The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Mammalian Sirtuins: Biological Insights and Disease Relevance
Open accessAbstract
Aging is accompanied by a decline in the healthy function of multiple organ systems, leading to increased incidence and mortality from diseases such as type II diabetes mellitus, neurodegenerative diseases, cancer, and cardiovascular disease. Historically, researchers have focused on investigating individual pathways in isolated organs as a strategy to identify the root cause of a disease, with hopes of designing better drugs. Studies of aging in yeast led to the discovery of a family of conserved enzymes known as the sirtuins, which affect multiple pathways that increase the life span and the overall health of organisms. Since the discovery of the first known mammalian sirtuin, SIRT1, 10 years ago, there have been major advances in our understanding of the enzymology of sirtuins, their regulation, and their ability to broadly improve mammalian physiology and health span. This review summarizes and discusses the advances of the past decade and the challenges that will confront the field in the coming years.
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“Proposed drivers of physiological aging include the accumulation of DNA damage, increased ROS production, telomere shortening, cellular senescence, and defects in nuclear envelope architecture (Bernardes de Jesus and Blasco, 2013;Guarente, 2008;Haigis and Sinclair, 2009;Kennedy and Lamming, 2016;Soultoukis and Partridge, 2016;Steffen and Dillin, 2016).”
From In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. (2016) · cites this paper as Haigis and Sinclair, 2009
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“Sirtuins are NAD+‐dependent enzymes implicated in a range of physiological and pathophysiological conditions, including AS, diabetes mellitus, cancer, longevity, and neurodegeneration, through deacetylation of numerous substrates.42”
From Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway (2017) · cites this paper as [42]
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2 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
RetractedRETRACTED: Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex
Zhang, Q., Wang, S.-Y., Fleuriel, C., Leprince, D., Rocheleau, J. V., Piston, D. W., & Goodman, R. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610590104 · Cited by 171
RetractedCancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Self-citationLagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Self-citationTranscriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239
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Flagged first, then by citations
Research works printed but not linked: 237
- 10.1016/S0092-8674(00)80493-6 · DOI · Paper page
- 10.1038/scientificamerican0306-48 · DOI
- 10.1016/j.tibs.2007.09.008 · DOI
- 10.1006/bbrc.1999.0897 · DOI
- 10.1101/gad.11.2.241 · DOI
- 10.1101/gad.11.2.255 · DOI
- 10.1126/science.1080418 · DOI
- 10.1186/gb-2004-5-5-224 · DOI
- 10.1038/35065638 · DOI · Paper page
- 10.1016/j.mad.2005.09.005 · DOI
- 10.1073/pnas.0404184101 · DOI · Paper page
- 10.1006/bbrc.2000.3000 · DOI · Paper page
- 10.1074/jbc.273.48.31788 · DOI
- 10.1016/S1097-2765(03)00038-8 · DOI
- 10.1073/pnas.250422697 · DOI
- 10.1006/bbrc.2000.3854 · DOI
- 10.1016/j.cell.2006.06.057 · DOI · Paper page
- 10.1016/S0092-8674(00)81671-2 · DOI
- 10.1016/S0955-0674(00)00202-7 · DOI
- 10.1021/bi011858j · DOI
- 10.1074/jbc.M407484200 · DOI
- 10.1021/bi049592e · DOI
- 10.2174/138161209787185797 · DOI
- 10.1016/j.chembiol.2008.09.009 · DOI
- 10.1146/annurev.biochem.74.082803.133500 · DOI · Paper page
- 10.1016/j.molcel.2004.12.032 · DOI
- 10.1021/bi034959l · DOI
- 10.1016/S1097-2765(04)00082-6 · DOI
- 10.1074/jbc.M804681200 · DOI
- 10.1128/MCB.24.3.1301-1312.2004 · DOI · Paper page
- 10.1016/S0092-8674(04)00416-7 · DOI · Paper page
- 10.1002/1521-4141(200211)32:11<3225::AID-IMMU3225>3.0.CO;2-L · DOI
- 10.1016/j.exger.2006.06.003 · DOI
- 10.1016/j.cell.2007.07.035 · DOI · Paper page
- 10.1074/jbc.M109.016469 · DOI
- 10.1007/s12013-008-9041-4 · DOI
- 10.1146/annurev.nutr.28.061807.155443 · DOI · Paper page
- 10.1126/science.1060698 · DOI · Paper page
- 10.1126/science.1171641 · DOI · Paper page
- 10.1096/fj.09-129148 · DOI
- 10.1126/science.1170803 · DOI · Paper page
- 10.1016/j.bbrc.2006.08.066 · DOI
- 10.2119/2006-00099.Lund · DOI
- 10.1016/j.cell.2005.03.035 · DOI
- 10.1074/jbc.M513741200 · DOI
- 10.1074/jbc.M208997200 · DOI
- 10.1042/BJ20070140 · DOI
- 10.1371/journal.pone.0000784 · DOI
- 10.1074/jbc.M609554200 · DOI
- 10.1016/S1097-2765(04)00094-2 · DOI
- 10.1083/jcb.200205057 · DOI
- 10.1073/pnas.0603968103 · DOI · Paper page
- 10.1042/BJ20080336 · DOI
- 10.1016/j.bbrc.2007.11.122 · DOI
- 10.1101/gad.1527307 · DOI
- 10.1074/jbc.M109.014928 · DOI
- 10.1016/j.mad.2005.03.019 · DOI
- 10.1111/j.1474-9726.2006.00236.x · DOI
- 10.1096/fj.03-1464fje · DOI
- 10.1038/35041700 · DOI
- 10.1126/science.1113611 · DOI
- 10.1371/journal.pgen.0010069 · DOI
- 10.1016/j.cell.2005.08.042 · DOI
- 10.1371/journal.pbio.0050261 · DOI · Paper page
- 10.1074/jbc.M111773200 · DOI
- 10.1016/S0531-5565(00)00084-X · DOI · Paper page
- 10.1016/j.mad.2004.01.006 · DOI
- 85. Sinclair DA, Howitz KT. 2006. Dietary Restriction, Hormesis, and Small Molecule Mimetics . Amsterdam/Boston: Elsevier. 660pp. · DOI
- 10.1126/science.1099196 · DOI · Paper page
- 10.1111/j.1474-9726.2007.00335.x · DOI · Paper page
- 10.1016/j.cmet.2008.08.014 · DOI
- 10.1073/pnas.0802917105 · DOI · Paper page
- 10.1016/j.cmet.2008.05.004 · DOI · Paper page
- 10.1128/MCB.23.1.38-54.2003 · DOI · Paper page
- 10.1038/ncb1468 · DOI
- 10.1126/science.1101731 · DOI
- 10.1016/j.cell.2005.08.011 · DOI
- 10.1161/CIRCRESAHA.108.193102 · DOI
- 10.4161/cc.8.5.7753 · DOI
- 10.1016/j.taap.2008.12.021 · DOI
- 10.1016/j.bbrc.2008.09.086 · DOI
- 10.1073/pnas.0801613105 · DOI
- 10.1083/jcb.200809167 · DOI
- 10.1128/MCB.26.1.28-38.2006 · DOI
- 10.1021/jm050100l · DOI
- 10.1186/1752-0509-3-31 · DOI · Paper page
- 10.1038/nrd2665 · DOI
- 10.1073/pnas.0403493101 · DOI · Paper page
- 10.1016/j.femsyr.2004.06.015 · DOI
- 10.1016/j.devcel.2005.09.017 · DOI
- 10.1016/j.mad.2007.07.007 · DOI
- 10.1074/jbc.M500655200 · DOI · Paper page
- 10.1177/1087057106294710 · DOI
- 122. Galonek H, Miller C, Israelian K, Ribish S, Lynch AV, et al. 2009. Enzymatic and cellular activity of small molecule activators of SIRT1 . Presented at NAD Metab. Signal., FASEB J. Conf., Carefree, Ariz.
- 10.1016/j.molcel.2008.09.011 · DOI
- 10.1016/j.cmet.2007.08.014 · DOI · Paper page
- 10.1038/onc.2009.147 · DOI
- 10.1016/j.molcel.2007.08.030 · DOI
- 10.1523/JNEUROSCI.3052-08.2008 · DOI
- 10.1038/nature06515 · DOI
- 10.1038/nature06500 · DOI
- 10.1371/journal.pone.0004020 · DOI
- 10.1016/S0092-8674(00)81410-5 · DOI · Paper page
- 10.1016/j.febslet.2007.11.034 · DOI · Paper page
- 10.1016/j.cmet.2009.02.006 · DOI · Paper page
- 10.1038/nature07349 · DOI · Paper page
- 10.1097/MOL.0b013e328328d0a4 · DOI · Paper page
- 10.1016/j.devcel.2008.04.012 · DOI
- 10.1038/sj.emboj.7601633 · DOI · Paper page
- 10.1152/ajpgi.90358.2008 · DOI · Paper page
- 10.1152/ajpgi.00575.2007 · DOI
- 10.1016/j.molcel.2007.07.032 · DOI
- 10.1073/pnas.0712145105 · DOI
- 10.1016/j.cmet.2005.07.001 · DOI
- 10.1038/nature02583 · DOI
- 10.1074/jbc.M607215200 · DOI
- 10.1146/annurev.genet.39.110304.095751 · DOI · Paper page
- 10.1073/pnas.222538099 · DOI
- 10.1128/MCB.01636-07 · DOI · Paper page
- 10.1073/pnas.0604392103 · DOI · Paper page
- 10.1016/j.jmb.2008.07.048 · DOI · Paper page
- 10.1073/pnas.0803790105 · DOI · Paper page
- 10.1002/pro.50 · DOI
- 10.1016/j.ygeno.2006.09.004 · DOI
- 10.1074/jbc.M705488200 · DOI · Paper page
- 10.1016/j.ymgme.2003.10.013 · DOI
- 10.1128/MCB.00426-08 · DOI
- 10.1016/j.ccr.2008.04.009 · DOI
- 10.1038/nrc2562 · DOI
- 10.1016/S0092-8674(01)00524-4 · DOI · Paper page
- 10.1016/S0092-8674(01)00527-X · DOI
- 10.1016/j.cell.2008.10.025 · DOI · Paper page
- 10.7150/ijbs.5.147 · DOI
- 10.1038/onc.2008.388 · DOI
- 10.1158/0008-5472.CAN-07-0085 · DOI
- 10.1038/sj.leu.2403910 · DOI
- 10.1002/biot.200700087 · DOI
- 10.1007/s00403-006-0725-6 · DOI
- 10.1016/j.ccr.2008.09.001 · DOI
- 10.1245/s10434-008-9940-z · DOI
- 10.1074/jbc.M702990200 · DOI
- 10.4161/cc.8.8.8245 · DOI
- 10.1016/j.bbrc.2003.08.029 · DOI
- 10.1038/nature07861 · DOI
- 10.1038/sj.onc.1209857 · DOI
- 10.1038/sj.bjc.6603384 · DOI
- 10.1038/sj.bjc.6600635 · DOI
- 10.1158/0008-5472.CAN-05-1923 · DOI
- 10.1038/onc.2008.436 · DOI
- 10.1016/S0092-8674(01)00524-4 · DOI · Paper page
- 10.1016/j.ccr.2008.03.004 · DOI
- 10.1073/pnas.1934713100 · DOI · Paper page
- 10.1038/sj.onc.1209049 · DOI
- 10.1016/j.yjmcc.2007.08.008 · DOI
- 10.1371/journal.pone.0001710 · DOI
- 10.1016/j.cell.2008.11.008 · DOI
- 10.1101/gad.435107 · DOI · Paper page
- 10.4161/cc.7.14.6267 · DOI
- 10.4161/cc.6.23.5026 · DOI
- 10.4161/cc.7.10.5883 · DOI
- 10.1093/ajcn/55.6.1250S · DOI
- 10.1038/nrd2060 · DOI · Paper page
- 10.1016/S0960-9822(00)00002-6 · DOI · Paper page
- 10.1038/ng0994-66 · DOI
- 10.1111/j.1474-9726.2006.00191.x · DOI
- 10.1016/S0092-8674(00)80773-4 · DOI · Paper page
- 10.1016/S0960-9822(99)80339-X · DOI
- 10.1128/MCB.21.16.5359-5373.2001 · DOI
- 10.1128/MCB.25.12.4903-4913.2005 · DOI
- 10.1016/j.molcel.2007.05.029 · DOI
- 10.1126/science.275.5297.218 · DOI · Paper page
- 10.1128/MCB.23.9.3173-3185.2003 · DOI
- 10.1016/j.bbrc.2009.06.113 · DOI
- 10.1158/0008-5472.CAN-05-3617 · DOI
- 10.4161/cc.6.21.4866 · DOI
- 10.1016/j.cell.2005.11.044 · DOI · Paper page
- 10.1002/jcb.21140 · DOI
- 10.1038/cdd.2008.122 · DOI
- 10.1161/01.CIR.0000140677.20606.0E · DOI
- 10.1001/jama.295.13.1539 · DOI · Paper page
- 10.1128/MMBR.67.3.376-399.2003 · DOI
- 10.2174/138161209787185742 · DOI
- 10.1093/cvr/cvn245 · DOI
- 10.1093/eurheartj/ehm149 · DOI
- 10.1152/ajpgi.00016.2009 · DOI
- 10.1128/MCB.00705-08 · DOI
- 10.1016/j.cmet.2008.06.011 · DOI · Paper page
- 10.1152/ajpheart.00235.2008 · DOI
- 10.1161/01.CIR.0000029925.18593.5C · DOI
- 10.1016/j.yjmcc.2006.10.018 · DOI
- Rush JW, 2007, Exp. Biol. Med., 232, 814, 10.3181/00379727-232-2320814 · DOI
- 10.1073/pnas.0704329104 · DOI · Paper page
- 10.1371/journal.pmed.0040076 · DOI · Paper page
- 10.1111/j.1474-9726.2009.00453.x · DOI
- 10.1093/cvr/cvn224 · DOI · Paper page
- 10.1161/CIRCRESAHA.107.152165 · DOI
- 10.1172/JCI23126 · DOI
- 10.1042/BST0340731 · DOI
- 10.1016/j.cell.2006.12.029 · DOI · Paper page
- 10.1016/S0006-291X(02)03020-6 · DOI
200 of 237 shown
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Metadata
- Authors
- Haigis, M. C., & Sinclair, D. A.
- Affiliations
- Harvard University (US)
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2010-01-01
- Volume
- 5
- Issue
- 1
- Pages
- 253-295
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- PMC
- PMC2866163
- OpenAlex
- W2118964113
- Cited by
- 2,085
- References
- 56
- Citations by year
- 2026: 78 · 2025: 118 · 2024: 80 · 2023: 113 · 2022: 123 · 2021: 152 · 2020: 143 · 2019: 124 · 2018: 148 · 2017: 115 · 2016: 142 · 2015: 117 · 2014: 154 · 2013: 145 · 2012: 149
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Pathology Mechanisms of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG032375, P01AG027916, R01AG028730, R01AG019719)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- sirtuins, SIRT1, aging, healthspan, longevity, type 2 diabetes, neurodegenerative diseases, cancer, cardiovascular disease
- MeSH terms
- Aging, Animals, Cardiovascular Diseases, Humans, Longevity, Metabolic Diseases, Neoplasms, Neurodegenerative Diseases, Sirtuins
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