The Steroid and Thyroid Hormone Receptor Superfamily

A human retinoic acid receptor which belongs to the family of nuclear receptors

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Identification of a receptor for the morphogen retinoic acid

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Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase

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In vivo sequence requirements of the SV40 early promoter region

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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519

Gene regulation by steroid hormones

Beato, M. (1989) · Cell · doi:10.1016/0092-8674(89)90237-7 · Cited by 3,383

ERβ: Identification and characterization of a novel human estrogen receptor

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Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study

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Nuclear Receptors and Lipid Physiology: Opening the X-Files

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Physiological and Molecular Basis of Thyroid Hormone Action

Yen, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1097 · Cited by 2,011

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

Couse, J. F., & Korach, K. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0370 · Cited by 2,045

Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

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Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated

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Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B

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Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

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Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators

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BRASSINOSTEROIDS: Essential Regulators of Plant Growth and Development

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Molecular Aspects of Thyroid Hormone Actions

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Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

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Identification of a nuclear receptor that is activated by farnesol metabolites

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Nuclear Receptors, RXR, and the Big Bang

Evans, R. M., & Mangelsdorf, D. J. (2014) · Cell · doi:10.1016/j.cell.2014.03.012 · Cited by 1,200

The biology of the glucocorticoid receptor: New signaling mechanisms in health and disease

Oakley, R. H., & Cidlowski, J. A. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.09.007 · Cited by 1,068

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.

Sladek, F. M., Zhong, W. M., Lai, E., & Darnell, J. E. (1990) · Genes & Development · doi:10.1101/gad.4.12b.2353 · Cited by 1,027

Chromatin accessibility pre-determines glucocorticoid receptor binding patterns

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Neuroendocrine Regulation of Immunity

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Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids.

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The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene

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Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors

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Molecular Control of Immune/Inflammatory Responses: Interactions Between Nuclear Factor-κB and Steroid Receptor-Signaling Pathways

McKay, L. I., & Cidlowski, J. A. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0375 · Cited by 805

A Null Mutation in Murine CD36 Reveals an Important Role in Fatty Acid and Lipoprotein Metabolism

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The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements

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Steroidogenic factor 1: a key determinant of endocrine development and function

Parker, K. L., & Schimmer, B. P. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0301 · Cited by 764

CDK-Independent Activation of Estrogen Receptor by Cyclin D1

Zwijsen, R. M. L., Wientjens, E., Klompmaker, R., van der Sman, J., Bernards, R., & Michalides, R. J. A. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81879-6 · Cited by 720

Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants

Skulachev, V. P. (1996) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500005795 · Cited by 703

Class II histone deacetylases: versatile regulators

Verdin, E., Dequiedt, F., & Kasler, H. G. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00073-8 · Cited by 664

Transcription Factors, Normal Myeloid Development, and Leukemia

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Molecular determinants of crosstalk between nuclear receptors and toll-like receptors

Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.029 · Cited by 647

Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans

Bamberger, C. M., Bamberger, A. M., de Castro, M., & Chrousos, G. P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117943 · Cited by 642

Transcriptional activation and nuclear targeting signals of the human androgen receptor.

Simental, J. A., Sar, M., Lane, M. V., French, F. S., & Wilson, E. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52466-2 · Cited by 631

Cytochrome P450-mediated metabolism of estrogens and its regulation in human

Tsuchiya, Y., Nakajima, M., & Yokoi, T. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.10.007 · Cited by 616

Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system

Whitnall, M. H. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90035-q · Cited by 582

The neuronal mineralocorticoid eeceptor as a mediator of glucocorticoid response

Arriza, J. L., Simerly, R. B., Swanson, L. W., & Evans, R. M. (1988) · Neuron · doi:10.1016/0896-6273(88)90136-5 · Cited by 591

Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase.

Metzger, D., Clifford, J., Chiba, H., & Chambon, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6991 · Cited by 570

Characterization of sgk, a Novel Member of the Serine/Threonine Protein Kinase Gene Family Which Is Transcriptionally Induced by Glucocorticoids and Serum

Webster, M. K., Goya, L., Ge, Y., Maiyar, A. C., & Firestone, G. L. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.4.2031-2040.1993 · Cited by 581

The Human Glucocorticoid Receptor β Isoform

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Nongenomic steroid action: controversies, questions, and answers

LÖSEL, R. M., FALKENSTEIN, E., FEURING, M., SCHULTZ, A., TILLMANN, H.-C., ROSSOL-HASEROTH, K., & WEHLING, M. (2003) · Physiological Reviews · doi:10.1152/physrev.00003.2003 · Cited by 561

Control and biochemical nature of the ecdysteroidogenic pathway

Gilbert, L. I., Rybczynski, R., & Warren, J. T. (2002) · Annual Review of Entomology · doi:10.1146/annurev.ento.47.091201.145302 · Cited by 532

Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization

Jenster, G., van der Korput, H. A. G. M., van Vroonhoven, C., van der Kwast, T. H., Trapman, J., & Brinkmann, A. O. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-10-1396 · Cited by 523

The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling

Dauvois, S., White, R., & Parker, M. G. (1993) · Journal of Cell Science · doi:10.1242/jcs.106.4.1377 · Cited by 522

Orphan Nuclear Receptors: Shifting Endocrinology into Reverse

Kliewer, S. A., Lehmann, J. M., & Willson, T. M. (1999) · Science · doi:10.1126/science.284.5415.757 · Cited by 499

Non-genomic actions of androgens

Foradori, C. D., Weiser, M. J., & Handa, R. J. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.10.005 · Cited by 493

Peroxisome proliferator-activated receptors: insight into multiple cellular functions

Escher, P., & Wahli, W. (2000) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(99)00231-6 · Cited by 491

The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates

Mlodzik, M., Hiromi, Y., Weber, U., Goodman, C. S., & Rubin, G. M. (1990) · Cell · doi:10.1016/0092-8674(90)90737-y · Cited by 457

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

Angel, P., & Karin, M. (1991) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(91)90011-9 · Cited by 450

The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

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Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it

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Progestogens Used in Postmenopausal Hormone Therapy: Differences in Their Pharmacological Properties, Intracellular Actions, and Clinical Effects

Stanczyk, F. Z., Hapgood, J. P., Winer, S., & Mishell, D. R. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1008 · Cited by 429

Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties

Rupprecht, R. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00064-1 · Cited by 427

Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction

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Identification of two transcription activation units in the N-terminal domain of the human androgen receptor

Jenster, G., van der Korput, H. A. G. M., Trapman, J., & Brinkmann, A. O. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7341 · Cited by 419

Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificities

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Ligands of peroxisome proliferator-activated receptor γ modulate profibrogenic and proinflammatory actions in hepatic stellate cells

Marra, F., Efsen, E., Romanelli, R. G., Caligiuri, A., Pastacaldi, S., Batignani, G., Bonacchi, A., Caporale, R., Laffi, G., Pinzani, M., et al. (2000) · Gastroenterology · doi:10.1053/gast.2000.9365 · Cited by 409

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

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Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1.

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Gonadal steroid hormones and the hypothalamo–pituitary–adrenal axis

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Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor

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Hormones and the physiological architecture of life history evolution

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Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance

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Cellular processing of the glucocorticoid receptor gene and protein: New mechanisms for generating tissue-specific actions of glucocorticoids

Oakley, R. H., & Cidlowski, J. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.179325 · Cited by 373

A Novel Orphan Receptor Specific for a Subset of Thyroid Hormone-Responsive Elements and Its Interaction with the Retinoid/Thyroid Hormone Receptor Subfamily

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Ets target genes: past, present and future

Sementchenko, V. I., & Watson, D. K. (2000) · Oncogene · doi:10.1038/sj.onc.1204034 · Cited by 371

Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor α.

Luo, J., Sladek, R., Carrier, J., Bader, J.-A., Richard, D., & Giguère, V. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.7947-7956.2003 · Cited by 370

Differentiation therapy of leukemia: 3 decades of development.

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PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis

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Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: Presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity

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Role of nuclear progesterone receptor isoforms in uterine pathophysiology

Patel, B., Elguero, S., Thakore, S., Dahoud, W., Bedaiwy, M., & Mesiano, S. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmu056 · Cited by 353

The five rs of glucocorticoid action during inflammation: Ready, reinforce, repress, resolve, and restore

Busillo, J. M., & Cidlowski, J. A. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.11.005 · Cited by 339

Biochemical basis of thyroid hormone action in the heart.

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The role of PPARα in lipid metabolism and obesity: Focusing on the effects of estrogen on PPARα actions

Yoon, M. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.02.004 · Cited by 336

Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.

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Selective Progesterone Receptor Modulator Development and Use in the Treatment of Leiomyomata and Endometriosis

Chwalisz, K., Perez, M. C., DeManno, D., Winkel, C., Schubert, G., & Elger, W. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0001 · Cited by 310

A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry

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Comparative distribution of estrogen receptor-α (ER-α) and β (ER-β) mRNA in the rat pituitary, gonad, and reproductive tract

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Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription

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Multiple aspects of mineralocorticoid selectivity

Farman, N., & Rafestin-Oblin, M.-E. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.280.2.f181 · Cited by 268

Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes

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Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor protein

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Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome

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CREB-binding protein in androgen receptor-mediated signaling

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A germline mutation in the androgen receptor gene in two brothers with breast cancer and Reifenstein syndrome

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Development of selective androgen receptor modulators (SARMs)

Narayanan, R., Coss, C. C., & Dalton, J. T. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.06.013 · Cited by 251

The Physiology of Human Glucocorticoid Receptor β (hGRβ) and Glucocorticoid Resistance

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Negative regulation of nuclear factor-kappaB activation and function by glucocorticoids

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Extensive In Vivo Metabolite-Protein Interactions Revealed by Large-Scale Systematic Analyses

Li, X., Gianoulis, T. A., Yip, K. Y., Gerstein, M., & Snyder, M. (2010) · Cell · doi:10.1016/j.cell.2010.09.048 · Cited by 237

The ROR nuclear orphan receptor subfamily: Critical regulators of multiple biological processes

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Molecular basis of androgenetic alopecia: from androgen to paracrine mediators through dermal papilla

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Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in cv-1 cells: A comparison of their glucocorticoid and mineralocorticoid properties

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Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements.

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Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation

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Gonadal steroids regulate oxytocin receptors but not vasopressin receptors in the brain of male and female rats. An autoradiographical study

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Ethinyl estradiol and 17β-estradiol in combined oral contraceptives: pharmacokinetics, pharmacodynamics and risk assessment

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A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat.

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