.2011 · Cited by 542

Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain

Akbar, A., Yiangou, Y., Facer, P., Walters, J. R. F., Anand, P., & Ghosh, S. (2008) · Gut · doi:10.1136/gut.2007.138982 · Cited by 526

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

Gavva, N. R., Treanor, J. J. S., Garami, A., Fang, L., Surapaneni, S., Akrami, A., Alvarez, F., Bak, A., Darling, M., Gore, A., et al. (2008) · Pain · doi:10.1016/j.pain.2008.01.024 · Cited by 525

Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton

Faul, C., Asanuma, K., Yanagida-Asanuma, E., Kim, K., & Mundel, P. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.06.006 · Cited by 524

2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3

Hu, H.-Z., Gu, Q., Wang, C., Colton, C. K., Tang, J., Kinoshita-Kawada, M., Lee, L.-Y., Wood, J. D., & Zhu, M. X. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404164200 · Cited by 517

A common mechanism underlies stretch activation and receptor activation of TRPC6 channels

Spassova, M. A., Hewavitharana, T., Xu, W., Soboloff, J., & Gill, D. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606894103 · Cited by 517

Increased Vascular Smooth Muscle Contractility in TRPC6−/− Mice

Dietrich, A., Mederos y Schnitzler, M., Gollasch, M., Gross, V., Storch, U., Dubrovska, G., Obst, M., Yildirim, E., Salanova, B., Kalwa, H., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.6980-6989.2005 · Cited by 513

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

Shen, D., Wang, X., Li, X., Zhang, X., Yao, Z., Dibble, S., Dong, X.-P., Yu, T., Lieberman, A. P., Showalter, H. D., et al. (2012) · Nature Communications · doi:10.1038/ncomms1735 · Cited by 495

TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A2and 12-Lipoxygenase

Shim, W.-S., Tak, M.-H., Lee, M.-H., Kim, M., Kim, M., Koo, J.-Y., Lee, C.-H., Kim, M., & Oh, U. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4643-06.2007 · Cited by 465

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

Caceres, A. I., Brackmann, M., Elia, M. D., Bessac, B. F., del Camino, D., D'Amours, M., Witek, J. S., Fanger, C. M., Chong, J. A., Hayward, N. J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900591106 · Cited by 463

Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel

Sun, M. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.17.2471 · Cited by 461

Characterization of the mouse cold‐menthol receptor TRPM8 and vanilloid receptor type‐1 VR1 using a fluorometric imaging plate reader (FLIPR) assay

Behrendt, H., Germann, T., Gillen, C., Hatt, H., & Jostock, R. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705652 · Cited by 458

Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor

Li, Y., Jia, Y.-C., Cui, K., Li, N., Zheng, Z.-Y., Wang, Y.-Z., & Yuan, X.-B. (2005) · Nature · doi:10.1038/nature03477 · Cited by 450

TRPA1 is a major oxidant sensor in murine airway sensory neurons

Bessac, B. F., Sivula, M., von Hehn, C. A., Escalera, J., Cohn, L., & Jordt, S.-E. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34192 · Cited by 449

HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity

Eid, S. R., Crown, E. D., Moore, E. L., Liang, H. A., Choong, K.-C., Dima, S., Henze, D. A., Kane, S. A., & Urban, M. O. (2008) · Molecular Pain · doi:10.1186/1744-8069-4-48 · Cited by 447

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

Kremeyer, B., Lopera, F., Cox, J. J., Momin, A., Rugiero, F., Marsh, S., Woods, C. G., Jones, N. G., Paterson, K. J., Fricker, F. R., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.030 · Cited by 443

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

Imamachi, N., Park, G. H., Lee, H., Anderson, D. J., Simon, M. I., Basbaum, A. I., & Han, S.-K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905605106 · Cited by 443

Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper

Szallasi, A., & Blumberg, P. M. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90269-8 · Cited by 438

Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension

Yu, Y., Fantozzi, I., Remillard, C. V., Landsberg, J. W., Kunichika, N., Platoshyn, O., Tigno, D. D., Thistlethwaite, P. A., Rubin, L. J., & Yuan, J. X.-J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405908101 · Cited by 430

Camphor Activates and Strongly Desensitizes the Transient Receptor Potential Vanilloid Subtype 1 Channel in a Vanilloid-Independent Mechanism

Xu, H., Blair, N. T., & Clapham, D. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2574-05.2005 · Cited by 420

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

(2006) · CRC Press eBooks · doi:10.1201/9781420005844 · Cited by 418

A Role of TRPA1 in Mechanical Hyperalgesia is Revealed by Pharmacological Inhibition

Petrus, M., Peier, A. M., Bandell, M., Hwang, S. W., Huynh, T., Olney, N., Jegla, T., & Patapoutian, A. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-40 · Cited by 418

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

Everaerts, W., Zhen, X., Ghosh, D., Vriens, J., Gevaert, T., Gilbert, J. P., Hayward, N. J., McNamara, C. R., Xue, F., Moran, M. M., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005333107 · Cited by 416

The functions of TRPA1 and TRPV1: moving away from sensory nerves

Fernandes, E., Fernandes, M., & Keeble, J. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01851.x · Cited by 411

TRPC3 and TRPC6 are essential for angiotensin II‐induced cardiac hypertrophy

Onohara, N., Nishida, M., Inoue, R., Kobayashi, H., Sumimoto, H., Sato, Y., Mori, Y., Nagao, T., & Kurose, H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601417 · Cited by 411

N-((1 S)-1-{[4-((2 S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I

Thorneloe, K. S., Sulpizio, A. C., Lin, Z., Figueroa, D. J., Clouse, A. K., McCafferty, G. P., Chendrimada, T. P., Lashinger, E. S. R., Gordon, E., Evans, L., et al. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.139295 · Cited by 411

TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination

Hartmann, J., Dragicevic, E., Adelsberger, H., Henning, H. A., Sumser, M., Abramowitz, J., Blum, R., Dietrich, A., Freichel, M., Flockerzi, V., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.009 · Cited by 404

More than cool: Promiscuous relationships of menthol and other sensory compounds

Macpherson, L. J., Hwang, S. W., Miyamoto, T., Dubin, A. E., Patapoutian, A., & Story, G. M. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.05.005 · Cited by 401

Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis.

Duncan, L. M., Deeds, J. D., Hunter, J., Shao, J., Holmgren, L. M., Woolf, E. A., Tepper, R. I., & Shyjan, A. W. (1998) · PubMed · Cited by 401

TRPP2 and TRPV4 form a polymodal sensory channel complex

Köttgen, M., Buchholz, B., Garcia-Gonzalez, M. A., Kotsis, F., Fu, X., Doerken, M., Boehlke, C., Steffl, D., Tauber, R., Wegierski, T., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200805124 · Cited by 397

TRPV2 Is Activated by Cannabidiol and Mediates CGRP Release in Cultured Rat Dorsal Root Ganglion Neurons

Qin, N., Neeper, M. P., Liu, Y., Hutchinson, T. L., Lubin, M. L., & Flores, C. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0504-08.2008 · Cited by 396

Increased Expression of Transient Receptor Potential Vanilloid-1 in Airway Nerves of Chronic Cough

Groneberg, D. A., Niimi, A., Dinh, Q. T., Cosio, B., Hew, M., Fischer, A., & Chung, K. F. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200402-174oc · Cited by 396

Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells

Wagner, T. F. J., Loch, S., Lambert, S., Straub, I., Mannebach, S., Mathar, I., Düfer, M., Lis, A., Flockerzi, V., Philipp, S. E., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1801 · Cited by 392

Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

Kiyonaka, S., Kato, K., Nishida, M., Mio, K., Numaga, T., Sawaguchi, Y., Yoshida, T., Wakamori, M., Mori, E., Numata, T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808793106 · Cited by 387

Functional Characterization of Homo- and Heteromeric Channel Kinases TRPM6 and TRPM7

Li, M., Jiang, J., & Yue, L. (2006) · The Journal of General Physiology · doi:10.1085/jgp.200609502 · Cited by 383

Cigarette smoke–induced neurogenic inflammation is mediated by α,β-unsaturated aldehydes and the TRPA1 receptor in rodents

Andrè, E., Campi, B., Materazzi, S., Trevisani, M., Amadesi, S., Massi, D., Creminon, C., Vaksman, N., Nassini, R., Civelli, M., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34886 · Cited by 372

Spider toxins activate the capsaicin receptor to produce inflammatory pain

Siemens, J., Zhou, S., Piskorowski, R., Nikai, T., Lumpkin, E. A., Basbaum, A. I., King, D., & Julius, D. (2006) · Nature · doi:10.1038/nature05285 · Cited by 359

Vanilloid receptor 1 immunoreactivity in inflamed human bowel

Yiangou, Y., Facer, P., Dyer, N., Chan, C., Knowles, C., Williams, N., & Anand, P. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04503-7 · Cited by 359

Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice

Marsch, R., Foeller, E., Rammes, G., Bunck, M., Kössl, M., Holsboer, F., Zieglgänsberger, W., Landgraf, R., Lutz, B., & Wotjak, C. T. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3303-06.2007 · Cited by 359

Accumulation of Free ADP-ribose from Mitochondria Mediates Oxidative Stress-induced Gating of TRPM2 Cation Channels

Perraud, A.-L., Takanishi, C. L., Shen, B., Kang, S., Smith, M. K., Schmitz, C., Knowles, H. M., Ferraris, D., Li, W., Zhang, J., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411446200 · Cited by 358

Molecular cloning of a widely expressed human homologue for the Drosophila trp gene

Zhu, X., Chu, P. B., Peyton, M., & Birnbaumer, L. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01038-g · Cited by 357

N-Oleoyldopamine, a Novel Endogenous Capsaicin-like Lipid That Produces Hyperalgesia

Chu, C. J., Huang, S. M., De Petrocellis, L., Bisogno, T., Ewing, S. A., Miller, J. D., Zipkin, R. E., Daddario, N., Appendino, G., Di Marzo, V., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211231200 · Cited by 345

TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis

Ye, L., Kleiner, S., Wu, J., Sah, R., Gupta, R. K., Banks, A. S., Cohen, P., Khandekar, M. J., Boström, P., Mepani, R. J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.034 · Cited by 343

Cyclic ADP-Ribose and Hydrogen Peroxide Synergize with ADP-Ribose in the Activation of TRPM2 Channels

Kolisek, M., Beck, A., Fleig, A., & Penner, R. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.033 · Cited by 340

Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C

Landouré, G., Zdebik, A. A., Martinez, T. L., Burnett, B. G., Stanescu, H. C., Inada, H., Shi, Y., Taye, A. A., Kong, L., Munns, C. H., et al. (2010) · Nature Genetics · doi:10.1038/ng.512 · Cited by 339

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

Thorneloe, K. S., Cheung, M., Bao, W., Alsaid, H., Lenhard, S., Jian, M.-Y., Costell, M., Maniscalco-Hauk, K., Krawiec, J. A., Olzinski, A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004276 · Cited by 337

TRPV1+ Sensory Neurons Control β Cell Stress and Islet Inflammation in Autoimmune Diabetes

Razavi, R., Chan, Y., Afifiyan, F. N., Liu, X. J., Wan, X., Yantha, J., Tsui, H., Tang, L., Tsai, S., Santamaria, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.10.038 · Cited by 336

Exome Sequencing Reveals Mutations in TRPV3 as a Cause of Olmsted Syndrome

Lin, Z., Chen, Q., Lee, M., Cao, X., Zhang, J., Ma, D., Chen, L., Hu, X., Wang, H., Wang, X., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.02.006 · Cited by 336

Plant-Derived Cannabinoids Modulate the Activity of Transient Receptor Potential Channels of Ankyrin Type-1 and Melastatin Type-8

De Petrocellis, L., Vellani, V., Schiano-Moriello, A., Marini, P., Magherini, P. C., Orlando, P., & Di Marzo, V. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.134809 · Cited by 336

Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding

Gevaert, T., Vriens, J., Segal, A., Everaerts, W., Roskams, T., Talavera, K., Owsianik, G., Liedtke, W., Daelemans, D., Dewachter, I., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31766 · Cited by 331

Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I

Kruse, M., Schulze-Bahr, E., Corfield, V., Beckmann, A., Stallmeyer, B., Kurtbay, G., Ohmert, I., Schulze-Bahr, E., Brink, P., & Pongs, O. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38292 · Cited by 327

Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades

AbouAlaiwi, W. A., Takahashi, M., Mell, B. R., Jones, T. J., Ratnam, S., Kolb, R. J., & Nauli, S. M. (2009) · Circulation Research · doi:10.1161/circresaha.108.192765 · Cited by 327

TRPV1 Receptors in the CNS Play a Key Role in Broad-Spectrum Analgesia of TRPV1 Antagonists

Cui, M., Honore, P., Zhong, C., Gauvin, D., Mikusa, J., Hernandez, G., Chandran, P., Gomtsyan, A., Brown, B., Bayburt, E. K., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1246-06.2006 · Cited by 318

Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

Bagal, S. K., Brown, A. D., Cox, P. J., Omoto, K., Owen, R. M., Pryde, D. C., Sidders, B., Skerratt, S. E., Stevens, E. B., Storer, R. I., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm3011433 · Cited by 316

A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain

Bohlen, C. J., Priel, A., Zhou, S., King, D., Siemens, J., & Julius, D. (2010) · Cell · doi:10.1016/j.cell.2010.03.052 · Cited by 311

Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)

McNamara, F. N., Randall, A., & Gunthorpe, M. J. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706040 · Cited by 310

Distribution and Function of the Hydrogen Sulfide–Sensitive TRPA1 Ion Channel in Rat Urinary Bladder

Streng, T., Axelsson, H. E., Hedlund, P., Andersson, D. A., Jordt, S.-E., Bevan, S., Andersson, K.-E., Högestätt, E. D., & Zygmunt, P. M. (2008) · European Urology · doi:10.1016/j.eururo.2007.10.024 · Cited by 308

Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange

Weissmann, N., Dietrich, A., Fuchs, B., Kalwa, H., Ay, M., Dumitrascu, R., Olschewski, A., Storch, U., Mederos y Schnitzler, M., Ghofrani, H. A., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606728103 · Cited by 304

Systemic Activation of the Transient Receptor Potential Vanilloid Subtype 4 Channel Causes Endothelial Failure and Circulatory Collapse: Part 2

Willette, R. N., Bao, W., Nerurkar, S., Yue, T.-L., Doe, C. P., Stankus, G., Turner, G. H., Ju, H., Thomas, H., Fishman, C. E., et al. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.134551 · Cited by 300

Induction of TRPC6 Channel in Acquired Forms of Proteinuric Kidney Disease

Mo[Combining Diaeresis]ller, C. C., Wei, C., Altintas, M. M., Li, J., Greka, A., Ohse, T., Pippin, J. W., Rastaldi, M. P., Wawersik, S., Schiavi, S., et al. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006091010 · Cited by 299

The puzzle of TRPV4 channelopathies

Nilius, B., & Voets, T. (2013) · EMBO reports · doi:10.1038/embor.2012.219 · Cited by 297

The thermo‐TRP ion channel family: properties and therapeutic implications

Vay, L., Gu, C., & McNaughton, P. A. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01601.x · Cited by 296

TRPM2 Functions as a Lysosomal Ca2+-Release Channel in β Cells

Lange, I., Yamamoto, S., Partida-Sanchez, S., Mori, Y., Fleig, A., & Penner, R. (2009) · Science Signaling · doi:10.1126/scisignal.2000278 · Cited by 295

Targeting TRP channels for pain relief

Brederson, J.-D., Kym, P. R., & Szallasi, A. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.03.003 · Cited by 293

The TRPV4 Cation Channel Mediates Stretch-evoked Ca2+ Influx and ATP Release in Primary Urothelial Cell Cultures

Mochizuki, T., Sokabe, T., Araki, I., Fujishita, K., Shibasaki, K., Uchida, K., Naruse, K., Koizumi, S., Takeda, M., & Tominaga, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.020206 · Cited by 291

Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia

Sun, H.-S., Jackson, M. F., Martin, L. J., Jansen, K., Teves, L., Cui, H., Kiyonaka, S., Mori, Y., Jones, M., Forder, J. P., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2395 · Cited by 287

Prostaglandin-Induced Activation of Nociceptive Neurons via Direct Interaction with Transient Receptor Potential A1 (TRPA1)

Taylor-Clark, T. E., Undem, B. J., MacGlashan, D. W., Ghatta, S., Carr, M. J., & McAlexander, M. A. (2008) · Molecular Pharmacology · doi:10.1124/mol.107.040832 · Cited by 287

Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy

Facer, P., Casula, M. A., Smith, G. D., Benham, C. D., Chessell, I. P., Bountra, C., Sinisi, M., Birch, R., & Anand, P. (2007) · BMC Neurology · doi:10.1186/1471-2377-7-11 · Cited by 282

Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior

Riccio, A., Li, Y., Moon, J., Kim, K.-S., Smith, K. S., Rudolph, U., Gapon, S., Yao, G. L., Tsvetkov, E., Rodig, S. J., et al. (2009) · Cell · doi:10.1016/j.cell.2009.03.039 · Cited by 281

Capsaicin (TRPV1 Agonist) Therapy for Pain Relief: Farewell or Revival?

Knotkova, H., Pappagallo, M., & Szallasi, A. (2008) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e318158ed9e · Cited by 279

Antagonistic Regulation of Actin Dynamics and Cell Motility by TRPC5 and TRPC6 Channels

Tian, D., Jacobo, S. M. P., Billing, D., Rozkalne, A., Gage, S. D., Anagnostou, T., Pavenstädt, H., Hsu, H.-H., Schlondorff, J., Ramos, A., et al. (2010) · Science Signaling · doi:10.1126/scisignal.2001200 · Cited by 279

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

Chen, J., Joshi, S. K., DiDomenico, S., Perner, R. J., Mikusa, J. P., Gauvin, D. M., Segreti, J. A., Han, P., Zhang, X.-F., Niforatos, W., et al. (2011) · Pain · doi:10.1016/j.pain.2011.01.049 · Cited by 276

Increased capsaicin receptor TRPV1 nerve fibres in the inflamed human oesophagus

Matthews, P. J., Aziz, Q., Facer, P., Davis, J. B., Thompson, D. G., & Anand, P. (2004) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200409000-00014 · Cited by 275

Proinflammatory Mediators Modulate the Heat-Activated Ion Channel TRPV1 via the Scaffolding Protein AKAP79/150

Zhang, X., Li, L., & McNaughton, P. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.015 · Cited by 275

TRPA1 Agonists Evoke Coughing in Guinea Pig and Human Volunteers

Birrell, M. A., Belvisi, M. G., Grace, M., Sadofsky, L., Faruqi, S., Hele, D. J., Maher, S. A., Freund-Michel, V., & Morice, A. H. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200905-0665oc · Cited by 275

Calcium Restores a Normal Proliferation Phenotype in Human Polycystic Kidney Disease Epithelial Cells

Yamaguchi, T., Hempson, S. J., Reif, G. A., Hedge, A.-M., & Wallace, D. P. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005060645 · Cited by 275

Calcineurin‐dependent cardiomyopathy is activated by TRPC in the adult mouse heart

Nakayama, H., Wilkin, B. J., Bodi, I., & Molkentin, J. D. (2006) · The FASEB Journal · doi:10.1096/fj.05-5560com · Cited by 272

Chromosome 4 localization of a second gene for autosomal dominant polycystic kidney disease

Peters, D. J. M., Spruit, L., Saris, J. J., Ravine, D., Sandkuijl, L. A., Fossdal, R., Boersma, J., van Eijk, R., Nørby, S., Constantinou-Deltas, C. D., et al. (1993) · Nature Genetics · doi:10.1038/ng1293-359 · Cited by 271

Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C

Auer-Grumbach, M., Olschewski, A., Papić, L., Kremer, H., McEntagart, M. E., Uhrig, S., Fischer, C., Fröhlich, E., Bálint, Z., Tang, B., et al. (2010) · Nature Genetics · doi:10.1038/ng.508 · Cited by 271

Monoterpenoid agonists of TRPV3

Vogt‐Eisele, A. K., Weber, K., Sherkheli, M. A., Vielhaber, G., Panten, J., Gisselmann, G., & Hatt, H. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707245 · Cited by 268

Resolvin D2 Is a Potent Endogenous Inhibitor for Transient Receptor Potential Subtype V1/A1, Inflammatory Pain, and Spinal Cord Synaptic Plasticity in Mice: Distinct Roles of Resolvin D1, D2, and E1

Park, C.-K., Xu, Z.-Z., Liu, T., Lü, N., Serhan, C. N., & Ji, R.-R. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4192-11.2011 · Cited by 261

Activation of TRPV1 by the Satiety Factor Oleoylethanolamide

Ahern, G. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305051200 · Cited by 257

Selective Role for TRPV4 Ion Channels in Visceral Sensory Pathways

Brierley, S. M., Page, A. J., Hughes, P. A., Adam, B., Liebregts, T., Cooper, N. J., Holtmann, G., Liedtke, W., & Blackshaw, L. A. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.074 · Cited by 255

TRPC Channels As Effectors of Cardiac Hypertrophy

Eder, P., & Molkentin, J. D. (2011) · Circulation Research · doi:10.1161/circresaha.110.225888 · Cited by 253

A-425619 [1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a Novel Transient Receptor Potential Type V1 Receptor Antagonist, Relieves Pathophysiological Pain Associated with Inflammation and Tissue Injury in Rats

Honore, P., Wismer, C. T., Mikusa, J., Zhu, C. Z., Zhong, C., Gauvin, D. M., Gomtsyan, A., El Kouhen, R., Lee, C.-H., Marsh, K., et al. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.083915 · Cited by 253

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system

Zimmermann, K., Lennerz, J. K., Hein, A., Link, A. S., Kaczmarek, J. S., Delling, M., Uysal, S., Pfeifer, J. D., Riccio, A., & Clapham, D. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115387108 · Cited by 252

The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans

Chizh, B. A., O’Donnell, M. B., Napolitano, A., Wang, J., Brooke, A. C., Aylott, M. C., Bullman, J. N., Gray, E. J., Lai, R. Y., Williams, P. M., et al. (2007) · Pain · doi:10.1016/j.pain.2007.06.006 · Cited by 250

N-(4-Tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2 H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: I. In Vitro Characterization and Pharmacokinetic Properties

Valenzano, K. J., Grant, E. R., Wu, G., Hachicha, M., Schmid, L., Tafesse, L., Sun, Q., Rotshteyn, Y., Francis, J., Limberis, J., et al. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.045674 · Cited by 250

Identification and characterization of novel TRPV4 modulators

Vincent, F., Acevedo, A., Nguyen, M. T., Dourado, M., DeFalco, J., Gustafson, A., Spiro, P., Emerling, D. E., Kelly, M. G., & Duncton, M. A. J. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.09.007 · Cited by 246

Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system

Holzer, P. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.03.006 · Cited by 245

Capsaicin Receptor: TRPV1 A Promiscuous TRP Channel

Pingle, S. C., Matta, J. A., & Ahern, G. P. (2007) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-540-34891-7_9 · Cited by 238

Hyperforin—a key constituent of St. John's wort specifically activates TRPC6 channels

Leuner, K., Kazanski, V., Muller, M., Essin, K., Henke, B., Gollasch, M., Harteneck, C., & Müller, W. E. (2007) · The FASEB Journal · doi:10.1096/fj.07-8110com · Cited by 238

Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity

Ma, S., Yu, H., Zhao, Z., Luo, Z., Chen, J., Ni, Y., Jin, R., Ma, L., Wang, P., Zhu, Z., et al. (2012) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjs001 · Cited by 238

Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C‐fibres by the endogenous autacoid 4‐oxononenal

Taylor‐Clark, T. E., McAlexander, M. A., Nassenstein, C., Sheardown, S. A., Wilson, S., Thornton, J., Carr, M. J., & Undem, B. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.153585 · Cited by 237

TRPC channels promote cerebellar granule neuron survival

Jia, Y., Zhou, J., Tai, Y., & Wang, Y. (2007) · Nature Neuroscience · doi:10.1038/nn1870 · Cited by 237

Transient Receptor Potential Ankyrin 1 Channel Localized to Non-Neuronal Airway Cells Promotes Non-Neurogenic Inflammation

Nassini, R., Pedretti, P., Moretto, N., Fusi, C., Carnini, C., Facchinetti, F., Viscomi, A. R., Pisano, A. R., Stokesberry, S., Brunmark, C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042454 · Cited by 237

Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease

Leuenroth, S. J., Okuhara, D., Shotwell, J. D., Markowitz, G. S., Yu, Z., Somlo, S., & Crews, C. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700499104 · Cited by 236

Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site

Nieto-Posadas, A., Picazo-Juárez, G., Llorente, I., Jara-Oseguera, A., Morales-Lázaro, S., Escalante-Alcalde, D., Islas, L. D., & Rosenbaum, T. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.712 · Cited by 232

Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion

Kyriazis, G. A., Soundarapandian, M. M., & Tyrberg, B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115183109 · Cited by 232

Inhibition of the transient receptor potential cation channel TRPM2 by 2‐aminoethoxydiphenyl borate (2‐APB)

Togashi, K., Inada, H., & Tominaga, M. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707675 · Cited by 230

A Transient Receptor Potential Vanilloid 4-Dependent Mechanism of Hyperalgesia Is Engaged by Concerted Action of Inflammatory Mediators

Alessandri-Haber, N., Dina, O. A., Joseph, E. K., Reichling, D., & Levine, J. D. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5385-05.2006 · Cited by 228

Interaction of Transient Receptor Potential Vanilloid 4, Integrin, and Src Tyrosine Kinase in Mechanical Hyperalgesia

Alessandri-Haber, N., Dina, O. A., Joseph, E. K., Reichling, D. B., & Levine, J. D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4497-07.2008 · Cited by 226

A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice

Becker, E. B. E., Oliver, P. L., Glitsch, M. D., Banks, G. T., Achilli, F., Hardy, A., Nolan, P. M., Fisher, E. M. C., & Davies, K. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810599106 · Cited by 225

Gain-of-Function Mutations in TRPM4 Cause Autosomal Dominant Isolated Cardiac Conduction Disease

Liu, H., El Zein, L., Kruse, M., Guinamard, R., Beckmann, A., Bozio, A., Kurtbay, G., Mégarbané, A., Ohmert, I., Blaysat, G., et al. (2010) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.109.930867 · Cited by 224

TRPC1 Channels Are Critical for Hypertrophic Signaling in the Heart

Seth, M., Zhang, Z.-S., Mao, L., Graham, V., Burch, J., Stiber, J., Tsiokas, L., Winn, M., Abramowitz, J., Rockman, H. A., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.206581 · Cited by 223

Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia

Patwardhan, A. M., Scotland, P. E., Akopian, A. N., & Hargreaves, K. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905415106 · Cited by 220

Critical role of TRPC6 channels in the formation of excitatory synapses

Zhou, J., Du, W., Zhou, K., Tai, Y., Yao, H., Jia, Y., Ding, Y., & Wang, Y. (2008) · Nature Neuroscience · doi:10.1038/nn.2127 · Cited by 216

Identification of ML204, a Novel Potent Antagonist That Selectively Modulates Native TRPC4/C5 Ion Channels

Miller, M., Shi, J., Zhu, Y., Kustov, M., Tian, J.-B., Stevens, A., Wu, M., Xu, J., Long, S., Yang, P., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.274167 · Cited by 215

A double-blind evaluation of topical capsaicin in pruritic psoriasis

Ellis, C. N., Berberian, B., Sulica, V. I., Alan Dodd, W., Jarratt, M. T., Katz, H. I., Prawer, S., Krueger, G., Rex, I. H., & Wolf, J. E. (1993) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(93)70208-b · Cited by 207

Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation

Monet, M., Gkika, D., Lehen'kyi, V., Pourtier, A., Abeele, F. V., Bidaux, G., Juvin, V., Rassendren, F., Humez, S., & Prevarsakaya, N. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.01.003 · Cited by 206

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis

Schattling, B., Steinbach, K., Thies, E., Kruse, M., Menigoz, A., Ufer, F., Flockerzi, V., Brück, W., Pongs, O., Vennekens, R., et al. (2012) · Nature Medicine · doi:10.1038/nm.3015 · Cited by 206

Upregulation of TRPC1 in the development of cardiac hypertrophy

Ohba, T., Watanabe, H., Murakami, M., Takahashi, Y., Iino, K., Kuromitsu, S., Mori, Y., Ono, K., Iijima, T., & Ito, H. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.10.020 · Cited by 205

Warm Temperature-sensitive Transient Receptor Potential Vanilloid 4 (TRPV4) Plays an Essential Role in Thermal Hyperalgesia

Todaka, H., Taniguchi, J., Satoh, J.-I., Mizuno, A., & Suzuki, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406260200 · Cited by 204

Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1

Gavva, N. R. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.08.003 · Cited by 203

Topical capsaicin—a novel and effective treatment for idiopathic intractable pruritus ani: a randomised, placebo controlled, crossover study

Lysy, J., Sistiery-Ittah, M., Israelit, Y., Shmueli, A., Strauss-Liviatan, N., Mindrul, V, Keret, D., & Goldin, E. (2003) · Gut · doi:10.1136/gut.52.9.1323 · Cited by 202

Loss of high-frequency glucose-induced Ca 2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5 −/− mice

Colsoul, B., Schraenen, A., Lemaire, K., Quintens, R., Van Lommel, L., Segal, A., Owsianik, G., Talavera, K., Voets, T., Margolskee, R. F., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913107107 · Cited by 201

Novel pyrazole compounds for pharmacological discrimination between receptor‐operated and store‐operated Ca 2+ entry pathways

Schleifer, H., Doleschal, B., Lichtenegger, M., Oppenrieder, R., Derler, I., Frischauf, I., Glasnov, T., Kappe, C., Romanin, C., & Groschner, K. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02126.x · Cited by 197

The ‘headache tree’ via umbellulone and TRPA1 activates the trigeminovascular system

Nassini, R., Materazzi, S., Vriens, J., Prenen, J., Benemei, S., De Siena, G., la Marca, G., Andrè, E., Preti, D., Avonto, C., et al. (2012) · Brain · doi:10.1093/brain/awr272 · Cited by 196

Oleoylethanolamide excites vagal sensory neurones, induces visceral pain and reduces short‐term food intake in mice via capsaicin receptor TRPV1

Wang, X., Miyares, R. L., & Ahern, G. P. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.081844 · Cited by 195

Association of a Mutation in TRPV3 with Defective Hair Growth in Rodents

Asakawa, M., Yoshioka, T., Matsutani, T., Hikita, I., Suzuki, M., Oshima, I., Tsukahara, K., Arimura, A., Horikawa, T., Hirasawa, T., et al. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700468 · Cited by 195

TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons

Anand, U., Otto, W. R., Facer, P., Zebda, N., Selmer, I., Gunthorpe, M. J., Chessell, I. P., Sinisi, M., Birch, R., & Anand, P. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.04.007 · Cited by 192

A Functional Single-Nucleotide Polymorphism in the TRPC6 Gene Promoter Associated With Idiopathic Pulmonary Arterial Hypertension

Yu, Y., Keller, S. H., Remillard, C. V., Safrina, O., Nicholson, A., Zhang, S. L., Jiang, W., Vangala, N., Landsberg, J. W., Wang, J.-Y., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.782458 · Cited by 191

Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice

Weissmann, N., Sydykov, A., Kalwa, H., Storch, U., Fuchs, B., Mederos y Schnitzler, M., Brandes, R. P., Grimminger, F., Meissner, M., Freichel, M., et al. (2012) · Nature Communications · doi:10.1038/ncomms1660 · Cited by 189

Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants

Willis, D. N., Liu, B., Ha, M. A., Jordt, S., & Morris, J. B. (2011) · The FASEB Journal · doi:10.1096/fj.11-188383 · Cited by 189

Herbal Compounds and Toxins Modulating TRP Channels

Vennekens, R., Vriens, J., & Nilius, B. (2008) · Current Neuropharmacology · doi:10.2174/157015908783769644 · Cited by 187

Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels

Parnas, M., Peters, M., Dadon, D., Lev, S., Vertkin, I., Slutsky, I., & Minke, B. (2009) · Cell Calcium · doi:10.1016/j.ceca.2008.11.009 · Cited by 187

Impact of the Gly573Ser Substitution in TRPV3 on the Development of Allergic and Pruritic Dermatitis in Mice

Yoshioka, T., Imura, K., Asakawa, M., Suzuki, M., Oshima, I., Hirasawa, T., Sakata, T., Horikawa, T., & Arimura, A. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.245 · Cited by 184

TRPA1 Modulation of Spontaneous and Mechanically Evoked Firing of Spinal Neurons in Uninjured, Osteoarthritic, and Inflamed Rats

McGaraughty, S., Chu, K. L., Perner, R. J., DiDomenico, S., Kort, M. E., & Kym, P. R. (2010) · Molecular Pain · doi:10.1186/1744-8069-6-14 · Cited by 183

Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain

Moussaieff, A., Rimmerman, N., Bregman, T., Straiker, A., Felder, C. C., Shoham, S., Kashman, Y., Huang, S. M., Lee, H., Shohami, E., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-101865 · Cited by 182

Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice

Uchida, K., Dezaki, K., Damdindorj, B., Inada, H., Shiuchi, T., Mori, Y., Yada, T., Minokoshi, Y., & Tominaga, M. (2011) · Diabetes · doi:10.2337/db10-0276 · Cited by 182

Transient Receptor Potential Vanilloid-4 Has a Major Role in Visceral Hypersensitivity Symptoms

Cenac, N., Altier, C., Chapman, K., Liedtke, W., Zamponi, G., & Vergnolle, N. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.05.024 · Cited by 181

Nitrooleic Acid, an Endogenous Product of Nitrative Stress, Activates Nociceptive Sensory Nerves via the Direct Activation of TRPA1

Taylor-Clark, T. E., Ghatta, S., Bettner, W., & Undem, B. J. (2009) · Molecular Pharmacology · doi:10.1124/mol.108.054445 · Cited by 180

The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

Romano, B., Borrelli, F., Fasolino, I., Capasso, R., Piscitelli, F., Cascio, M., Pertwee, R., Coppola, D., Vassallo, L., Orlando, P., et al. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12120 · Cited by 179

Structural and molecular basis of the assembly of the TRPP2/PKD1 complex

Yu, Y., Ulbrich, M. H., Li, M.-H., Buraei, Z., Chen, X.-Z., Ong, A. C. M., Tong, L., Isacoff, E. Y., & Yang, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903684106 · Cited by 178

Structure–function relationship of the TRP channel superfamily

Owsianik, G., D'hoedt, D., Voets, T., & Nilius, B. (2006) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/s10254-005-0006-0 · Cited by 177

The emerging role of TRPV1 in diabetes and obesity

Suri, A., & Szallasi, A. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.10.016 · Cited by 177

Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti‐nociception

Bang, S., Yoo, S., Yang, T., Cho, H., Kim, Y., & Hwang, S. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00909.x · Cited by 176

Physiologic and Antinociceptive Effects of Intrathecal Resiniferatoxin in a Canine Bone Cancer Model

Brown, D. C., Iadarola, M. J., Perkowski, S. Z., Erin, H., Shofer, F. S., Karai, L., Oláh, Z., & Mannes, A. J. (2005) · Anesthesiology · doi:10.1097/00000542-200511000-00020 · Cited by 175

Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations

Mukerji, G., Yiangou, Y., Corcoran, S. L., Selmer, I. S., Smith, G. D., Benham, C. D., Bountra, C., Agarwal, S. K., & Anand, P. (2006) · BMC Urology · doi:10.1186/1471-2490-6-6 · Cited by 174

TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway

Tai, Y., Feng, S., Ge, R., Du, W., Zhang, X., He, Z., & Wang, Y. (2008) · Journal of Cell Science · doi:10.1242/jcs.026906 · Cited by 174

TRPM8 activation attenuates inflammatory responses in mouse models of colitis

Ramachandran, R., Hyun, E., Zhao, L., Lapointe, T. K., Chapman, K., Hirota, C. L., Ghosh, S., McKemy, D. D., Vergnolle, N., Beck, P. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217431110 · Cited by 173

Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice

Mathar, I., Vennekens, R., Meissner, M., Kees, F., Van der Mieren, G., Camacho Londoño, J. E., Uhl, S., Voets, T., Hummel, B., van den Bergh, A., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41348 · Cited by 170

Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1

Materazzi, S., Nassini, R., Andrè, E., Campi, B., Amadesi, S., Trevisani, M., Bunnett, N. W., Patacchini, R., & Geppetti, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802354105 · Cited by 170

Inhibitory effect of cannabichromene, a major non‐psychotropic cannabinoid extracted from Cannabis sativa, on inflammation‐induced hypermotility in mice

Izzo, A. A., Capasso, R., Aviello, G., Borrelli, F., Romano, B., Piscitelli, F., Gallo, L., Capasso, F., Orlando, P., & Di Marzo, V. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01879.x · Cited by 168

The Concise Guide to PHARMACOLOGY 2013/14: Overview

Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., McGrath, J. C., Catterall, W. A., Spedding, M., Peters, J. A., Harmar, A. J., et al. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12444 · Cited by 168

Transient receptor potential channelopathies

Nilius, B., & Owsianik, G. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0788-2 · Cited by 168

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

Zhang, M., Ma, Y., Ye, X., Zhang, N., Pan, L., & Wang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01464-x · Cited by 522

TRPV4: molecular conductor of a diverse orchestra

White, J. P. M., Cibelli, M., Urban, L., Nilius, B., McGeown, J. G., & Nagy, I. (2016) · Physiological Reviews · doi:10.1152/physrev.00016.2015 · Cited by 405

Physiology and Pathophysiology of Itch

Cevikbas, F., & Lerner, E. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00017.2019 · Cited by 282

Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis

Garami, A., Shimansky, Y. P., Rumbus, Z., Vizin, R. C. L., Farkas, N., Hegyi, J., Szakacs, Z., Solymar, M., Csenkey, A., Chiche, D. A., et al. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107474 · Cited by 159

The impact of temperature on the skin barrier and atopic dermatitis

Hui-Beckman, J. W., Goleva, E., Leung, D. Y. M., & Kim, B. E. (2023) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2023.08.007 · Cited by 58