Cited by 150Muscle metabolism and nutritionMetabolism, Diabetes, and CancerMuscle Physiology and Disorders

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Influence of muscle glycogen availability on ERK1/2 and Akt signaling after resistance exercise in human skeletal muscle

Creer, Andrew, Gallagher, Philip, Slivka, Dustin, Jemiolo, Bozena, Fink, William, Trappe, Scott·2005·Journal of Applied Physiology

DOI 10.1152/japplphysiol.00110.2005

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Abstract

Two pathways that have been implicated for cellular growth and development in response to muscle contraction are the extracellular signal-regulated kinase (ERK1/2) and Akt signaling pathways. Although these pathways are readily stimulated after exercise, little is known about how nutritional status may affect stimulation of these pathways in response to resistance exercise in human skeletal muscle. To investigate this, experienced cyclists performed 30 repetitions of knee extension exercise at 70% of one repetition maximum after a low (2%) or high (77%) carbohydrate (LCHO or HCHO) diet, which resulted in low or high (approximately 174 or approximately 591 mmol/kg dry wt) preexercise muscle glycogen content. Muscle biopsies were taken from the vastus lateralis before, approximately 20 s after, and 10 min after exercise. ERK1/2 and p90 ribosomal S6 kinase phosphorylation increased (P < or = 0.05) 10 min after exercise, regardless of muscle glycogen availability. Akt phosphorylation was elevated (P < 0.05) 10 min after exercise in the HCHO trial but was unaffected after exercise in the LCHO trial. Mammalian target of rapamycin phosphorylation was similar to that of Akt during each trial; however, change or lack of change was not significant. In conclusion, the ERK1/2 pathway appears to be unaffected by muscle glycogen content. However, muscle glycogen availability appears to contribute to regulation of the Akt pathway, which may influence cellular growth and adaptation in response to resistance exercise in a low-glycogen state.

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Method
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“Subsequent works also showed an increase in ERK1/2 phosphorylation in response to resistance exercise [177,178].”
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Background
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Method
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BackgroundResult
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Background
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Background
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“Similar to ERK1/2 phosphorylation, alterations in p90RSK phosphorylation (Ser(380) and Thr(573)) have been observed within 10 min of exercise cessation (33, 114), and p90RSK phosphorylation (Ser(380) and Thr(573)) can remain elevated for 5–24 h postexercise, depending on the phosphorylation site measured (25, 124).”
Background
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“Indeed, evidence is accumulating that nutrient manipulation can serve as a potent modulator of many of the acute responses to both endurance (15) and resistance exercise (7, 11).”
Background
Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise
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“by Creer and colleagues (11) showed an attenuation in Akt”
Background
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“The rate of utilization of IMTG during resistance exercise appears to be in part dictated by the starting concentration such that greater IMTG content results in increased rates of IMTG degradation (92).”
Background
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“Although early studies suggested that Akt was not activated by either contraction (2, 25, 39) or physical exercise (26, 46, 48), more recent data from our laboratory and those of others have convincingly shown that Akt is activated by exercise and contraction in both rodent (3, 28, 30, 34, 36) and human skeletal muscl…”
Result
Influence of supplementation with branched-chain amino acids in combination with resistance exercise on p70S6 kinase phosphorylation in resting and exercising human skeletal muscle
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“These findings are in agreement with some (Coffey et al. 2006, Deshmukh et al. 2006, Eliasson et al. 2006) but no all (Creer et al. 2005, Blomstrand et al. 2006, Dreyer et al. 2006, Deldicque et al. 2008, Terzis et al. 2008) earlier studies of contractile activity on Akt phosphorylation.”
Result
The Effect of Carbohydrate Intake on Strength and Resistance Training Performance: A Systematic Review
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“For example, Creer et al. (2005) showed that the degree of exercise-induced Akt serine phosphorylation is positively related to the amount of muscle glycogen.”
Background
Low-intensity resistance training attenuates dexamethasone-induced atrophy in the flexor hallucis longus muscle
Macedo, A. G., Krug, A. L. O., Herrera, N. A., Zago, A. S., Rush, J. W. E., & Amaral, S. L. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.05.010 · Cited by 55
Nutrition for the sprinter
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“Both translational (Bolster, Jefferson, & Kimball, 2004) and transcriptional (Creer et al., 2005; Psilander, Damsgaard, & Pilegaard, 2003) mechanisms are stimulated by resistance exercise, but the bulk of the increase in muscle protein synthesis is translational (Chesley, MacDougall, Tarnopolsky, Atkinson, & Smith, 19…”
Background
Ibuprofen treatment blunts early translational signaling responses in human skeletal muscle following resistance exercise
Markworth, J. F., Vella, L. D., Figueiredo, V. C., & Cameron‐Smith, D. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01299.2013 · Cited by 59
The effect of concurrent training organisation in youth elite soccer players
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“Whereas, completing strength training in the face of low muscle glycogen stores can have a negative impact on training performance and adaptation (Churchley et al. 2007; Creer et al. 2005).”
Background
Resistance Exercise, Skeletal Muscle FOXO3A, and 85-Year-Old Women
Williamson, D. L., Raue, U., Slivka, D. R., & Trappe, S. W. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq005 · Cited by 53
Effects of Elevated Circulating Hormones on Resistance Exercise-Induced Akt Signaling
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“Specifically, the present results contribute to a growing body of literature demonstrating that in humans, exercise-induced signaling of Akt and/or its downstream targets is modulated by ingestion of branchedchain amino acids (20), glycogen availability (10), muscle action (11,13), muscle fiber type examined (22), and…”
BackgroundResult
Effects of skeletal muscle energy availability on protein turnover responses to exercise
Smiles, W. J., Hawley, J. A., & Camera, D. M. (2016) · Journal of Experimental Biology · doi:10.1242/jeb.125104 · Cited by 48
“Of note is that the time courses of many of these intracellular events typically peak in the 3–4 h period post-exercise and have returned to pre-exercise baseline values within 24 h (Creer et al., 2005).”
COX Inhibitor Influence on Skeletal Muscle Fiber Size and Metabolic Adaptations to Resistance Exercise in Older Adults
Trappe, T. A., Ratchford, S. M., Brower, B. E., Liu, S. Z., Lavin, K. M., Carroll, C. C., Jemioło, B., & Trappe, S. W. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv231 · Cited by 52
Resistance training increases skeletal muscle oxidative capacity and net intramuscular triglyceride breakdown in type I and II fibres of sedentary males
Shepherd, S. O., Cocks, M. S., Tipton, K. D., Witard, O. C., Ranasinghe, A. M., Barker, T. A., Wagenmakers, A. J. M., & Shaw, C. S. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.078014 · Cited by 52
“A number of studies have previously shown that IMTG are reduced following an acute bout of resistance exercise (Essen-Gustavsson & Tesch, 1990; Creer et al. 2005; Koopman et al. 2006) and that rates of IMTG synthesis increase in the period following exercise-induced IMTG depletion (Schenk &…”
BackgroundResult
Molecular, neuromuscular, and recovery responses to light versus heavy resistance exercise in young men
Haun, C. T., Mumford, P. W., Roberson, P. A., Romero, M. A., Mobley, C. B., Kephart, W. C., Anderson, R. G., Colquhoun, R. J., Muddle, T. W. D., Luera, M. J., et al. (2017) · Physiological Reports · doi:10.14814/phy2.13457 · Cited by 48
“studies comparing acute and subchronic responses to RT have revealed strikingly similar anabolic signaling outcomes (Creer et al. 2005; Dreyer et al. 2006; Burd et al. 2010; Fry et al. 2010; Mitchell et al. 2012; Morton et al. 2016b).”
Background
Beyond Menstrual Dysfunction: Does Altered Endocrine Function Caused by Problematic Low Energy Availability Impair Health and Sports Performance in Female Athletes?
Ihalainen, J. K., Mikkonen, R. S., Ackerman, K. E., Heikura, I. A., Mjøsund, K., Valtonen, M., & Hackney, A. C. (2024) · Sports Medicine · doi:10.1007/s40279-024-02065-6 · Cited by 61
“…has been demonstrated to negatively affect cellular growth and adaptation in response to resistance exercise independently of hormonal responses [135], while exercise nutrient interactions influence cascades that affect protein regulatory systems during both exercise and recovery where energy…”
Background
Innovations in athletic preparation: Role of substrate availability to modify training adaptation and performance
Hawley, J. A., Gibala, M. J., & Bermon, S. (2007) · Journal of Sports Sciences · doi:10.1080/02640410701607411 · Cited by 43
“…Hawley et al., 2000; Stepto et al., 2002), as well as on many of the acute regulatory processes underlying gene expression (Arkinstall, Tunstall, Cameron-Smith, & Hawley, 2004b; Cameron-Smith et al., 2003; Churchley et al., 2007; Creer et al., 2005) and cell signalling (Wojtaszewski et al., 2003).”
Background
Skeletal muscle signaling response to sprint exercise in men and women
Fuentes, T., Guerra, B., Ponce-González, J. G., Morales-Alamo, D., Guadalupe-Grau, A., Olmedillas, H., Rodríguez-García, L., Feijoo, D., De Pablos-Velasco, P., Fernández-Pérez, L., et al. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2164-0 · Cited by 36
Paleolithic Diet—Effect on the Health Status and Performance of Athletes?
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“For example, there is no evidence that carbohydrates are required for mTORC-1 (mammalian target of rapamycin complex-1) signaling during muscle protein synthesis [103], when dietary protein intake is sufficient [102].”
Background
Is sprint exercise a leptin signaling mimetic in human skeletal muscle?
Guerra, B., Olmedillas, H., Guadalupe‐Grau, A., Ponce‐González, J. G., Morales‐Álamo, D., Fuentes, T., Chapinal, E., Fernández‐Pérez, L., de Pablos-Velasco, P. L., Santana, A., et al. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00805.2010 · Cited by 34
Effects of Resistance Exercise Intensity on Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase Activation in Men
Taylor, L. W., Wilborn, C., Kreider, R. B., & Willoughby, D. S. (2011) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e318242f92d · Cited by 34
“1 repetition maximum (1RM) of the knee extension exercise) increases ERK1/2 activity within 30 minutes of exercise (7,14,31).”
Background
Concurrent exercise and muscle protein synthesis: implications for exercise countermeasures in space.
Carrithers, J. A., Carroll, C. C., Coker, R. H., Sullivan, D. H., & Trappe, T. A. (2007) · PubMed · Cited by 32
Influence of resistance exercise intensity and metabolic stress on anabolic signaling and expression of myogenic genes in skeletal muscle
Popov, D. V., Lysenko, E. A., Bachinin, A. V., Miller, T. F., Kurochkina, N. S., Kravchenko, I. V., Furalyov, V. A., & Vinogradova, O. L. (2015) · Muscle & Nerve · doi:10.1002/mus.24314 · Cited by 32
Effect of acute exercise on glucose tolerance following post-exercise feeding
Venables, M., Shaw, C. S., Jeukendrup, A. E., & Wagenmakers, A. J. M. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0464-1 · Cited by 31
“The evidence from these studies (Creer et al. 2005; Hernandez et al. 2000) and that from the present study appears to indicate that RE followed by carbohydrate feeding to enhance glycogen re-synthesis is beneficial if not crucial to the enhancement of glucose tolerance in the post-exercise period.”
Influential
Contraction-induced changes in TNFα and Akt-mediated signalling are associated with increased myofibrillar protein in rat skeletal muscle
Karagounis, L. G., Yaspelkis, B. B., Reeder, D. W., Lancaster, G. I., Hawley, J. A., & Coffey, V. G. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1427-5 · Cited by 31
“Moreover, Akt phosphorylation and activity have previously been shown to both increase/decrease (Bolster et al. 2003; Coffey et al. 2005, 2007; Creer et al. 2005; Dreyer et al. 2006; Nader and Esser 2001; Sakamoto et al. 2004 )o r remain unchanged (Coffey et al. 2005; Eliasson et al. 2006; Nader and Esser 2001; Widegr…”
Background
Physical loading in professional soccer players: Implications for contemporary guidelines to encompass carbohydrate periodization
Anderson, L. J., Drust, B., Close, G. L., & Morton, J. P. (2022) · Journal of Sports Sciences · doi:10.1080/02640414.2022.2044135 · Cited by 34
“In addition, commencing strength training in conditions of low muscle glycogen (<200 mmol.kg−1 dry weight) may reduce associated mTOR signalling (Churchley et al., 2007; Creer et al., 2005).”
Background
The Order of Exercise during Concurrent Training for Rehabilitation Does Not Alter Acute Genetic Expression, Mitochondrial Enzyme Activity or Improvements in Muscle Function
MacNeil, L., Glover, E. I., Bergstra, T. G., Safdar, A., & Tarnopolsky, M. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109189 · Cited by 33
“has been suggested that the adaptive processes may interfere with one another [7,8], thereby attenuating the optimal adaptation that could be achieved from either mode individually.”
Background
Carbohydrate intake and resistance-based exercise: are current recommendations reflective of actual need?
Escobar, K. A., VanDusseldorp, T. A., & Kerksick, C. M. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516003949 · Cited by 34
“Low-CHO diets may not be as detrimental as typically espoused, as investigations have demonstrated that CHO intakes less than the moderately high recommendation does not hinder acute resistance exercise performance((30,32)) or the subsequent cellular responses responsible for adaptation, including translation initiati…”
BackgroundInfluential
A putative low-carbohydrate ketogenic diet elicits mild nutritional ketosis but does not impair the acute or chronic hypertrophic responses to resistance exercise in rodents
Roberts, M. D., Holland, A. M., Kephart, W. C., Mobley, C. B., Mumford, P. W., Lowery, R. P., Fox, C. D., McCloskey, A. E., Shake, J. J., Mesquita, P. H. C., et al. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00837.2015 · Cited by 28
“(5) reported that 3 days of a LCKD, which decreased skeletal muscle glycogen, did not hamper intramuscular anabolic signaling (i.”
Background
Fat and carbohydrate for exercise
Burke, L. M., & Hawley, J. A. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000232911.69236.3b · Cited by 28
Impact of local heating and cooling on skeletal muscle transcriptional response related to myogenesis and proteolysis
Zak, R., Hassenstab, B., Zuehlke, L. K., Heesch, M., Shute, R. J., Laursen, T. L., Salle, D. T. L., & Slivka, D. R. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3749-z · Cited by 26
Elevation of myostatin and FOXOs in prolonged muscular impairment induced by eccentric contractions in rat medial gastrocnemius muscle
Ochi, E., Hirose, T., Hiranuma, K., Min, S.-K., Ishii, N., & Nakazato, K. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00278.2009 · Cited by 25
Nutritional Considerations for Bouldering
Gibson-Smith, E., Storey, R., & Ranchordas, M. K. (2017) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2017-0043 · Cited by 26
Resistance Exercise–induced Regulation of Muscle Protein Synthesis to Intraset Rest
Salvador, A. F., Askow, A. T., McKenna, C. F., FANG, H.-Y., Skinner, S. K., Li, Z. A., ULANOV, A. V., Paluska, S. A., Petruzzello, S. J., Boppart, M. D., et al. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002213 · Cited by 27
Basal and insulin‐stimulated pyruvate dehydrogenase complex activation, glycogen synthesis and metabolic gene expression in human skeletal muscle the day after a single bout of exercise
Stephens, F. B., Norton, L., Jewell, K., Chokkalingam, K., Parr, T., & Tsintzas, K. (2010) · Experimental Physiology · doi:10.1113/expphysiol.2009.051367 · Cited by 20
“This was important, because muscle glycogen content is inversely related to glycogen synthase activity (Nielsen et al. 2001) and has also been suggested to affect metabolic gene expression (Pilegaard et al. 2002; Garcia-Roves et al. 2003) and Akt phosphorylation (Creer et al. 2005).”
Background
Altering Endogenous Carbohydrate Availability to Support Training Adaptations
Philp, A., Burke, L. M., & Baar, K. (2011) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000329279 · Cited by 20
Effects of exercise on muscle glycogen synthesis signalling and enzyme activities in pigs carrying the PRKAG3 mutation
Granlund, A., Kotova, O., Benziane, B., Galuska, D., Jensen‐Waern, M., Chibalin, A., & Essén-Gustavsson, B. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2009.051326 · Cited by 19
“subjects had been on a high-carbohydrate diet, resulting in high muscle glycogen levels, in comparison to a low-carbohydrate diet, resulting in low muscle glycogen levels (Creer et al. 2005).”
Background
MAPK, androgen, and glucocorticoid receptor phosphorylation following high-frequency resistance exercise non-functional overreaching
Nicoll, J. X., Fry, A. C., Mosier, E. M., Olsen, L. A., & Sontag, S. A. (2019) · European Journal of Applied Physiology · doi:10.1007/s00421-019-04200-y · Cited by 21
Signaling Responses After Varying Sequencing of Strength and Endurance Training in a Fed State
Jones, T. W., Walshe, I. H., Hamilton, D. L., Howatson, G., Russell, M., Price, O. J., Gibson, A. S. C., & French, D. N. (2016) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2015-0534 · Cited by 18
Periexercise coingestion of branched-chain amino acids and carbohydrate in men does not preferentially augment resistance exercise–induced increases in phosphatidylinositol 3 kinase/protein kinase B–mammalian target of rapamycin pathway markers indicative of muscle protein synthesis
Ferreira, M. P., Li, R., Cooke, M. B., Kreider, R. B., & Willoughby, D. S. (2014) · Nutrition Research · doi:10.1016/j.nutres.2013.12.007 · Cited by 16
“Protein kinase B has been shown to rapidly and transiently increase in phosphorylation after exercise [32], although, Akt phosphorylation in response to RE may or may not correlate with the”
Background
Nutrition and Football
Maughan, R. (2006) · Routledge eBooks · doi:10.4324/9780203967430 · Cited by 21
The guardian of the genome p53 regulates exercise‐induced mitochondrial plasticity beyond organelle biogenesis
Smiles, W. J., & CAMERA, D. M. (2017) · Acta Physiologica · doi:10.1111/apha.13004 · Cited by 15
“Peak cellular signalling events manifest within 3-4 hours post-exercise and return to baseline by ~24 hours.(124) During this post-exercise ‘window’ of heightened cellular signalling and metabolism, skeletal muscle retains its sensitivity to nutrient ingestion, in particular the anabolic effects of protein ingestion.”
Background
Training for Performance: Insights From Molecular Biology
Coffey, V. G., & Hawley, J. A. (2006) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.1.3.284 · Cited by 15
Effectiveness of Whey Protein Hydrolysate and Milk-Based Formulated Drinks on Recovery of Strength and Power Following Acute Resistance Exercise
Gee, T., Woolrich, T. J., & Smith, M. F. (2019) · Journal of Human Kinetics · doi:10.2478/hukin-2019-0066 · Cited by 15
“…stores, thus influencing the regulation of molecular signalling pathways such as Akt and mTOR which affect cellular growth and adaptation in response to resistance exercise, and contribute to an anabolic hormonal environment by increasing insulin (Børsheim et al., 2004; Creer et al., 2005).”
Background
Strength and Conditioning for Competitive Rowers
Nugent, F. J., Flanagan, E. P., Wilson, F., & Warrington, G. D. (2020) · Strength and conditioning journal · doi:10.1519/ssc.0000000000000531 · Cited by 15
“A number of mechanisms have been proposed to explain the interference between resistance and endurance training (20,37,52,76,78,89,103).”
Background
Activated Lymphocytes Secretome Inhibits Differentiation and Induces Proliferation of C2C12 Myoblasts
Al-Shanti, N., Durcan, P. J., Al-Dabbagh, S., Dimchev, G., & Stewart, C. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356655 · Cited by 16
Effects of time of day on resistance exercise-induced anabolic signaling in skeletal muscle
Sedliak, M., Zeman, M., Buzgó, G., Cvečka, J., Hamar, D., Laczo, E., Zelko, A., Okuliarová, M., Raastad, T., Nilsen, T. S., et al. (2012) · Biological Rhythm Research · doi:10.1080/09291016.2012.740314 · Cited by 14
“It can be speculated that low muscle glycogen levels decrease resistance exercise response of Akt phosphorylation (Creer et al. 2005) and may be thus the reason for the lack of Akt responses in some individuals in the morning in the present study.”
Background
Ingestion of 10 grams of whey protein prior to a single bout of resistance exercise does not augment Akt/mTOR pathway signaling compared to carbohydrate
Cooke, M. B., Bounty, P. L., Buford, T. W., Shelmadine, B., Redd, L., Hudson, G. M., & Willoughby, D. S. (2011) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-8-18 · Cited by 11
“A series of studies have demonstrated that contractile activity either positively or negatively regulates Akt activity [15,37-39], while others failed to find any change [40-42].”
Background
Metabolic and molecular changes associated with the increased skeletal muscle insulin action 24–48 h after exercise in young and old humans
Stephens, F. B., & Tsintzas, K. (2018) · Biochemical Society Transactions · doi:10.1042/bst20170198 · Cited by 11
“Indeed, glycogen depletion has been suggested to affect metabolic gene expression (42, 43) and activation of key insulin signalling proteins (44).”
Background
Resistance‐only and concurrent exercise induce similar myofibrillar protein synthesis rates and associated molecular responses in moderately active men before and after training
Lee, M. J.-C., Caruana, N. J., Saner, N. J., Kuang, J., Stokes, T., Mcleod, J. C., Oikawa, S. Y., Bishop, D. J., Bartlett, J. D., & Phillips, S. M. (2023) · The FASEB Journal · doi:10.1096/fj.202302024r · Cited by 12
“68,81 However, in the present study, acute periods of low muscle glycogen did not attenuate MyoPS, nor mTORC1 signaling.”
Background
Muscle glycogen resynthesis, signalling and metabolic responses following acute exercise in exercise-trained pigs carrying the PRKAG3 mutation
Essén-Gustavsson, B., Granlund, A., Benziane, B., Jensen‐Waern, M., & Chibalin, A. (2011) · Experimental Physiology · doi:10.1113/expphysiol.2011.057620 · Cited by 7
“A study on humans also found that pAkt Ser(473) was more elevated after exercise when subjects had been on a high-carbohydrate diet, causing high muscle glycogen levels, than when on a low-carbohydrate diet, causing low muscle glycogen levels (Creer et al. 2005).”
Background
Molecular Signals and Skeletal Muscle Adaptation to Exercise
Wilson, M. D. (2013) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 5

Authors: Creer, A., Gallagher, P., Slivka, D., Jemiolo, B., Fink, W., & Trappe, S.
Affiliations: Ball State University (US)
ORCID: Creer, Andrew
Gallagher, Philip
Slivka, Dustin
Trappe, Scott
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 2005-09
Volume: 99
Issue: 3
Pages: 950-956
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/japplphysiol.00110.2005
OpenAlex: W2166195206
Cited by: 150
References: 47
Citations by year: 2025: 1 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 8 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 18 · 2013: 10 · 2012: 9
FWCI: 3.52
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 18409, R01AG018409)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: muscle glycogen, resistance training, ERK signaling, Akt signaling, p90 ribosomal S6 kinase, mTOR, skeletal muscle, dietary carbohydrates, muscle hypertrophy, vastus lateralis, exercise adaptation
MeSH terms: Adult, Dietary Carbohydrates, Glycogen, Humans, Knee Joint, Male, Muscle Contraction, Physical Endurance, Proto-Oncogene Proteins, Signal Transduction, Protein Serine-Threonine Kinases, Muscle, Skeletal, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Proto-Oncogene Proteins c-akt

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Influence of muscle glycogen availability on ERK1/2 and Akt signaling after resistance exercise in human skeletal muscle

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