Cited by 7,864Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesAlzheimer's disease research and treatments

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Mild cognitive impairment as a diagnostic entity

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Petersen, R. C.·2004·Journal of Internal Medicine

DOI 10.1111/j.1365-2796.2004.01388.x

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Abstract

The concept of cognitive impairment intervening between normal ageing and very early dementia has been in the literature for many years. Recently, the construct of mild cognitive impairment (MCI) has been proposed to designate an early, but abnormal, state of cognitive impairment. MCI has generated a great deal of research from both clinical and research perspectives. Numerous epidemiological studies have documented the accelerated rate of progression to dementia and Alzheimer's disease (AD) in MCI subjects and certain predictor variables appear valid. However, there has been controversy regarding the precise definition of the concept and its implementation in various clinical settings. Clinical subtypes of MCI have been proposed to broaden the concept and include prodromal forms of a variety of dementias. It is suggested that the diagnosis of MCI can be made in a fashion similar to the clinical diagnoses of dementia and AD. An algorithm is presented to assist the clinician in identifying subjects and subclassifying them into the various types of MCI. By refining the criteria for MCI, clinical trials can be designed with appropriate inclusion and exclusion restrictions to allow for the investigation of therapeutics tailored for specific targets and populations.

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“org that some MCI patients may revert to normal or near-normal cognition, though they are at higher risk of progressing to dementia (Petersen, 2004; Koepsell and Monsell, 2012; Shimada et al., 2019).”
BackgroundInfluential
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“Similar research could address whether measurements of CB predict crash records of older drivers with mental decline due to aging, AD, or forms of “mild cognitive impairment” (MCI) that may precede dementia (Grundman, Petersen, & Ferris, 2004; Petersen, 2004).”
Result
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Background
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Self-citation
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Authors: Petersen, R. C.
Affiliations: Mayo Clinic (US)
Corresponding author: Petersen, R. C.
ORCID: Petersen, R. C.
Venue: Journal of Internal Medicine
Publisher: Wiley
Published: 2004-08-20
Volume: 256
Issue: 3
Pages: 183-194
ISSN: 0954-6820 (ISSN-L)
1365-2796
DOI: 10.1111/j.1365-2796.2004.01388.x
OpenAlex: W2028436804
Cited by: 7,864
References: 12
Citations by year: 2026: 344 · 2025: 493 · 2024: 478 · 2023: 440 · 2022: 475 · 2021: 535 · 2020: 499 · 2019: 479 · 2018: 433 · 2017: 428 · 2016: 385 · 2015: 402 · 2014: 395 · 2013: 391 · 2012: 367
FWCI: 13.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 10483, AG-06786, AG 16574, U01AG006786, P50AG016574)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: mild cognitive impairment, dementia, Alzheimer's disease, prodromal dementia, MCI classification, diagnostic criteria, conversion to dementia, cognitive aging
MeSH terms: Aged, Alzheimer Disease, Cognition Disorders, Humans, Neuropsychological Tests, Terminology as Topic, Psychiatric Status Rating Scales

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