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Estimating Consumer Exposure to PFOS and PFOA
Abstract
Perfluorinated compounds have been used for more than 50 years as process aids, surfactants, and for surface protection. This study is a comprehensive assessment of consumer exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) from a variety of environmental and product-related sources. To identify relevant pathways leading to consumer exposure to PFOS and PFOA a scenario-based approach has been applied. Scenarios represent realistic situations where age- and gender-specific exposure occurs in the everyday life of consumers. We find that North American and European consumers are likely to experience ubiquitous and long-term uptake doses of PFOS and PFOA in the range of 3 to 220 ng per kg body weight per day (ng/kg(bw)/day) and 1 to 130 ng/kg(bw)/day, respectively. The greatest portion of the chronic exposure to PFOS and PFOA is likely to result from the intake of contaminated foods, including drinking water. Consumer products cause a minor portion of the consumer exposure to PFOS and PFOA. Of these, it is mainly impregnation sprays, treated carpets in homes, and coated food contact materials that may lead to consumer exposure to PFOS and PFOA. Children tend to experience higher total uptake doses (on a body weight basis) than teenagers and adults because of higher relative uptake via food consumption and hand-to-mouth transfer of chemical from treated carpets and ingestion of dust. The uptake estimates based on scenarios are within the range of values derived from blood serum data by applying a one-compartment pharmacokinetic model.
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“Thus, the homologue pattern of PFASs in cosmetics appear to follow the same trend as treated textiles and papers where recent studies typically report the highest concentrations and detection frequency for C6 compounds.”
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Kjeldsen, L. S., & Bonefeld‐Jørgensen, E. C. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-013-1753-3 · Cited by 352
“Other routes of exposure include drinking water, inhalation of indoor air and household dust, and to a lesser extent, dermal contact with consumer products containing PFCs (Trudel et al. 2008; Fromme et al. 2009; Haug et al. 2011).”
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“Neither can intake via dust and air (Trudel et al. 2008), or through food or from food contact materials explain human blood levels or profiles of PFCA and PFSA, which are the fluorochemicals that predominantly are monitored for (Leo et al.”
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Haug, L. S., Thomsen, C., Brantsæter, A. L., Kvalem, H. E., Haugen, M. A., Becher, G., Alexander, J., Meltzer, H. M., & Knutsen, H. K. (2010) · Environment International · doi:10.1016/j.envint.2010.05.016 · Cited by 346
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“, food consumption) are expected to bemuchhigher than via consumption of drinking water, except in cases of highly contaminated drinking water (Egeghy and Lorber, 2011; Lorber, 2008; Trudel et al., 2008; Vestergren and Cousins, 2009).”
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“The reason for this is the higher relative uptake via food consumption, hand-to-mouth transfer of the chemicals from carpets, and ingestion of dust (Trudel et al. 2008).”
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“Although the relative importance of the various potential routes of exposure to these compounds still remains unknown, it has been suggested that food and food packaging, water, house dust, and airborne sources may all be significant (see reviews by D'Hollander et al., 2010; Kantiani et al., 2010; Trudel et al., 2008).”
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“100,101 The 2003–2004 NHANES revealed that >98% of the US population has detectable concentrations of PFCs in their blood, including perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA).”
Dietary exposure to perfluoroalkyl acids for the Swedish population in 1999, 2005 and 2010
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“Exposure modeling studies have unanimously concluded that direct exposure via the diet is the major ongoing exposure pathway for perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) to the general population (Egeghy and Lorber, 2011; Fromme et al., 2009; Lorber and Egeghy, 2011; Trudel et al., 2008;…”
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“Several studies report on the importance of breast milk consumption in determining infants' PFAS exposure (Haug et al., 2011a; Liu et al., 2011; Thomsen et al., 2010; Trudel et al., 2008).”
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Estimating the contribution of precursor compounds in consumer exposure to PFOS and PFOA
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“Another assessment of exposure to PFOA and PFOS from consumer products and environmental media revealed that intake of contaminated food tends to dominate exposure of a general population (Trudel et al., 2008).”
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“Exposure is most likely due to ingestion from contaminated food or water, although other routes such as fumes from treated fabrics within the home are possible (Trudel et al., 2008).”
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“They do not adequately consider other exposure pathways, particularly food, which is normally considered to be the main PFC exposure route (Trudel et al. 2008; Vestergren and Cousins 2009) and which can be impacted by various pathways (Fig.”
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“Similar estimates of the fraction of PFOA absorbed in humans that are highly exposed to PFOA have been used previously (Thompson et al. 2010; Trudel et al. 2008).”
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“Of these, it is mainly impregnation sprays, treated carpets in homes, and coated food contact materials that may lead to consumer exposure to PFOS and PFOA ( Trudel et al. 2008 ).”
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Dietary Habits Related to Food Packaging and Population Exposure to PFASs
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“Human exposure in the general population can occur through diet, drinking water, air, dust, and direct contact with products (Trudel et al. 2008).”
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Concentrations of PFOS, PFOA and other perfluorinated alkyl acids in Australian drinking water
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Long-Term Environmental Fate of Perfluorinated Compounds after Accidental Release at Toronto Airport
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Egeghy, P. P., & Lorber, M. (2010) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2009.73 · Cited by 153
“Most recently, two studies provide detailed assessments of all relevant pathways of exposure from direct and indirect sources (Trudel et al., 2008; Fromme et al., 2009).”
BackgroundMethodResultInfluentialJogsten, I. E., Perelló, G., Llebaria, X., Bigas, E., Martí-Cid, R., Kärrman, A., & Domingo, J. L. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.04.004 · Cited by 152
Berg, V., Nøst, T. H., Huber, S., Rylander, C., Hansen, S., Veyhe, A. S., Fuskevåg, O., Odland, J. Ø., & Sandanger, T. M. (2014) · Environment International · doi:10.1016/j.envint.2014.04.010 · Cited by 154
“…meat generally have the highest PFAS concentrations as well as a large variation in intake (Cornelis et al., 2012; Domingo et al., 2012; Haug et al., 2010a; Herzke et al., 2013; Hlouskova et al., 2013; Noorlander et al., 2011; Tittlemier et al., 2007; Trudel et al., 2008; Vestergren et al., 2012).”
BackgroundEarly life exposure to per- and polyfluoroalkyl substances (PFASs): a critical review
Winkens, K., Vestergren, R., Berger, U., & Cousins, I. T. (2017) · Emerging Contaminants · doi:10.1016/j.emcon.2017.05.001 · Cited by 145
Self-citationLong, M., Ghisari, M., & Bonefeld-Jørgensen, E. C. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-013-1628-7 · Cited by 144
Hu, X. C., Tokranov, A. K., Liddie, J. M., Zhang, X., Grandjean, P., Hart, J. E., Laden, F., Sun, Q., Yeung, L. W. Y., & Sunderland, E. M. (2019) · Environmental Health Perspectives · doi:10.1289/ehp4093 · Cited by 152
“TK models can be used to assess the relative importance of di ff erent exposure sources (Lorber and Egeghy 2011; Trudel et al. 2008; Vestergren and Cousins 2009) and to establish benchmark doses for PFAS from toxicological and epidemiological studies (Goeden et al. 2019).”
Raymer, J. H., Michael, L. C., Studabaker, W. B., Olsen, G. W., Sloan, C. S., Wilcosky, T. C., & Walmer, D. K. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.05.024 · Cited by 144
Development of PBPK models for PFOA and PFOS for human pregnancy and lactation life stages
Loccisano, A. E., Longnecker, M. P., Campbell, J. L., Andersen, M. E., & Clewell, H. J. (2013) · Journal of Toxicology and Environmental Health, Part A · doi:10.1080/15287394.2012.722523 · Cited by 141
“Because food intake has been suggested to be the main exposure route to PFAA in adult general populations (Fromme et al., 2009; Trudel et al., 2008; Vestergren and Cousins, 2009; Tittlemier et al., 2007), food intake by women in these life stages is probably the most important exposure route to consider when estimatin…”
BackgroundVerma, S., Varma, R. S., & Nadagouda, M. N. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.148987 · Cited by 146
Miralles-Marco, A., & Harrad, S. (2015) · Environment International · doi:10.1016/j.envint.2015.02.002 · Cited by 141
“, 2008); food contaminated via bioaccumulation, has been suggested by several authors as the principal pathway of direct human exposure to PFOS; (D'Hollander et al., 2010; Fromme et al., 2007a, 2009; Trudel et al., 2008; Kärrman et al., 2009; Vestergren et al., 2008; Herzke et al., 2013).”
BackgroundMethodOjo, A. F., Peng, C., & Ng, J. C. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114182 · Cited by 139
Gebbink, W. A., Berger, U., & Cousins, I. T. (2014) · Environment International · doi:10.1016/j.envint.2014.10.013 · Cited by 143
Self-citationHighly fluorinated amphiphilic molecules and self-assemblies with biomedical potential
Riess, J. G. (2009) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2009.05.008 · Cited by 143
Ericson Jogsten, I., Nadal, M., van Bavel, B., Lindström, G., & Domingo, J. L. (2012) · Environment International · doi:10.1016/j.envint.2011.09.004 · Cited by 138
“A number of sources of human PFC exposure have been explored, suggesting food as the dominant pathway of PFC exposure (Fromme et al., 2009; Trudel et al., 2008; Vestergren and Cousins, 2009).”
BackgroundPerfluorinated alkyl substances (PFASs) in household dust in Central Europe and North America
Karásková, P., Venier, M., Melymuk, L. E., Bečanová, J., Vojta, Š., Prokeš, R., Diamond, M. L., & Klánová, J. (2016) · Environment International · doi:10.1016/j.envint.2016.05.031 · Cited by 137
Daly, E. R., Chan, B. P., Talbot, E. A., Nassif, J., Bean, C., Cavallo, S. J., Metcalf, E., Simone, K. E., & Woolf, A. D. (2018) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2018.02.007 · Cited by 140
Nelson, J. W., Scammell, M. K., Hatch, E. E., & Webster, T. F. (2012) · Environmental Health · doi:10.1186/1476-069x-11-10 · Cited by 147
“In particular they are used in food packaging and carpeting and textile treatments [8].”
BackgroundWu, X., Bennett, D. H., Calafat, A. M., Kato, K., Strynar, M. J., Andersen, E., Moran, R. E., Tancredi, D. J., Tulve, N. S., & Hertz‐Picciotto, I. (2014) · Environmental Research · doi:10.1016/j.envres.2014.09.026 · Cited by 136
“While food has been identified as the major pathway for the majority of the population in several studies that modeled PFC exposure through multiple pathways (Egeghy and Lorber, 2011; Trudel et al., 2008; Vestergren et al., 2012), dust ingestion was postulated to be important for children and potentially for adults wi…”
BackgroundDomazet, S. L., Grøntved, A., Timmermann, C. A. G., Nielsen, F., & Jensen, T. K. (2016) · Diabetes Care · doi:10.2337/dc16-0269 · Cited by 131
Kataria, A., Trachtman, H., Málaga-Diéguez, L., & Trasande, L. (2015) · Environmental Health · doi:10.1186/s12940-015-0077-9 · Cited by 133
“PFAAs have found wide utility when polymerized in stain-resistant sprays for carpets and upholstery, fireretarding foams, and nonstick cooking surfaces and food packaging, such as microwave popcorn bags and pizza packaging [2].”
BackgroundAlves, A. V., Tsianou, M., & Alexandridis, P. (2020) · Surfaces · doi:10.3390/surfaces3040037 · Cited by 136
Singh, K., Kumar, N., Yadav, A. K., Singh, R. D., & Kumar, K. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.145064 · Cited by 136
Relationship between dietary exposure and serum perfluorochemical (PFC) levels—A case study
Kärrman, A., Harada, K. H., Inoue, K., Takasuga, T., Ohi, E., & Koizumi, A. (2009) · Environment International · doi:10.1016/j.envint.2009.01.010 · Cited by 129
Polyfluorinated Compounds in Serum Linked to Indoor Air in Office Environments
Fraser, A. J., Webster, T. F., Watkins, D. J., Nelson, J. W., Stapleton, H. M., Calafat, A. M., Kato, K., Shoeib, M., Vieira, V. M., & McClean, M. D. (2012) · Environmental Science & Technology · doi:10.1021/es2038257 · Cited by 127
Winkens, K., Giovanoulis, G., Koponen, J., Vestergren, R., Berger, U., Karvonen, A. M., Pekkanen, J., Kiviranta, H., & Cousins, I. T. (2018) · Environment International · doi:10.1016/j.envint.2018.06.009 · Cited by 127
“Though the dermal uptake via dust was previously calculated to contribute< 1% to the total uptake of each, PFOA and PFOS, in any exposure scenario (Trudel et al., 2008; Vestergren et al., 2008).”
BackgroundSelf-citationCai, Y., Li, J., Yi, L., Yan, X., & Li, J. (2018) · Applied Surface Science · doi:10.1016/j.apsusc.2018.04.186 · Cited by 123
Pozzebon, E. A., & Seifert, L. (2023) · Environmental Health · doi:10.1186/s12940-023-01008-4 · Cited by 139
Perfluorochemicals and Human Semen Quality: The LIFE Study
Louis, G. M. B., Chen, Z., Schisterman, E. F., Kim, S., Sweeney, A., Sundaram, R., Lynch, C. D.-J., Gore‐Langton, R. E., & Barr, D. B. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307621 · Cited by 124
“The migration straw was used so the lab could microscopically assess the distance the vanguard sperm traveled to the nearest millimeter, which indicated sperm motility at the time of collection, in light of using next-day analysis (Turner and Schrader 2006).”
MethodZushi, Y., Hogarh, J. N., & Masunaga, S. (2011) · Clean Technologies and Environmental Policy · doi:10.1007/s10098-011-0375-z · Cited by 123
“Higher exposure per body weight for infants compared with adults was also reported from a scenariobased approach (Trudel et al. 2008).”
BackgroundRecent advances on synthesis of potentially non-bioaccumulable fluorinated surfactants
Zaggia, A., & Ameduri, B. M. (2012) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2012.04.001 · Cited by 123
Dermal uptake: An important pathway of human exposure to perfluoroalkyl substances?
Ragnarsdóttir, O., Abdallah, M. A., & Harrad, S. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119478 · Cited by 129
Sonnenberg, N. K., Ojewole, A. E., Ojewole, C. O., Lucky, O. P., & Kusi, J. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20216984 · Cited by 124
“Human exposure to PFAS has been linked to both occupational [6] and non-occupational settings [12].”
BackgroundHeo, J.-J., Lee, J., Kim, S., & Oh, J. (2014) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2014.07.004 · Cited by 121
Time trends of perfluorinated alkyl acids in serum from Danish pregnant women 2008–2013
Bjerregaard‐Olesen, C., Bach, C. C., Long, M., Ghisari, M., Bossi, R., Bech, B. H., Nohr, E. A., Henriksen, T. B., Olsen, J., & Bonefeld‐Jørgensen, E. C. (2016) · Environment International · doi:10.1016/j.envint.2016.02.010 · Cited by 117
Metadata
- Authors
- Trudel, D., Horowitz, L., Wormuth, M., Scheringer, M., Cousins, I. T., & Hungerbühler, K.
- Affiliations
- ETH Zurich (CH)
- Stockholm University (SE)
- Corresponding author
- Scheringer, Martin
- Venue
- Risk Analysis
- Publisher
- Wiley
- Published
- 2008-04
- Volume
- 28
- Issue
- 2
- Pages
- 251-269
- ISSN
- 0272-4332 (ISSN-L)
- 1539-6924
- OpenAlex
- W2038447616
- Cited by
- 514
- References
- 79
- Citations by year
- 2026: 24 · 2025: 32 · 2024: 40 · 2023: 30 · 2022: 36 · 2021: 38 · 2020: 31 · 2019: 29 · 2018: 26 · 2017: 25 · 2016: 21 · 2015: 21 · 2014: 24 · 2013: 24 · 2012: 23
- FWCI
- 21.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Risk Analysis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesamt für Gesundheit
- Health Canada
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Water Science and Technology › Fluoride Effects and Removal
- Keywords
- PFOS, perfluorooctanoic acid, perfluorinated compounds, consumer exposure, exposure assessment, food contamination, drinking water contamination, consumer goods, food contact materials, children's exposure, dust ingestion, one-compartment model
- MeSH terms
- Adolescent, Adult, Caprylates, Child, Child, Preschool, Dust, Environmental Exposure, Environmental Monitoring, Environmental Pollutants, Female, Fluorocarbons, Humans, Infant, Male, Water Pollutants, Chemical, Air Pollution, Indoor, Alkanesulfonic Acids
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