The Biologic Clock: The Mitochondria?

HARMAN, DENHAM·1972·Journal of the American Geriatrics Society

DOI 10.1111/j.1532-5415.1972.tb00787.x

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Abstract

The author suggests that the maximal life span of a given mammalian species is largely an expression of genetic control over the rate of oxygen utilization. The latter determines the rate of accumulation of mitochondrial damage produced by free radical reactions, the rate increasing with the rate of oxygen consumption, which ultimately causes death.

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Authors: HARMAN, D.
Venue: Journal of the American Geriatrics Society
Publisher: Wiley
Published: 1972-04
Volume: 20
Issue: 4
Pages: 145-147
ISSN: 0002-8614 (ISSN-L)
1532-5415
DOI: 10.1111/j.1532-5415.1972.tb00787.x
OpenAlex: W2068337326
Cited by: 1,991
References: 0
FWCI: 0.39
Type: journal article
Language: en
Open access: closed

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The Biologic Clock: The Mitochondria?

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