The DOI matches its Crossref record; 128 of the 130 references it cites were found in a registry or an index; 4 of the 158 sources its claims cite were checked for support.
Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France
Open accessAbstract
Endometriosis, defined as estrogen-dependent lesions containing endometrial glands and stroma outside the uterus, is a chronic and often painful gynecological condition that affects 6% to 10% of reproductive age women. Endometriosis has estimated annual costs of US $12 419 per woman (approximately €9579), comprising one-third of the direct health care costs with two-thirds attributed to loss of productivity. Decreased quality of life is the most important predictor of direct health care and total costs. It has been estimated that there is a mean delay of 6.7 years between onset of symptoms and a surgical diagnosis of endometriosis, and each affected woman loses on average 10.8 hours of work weekly, mainly owing to reduced effectiveness while working. To encourage and facilitate research into this debilitating disease, a consensus workshop to define future directions for endometriosis research was held as part of the 11th World Congress on Endometriosis in September 2011 in Montpellier, France. The objective of this workshop was to review and update the endometriosis research priorities consensus statement developed following the 10th World Congress on Endometriosis in 2008.(1) A total of 56 recommendations for research have been developed, grouped under 6 subheadings: (1) diagnosis, (2) classification and prognosis, (3) clinical trials, treatment, and outcomes, (4) epidemiology, (5) pathophysiology, and (6) research policy. By producing this consensus international research priorities statement, it is the hope of the workshop participants that researchers will be encouraged to develop new interdisciplinary research proposals that will attract increased funding support for work on endometriosis.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
This workshop report updates the 2008 consensus research priorities for endometriosis from the 2011 World Congress, producing 56 recommendations across six domains. It summarizes background burden data and expert recommendations for diagnosis, classification, clinical trials, epidemiology, pathophysiology, and research policy.
Key findings
- Endometriosis affects an estimated 6% to 10% of reproductive-age women; annual costs are estimated at US $12,419 per woman (approximately €9,579), comprising one-third direct health care costs and two-thirds productivity loss, with a mean 6.7-year delay between symptom onset and surgical diagnosis and an average 10.8 hours of work lost weekly.
- Between the 2008 and 2011 World Congress meetings, 3,176 new endometriosis publications were recorded on PubMed, a 21.5% increase over the total number published prior to 2008; major contributions included the first two genome-wide association studies and ongoing nerve fiber work.
- The workshop developed 56 research recommendations grouped under 6 subheadings: diagnosis; classification and prognosis; clinical trials, treatment, and outcomes; epidemiology; pathophysiology; and research policy.
- Recommendations emphasize noninvasive biomarkers, imaging advances, better classification/prognostic tools, adequately powered multicenter randomized controlled trials with quality-of-life and live-birth outcomes, pain mechanisms, genetic/environmental/diet/BMI research, inflammation/oxidative stress/neuroangiogenesis/stem cells/apoptosis/miRNAs, and biobanks/registries/multidisciplinary approaches.
Methods
- Consensus workshop held at the 11th World Congress on Endometriosis in September 2011 in Montpellier, France, convened by the World Endometriosis Society and World Endometriosis Research Foundation to review and update the 2008 consensus statement.
- 58 participants from 19 countries attended; the meeting used 6 moderated sessions, with each moderator reviewing progress, discussing whether 2008 recommendations needed updating, leading discussion, and producing a written summary incorporated into the final report.
- Narrative synthesis of expert discussion and literature; no primary data collection or systematic review methods are described.
Limitations
- Stated limitations: Not stated in the paper.
- Evident from text: this is a consensus workshop report; the recommendations are described as “by no means proscriptive” and are based on expert discussion rather than primary empirical testing.
- Evident from text: many recommendations call for larger, well-designed, adequately powered studies and validation, indicating evidence gaps and limitations in the existing literature.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
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Cites
Statistics
Verification
Claims the paper makes
127 Not checked yet · 12 No basis given · 4 Own result · 3 Supported · 2 Own interpretation · 1 Supported so far
Every source the paper cites for this claim was checked and supports it.
In the paper
“Peritoneal endometriosis is characterized by increased numbers of peritoneal macrophages and their secreted products.69”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Supportedcites [69] Lousse JC, Van Langendonckt A, Defrere S, Ramos RG, Colette S, Donnez J. Peritoneal endometriosis is an inflammatory disease. Front Biosci (Elite Ed). 2012;4(1):23–40. source
The Abstract states the claim directly. The Introduction also reports increased numbers of activated macrophages in the peritoneal fluid of women with endometriosis and describes the products they secrete. (LLM, conf=0.95)
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“The newly identified SRC-1 isoform functional axis promotes pathogenic progression of endometriosis.111”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Apoptosis
What the sources say
- Supportedcites [111] Han SJ, Hawkins SM, Begum K, et al. A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med. 2012;18(7):1102–1111. source
The Results section ('The role of SRC-1 isoform in the progression of endometriosis') states that the activated TNF-α/MMP9 axis produces an SRC-1 C-terminal isoform that protects ectopic endometrium from cell death and enhances its invasive capacity. This directly supports the claimed role of the newly identified functional axis in endometriosis progression. (LLM, conf=0.95)
plaindirect- Asserted: passes — The authors put it forward as true.
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- Supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“although a number of emerging endometriosis research fields had significantly increased publication rates including stem cells, proteomics, genomics, angiogenesis, vasculogenesis, genetics, and inflammation.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Between the 2008 and 2011 WCE meetings, a total of 3176 new scientific publications on endometriosis were recorded on PubMed.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The vast majority of the publications were in established areas of endometriosis research, including etiology, surgery, histology, pathology, pain, cancer, and fertility”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
plain- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This represents a 21.5% increase in the total number of scientific papers published prior to 2008 in the field”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“One area of research need that was repeatedly highlighted at the 2011 meeting was work on all aspects of pain.34”
- Also stated in: § Discussion · plain
“The meeting recognized the impact that pain has on many women with endometriosis and attached significant priority to the need for research on all aspects of pain, including basic mechanisms, classification, and treatment.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Discussion
What the sources say
- Not checked yetcites [34] Stratton P, Berkley KJ. Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Hum Reprod Update. 2011;17(3):327–346. source
plain- Asserted: passes — The authors put it forward as true.
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- Also stated in: § Discussion · plain
In the paper
“A recent systematic review of 182 relevant articles that assessed over 200 potential biomarkers identified several reports of endometrial differences which have the potential to be biomarkers for endometriosis.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Diagnosis
What the sources say
- Not checked yetcites [18] May KE, Villar J, Kirtley S, Kennedy SH, Becker CM. Endometrial alterations in endometriosis: a systematic review of putative biomarkers. Hum Reprod Update. 2011;17(5):637–653. source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Professional guidelines for the clinical management of endometriosis have been developed, [28][29][30][31][32]”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Clinical Trials, Treatment, and Outcomes
What the sources say
- Not checked yetcites [28][29][30][31][32]
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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In the paper
“There is only limited evidence to support the use of progestagens and antiprogestagens for pain associated with endometriosis.35”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [35] Brown J, Kives S, Akhtar M. Progestagens and anti-progestagens for pain associated with endometriosis. Cochrane Database Syst Rev. 2012;3:CD002122.
plain- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 39
- Probably not a substantial claim. 21
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Not surprisingly, ectopic and eutopic endometrium produce neurotrophic factors, 83 some of which are differentially expressed in cases of endometrioisis 84 and could serve as minimally invasive endometriosis biomarkers.85”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [83] Borghese B, Vaiman D, Mondon F, et al. [Neurotrophins and pain in endometriosis]. Gynecol Obstet Fertil. 2010;38(7–8):442–446. source
- Supportedcites [84] Browne AS, Yu J, Huang RP, Francisco AM, Sidell N, Taylor RN. Proteomic identification of neurotrophins in the eutopic endometrium of women with endometriosis. Fertil Steril. 2012;98(3):713–719. source
Citation 85 is attached to the biomarker clause. The Discussion (page not provided) proposes that measuring differentially expressed neurotrophins in endometrial biopsies could provide biomarkers and describes minimally invasive diagnostic use. (LLM, conf=0.92)
- Not checked yetcites [85] Giannini A, Bucci F, Luisi S, Cela V, Pluchino N, Merlini S. Brain-derived neurotrophic factor in plasma of women with endometriosis. J Endometriosis. 2010;2(3):144–145. source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
Every source the paper cites for this claim was checked and supports it.
In the paper
“Significantly increased presence of endometrial cells and altered immune environment has also been demonstrated in uterine-draining lymph nodes in the baboon model of induced endometriosis.99”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Angiogenesis and Lymphangiogenesis
What the sources say
- Supportedcites [99] Hey-Cunningham AJ, Fazleabas AT, Braundmeier AG, Markham R, Fraser IS, Berbic M. Endometrial stromal cells and immune cell populations within lymph nodes in a nonhuman primate model of endometriosis. Reprod Sci. 2011;18(8):747–754. source
The Discussion reports significantly increased CD10-positive endometrial stromal cells in femoral lymph nodes of baboons with induced endometriosis compared with controls. It also reports changes in immune-cell populations and antigen expression. These femoral nodes drain both the uterus and the peritoneal cavity. (LLM, conf=0.90)
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Supported
In the paper
“Endometriosis affects an estimated 6% to 10% of women in the reproductive age group.3”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
What the sources say
- Not checked yetcites [3] Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North Am. 1997;24(2):235–258. source
hedged- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“estimated annual costs of US $12 419 per woman (approximately €9579), comprising one-third of the direct health care costs with two-thirds attributed to loss of productivity.6”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
What the sources say
- Not checked yetcites [6] Simoens S, Dunselman G, Dirksen C, et al. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Hum Reprod. 2012;27(5):1292–1299. source
hedged- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“However, this classification system does not appear to be widely used.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Classification and Prognosis
hedged- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it. The paper may give no reason why it holds.
In the paper
“Oral CHM may have a better overall treatment effect than danazol; it may be more effective in relieving dysmenorrhea and shrinking adnexal masses when used in conjunction with a CHM enema.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [37] Flower A, Liu JP, Lewith G, Little P, Li Q. Chinese herbal medicine for endometriosis. Cochrane Database Syst Rev. 2012;5:CD006568.
hedgedconditional- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“Endometriosis occurs in adolescents, and presenting symptoms may vary from those seen in adult women with the disease.38”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [38] Laufer MR, Sanfilippo J, Rose G. Adolescent endometriosis: diagnosis and treatment approaches. J Pediatr Adolesc Gynecol. 2003;16(suppl 3):S3–S11. source
hedged- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“Different techniques for diagnostic and preoperative imaging of endometriosis are being explored, including ultrasound, computed tomography, and magnetic resonance imaging.21”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [21] Chamie LP, Blasbalg R, Pereira RM, Warmbrand G, Serafini PC. Findings of pelvic endometriosis at transvaginal us, mr imaging, and laparoscopy. Radiographics. 2011;31(4):E77–E100. source
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“A refinement of the rAFS/rASRM criteria is the ENZIAN classification system, developed to describe more severe disease.25”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Classification and Prognosis
What the sources say
- Not checked yetcites [25] Tuttlies F, Keckstein J, Ulrich U, et al. [ENZIAN-score, a classification of deep infiltrating endometriosis]. Zentralbl Gynakol. 2005;127(5):275–281. source
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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It may state two separate claims as one.
In the paper
“Loss of work productivity translated into significant costs, ranging from US $208 in Nigeria to US $23 712 in Italy per woman per year.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
What the sources say
- Not checked yetcites [7] Nnoaham KE, Hummelshoj L, Webster P, et al. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril. 2011;96(2):366–373 e368. source
plaindirect- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Based on a review of best available evidence, pain recurrence and reoperation rates after conservative surgery for symptomatic endometriosis are high and probably underestimated.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Clinical Trials, Treatment, and Outcomes
What the sources say
- Not checked yetcites [33] Vercellini P, Crosignani PG, Abbiati A, Somigliana E, Vigano P, Fedele L. The effect of surgery for symptomatic endometriosis: the other side of the story. Hum Reprod Update. 2009;15(2):177–188. source
hedged- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“The state of advancement and the results of novel treatments studied in registered trials (www.ClinicalTrials.gov)have recently been reviewed.36”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [36] Streuli I, de Ziegler D, Borghese B, Santulli P, Batteux F, Chapron C. New treatment strategies and emerging drugs in endometriosis[published online march 23, 2012]. Expert Opin Emerg Drugs. 2012. source
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“The EFI is a simple, robust, and validated clinical tool that provides reassurance to those patients with good prognoses and avoids wasting time and treatment for those with poor prognoses.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Classification and Prognosis
What the sources say
- Not checked yetcites [27] Adamson GD, Pasta DJ. Endometriosis fertility index: the new, validated endometriosis staging system. Fertil Steril. 2010;94(5):1609–1615. source
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“In China, treatment of endometriosis using Chinese herbal medicine (CHM) is routine, and considerable research into the role of CHM in alleviating pain, promoting fertility, and preventing relapse has taken place.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“Genetic and environmental factors contribute to endometriosis risk and the disease is inherited as a complex trait.[41][42][43][44][45]”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Epidemiology
What the sources say
- Not checked yetcites [41][42][43][44][45]
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Methodological drawbacks limit considerably the validity of observational, noncomparative studies on the effect of laparoscopy, identifying the need for prospective, multicenter randomized controlled trials.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Clinical Trials, Treatment, and Outcomes
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“However, these classifications are restricted to a limited number of criteria and are not particularly valuable for predicting many of the parameters needed for clinical management, including pain or fertility outcomes.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Classification and Prognosis
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“However, the authors concluded that larger studies in well-defined populations are required to determine their true usefulness.18”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Diagnosis
What the sources say
- Not checked yetcites [18] May KE, Villar J, Kirtley S, Kennedy SH, Becker CM. Endometrial alterations in endometriosis: a systematic review of putative biomarkers. Hum Reprod Update. 2011;17(5):637–653. source
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“The authors concluded that post-surgical administration of CHM may have comparable benefits to gestrinone but with fewer side effects.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [37] Flower A, Liu JP, Lewith G, Little P, Li Q. Chinese herbal medicine for endometriosis. Cochrane Database Syst Rev. 2012;5:CD006568.
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Furthermore, there is a paucity of data on longterm outcomes and little data on cost-effectiveness and QoL.16”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Diagnosis
What the sources say
- Not checked yetcites [16] Hori Y. Diagnostic laparoscopy guidelines: This guideline was prepared by the SAGES Guidelines Committee and reviewed and approved by the Board of Governors of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), November 2007. Surg Endosc. 2008;22(5):1353–1383. source
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“Currently, The American Association of Gynecologic Laparoscopists is developing a categorization system that will be more focused on pain.26”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Classification and Prognosis
What the sources say
- Not checked yetcites [26] Adamson GD. Endometriosis classification: an update. Curr Opin Obstet Gynecol. 2011;23(4):213–220. source
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Current treatment options for women with endometriosisassociated pain and/or infertility include surgery, medical treatment, alternative therapies, and assisted reproduction.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Clinical Trials, Treatment, and Outcomes
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Each affected woman lost on average 10.8 hours of work weekly, mainly owing to reduced effectiveness while working.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
What the sources say
- Not checked yetcites [7] Nnoaham KE, Hummelshoj L, Webster P, et al. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril. 2011;96(2):366–373 e368. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“However, studies in Australian twins, 45 in the Icelandic population, 43 and in rhesus macaques 49 provide strong evidence for a genetic contribution to the disease with the heritability of endometriosis estimated to be around 50%. 45”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Epidemiology
What the sources say
- Not checked yetcites [45] Treloar SA, O’Connor DT, O’Connor VM, Martin NG. Genetic influences on endometriosis in an Australian twin sample. sueT@qimr.edu.au. Fertil Steril. 1999;71(4):701–710. source
- Not checked yetcites [43] Stefansson H, Geirsson RT, Steinthorsdottir V, et al. Genetic factors contribute to the risk of developing endometriosis. Hum Reprod. 2002;17(3):555–559. source
- Not checked yetcites [49] Zondervan KT, Weeks DE, Colman R, et al. Familial aggregation of endometriosis in a large pedigree of rhesus macaques. Hum Reprod. 2004;19(2):448–455. source
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Increased total fat consumption was associated with decreased endometriosis risk and increased b-carotene consumption and servings of fruit were associated with increased risk.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [53] Trabert B, Peters U, De Roos AJ, Scholes D, Holt VL. Diet and risk of endometriosis in a population-based case-control study. Br J Nutr. 2011;105(3):459–467. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Diet plausibly has a role in the etiology of endometriosis through effects at various levels including on steroid hormones; however, few published studies have examined diet and endometriosis risk, 52 resulting in no clear consensus recommendations.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [52] Fjerbaek A, Knudsen UB. Endometriosis, dysmenorrhea and diet–what is the evidence? Eur J Obstet Gynecol Reprod Biol. 2007;132(2): 140–147. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Autoimmune diseases that may be associated with endometriosis include systemic lupus erythematosus (SLE), hypothyroidism, rheumatoid arthritis, Sjo ¨gren syndrome, and multiple sclerosis.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Human epithelial and stromal endometrial cells express nuclear factor-kappa B (NF-kB) proteins; NF-kB-mediated gene transcription promotes inflammation, invasion, angiogenesis, and cell proliferation and inhibits apoptosis of endometriotic cells.63”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Not checked yetcites [63] Gonzalez-Ramos R, Van Langendonckt A, Defrere S, et al. Involvement of the nuclear factor-kappaB pathway in the pathogenesis of endometriosis. Fertil Steril. 2010;94(6):1985–1994. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“However, evidence is mixed on the usefulness of anti-inflammatory agents to treat endometriosis symptoms, with a recent review concluding that there is no enough evidence to support the use of the antiinflammatory pentoxifylline in the management of subfertility and relief of pain from endometriosis.65”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Not checked yetcites [65] Lu D, Song H, Li Y, Clarke J, Shi G. Pentoxifylline for endometriosis. Cochrane Database Syst Rev. 2012;1: CD007677.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“The dysregulation of ROS production in endometriotic cells correlates with a proproliferative phenotype and may be implicated in the spreading of the disease.75”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Oxidative Stress
What the sources say
- Not checked yetcites [75] Ngo C, Chereau C, Nicco C, Weill B, Chapron C, Batteux F. Reactive oxygen species controls endometriosis progression. Am J Pathol. 2009;175(1):225–234. source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“There was also a suggestion of decreased endometriosis risk associated with the consumption of dairy products.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [53] Trabert B, Peters U, De Roos AJ, Scholes D, Holt VL. Diet and risk of endometriosis in a population-based case-control study. Br J Nutr. 2011;105(3):459–467. source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Taken together, these reports show that endometriotic lesions can develop their own nerve supply, thereby creating a direct and 2-way interaction between lesions and the CNS.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“These results are consistent with clinical and pathological findings observed in patients with endometriosis, compatible with the ectopic endometrium as a source of pain.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [89] Alvarez P, Chen X, Hendrich J, et al. Ectopic uterine tissue as a chronic pain generator. Neuroscience. 2012;225:269–282. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In a rat model of autotransplantation of endometrium to the gastrocnemius muscle, cystic lesions developed within 2 weeks with stromal invasion of the muscle, nociceptor nerve fibers, and neuronal sprouting, and persistent mechanical hyperalgesia at the site of the lesions.89”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [89] Alvarez P, Chen X, Hendrich J, et al. Ectopic uterine tissue as a chronic pain generator. Neuroscience. 2012;225:269–282. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“It has been reported that endometrial biopsy, with detection of nerve fibres, provides a reliability of diagnosis of endometriosis which is close to the accuracy of laparoscopic assessment by experienced gynecological laparoscopists.86”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [86] Al-Jefout M, Dezarnaulds G, Cooper M, et al. Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study. Hum Reprod. 2009;24(12):3019–3024. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Endometriotic cells display higher endogenous oxidative stress with an increase in ROS production, alterations in ROS detoxification pathways, and a drop in catalase levels.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Oxidative Stress
What the sources say
- Not checked yetcites [75] Ngo C, Chereau C, Nicco C, Weill B, Chapron C, Batteux F. Reactive oxygen species controls endometriosis progression. Am J Pathol. 2009;175(1):225–234. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Yet causality remains an enigma, because pain symptoms attributed to endometriosis occur in women without endometriosis and because pain symptoms and severity correlate poorly with lesion characteristics.34”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [34] Stratton P, Berkley KJ. Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Hum Reprod Update. 2011;17(3):327–346. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In a rat autotransplantation model of endometrium to the mesentery, vascularized endometriotic cysts become innervated with sensory and sympathetic fibers, and rats subsequently exhibit vaginal hyperalgesia.81”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [81] McAllister SL, Dmitrieva N, Berkley KJ. Sprouted innervation into uterine transplants contributes to the development of hyperalgesia in a rat model of endometriosis. PLoS One. 2012;7(2):e31758. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Intralesional, but not contralateral, injection of progesterone was dose-dependently antihyperalgesic as was systemic administration of leuprolide.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [89] Alvarez P, Chen X, Hendrich J, et al. Ectopic uterine tissue as a chronic pain generator. Neuroscience. 2012;225:269–282. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Corticotropin-releasing hormone and urocortin are expressed by endometriotic tissue and their deranged expression in endometrium of patients with endometriosis suggests that these neuropeptides may also participate in the pathogenesis of endometriosis.88”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [88] Novembri R, Borges LE, Carrarelli P, et al. Impaired CRH and urocortin expression and function in eutopic endometrium of women with endometriosis. J Clin Endocrinol Metab. 2011;96(4):1145–1150. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Removing cysts before they acquired functional innervation prevented vaginal hyperalgesia from developing, whereas sham cyst removal did not.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [81] McAllister SL, Dmitrieva N, Berkley KJ. Sprouted innervation into uterine transplants contributes to the development of hyperalgesia in a rat model of endometriosis. PLoS One. 2012;7(2):e31758. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In human studies, it has been reported that there is an imbalance between sympathetic and sensory nerve fibres in peritoneal endometriosis as well as an altered modulation of peritoneal fluids from patients with endometriosis on sympathetic and sensory innervation, which might directly be involved in the maintenance of inflammation and pain.82”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [82] Arnold J, Barcena de Arellano ML, Ruster C, et al. Imbalance between sympathetic and sensory innervation in peritoneal endometriosis. Brain Behav Immun. 2012;26(1):132–141. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In a study of pelvic inflammatory disease in 109 women, 22 at laparoscopy had salpingitis, 19 had adhesions without salpingitis, 20 had endometriosis or ovarian pathology, and 48 no observable abnormality.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Role of the Microbiome in Endometriosis
What the sources say
- Not checked yetcites [119] Taylor-Robinson D, Jensen JS, Svenstrup H, Stacey CM. Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. Int J STD AIDS. 2012;23(1):18–24. source
plainn = 109- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In contrast to full-length SRC-1, the endometriotic 70-kDa SRC-1 C-terminal fragment prevents TNF-a-mediated apoptosis in human endometrial epithelial cells and causes the epithelial-mesenchymal transition and the invasion of human endometrial cells that are hallmarks of progressive endometriosis.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Apoptosis
What the sources say
- Not checked yetcites [111] Han SJ, Hawkins SM, Begum K, et al. A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med. 2012;18(7):1102–1111. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“They conclude that this could influence the expression of angiogenic factors and play a role in the pathogenesis of endometriosis.114”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Endometriosis-Related MicroRNAs Work
What the sources say
- Not checked yetcites [114] Ramon LA, Braza-Boils A, Gilabert-Estelles J, et al. micro-RNAs expression in endometriosis and their relation to angiogenic factors. Hum Reprod. 2011;26(5):1082–1090. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“The results reported for the whole group of women with pain highlight the difficulties in making a precise microbial diagnosis and highlight the need for further investigation into the links between the microbiome, pain, and endometriosis.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Role of the Microbiome in Endometriosis
What the sources say
- Not checked yetcites [119] Taylor-Robinson D, Jensen JS, Svenstrup H, Stacey CM. Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. Int J STD AIDS. 2012;23(1):18–24. source
plaincorrelationaln = 109- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Endometrial BCL-2 expression may be stimulated by estrogen and downregulated by progesterone.110”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Apoptosis
What the sources say
- Not checked yetcites [110] Nasu K, Nishida M, Kawano Y, et al. Aberrant expression of apoptosis-related molecules in endometriosis: a possible mechanism underlying the pathogenesis of endometriosis. Reprod Sci. 2011;18(3):206–218. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“The authors concluded that greater scrutiny of the preclinical efficacy of models, end points, and experimental designs are needed if the desire of translating novel treatment approaches is to be realized in women with endometriosis.115”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Animal and Other Preclinical Models
What the sources say
- Not checked yetcites [115] Pullen N, Birch CL, Douglas GJ, Hussain Q, Pruimboom-Brees I, Walley RJ. The translational challenge in the development of new and effective therapies for endometriosis: a review of confidence from published preclinical efficacy studies. Hum Reprod Update. 2011;17(6):791–802. source
plainconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
None of the sources cited for this claim have been checked yet.
In the paper
“Clonogenic cells and side populations have been identified in human endometrium; these cells are few in number and have the ability to give rise to a variety of differentiated cell types.101,102”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Stem Cells
What the sources say
- Not checked yetcites [101] Chan RW, Schwab KE, Gargett CE. Clonogenicity of human endometrial epithelial and stromal cells. Biol Reprod. 2004;70(6): 1738–1750. source
- Not checked yetcites [102] Kato K, Yoshimoto M, Kato K, et al. Characterization of side-population cells in human normal endometrium. Human Reproduction. 2007;22(5):1214–1223. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Women with endometriosis are reported to have reduced endometrial apoptosis with increased expression of antiapoptotic and decreased expression of proapoptotic factors.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Apoptosis
What the sources say
- Not checked yetcites [109] Taniguchi F, Kaponis A, Izawa M, et al. Apoptosis and endometriosis. Front Biosci (Elite Ed). 2011;3(2):648–662. source
- Not checked yetcites [110] Nasu K, Nishida M, Kawano Y, et al. Aberrant expression of apoptosis-related molecules in endometriosis: a possible mechanism underlying the pathogenesis of endometriosis. Reprod Sci. 2011;18(3):206–218. source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In endometriosis, there is altered expression of BCL-2 in the eutopic endometrium and thereby fewer apoptotic cells and abnormal survival in ectopic sites.109”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Apoptosis
What the sources say
- Not checked yetcites [109] Taniguchi F, Kaponis A, Izawa M, et al. Apoptosis and endometriosis. Front Biosci (Elite Ed). 2011;3(2):648–662. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Currently, there are no definitive markers to allow isolation and characterization of endometrial progenitor or stem cells, and it is unknown what drives the recruitment and homing of these cells to eutopic endometrium or ectopic sites.107,108”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Stem Cells
What the sources say
- Not checked yetcites [107] Du H, Taylor HS. Contribution of bone marrow-derived stem cells to endometrium and endometriosis. Stem Cells. 2007;25(8):2082–2086. source
- Not checked yetcites [108] Sasson IE, Taylor HS. Stem cells and the pathogenesis of endometriosis. Ann N Y Acad Sci. 2008;1127(1):106–115. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Other workers have shown that expression levels of miRNAs related to angiogenesis were different in eutopic endometrium from that observed in ovarian endometrioma.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Endometriosis-Related MicroRNAs Work
What the sources say
- Not checked yetcites [114] Ramon LA, Braza-Boils A, Gilabert-Estelles J, et al. micro-RNAs expression in endometriosis and their relation to angiogenic factors. Hum Reprod. 2011;26(5):1082–1090. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“The authors conclude that miRNAs may play an important role in endometriotic lesion development, including regulatory functions associated with hypoxia, inflammation, tissue repair, TGF-b-regulated pathways, cell growth, cell proliferation, apoptosis, extracellular matrix remodeling, and angiogenesis.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Endometriosis-Related MicroRNAs Work
What the sources say
- Not checked yetcites [112] Teague EM, Print CG, Hull ML. The role of microRNAs in endometriosis and associated reproductive conditions. Hum Reprod Update. 2010;16(2):142–165. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“In all laparoscopic categories, Ureaplasma spp and Mycoplasma hominis, but not Mycoplasma genitalium, were at least as common in the cervix/vagina as Chlamydia trachomatis and equally frequent in the endometrium.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Role of the Microbiome in Endometriosis
What the sources say
- Not checked yetcites [119] Taylor-Robinson D, Jensen JS, Svenstrup H, Stacey CM. Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. Int J STD AIDS. 2012;23(1):18–24. source
plainn = 109- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Thus, studies focused on gene regulation using transgenic models will provide valuable insights into mechanisms that may contribute to endometriosis.116,117,111”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Use of Targeted Transgenic Models
What the sources say
- Not checked yetcites [116] Jeong JW, Lee HS, Lee KY, et al. Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc Natl Acad Sci U S A. 2009;106(21):8677–8682. source
- Not checked yetcites [117] Jeong JW, Lee HS, Franco HL, et al. beta-catenin mediates glandular formation and dysregulation of beta-catenin induces hyperplasia formation in the murine uterus. Oncogene. 2009;28(1):31–40. source
- Not checked yetcites [111] Han SJ, Hawkins SM, Begum K, et al. A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med. 2012;18(7):1102–1111. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence.
In the paper
“The meeting recognized the impact that pain has on many women with endometriosis and attached significant priority to the need for research on all aspects of pain, including basic mechanisms, classification, and treatment.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Discussion
What the sources say
- Not checked yetcites [34] Stratton P, Berkley KJ. Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Hum Reprod Update. 2011;17(3):327–346. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
Peritoneal oxidative stress is one of the major constituents of the endometriosis-associated inflammatory response.
“Peritoneal oxidative stress is thought to be one of the major constituent of the endometriosis-associated inflammatory response.”
The paper relies on this without support.
Excessive production of ROS, secondary to peritoneal influx of prooxidants such as heme and iron, may induce cellular damage and increased proinflammatory gene expression through NF-kB activation.
“Excessive production of reactive oxygen species (ROS), secondary to peritoneal influx of prooxidants such as heme and iron, may induce cellular damage and increased proinflammatory gene expression through NF-kB activation.”
The paper relies on this without support.
ROS are proinflammatory mediators that modulate cell proliferation.
“The ROS are proinflammatory mediators that modulate cell proliferation.”
The paper relies on this without support.
The presence of unmyelinated sensory nerve fibers in the functional layer of endometrium and increased nerve fiber density in endometrium and myometrium in women with endometriosis suggests a possible role in pain perception.
“The presence of unmyelinated sensory nerve fibers in the functional layer of endometrium and a significantly increased nerve fiber density in endometrium and myometrium in women with endometriosis suggests a possible role in pain perception.”
The paper relies on this without support.
Angiogenesis and lymphangiogenesis are critical processes in the pathogenesis of endometriosis.
“Angiogenesis and lymphangiogenesis, or the development of new blood and lymphatic vessels from preexisting ones, are critical processes in the pathogenesis of endometriosis.”
The paper relies on this without support.
Clinical evidence for the efficacy of antiangiogenic endometriosis therapy is still lacking.
“However, clinical evidence for their efficacy in antiangiogenic endometriosis therapy is still lacking.”
The paper relies on this without support.
Progenitor stem cells have the capacity to generate endometriosis if shed in a retrograde fashion.
“It is also likely that these same progenitor stem cells have the capacity to generate endometriosis if shed in a retrograde fashion.”
The paper relies on this without support.
Stem cells not of uterine origin may migrate to and cause or contribute to endometriotic lesions.
“It is also possible that stem cells that are not of uterine origin may migrate to and cause or contribute to endometriotic lesions, both in the peritoneal cavity and in the rarer instances where endometriosis occurs outside of the peritoneal cavity.”
The paper relies on this without support.
Progestins have overall anti-inflammatory activity.
“Progestins have overall anti-inflammatory activity, and there appears to be progesterone resistance in endometriotic lesions and eutopic endometrium of women with endometriosis.”
The paper relies on this without support.
There is progesterone resistance in endometriotic lesions and eutopic endometrium of women with endometriosis.
“Progestins have overall anti-inflammatory activity, and there appears to be progesterone resistance in endometriotic lesions and eutopic endometrium of women with endometriosis.”
The paper relies on this without support.
Different progestins have different glucocorticoid and androgenic activity.
“Given that different progestins have different glucocorticoid and androgenic activity there may be opportunities for modifying treatments to improve outcomes.”
The paper relies on this without support.
Selective progesterone receptor modulators (SPRMs) may have a role in treating endometriosis.
“Selective progesterone receptor modulators (SPRMs) may also have a role in treating endometriosis, although evidence to support this is lacking to date.”
The paper relies on this without support.
Expression of VEGF-C and VEGF-D and their receptors neuropilin 2 is dysregulated in the endometrium from women with endometriosis.
“It has recently been demonstrated that expression of the potent lymphangiogenic growth factors VEGF-C and VEGF-D and their receptors neuropilin 2 is dysregulated in the endometrium from women with endometriosis.”
The paper relies on this without support.
Endometriosis organizations, often led by women with endometriosis, have greater credibility with politicians and the general public than scientists or physicians, giving them greater access to media and better effectiveness for educational campaigns.
“Endometriosis Organizations, which are often led by women with endometriosis, have the ability to raise public awareness about the challenges posed by endometriosis more effectively than scientists or physicians, not the least because they are seen by politicians and the general public to have greater credibility.This gives greater access to media and better effectiveness for educational campaigns”
The paper relies on this without support.
Different endometriosis organizations have been responsible for multimillion dollar outreach campaigns, public service announcement campaigns, numerous outreach mailings, e-mail blitzes, educational outreach videos, books, and brochures.
“Different endometriosis organizations have been responsible for multimillion dollar outreach campaigns, public service announcement campaigns, numerous outreach mailings, and e-mail blitzes to key stakeholders, educational outreach videos, books, and brochures”
The paper relies on this without support.
These activities have contributed significantly to raising the profile of endometriosis as a disease.
“This has contributed significantly to raising the profile of endometriosis as a disease”
The paper relies on this without support.
Women with endometriosis often have more persuasive power with government bodies, politicians, and institutions than others.
“Women with endometriosis often have more persuasive power with government bodies, politicians, and institutions”
The paper relies on this without support.
Personal stories and sharing experience and impact of a disease are more powerful than simply asking for research funds.
“Personal stories and sharing experience and impact of a disease are more powerful than simply asking for research funds, and women with endometriosis have more political capital as they can represent a significant block of votes”
The paper relies on this without support.
Women with endometriosis have more political capital because they can represent a significant block of votes.
“Personal stories and sharing experience and impact of a disease are more powerful than simply asking for research funds, and women with endometriosis have more political capital as they can represent a significant block of votes”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“the invasive nature of surgery, coupled with the lack of a laboratory biomarker for the disease, results in a mean latency of 7–11 years from onset of symptoms to definitive diagnosis.”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [11]
In the citing paper
“Although there is consensus in the World Endometriosis Society that the development of a reliable noninvasive test is one of the top research priorities in endometriosis [11, 21]”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [11]
In the citing paper
“It also is a direct answer to the key priority of phenome data collection and SOP harmonization identified in Endometriosis Research Directions workshops held in 2008 (12) and 2011 (2)”
In the citing paper
“it may be that the inclusion of different patient populations in studies, which cannot be adequately defined or recognized as they have been poorly characterized, has led to conflicting results between studies of different populations (2).”
Citations
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Liu, F., Wang, L., Zhang, X.-X., Min, S.-Y., Liu, Y.-X., Zuo, Z., Jin, Z., & Zhu, Z. (2015) · Europe PMC (PubMed Central) · Cited by 7
mRNA and miRNA Biomarkers for Endometriosis
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Self-citationBayesian network modelling for early diagnosis and prediction of EndometriosisPreprint
Collins, R., & Fenton, N. (2020) · medRxiv · doi:10.1101/2020.11.04.20225946 · Cited by 5
Marroquin, J. M., Krall, J. R., Schliep, K. C., Farland, L. V., Vimalkumar, K., Kannan, K., & Pollack, A. Z. (2025) · Environmental Health Perspectives · doi:10.1289/ehp15852 · Cited by 5
“40 In addition, while this study tested for nine speci fi c PFAS, there are more than 4,000 in production, 41 and while we did recruit participants from two di ff erent sites, the locations might not be representative of more-contaminated sites.”
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Oxidative stress markers cannot be used as endometriosis biomarkers in infertile patients
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“Endometriosis is a common benign gynaecological disease with an estimated prevalence of 10% worldwide, which increases to 50% in women with infertility or chronic pain [1].”
BackgroundWettstein, M., Imesch, P., Witzel, I., & Metzler, J. M. (2024) · Journal of Endometriosis and Uterine Disorders · doi:10.1016/j.jeud.2024.100076 · Cited by 4
Endometriosis: an old problem without a current solution
Hummelshøj, L. (2016) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13075 · Cited by 4
Mandeville, J., Best, D., & Waterman, F. (2021) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.1177/22840265211024437 · Cited by 4
Die Patientin mit chronischem Unterbauchschmerz in der Versorgungsrealität
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Biomarkers of endometriosis: How far have we come and where are we going?
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Anti-angiogenesis effect and mechanism study of Huangzhi Neiyi capsule in a rat endometriosis model
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Overexpression of miR-21-5p as a potential pathogenesis marker for ovarian endometriosis
Mahmoud, M., WalyEldeen, A. A., samie, M. A., Sadek, A. M., ElAkhras, S., Samir, M., Ahmed, O., Sayed, R. M. S., Baiomy, A. A., Ibrahim, S., et al. (2025) · The Journal of Basic and Applied Zoology · doi:10.1186/s41936-024-00414-5 · Cited by 4
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The development of a preclinical swine model for endometriosis
Omenge, H., Barrier, B. F., Monarch, K., Kiesewetter, E., Schlink, S., Sponchiado, M., Prather, R. S., Geisert, R. D., Kim, T., Shin, J., et al. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf118 · Cited by 3
The diagnosis of endometriosis with the help of mass spectrometry (a review)
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Ekstrak Etanol Moringa Oleifera Lam Terhadap Folikulogenesis Pada Mencit Model Endometriosis
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Exosomal miRNAs as novel potential biomarkers for endometriosisPreprint
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Peripheral Blood Biomarkers for Endometriosis
Fassbender, A., Dorien, O., Becker, C. M., & D’Hooghe, T. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-59856-7_7 · Cited by 2
Self-citationEffects of Curcumin in Management of Endometriosis a Hormonal Disorder Disease in Female
Savant, P. B., Kareppa, M. S., & Shinde, A. U. (2021) · Research Journal of Pharmacognosy and Phytochemistry · doi:10.52711/0975-4385.2021.00031 · Cited by 2
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“TGFB1 signalling also contributes to a range of disease processes including inflammation, peritoneal adhesion formation, scar formation and fibrosis (8-10); these are all processes central to the aetiology of endometriosis (11, 12).”
BackgroundSelf-citationEndometriosis in the Colon with Intestinal Obstruction: Case Report and Literature Review
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Endometriosis and Diagnostic Delay: The Patient’s Perspective
Apers, S., Dancet, E. A. F., & D’Hooghe, T. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-59856-7_4 · Cited by 2
Self-citationRelationship between endometriosis and vitamin D status - a review
Paliga, M., & Horák, S. (2019) · Clinical and Experimental Obstetrics & Gynecology · doi:10.12891/ceog4936.2019 · Cited by 2
“Endometriosis is a chronic and often painful disease, characterised by the presence of estrogen-dependent lesions outside the uterus [15].”
BackgroundGynaecologic History During Adolescence to Predict Endometriosis Earlier
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ЕНДОМЕТРІОЗ: ДОСЯГНЕННЯ ТА ПИТАННЯ В СВІТОВИХ ДОСЛІДЖЕННЯХ
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“Endometriosis is a chronic, estrogen-dependent inflammatory condition that significantly affects women’s quality of life and fertility [1,2].”
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“The 3rd International Consensus Workshop on Research Priorities in Endometriosis (2014) [23] reiterated the need for a precise definition of such centres.”
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“The research priorities consensus statement summarized in this issue builds on earlier efforts to develop research directions for endometriosis.(11,12) The São Paulo workshop was attended by 60 participants from a total of 19 countries.”
BackgroundImaging diagnosis of deep infiltrating endometriosis
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Etamsylate Causes Regression of Endometriosis Lesions in a Rat Model
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Metadata
- Authors
- Rogers, P. A. W., D’Hooghe, T. M., Fazleabas, A., Giudice, L. C., Montgomery, G. W., Petraglia, F., & Taylor, R. N.
- Affiliations
- Royal Women's Hospital (AU)
- Universitair Ziekenhuis Leuven (BE)
- Michigan State University (US)
- University of California, San Francisco (US)
- QIMR Berghofer Medical Research Institute (AU)
- University of Siena (IT)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Rogers, Peter A. W.
- ORCID
- Venue
- Reproductive Sciences
- Published
- 2013-05
- Volume
- 20
- Issue
- 5
- Pages
- 483-499
- ISSN
- 1933-7191 (ISSN-L)
- 1933-7205
- PMC
- PMC3635070
- OpenAlex
- W2103672022
- Semantic Scholar
- 63a4d6c6f314f869bfec6ec5c5d35efc1db55094
- Cited by
- 154
- References
- 130
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 9 · 2022: 7 · 2021: 16 · 2020: 15 · 2019: 6 · 2018: 5 · 2017: 16 · 2016: 23 · 2015: 19 · 2014: 28 · 2013: 1
- FWCI
- 28.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Reproductive Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD055764, U54HD040093, 1U54HD40093, 1U54HD05576, U54HD055787)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, research priorities, consensus statement, endometriosis diagnosis, endometriosis classification, prognosis, clinical trials, treatment outcomes, pathophysiology, science policy, quality of life, economic burden, delayed diagnosis
- MeSH terms
- Animals, Endometriosis, Female, Forecasting, Humans, Prognosis, Consensus, Biomedical Research
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-10, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-10 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Cited sources are checked with a language model’s help (gpt-6-sol).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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