The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molecular Mechanisms of Axon Guidance
Abstract
Axons are guided along specific pathways by attractive and repulsive cues in the extracellular environment. Genetic and biochemical studies have led to the identification of highly conserved families of guidance molecules, including netrins, Slits, semaphorins, and ephrins. Guidance cues steer axons by regulating cytoskeletal dynamics in the growth cone through signaling pathways that are still only poorly understood. Elaborate regulatory mechanisms ensure that a given cue elicits the right response from the right axons at the right time but is otherwise ignored. With such regulatory mechanisms in place, a relatively small number of guidance factors can be used to generate intricate patterns of neuronal wiring.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Stein, E., & Tessier-Lavigne, M. (2001) · Science · doi:10.1126/science.1058445 · Cited by 601
Retracted
Cited by
Astrocyte scar formation aids central nervous system axon regeneration
Anderson, M. A., Burda, J. E., Ren, Y., Ao, Y., O’Shea, T. M., Kawaguchi, R., Coppola, G., Khakh, B. S., Deming, T. J., & Sofroniew, M. V. (2016) · Nature · doi:10.1038/nature17623 · Cited by 1,851
Common mechanisms of nerve and blood vessel wiring
Carmeliet, P., & Tessier-Lavigne, M. (2005) · Nature · doi:10.1038/nature03875 · Cited by 1,085
The development of nociceptive circuits
Fitzgerald, M. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1701 · Cited by 778
Wiring optimization can relate neuronal structure and function
Chen, B. L., Hall, D. H., & Chklovskii, D. B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506806103 · Cited by 650
The Indispensable Roles of Microglia and Astrocytes during Brain Development
Reemst, K., Noctor, S. C., Lucassen, P. J., & Hol, E. M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00566 · Cited by 516
Suppression of bone formation by osteoclastic expression of semaphorin 4D
Negishi-Koga, T., Shinohara, M., Komatsu, N., Bito, H., Kodama, T., Friedel, R. H., & Takayanagi, H. (2011) · Nature Medicine · doi:10.1038/nm.2489 · Cited by 498
Semaphorin Regulation of Cellular Morphology
Tran, T. S., Kolodkin, A. L., & Bharadwaj, R. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010605.093554 · Cited by 388
Hanson, M. G., & Landmesser, L. T. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.018 · Cited by 378
Biological applications of microfluidic gradient devices
Kim, S., Kim, H. J., & Jeon, N. L. (2010) · Integrative Biology · doi:10.1039/c0ib00055h · Cited by 366
Regulation of axonal regeneration after mammalian spinal cord injury
Zheng, B., & Tuszynski, M. H. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00562-y · Cited by 328
Calcium Signaling in Neuronal Motility
Zheng, J. Q., & Poo, M.-M. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123221 · Cited by 292
Nóbrega-Pereira, S., Kessaris, N., Du, T., Kimura, S., Anderson, S. A., & Marín, O. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.024 · Cited by 256
Wnt signaling in neural circuit assembly
Salinas, P. C., & Zou, Y. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125649 · Cited by 274
Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia
Bernier, L.-P., Bohlen, C. J., York, E. M., Choi, H. B., Kamyabi, A., Dissing-Olesen, L., Hefendehl, J. K., Collins, H. Y., Stevens, B., Barres, B. A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.010 · Cited by 211
Faissner, A., Pyka, M., Geissler, M., Sobik, T., Frischknecht, R., Gundelfinger, E. D., & Seidenbecher, C. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.01.001 · Cited by 207
Connecting Vascular and Nervous System Development: Angiogenesis and the Blood-Brain Barrier
Tam, S. J., & Watts, R. J. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-152829 · Cited by 197
Transcriptional Programs of Circuit Assembly in the Drosophila Visual System
Kurmangaliyev, Y. Z., Yoo, J., Valdes-Aleman, J., Sanfilippo, P., & Zipursky, S. L. (2020) · Neuron · doi:10.1016/j.neuron.2020.10.006 · Cited by 166
Piper, M., & Holt, C. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.111746 · Cited by 196
Peripheral changes in endometriosis-associated pain
Morotti, M., Vincent, K., Brawn, J., Zondervan, K. T., & Becker, C. M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu021 · Cited by 198
Wiring the Vascular Network with Neural Cues: A CNS Perspective
Wälchli, T., Wacker, A., Frei, K., Regli, L., Schwab, M. E., Hoerstrup, S. P., Gerhardt, H., & Engelhardt, B. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.038 · Cited by 178
Transcriptional regulation of vertebrate axon guidance and synapse formation
Polleux, F., Ince-Dunn, G., & Ghosh, A. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2118 · Cited by 168
Implications of vascular endothelial growth factor for postischemic neurovascular remodeling
Hermann, D. M., & Zechariah, A. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.100 · Cited by 162
The origins of the vocal brain in humans
Belyk, M., & Brown, S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.014 · Cited by 144
Martini, F. J., Valiente, M., López Bendito, G., Szabó, G., Moya, F., Valdeolmillos, M., & Marín, O. (2009) · Development · doi:10.1242/dev.025502 · Cited by 147
Mechanosensory neurite termination and tiling depend on SAX-2 and the SAX-1 kinase.
Gallegos, M. E., & Bargmann, C. I. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.021 · Cited by 124
Kolk, S. M., Gunput, R.-A. F., Tran, T. S., van den Heuvel, D. M. A., Prasad, A. A., Hellemons, A. J. C. G. M., Adolfs, Y., Ginty, D. D., Kolodkin, A. L., Burbach, J. P. H., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2521-09.2009 · Cited by 114
Effects of gut microbiota on the microRNA and mRNA expression in the hippocampus of mice
Chen, J.-J., Zeng, B.-H., Li, W.-W., Zhou, C.-J., Fan, S.-H., Cheng, K., Zeng, L., Zheng, P., Fang, L., Wei, H., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.01.021 · Cited by 111
Riggio, C., Calatayud, M. P., Giannaccini, M., Sanz, B., Torres, T. E., Fernández-Pacheco, R., Ripoli, A., Ibarra, M. R., Dente, L., Cuschieri, A., et al. (2014) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.12.008 · Cited by 112
Assembloid models of cell-cell interaction to study tissue and disease biology
Onesto, M. M., Kim, J.-I., & Pasca, S. P. (2024) · Cell Stem Cell · doi:10.1016/j.stem.2024.09.017 · Cited by 107
Pagliardini, S., Ren, J., Wevrick, R., & Greer, J. J. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62964-1 · Cited by 99
Isl1 is required for multiple aspects of motor neuron development
Liang, X., Song, M.-R., Xu, Z., Lanuza, G. M., Liu, Y., Zhuang, T., Chen, Y., Pfaff, S. L., Evans, S. M., & Sun, Y. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.04.007 · Cited by 100
Simultaneous or Sequential Orthogonal Gradient Formation in a 3D Cell Culture Microfluidic Platform
Uzel, S. G. M., Amadi, O. C., Pearl, T. M., Lee, R. T., So, P. T. C., & Kamm, R. D. (2016) · Small · doi:10.1002/smll.201501905 · Cited by 100
Physical activity and brain development
Gomes da Silva, S., & Arida, R. M. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.1077115 · Cited by 89
TGFβ-Smad2 Signaling Regulates the Cdh1-APC/SnoN Pathway of Axonal Morphogenesis
Stegmüller, J., Huynh, M. A., Yuan, Z., Konishi, Y., & Bonni, A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3061-07.2008 · Cited by 86
Leggere, J. C., Saito, Y., Darnell, R. B., Tessier-Lavigne, M., Junge, H. J., & Chen, Z. (2016) · eLife · doi:10.7554/elife.14264 · Cited by 67
Neurotransmitters and the Development of Neuronal Circuits
Ruediger, T., & Bolz, J. (2007) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-387-76715-4_8 · Cited by 62
Transcriptional Control of Neuronal Migration in the Developing Mouse Brain
Nobrega-Pereira, S., & Marin, O. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp044 · Cited by 57
Witteveen, J. S., Middelman, A., van Hulten, J. A., Martens, G. J. M., Homberg, J. R., & Kolk, S. M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00143 · Cited by 53
Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin
Hartwig, C., Veske, A., Krejcova, S., Rosenberger, G., & Finckh, U. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-53 · Cited by 53
Common cues regulate neural and vascular patterning
Jones, C. A., & Li, D. Y. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2007.07.004 · Cited by 40
Runko, E., & Kaprielian, Z. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2385-04.2004 · Cited by 36
Boltshauser, E., Huisman, T., & Poretti, A. (2014) · Seminars in Neurology · doi:10.1055/s-0034-1386762 · Cited by 20
A dual larynx motor networks hypothesis
Belyk, M., Eichert, N., & McGettigan, C. (2021) · Philosophical Transactions of the Royal Society B · doi:10.1098/rstb.2020.0392 · Cited by 17
A pathway-centered analysis of pig domestication and breeding in Eurasia
Leno-Colorado, J., Hudson, N. J., Reverter, A., & Pérez-Enciso, M. (2017) · G3 Genes Genomes Genetics · doi:10.1534/g3.117.042671 · Cited by 14
Cellular and Molecular Mechanisms Underlying Synaptic Subcellular Specificity
Wang, M., Fan, J., & Shao, Z. (2024) · Brain Sciences · doi:10.3390/brainsci14020155 · Cited by 4
“Many secreted signaling molecules, originally identified as guidance cues, are found to play multiple roles in neuronal development, including neurogenesis, cell migration, and synaptogenesis [16–19].”
Background
Metadata
- Authors
- Dickson, B. J.
- Venue
- Science
- Published
- 2002-12-06
- Volume
- 298
- Issue
- 5600
- Pages
- 1959-1964
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2033712349
- Cited by
- 1,425
- References
- 1
- FWCI
- 27.48
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
