The Biologic Clock: The Mitochondria?

HARMAN, DENHAM·1972·Journal of the American Geriatrics Society

DOI 10.1111/j.1532-5415.1972.tb00787.x

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Abstract

The author suggests that the maximal life span of a given mammalian species is largely an expression of genetic control over the rate of oxygen utilization. The latter determines the rate of accumulation of mitochondrial damage produced by free radical reactions, the rate increasing with the rate of oxygen consumption, which ultimately causes death.

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“mtDNA damage and ROS Harman first suggested the free radical theory of aging more than 40 years ago [18] .”
Background
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Authors: HARMAN, D.
Venue: Journal of the American Geriatrics Society
Publisher: Wiley
Published: 1972-04
Volume: 20
Issue: 4
Pages: 145-147
ISSN: 0002-8614 (ISSN-L)
1532-5415
DOI: 10.1111/j.1532-5415.1972.tb00787.x
OpenAlex: W2068337326
Cited by: 1,991
References: 0
FWCI: 0.39
Type: journal article
Language: en
Open access: closed

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

The Biologic Clock: The Mitochondria?

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