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Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival
Abstract
In this study, we report for the first time reduced expression of the let-7 microRNA in human lung cancers. Interestingly, 143 lung cancer cases that had undergone potentially curative resection could be classified into two major groups according to let-7 expression in unsupervised hierarchical analysis, showing significantly shorter survival after potentially curative resection in cases with reduced let-7 expression (P = 0.0003). Multivariate COX regression analysis showed this prognostic impact to be independent of disease stage (hazard ratio = 2.17; P = 0.009). In addition, overexpression of let-7 in A549 lung adenocarcinoma cell line inhibited lung cancer cell growth in vitro. This study represents the first report of reduced expression of let-7 and the potential clinical and biological effects of such a microRNA alteration.
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Metadata
- Authors
- Takamizawa, J., Konishi, H., Yanagisawa, K., Tomida, S., Osada, H., Endoh, H., Harano, T., Yatabe, Y., Nagino, M., Nimura, Y., Mitsudomi, T., & Takahashi, T.
- Venue
- Cancer Research
- Published
- 2004-06-01
- Volume
- 64
- Issue
- 11
- Pages
- 3753-3756
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2110666579
- Cited by
- 2,354
- References
- 9
- FWCI
- 27.55
- Type
- journal article
- Language
- en
- Open access
- closed
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