The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Reconstituting Organ-Level Lung Functions on a Chip
Open accessAbstract
Just Breathe: Design of artificial systems that mimic in vivo organs could provide a better alternative for understanding mechanisms underlying physiological responses than current cell-based models or animal tests. Huh et al. (p. 1662 ) have created a tissue-tissue interface of human-cultured epithelial cells and endothelial cells together, with extracellular matrix in a device that models the alveolar-capillary interface of the human lung. The device mimicked physiological organ-level functions, including pathogen-induced inflammatory responses and responses to cytokine exposure. Breathing-type movements affected acute pulmonary cell toxicity and proinflammatory activity of widely used nanoparticulates.
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“most models rely on the integration of only a few, pre-defined immune cell types, which, however, does not emulate the complexity of in vivo immunoregulation”
From Human disease models in drug development (2023) · cites this paper as [143]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Biomechanical stimuli, such as shear stress, stretching or compression, influence (patho)physiological processes142–147”
From Human disease models in drug development (2023) · cites this paper as [143]
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In the citing paper
“Regarding the chip’s main structure, the traditional choice is poly(dimethylsiloxane) (PDMS) (Huh et al., 2010), a silicone rubber that is easily fabricated using lithographic design templates. This choice provides flexibility in the design, oxygen permeability, optical transparency, and biocompatibility.”
From Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility (2024) · cites this paper as Huh et al., 2010
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In the citing paper
“This problem can be partially resolved using shaking cultures23 93, spinning bioreactors or suspension under continuous agitation23, or in continuously stirred bioreactors93.”
From Organoids (2022) · cites this paper as [93]
Experimental — accuracy not yet measuredIn the citing paper
“Earlier, Huh et al.131 used a bionic microsystem to reconstruct the alveolar–capillary interface of the key function of the human lung. This model can produce a complex, integrated organ-level response to bacteria and inflammatory cytokines entering the alveolar space.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [131]
In the citing paper
“Unlike simple two-dimensional cell cultures, the development of biomimetic organ-on-a-chip and tissue-on-a-chip systems may enable researchers to more accurately predict the behaviour of nanomedicines in a controlled setting by considering cell-cell interactions, interstitial flow and nanoparticle transport in three dimensions93,94.”
From How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation (2018) · cites this paper as [93]
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Metadata
- Authors
- Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E.
- Affiliations
- Boston Children's Hospital (US)
- Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.
- Corresponding author
- Ingber, Donald E.
- Venue
- Science
- Published
- 2010-06-25
- Volume
- 328
- Issue
- 5986
- Pages
- 1662-1668
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC8335790
- OpenAlex
- W2076922024
- Cited by
- 4,250
- References
- 41
- Citations by year
- 2026: 337 · 2025: 311 · 2024: 372 · 2023: 369 · 2022: 367 · 2021: 371 · 2020: 300 · 2019: 302 · 2018: 286 · 2017: 288 · 2016: 220 · 2015: 166 · 2014: 188 · 2013: 156 · 2012: 110
- FWCI
- 68.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Environmental Health Sciences (R01ES016665)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Keywords
- organ-on-a-chip, lung-on-a-chip, cyclic strain, silica nanoparticles, nanoparticle uptake, nanoparticle transport, inflammation, bacterial infection, inhalation exposure, alternatives to animal testing, drug screening, toxicology
- MeSH terms
- Air, Animals, Capillaries, Capillary Permeability, Cells, Cultured, Escherichia coli, Humans, Immunity, Innate, Inflammation, Lung, Pulmonary Alveoli, Respiration, Silicon Dioxide, Stress, Mechanical, Blood-Air Barrier, Oxidative Stress, Neutrophil Infiltration, Biomimetic Materials, Endothelial Cells, Microfluidic Analytical Techniques, Mice, Nanoparticles, Microtechnology, Alveolar Epithelial Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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