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Cited by 321

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Lymphatic System in Cardiovascular Medicine

Open access
Aspelund, Aleksanteri, Robciuc, Marius R., Karaman, Sinem, Makinen, Taija, Alitalo, Kari·2016·Circulation Research
DOI 10.1161/circresaha.115.306544
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Abstract

The mammalian circulatory system comprises both the cardiovascular system and the lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a unidirectional transit pathway from the extracellular space to the venous system. It actively regulates tissue fluid homeostasis, absorption of gastrointestinal lipids, and trafficking of antigen-presenting cells and lymphocytes to lymphoid organs and on to the systemic circulation. The cardinal manifestation of lymphatic malfunction is lymphedema. Recent research has implicated the lymphatic system in the pathogenesis of cardiovascular diseases including obesity and metabolic disease, dyslipidemia, inflammation, atherosclerosis, hypertension, and myocardial infarction. Here, we review the most recent advances in the field of lymphatic vascular biology, with a focus on cardiovascular disease.

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Metadata

Authors
Aspelund, A., Robciuc, M. R., Karaman, S., Makinen, T., & Alitalo, K.
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016-02-05
Volume
118
Issue
3
Pages
515-530
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/circresaha.115.306544
OpenAlex
W2344803633
Cited by
321
References
15
FWCI
16.53
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Lymphatic System in Cardiovascular Medicine. https://app.cochat.ai/papers/10.1161/circresaha.115.306544
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Aspelund, A., Robciuc, M. R., Karaman, S., Makinen, T., & Alitalo, K. (2016). Lymphatic System in Cardiovascular Medicine. Circulation Research. https://doi.org/10.1161/circresaha.115.306544

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