The Steroid and Thyroid Hormone Receptor Superfamily

A human retinoic acid receptor which belongs to the family of nuclear receptors

Petkovich, M., Brand, N. J., Krust, A., & Chambon, P. (1987) · Nature · doi:10.1038/330444a0 · Cited by 2,214

Identification of a receptor for the morphogen retinoic acid

Giguere, V., Ong, E. S., Segui, P., & Evans, R. M. (1987) · Nature · doi:10.1038/330624a0 · Cited by 1,965

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase

Poland, A., Glover, E., & Kende, A. S. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33205-2 · Cited by 1,370

In vivo sequence requirements of the SV40 early promoter region

Benoist, C., & Chambon, P. (1981) · Nature · doi:10.1038/290304a0 · Cited by 1,074

Progesterone: the ultimate endometrial tumor suppressor

Yang, S., Thiel, K. W., & Leslie, K. K. (2011) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.01.005 · Cited by 194

CCAAT/enhancer binding protein ε is a potential retinoid target gene in acute promyelocytic leukemia treatment

Park, D. J., Chumakov, A. M., Vuong, P. T., Chih, D. Y., Gombart, A. F., Miller, W. H., & Koeffler, H. P. (1999) · Journal of Clinical Investigation · doi:10.1172/jci2887 · Cited by 187

A direct physical association between ETS and AP-1 transcription factors in normal human T cells

Bassuk, A. G., & Leiden, J. M. (1995) · Immunity · doi:10.1016/1074-7613(95)90092-6 · Cited by 186

Regulation of energy metabolism pathways by estrogens and estrogenic chemicals and potential implications in obesity associated with increased exposure to endocrine disruptors

Chen, J.-Q., Brown, T. R., & Russo, J. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.03.009 · Cited by 190

Nongenomic membrane actions of glucocorticoids in vertebrates

Borski, R. J. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00325-8 · Cited by 184

Glucocorticoid Resistance in the Squirrel Monkey Is Associated with Overexpression of the Immunophilin FKBP511

Reynolds, P. D., Ruan, Y., Smith, D. F., & Scammell, J. G. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5429 · Cited by 184

Glucocorticoid receptor action in beneficial and side effects of steroid therapy: lessons from conditional knockout mice

Kleiman, A., & Tuckermann, J. P. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.009 · Cited by 165

Glucocorticoid-induced osteoporosis: both in vivo and in vitro concentrations of glucocorticoids higher than physiological levels attenuate osteoblast differentiation.

Ishida, Y., & Heersche, J. N. M. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.12.1822 · Cited by 155

ROR nuclear receptors: Structures, related diseases, and drug discovery

Zhang, Y., Luo, X.-Y., Wu, D.-H., & Xu, Y. (2015) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.120 · Cited by 151

Intrinsically disordered proteins and multicellular organisms

Dunker, A. K., Bondos, S. E., Huang, F., & Oldfield, C. J. (2015) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.09.025 · Cited by 150

Ligand-induced repression of the glucocorticoid receptor gene is mediated by an NCoR1 repression complex formed by long-range chromatin interactions with intragenic glucocorticoid response elements

Ramamoorthy, S., & Cidlowski, J. A. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01151-12 · Cited by 146

Selective DNA recognition by the androgen receptor as a mechanism for hormone-specific regulation of gene expression

Verrijdt, G. (2003) · Molecular Genetics and Metabolism · doi:10.1016/s1096-7192(03)00003-9 · Cited by 148

Estrogen and thyroid hormone interaction on regulation of gene expression.

Zhu, Y. S., Yen, P. M., Chin, W. W., & Pfaff, D. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12587 · Cited by 143

Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes

You, L. (2004) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2004.01.006 · Cited by 145

Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice

Crawford, P. A., Sadovsky, Y., Woodson, K., Lee, S. L., & Milbrandt, J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.8.4331 · Cited by 145

Dynamic regulation of glucocorticoid signalling in health and disease

Biddie, S. C., Conway-Campbell, B. L., & Lightman, S. L. (2012) · Rheumatology · doi:10.1093/rheumatology/ker215 · Cited by 143

Androgen regulation of satellite cell function

Chen, Y., Zajac, J. D., & MacLean, H. E. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05976 · Cited by 137

Allosteric Modulators of Steroid Hormone Receptors: Structural Dynamics and Gene Regulation

Kumar, R., & McEwan, I. J. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1033 · Cited by 135

Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and rapamycin.

Ning, Y. M., & Sánchez, E. R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53220-8 · Cited by 136

Steroid hormones as mediators of neural plasticity

McEwen, B. S., Coirini, H., Westlind-Danielsson, A., Frankfurt, M., Gould, E., Schumacher, M., & Woolley, C. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90067-f · Cited by 136

Stimulation of Brain Pregnenolone Synthesis by Mitochondrial Diazepam Binding Inhibitor Receptor Ligands In Vivo

Korneyev, A., Pan, B. S., Polo, A., Romeo, E., Guidotti, A., & Costa, E. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb13647.x · Cited by 132

The mitochondrion as a primary site of action of glucocorticoids: the interaction of the glucocorticoid receptor with mitochondrial DNA sequences showing partial similarity to the nuclear glucocorticoid responsive elements

Demonacos, C., Djordjevic-Markovic, R., Tsawdaroglou, N., & Sekeris, C. E. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00159-w · Cited by 131

Estrogen and Thyroid Hormone Receptor Interactions: Physiological Flexibility by Molecular Specificity

Vasudevan, N., Ogawa, S., & Pfaff, D. (2002) · Physiological Reviews · doi:10.1152/physrev.00014.2002 · Cited by 129

Effect of long-term ovariectomy and estrogen replacement on the expression of estrogen receptor gene in female rats

Mohamed, M., & Abdel-Rahman, A. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1420307 · Cited by 127

Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-κB and the glucocorticoid receptor

Doucas, V., Shi, Y., Miyamoto, S., West, A., Verma, I., & Evans, R. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220413297 · Cited by 125

DNA recognition by nuclear receptors

Claessens, F., & Gewirth, D. T. (2004) · Essays in Biochemistry · doi:10.1042/bse0400059 · Cited by 108

Genetic and Biochemical Analysis of p23 and Ansamycin Antibiotics in the Function of Hsp90-Dependent Signaling Proteins

Bohen, S. P. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.6.3330 · Cited by 106

Neurosteroids: molecular mechanisms of action and psychopharmacological significance

Rupprecht, R., Hauser, C. A. E., Trapp, T., & Holsboer, F. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00233-2 · Cited by 99

Differential recruitment of tetratricorpeptide repeat domain immunophilins to the mineralocorticoid receptor influences both heat-shock protein 90-dependent retrotransport and hormone-dependent transcriptional activity

Gallo, L. I., Ghini, A. A., Piwien Pilipuk, G., & Galigniana, M. D. (2007) · Biochemistry · doi:10.1021/bi701372c · Cited by 99

Induction of 11β-hydroxysteroid dehydrogenase type 1 but not -2 in human aortic smooth muscle cells by inflammatory stimuli

Cai, T.-Q., Wong, B., Mundt, S. S., Thieringer, R., Wright, S. D., & Hermanowski-Vosatka, A. (2001) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00041-3 · Cited by 98

Left Ventricular Performance and Remodeling in Rabbits After Myocardial Infarction: Effects of a Thyroid Hormone Analogue

Mahaffey, K. W., Raya, T. E., Pennock, G. D., Morkin, E., & Goldman, S. (1995) · Circulation · doi:10.1161/01.cir.91.3.794 · Cited by 94

Site-directed mutagenesis of the phosphorylation sites in the mouse glucocorticoid receptor.

Mason, S. A., & Housley, P. R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80568-7 · Cited by 94

Medroxyprogesterone acetate therapy in advanced breast cancer: the predictive value of androgen receptor expression.

Birrell, S. N., Roder, D. M., Horsfall, D. J., Bentel, J. M., & Tilley, W. D. (1995) · Journal of Clinical Oncology · doi:10.1200/jco.1995.13.7.1572 · Cited by 87

Protective features of peripheral monocytes/macrophages in stroke

Gliem, M., Schwaninger, M., & Jander, S. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.004 · Cited by 88

Negative regulation of the gene for the preprothyrotropin-releasing hormone from the mouse by thyroid hormone requires additional factors in conjunction with thyroid hormone receptors

Satoh, T., Yamada, M., Iwasaki, T., & Mori, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27919 · Cited by 82

Nuclear Receptors Nor1 and NGFI-B/Nur77 Play Similar, Albeit Distinct, Roles in the Hypothalamo-Pituitary-Adrenal Axis1

Fernandez, P. M., Brunel, F., Jimenez, M. A., Saez, J. M., Cereghini, S., & Zakin, M. M. (2000) · Endocrinology · doi:10.1210/endo.141.7.7562 · Cited by 85

Genetics of glucocorticoid regulation and posttraumatic stress disorder -what do we know?

Castro-Vale, I., van Rossum, E. F. C., Machado, J. C., Mota-Cardoso, R., & Carvalho, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.005 · Cited by 85

Selective Inhibition of NF-kB Activation and TNF-α Production in Macrophages by Red Blood Cell-Mediated Delivery of Dexamethasone

Crinelli, R., Antonelli, A., Bianchi, M., Gentilini, L., Scaramucci, S., & Magnani, M. (2000) · Blood Cells, Molecules, and Diseases · doi:10.1006/bcmd.2000.0298 · Cited by 84

Oxysterol signaling links cholesterol metabolism and inflammation via the liver X receptor in macrophages

Töröcsik, D., Szanto, A., & Nagy, L. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.02.002 · Cited by 82

Functional domains of the human androgen receptor

Jenster, G., van der Korput, J. A. G. M., Trapman, J., & Brinkmann, A. O. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90402-5 · Cited by 80

Emerging pathways of non-genomic glucocorticoid (GC) signalling in T cells

Boldizsar, F., Talaber, G., Szabo, M., Bartis, D., Palinkas, L., Nemeth, P., & Berki, T. (2010) · Immunobiology · doi:10.1016/j.imbio.2009.10.003 · Cited by 76

A Splice Variant of Estrogen Receptor β Missing Exon 3 Displays Altered Subnuclear Localization and Capacity for Transcriptional Activation*

Price, R. H., Butler, C. A., Webb, P., Uht, R., Kushner, P., & Handa, R. J. (2001) · Endocrinology · doi:10.1210/endo.142.5.8130 · Cited by 76

miR-194-3p represses the progesterone receptor and decidualization in eutopic endometrium from women with endometriosis

Pei, T., Liu, C., Liu, T., Xiao, L., Luo, B., Tan, J., Li, X., Zhou, G., Duan, C., & Huang, W. (2018) · Endocrinology · doi:10.1210/en.2018-00374 · Cited by 73

Glucocorticoid and thyroid hormone receptors in mitochondria of animal cells

Scheller, K., Seibel, P., & Sekerist, C. E. (2003) · International review of cytology · doi:10.1016/s0074-7696(02)22011-2 · Cited by 73

Difference in transcriptional activity of two homologous CYP21A genes.

Chang, S. F., & Chung, B. C. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.10.8544841 · Cited by 73

Kinases and protein phosphorylation as regulators of steroid hormone action

Weigel, N. L., & Moore, N. L. (2007) · Nuclear Receptor Signaling · doi:10.1621/nrs.05005 · Cited by 72

Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation

Yang, Y., Tse, A. K.-W., Li, P., Ma, Q., Xiang, S., Nicosia, S. V., Seto, E., Zhang, X., & Bai, W. (2011) · Oncogene · doi:10.1038/onc.2010.600 · Cited by 72

Effects of an Environmentally Relevant PFAS Mixture on Dopamine and Steroid Hormone Levels in Exposed Mice

Grønnestad, R., Johanson, S. M., Müller, M. H. B., Schlenk, D., Tanabe, P., Krøkje, Å., Jaspers, V. L. B., Jenssen, B. M., Ræder, E. M., Lyche, J. L., et al. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115670 · Cited by 65

The Interaction between Nuclear Receptor Corepressor and Histone Deacetylase 3 Regulates Both Positive and Negative Thyroid Hormone Action in Vivo

You, S.-H., Liao, X., Weiss, R. E., & Lazar, M. A. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0501 · Cited by 61

Impact of the GH-cortisol ratio on the age-dependent changes in body composition

Nass, R., & Thorner, M. O. (2002) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(02)00022-9 · Cited by 58

Glucocorticoids decrease the bioavailability of TGF-β which leads to a reduced TGF-β signaling in hepatic stellate cells

Bolkenius, U., Hahn, D., Gressner, A. M., Breitkopf, K., Dooley, S., & Wickert, L. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.164 · Cited by 54

The multifaceted mineralocorticoid receptor

Gomez‐Sanchez, E., & Gomez‐Sanchez, C. E. (2014) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2014.tb00569.x · Cited by 55

Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506.

Tai, P.-K. K., Albers, M. W., McDonnell, D. P., Chang, H., Schreiber, S. L., & Faber, L. E. (1994) · Biochemistry · doi:10.1021/bi00201a014 · Cited by 52

The Glucocorticoid Receptor and RU 486 in Man

BAMBERGER, C. M., & CHROUSOS, G. P. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb31385.x · Cited by 49

Expression and subcellular distribution of native estrogen receptor β in murine C2C12 cells and skeletal muscle tissue

Milanesi, L., Vasconsuelo, A., de Boland, A. R., & Boland, R. (2009) · Steroids · doi:10.1016/j.steroids.2009.01.005 · Cited by 47

TM4SF1, a novel primary androgen receptor target gene over‐expressed in human prostate cancer and involved in cell migration

Allioli, N., Vincent, S., Vlaeminck‐Guillem, V., Decaussin‐Petrucci, M., Ragage, F., Ruffion, A., & Samarut, J. (2011) · The Prostate · doi:10.1002/pros.21340 · Cited by 47

Identification of a novel melatonin-binding nuclear receptor: Vitamin D receptor

Fang, N., Hu, C., Sun, W., Xu, Y., Gu, Y., Wu, L., Peng, Q., Reiter, R. J., & Liu, L. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12618 · Cited by 46

Glucocorticoid and mineralocorticoid receptors in rat neocortical and hippocampal brain cells in culture: characterization and regulatory studies

Vedder, H., Weiβ, I., Holsboer, F., & Reul, J. M. H. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91351-r · Cited by 46

Unliganded Thyroid Hormone Receptor Regulates Metamorphic Timing via the Recruitment of Histone Deacetylase Complexes

Shi, Y.-B. (2013) · Current Topics in Developmental Biology · doi:10.1016/b978-0-12-396968-2.00010-5 · Cited by 46

Glucocorticoid activity of adrenal steroid precursors in untreated patients with congenital adrenal hyperplasia

Engels, M., Pijnenburg-Kleizen, K. J., Utari, A., Faradz, S. M. H., Oude-Alink, S., van Herwaarden, A. E., Span, P. N., Sweep, F. C., & Claahsen-van der Grinten, H. L. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00547 · Cited by 43

Association of the 90-kDa heat shock protein does not affect the ligand-binding ability of androgen receptor

Nemoto, T., Ohara-Nemoto, Y., & Ota, M. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90088-z · Cited by 41

Gender- and age-related differences in the regulatory influence of thyroid hormone on the contractility and myosin composition of single rat soleus muscle fibres

Yu, F., Degens, H., Li, X., & Larsson, L. (1998) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s004240050741 · Cited by 40

Brassinosteroids Plant counterparts to animal steroid hormones?

Clouse, S. D. (2002) · Vitamins & Hormones · doi:10.1016/s0083-6729(02)65065-4 · Cited by 40

Impact of excess aldosterone on glucose homeostasis in adult male rat

Selvaraj, J., Muthusamy, T., Srinivasan, C., & Balasubramanian, K. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.06.030 · Cited by 38

Endocrine factors in the hypothalamic regulation of food intake in females: a review of the physiological roles and interactions of ghrelin, leptin, thyroid hormones, oestrogen and insulin

Somogyi, V., Gyorffy, A., Scalise, T. J., Kiss, D. S., Goszleth, G., Bartha, T., Frenyo, V. L., & Zsarnovszky, A. (2011) · Nutrition Research Reviews · doi:10.1017/s0954422411000035 · Cited by 37

Adrenal steroid metabolites accumulating in congenital adrenal hyperplasia lead to transactivation of the glucocorticoid receptor

Pijnenburg-Kleizen, K. J., Engels, M., Mooij, C. F., Griffin, A., Krone, N., Span, P. N., van Herwaarden, A. E., Sweep, F. C. G. J., & Claahsen-van der Grinten, H. L. (2015) · Endocrinology · doi:10.1210/en.2015-1087 · Cited by 35

Inhibition of phorbol ester‐induced monocytic differentiation by dexamethasone is associated with down‐regulation of c‐fos and c‐jun (AP‐1)

Hass, R., Brach, M., Kharbanda, S., Giese, G., Traub, P., & Kufe, D. (1991) · Journal of Cellular Physiology · doi:10.1002/jcp.1041490116 · Cited by 31

Retinoic Acid Attenuates Inducible Nitric Oxide Synthase (NOS2) Activation in Cultured Rat Cardiac Myocytes and Microvascular Endothelial Cells

Grosjean, S., Devaux, Y., Seguin, C., Meistelman, C., Zannad, F., Mertes, P.-M., Kelly, R. A., & Ungureanu-Longrois, D. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1356 · Cited by 29

Testosterone: an overview of biosynthesis, transport, metabolism and action

Rommerts, F. F. G. (1990) · Testosterone · doi:10.1007/978-3-662-00814-0_1 · Cited by 28

Insoluble, Speckled Cytosolic Distribution of Retinoic Acid Receptor Alpha Protein as a Marker of Hepatic Stellate Cell Activation In Vitro

Mezaki, Y., Yamaguchi, N., Yoshikawa, K., Miura, M., Imai, K., Itoh, H., & Senoo, H. (2009) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2009.953208 · Cited by 28

The helix 1–3 loop in the glucocorticoid receptor LBD is a regulatory element for FKBP cochaperones

Cluning, C., Ward, B. K., Rea, S. L., Arulpragasam, A., Fuller, P. J., & Ratajczak, T. (2013) · Molecular Endocrinology · doi:10.1210/me.2012-1023 · Cited by 26

Effect of ecdysterone on morphological and physiological processes in plants

Golovatskaya, I. F. (2004) · Russian Journal of Plant Physiology · doi:10.1023/b:rupp.0000028689.97402.d5 · Cited by 26

Phosphorylation of immunopurified rat liver glucocorticoid receptor by the catalytic subunit of cAMP-dependent protein kinase

Haske, T., Nakao, M., & Moudgil, V. K. (1994) · Molecular and Cellular Biochemistry · doi:10.1007/bf00926925 · Cited by 24

Syndromes of glucocorticoid and mineralocorticoid resistance

Zennaro, M. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1390127 · Cited by 19

Fifty years ago: The quest for steroid hormone receptors

Rousseau, G. G. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.05.005 · Cited by 18

Characterization of the glucocorticoid receptor in children undergoing cardiac surgery

Flores, S., Cooper, D. S., Opoka, A. M., Iliopoulos, I., Pluckebaum, S., Alder, M. N., Krallman, K. A., Sahay, R. D., Fei, L., & Wong, H. R. (2018) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000001572 · Cited by 7