The DOI matches its Crossref record; 128 of the 130 references it cites were found in a registry or an index; 11 of the 158 sources its claims cite were checked for support.
Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France
Open accessAbstract
Endometriosis, defined as estrogen-dependent lesions containing endometrial glands and stroma outside the uterus, is a chronic and often painful gynecological condition that affects 6% to 10% of reproductive age women. Endometriosis has estimated annual costs of US $12 419 per woman (approximately €9579), comprising one-third of the direct health care costs with two-thirds attributed to loss of productivity. Decreased quality of life is the most important predictor of direct health care and total costs. It has been estimated that there is a mean delay of 6.7 years between onset of symptoms and a surgical diagnosis of endometriosis, and each affected woman loses on average 10.8 hours of work weekly, mainly owing to reduced effectiveness while working. To encourage and facilitate research into this debilitating disease, a consensus workshop to define future directions for endometriosis research was held as part of the 11th World Congress on Endometriosis in September 2011 in Montpellier, France. The objective of this workshop was to review and update the endometriosis research priorities consensus statement developed following the 10th World Congress on Endometriosis in 2008.(1) A total of 56 recommendations for research have been developed, grouped under 6 subheadings: (1) diagnosis, (2) classification and prognosis, (3) clinical trials, treatment, and outcomes, (4) epidemiology, (5) pathophysiology, and (6) research policy. By producing this consensus international research priorities statement, it is the hope of the workshop participants that researchers will be encouraged to develop new interdisciplinary research proposals that will attract increased funding support for work on endometriosis.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
This workshop report updates the 2008 consensus research priorities for endometriosis from the 2011 World Congress, producing 56 recommendations across six domains. It summarizes background burden data and expert recommendations for diagnosis, classification, clinical trials, epidemiology, pathophysiology, and research policy.
Key findings
- Endometriosis affects an estimated 6% to 10% of reproductive-age women; annual costs are estimated at US $12,419 per woman (approximately €9,579), comprising one-third direct health care costs and two-thirds productivity loss, with a mean 6.7-year delay between symptom onset and surgical diagnosis and an average 10.8 hours of work lost weekly.
- Between the 2008 and 2011 World Congress meetings, 3,176 new endometriosis publications were recorded on PubMed, a 21.5% increase over the total number published prior to 2008; major contributions included the first two genome-wide association studies and ongoing nerve fiber work.
- The workshop developed 56 research recommendations grouped under 6 subheadings: diagnosis; classification and prognosis; clinical trials, treatment, and outcomes; epidemiology; pathophysiology; and research policy.
- Recommendations emphasize noninvasive biomarkers, imaging advances, better classification/prognostic tools, adequately powered multicenter randomized controlled trials with quality-of-life and live-birth outcomes, pain mechanisms, genetic/environmental/diet/BMI research, inflammation/oxidative stress/neuroangiogenesis/stem cells/apoptosis/miRNAs, and biobanks/registries/multidisciplinary approaches.
Methods
- Consensus workshop held at the 11th World Congress on Endometriosis in September 2011 in Montpellier, France, convened by the World Endometriosis Society and World Endometriosis Research Foundation to review and update the 2008 consensus statement.
- 58 participants from 19 countries attended; the meeting used 6 moderated sessions, with each moderator reviewing progress, discussing whether 2008 recommendations needed updating, leading discussion, and producing a written summary incorporated into the final report.
- Narrative synthesis of expert discussion and literature; no primary data collection or systematic review methods are described.
Limitations
- Stated limitations: Not stated in the paper.
- Evident from text: this is a consensus workshop report; the recommendations are described as “by no means proscriptive” and are based on expert discussion rather than primary empirical testing.
- Evident from text: many recommendations call for larger, well-designed, adequately powered studies and validation, indicating evidence gaps and limitations in the existing literature.
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Claims the paper makes
124 Not checked yet · 12 No basis given · 5 Supported · 4 Own result · 2 Own interpretation · 1 Supported so far · 1 Partly supported · accuracy not yet measured
Every source the paper cites for this claim was checked and supports it.
In the paper
“Peritoneal endometriosis is characterized by increased numbers of peritoneal macrophages and their secreted products.69”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Supportedcites [69] Lousse JC, Van Langendonckt A, Defrere S, Ramos RG, Colette S, Donnez J. Peritoneal endometriosis is an inflammatory disease. Front Biosci (Elite Ed). 2012;4(1):23–40. source
The Abstract states the claim directly. The Introduction also reports increased numbers of activated macrophages in the peritoneal fluid of women with endometriosis and describes the products they secrete. (LLM, conf=0.95)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“The development of endometriotic implants in an immunocompetent mouse model is inhibited by retinoic acid.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Supportedcites [70] Wieser F, Wu J, Shen Z, Taylor RN, Sidell N. Retinoic acid suppresses growth of lesions, inhibits peritoneal cytokine secretion, and promotes macrophage differentiation in an immunocompetent mouse model of endometriosis. Fertil Steril. 2012;97(6):1430–1437. source
The Abstract Conclusions state that retinoic acid inhibits the development of endometriotic implants. The Introduction identifies the model as an immunocompetent mouse model; no page numbers are supplied in our copy. (LLM, conf=0.94)
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Several authors have reported the presence of nerve fibers in endometriotic lesions.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Supportedcites [10] Wang G, Tokushige N, Fraser IS. Nerve fibers and menstrual cycle in peritoneal endometriosis. Fertil Steril. 2011;95(8):2772–2774. source
The Abstract reports nerve fibers in peritoneal endometriotic lesions in the authors’ own work and describes findings by Yao et al. and Mechsner et al. This supports the statement that several authors have reported their presence. (LLM, conf=0.94)
- Supportedcites [34] Stratton P, Berkley KJ. Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Hum Reprod Update. 2011;17(3):327–346. source
The 'Engaging the nervous system' section reports nerve fibers in endometriotic lesions from women and a rat model. It also describes clinical studies by several groups demonstrating sensory, sympathetic, and parasympathetic fibers in different lesion types. The claim accurately summarizes those reports. (LLM, conf=0.94)
- Supportedcites [78] Anaf V, Simon P, El Nakadi I, et al. Relationship between endometriotic foci and nerves in rectovaginal endometriotic nodules. Hum Reprod. 2000;15(8):1744–1750. source
The Results report S100-positive nerve structures within endometriotic glands and/or stroma. The conclusion also states that nerves occur within rectovaginal endometriotic nodules, making this paper an example of an author reporting nerve fibers in endometriotic lesions. Page numbers are not provided in our copy. (LLM, conf=0.92)
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“The newly identified SRC-1 isoform functional axis promotes pathogenic progression of endometriosis.111”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Apoptosis
What the sources say
- Supportedcites [111] Han SJ, Hawkins SM, Begum K, et al. A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med. 2012;18(7):1102–1111. source
The Results section ('The role of SRC-1 isoform in the progression of endometriosis') states that the activated TNF-α/MMP9 axis produces an SRC-1 C-terminal isoform that protects ectopic endometrium from cell death and enhances its invasive capacity. This directly supports the claimed role of the newly identified functional axis in endometriosis progression. (LLM, conf=0.95)
plaindirect- Asserted: passes — The authors put it forward as true.
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- Supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“although a number of emerging endometriosis research fields had significantly increased publication rates including stem cells, proteomics, genomics, angiogenesis, vasculogenesis, genetics, and inflammation.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
plain- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Between the 2008 and 2011 WCE meetings, a total of 3176 new scientific publications on endometriosis were recorded on PubMed.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The vast majority of the publications were in established areas of endometriosis research, including etiology, surgery, histology, pathology, pain, cancer, and fertility”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This represents a 21.5% increase in the total number of scientific papers published prior to 2008 in the field”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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In the paper
“One area of research need that was repeatedly highlighted at the 2011 meeting was work on all aspects of pain.34”
- Also stated in: § Discussion · plain
“The meeting recognized the impact that pain has on many women with endometriosis and attached significant priority to the need for research on all aspects of pain, including basic mechanisms, classification, and treatment.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Discussion
What the sources say
- Not checked yetcites [34] Stratton P, Berkley KJ. Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Hum Reprod Update. 2011;17(3):327–346. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Discussion · plain
In the paper
“A recent systematic review of 182 relevant articles that assessed over 200 potential biomarkers identified several reports of endometrial differences which have the potential to be biomarkers for endometriosis.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Diagnosis
What the sources say
- Not checked yetcites [18] May KE, Villar J, Kirtley S, Kennedy SH, Becker CM. Endometrial alterations in endometriosis: a systematic review of putative biomarkers. Hum Reprod Update. 2011;17(5):637–653. source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Professional guidelines for the clinical management of endometriosis have been developed, [28][29][30][31][32]”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Clinical Trials, Treatment, and Outcomes
What the sources say
- Not checked yetcites [28][29][30][31][32]
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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In the paper
“There is only limited evidence to support the use of progestagens and antiprogestagens for pain associated with endometriosis.35”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [35] Brown J, Kives S, Akhtar M. Progestagens and anti-progestagens for pain associated with endometriosis. Cochrane Database Syst Rev. 2012;3:CD002122.
plain- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“diagnostic laparoscopy has been shown by subsequent histopathological testing to confirm the diagnosis in 78% to 84% of the patients, 11,12”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Diagnosis
What the sources say
- Not checked yetcites [11] Wood C, Kuhn R, Tsaltas J. Laparoscopic diagnosis of endometriosis. Aust N Z J Obstet Gynaecol. 2002;42(3):277–281. source
- Not checked yetcites [12] Mettler L, Schollmeyer T, Lehmann-Willenbrock E, et al. Accuracy of laparoscopic diagnosis of endometriosis. JSLS. 2003;7(1):15–18.
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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In the paper
“Peptide fingerprinting using proteomic analysis of plasma may also have utility as a noninvasive or semi-invasive diagnostic for endometriosis.20”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Diagnosis
What the sources say
- Not checked yetcites [20] Fassbender A, Waelkens E, Verbeeck N, et al. Proteomics analysis of plasma for early diagnosis of endometriosis. Obstet Gynecol. 2012;119(2 Pt 1):276–285. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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In the paper
“In a large multicenter French study (n ¼ 29 966), diagnostic and therapeutic laparoscopy were found to be associated with a 3.3 per 100 000 mortality and a 4.6 per 1000 morbidity risk.17”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Diagnosis
What the sources say
- Not checked yetcites [17] Chapron C, Querleu D, Bruhat MA, et al. Surgical complications of diagnostic and operative gynaecological laparoscopy: a series of 29,966 cases. Hum Reprod. 1998;13(4):867–872. source
plaincorrelationaln = 29,966- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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In the paper
“The endometriosis fertility index (EFI) is a clinical tool that predicts pregnancy rates in patients with surgically documented endometriosis who attempt non-in vitro fertilization conception.27”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Classification and Prognosis
What the sources say
- Not checked yetcites [27] Adamson GD, Pasta DJ. Endometriosis fertility index: the new, validated endometriosis staging system. Fertil Steril. 2010;94(5):1609–1615. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“A study in samples from Japanese women (1423 cases and 1318 controls) from the BioBank Japan 9 reported GWA in the noncoding RNA CDKN2BAS on chromosome 9p21.3.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Epidemiology
What the sources say
- Not checked yetcites [9] Uno S, Zembutsu H, Hirasawa A, et al. A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese. Nat Genet. 2010;42(8):707–710. source
plaincorrelationaln = 1,423- Asserted: passes — The authors put it forward as true.
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In the paper
“Decreased quality of life (QoL) was the most important predictor of direct health care and total costs.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
What the sources say
- Not checked yetcites [6] Simoens S, Dunselman G, Dirksen C, et al. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Hum Reprod. 2012;27(5):1292–1299. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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In the paper
“there was a delay of mean of 6.7 years, principally in the primary care, between onset of symptoms and a surgical diagnosis of endometriosis”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
What the sources say
- Not checked yetcites [7] Nnoaham KE, Hummelshoj L, Webster P, et al. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril. 2011;96(2):366–373 e368. source
plainn = 1,418- Asserted: passes — The authors put it forward as true.
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In the paper
“although significantly lower rates than this have also been reported.[13][14][15]”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Diagnosis
What the sources say
- Not checked yetcites [13][14][15]
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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None of the sources cited for this claim have been checked yet.
In the paper
“The revised American Fertility Society (rAFS) classification of endometriosis 23 and the revised American Society for Reproductive Medicine classification of endometriosis, 1996 24 have been the most widely used classification criteria for endometriosis.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Classification and Prognosis
What the sources say
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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In the paper
“More recently it was reported that in plasma samples obtained during menstruation, multivariate analysis of 4 biomarkers (annexin V, VEGF, CA-125, and sICAM-1/or glycodelin) enabled the diagnosis of endometriosis undetectable by ultrasound with a sensitivity of 81% to 90% and a specificity of 63% to 81% in independent training and test data sets.19”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Diagnosis
What the sources say
- Not checked yetcites [19] Vodolazkaia A, El-Aalamat Y, Popovic D, et al. Evaluation of a panel of 28 biomarkers for the non-invasive diagnosis of endometriosis. Hum Reprod. 2012;27(9):2698–2711. source
plaindirect- Asserted: passes — The authors put it forward as true.
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The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Although the resolution of imaging techniques continues to improve, their current diagnostic accuracy remains significantly inferior to direct laparoscopic visualization.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“There has been a recent Cochrane Systematic Review of the effectiveness and safety of CHM in alleviating endometriosis-related pain and infertility.37”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [37] Flower A, Liu JP, Lewith G, Little P, Li Q. Chinese herbal medicine for endometriosis. Cochrane Database Syst Rev. 2012;5:CD006568.
plain- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“A recent retrospective study of pregnancy outcome in women with peritoneal, ovarian, and rectovaginal endometriosis found elevated levels of miscarriage, ectopic pregnancy, gestational hypertension/preeclampsia, preterm delivery, placental abruption, and placenta praevia.39,40”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [39] Vercellini P, Parazzini F, Pietropaolo G, Cipriani S, Frattaruolo M, Fedele L. Pregnancy outcome in women with peritoneal, ovarian and rectovaginal endometriosis: a retrospective cohort study. BJOG. 2012;119(12):1538–1543. source
- Not checked yetcites [40] Stephansson O, Kieler H, Granath F, Falconer H. Endometriosis, assisted reproduction technology, and risk of adverse pregnancy outcome. Hum Reprod. 2009;24(9):2341–2347. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“However, the quality of the available literature on the efficacy of diagnostic laparoscopy as it relates to patient outcome is limited, as almost all of the available studies are retrospective studies from single institutions.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Diagnosis
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“However, the extent and duration of the therapeutic benefit are still poorly defined.33”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Clinical Trials, Treatment, and Outcomes
What the sources say
- Not checked yetcites [33] Vercellini P, Crosignani PG, Abbiati A, Somigliana E, Vigano P, Fedele L. The effect of surgery for symptomatic endometriosis: the other side of the story. Hum Reprod Update. 2009;15(2):177–188. source
plain- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“Analysis of the International ENDO-GENE data provided independent evidence for a genetic contribution to disease risk supporting results from earlier family-based studies.8,[43][44][45]”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Epidemiology
What the sources say
- Not checked yetcites [8] Painter JN, Anderson CA, Nyholt DR, et al. Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nat Genet. 2011;43(1):51–54. source
- Not checked yetcites [43][44][45]
plaincorrelational- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“The ENDOGENE study also replicated evidence for association near the WNT4 gene on 1p36.12 previously reported in the Japanese study.8,9”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Epidemiology
What the sources say
- Not checked yetcites [8] Painter JN, Anderson CA, Nyholt DR, et al. Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nat Genet. 2011;43(1):51–54. source
- Not checked yetcites [9] Uno S, Zembutsu H, Hirasawa A, et al. A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese. Nat Genet. 2010;42(8):707–710. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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In the paper
“The results indicate that specific dietary components may be associated with endometriosis risk.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [53] Trabert B, Peters U, De Roos AJ, Scholes D, Holt VL. Diet and risk of endometriosis in a population-based case-control study. Br J Nutr. 2011;105(3):459–467. source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“The results also demonstrated stronger genetic loading of moderate to severe (stage B) endometriosis (rAFS stage III or IV disease) compared to minimal (stage A) endometriosis (rAFS stage I or II disease) 8 .”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Epidemiology
What the sources say
- Not checked yetcites [8] Painter JN, Anderson CA, Nyholt DR, et al. Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nat Genet. 2011;43(1):51–54. source
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Local inflammation plays a role in pain and infertility associated with the disease, and may be extensively involved in molecular and cellular processes leading to development of endometriosis.62”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Not checked yetcites [62] Defrere S, Gonzalez-Ramos R, Lousse JC, et al. Insights into iron and nuclear factor-kappa B (NF-kappaB) involvement in chronic inflammatory processes in peritoneal endometriosis. Histol Histopathol. 2011;26(8):1083–1092.
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“Above a given threshold for each disease, doubling study size doubles the number of genes or regions identified.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Epidemiology
What the sources say
- Not checked yetcites [51] Visscher PM, Brown MA, McCarthy MI, Yang J. Five years of GWAS discovery. Am J Hum Genet. 2012;90(1):7–24. source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Patients with the lowest BMI (<18.5) have been reported to be at a high risk of deep-infiltrating endometriosis.55”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [55] Lafay Pillet MC, Schneider A, Borghese B, et al. Deep infiltrating endometriosis is associated with markedly lower body mass index: a 476 case-control study. Hum Reprod. 2012;27(1):265–272. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Increasing the sample size for genetic studies in endometriosis will increase the number of markers and gene regions associated with disease risk.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Epidemiology
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Evidence from many complex traits show that the number of variants discovered is strongly correlated with experimental sample size.51”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Epidemiology
What the sources say
- Not checked yetcites [51] Visscher PM, Brown MA, McCarthy MI, Yang J. Five years of GWAS discovery. Am J Hum Genet. 2012;90(1):7–24. source
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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In the paper
“There is increasing evidence for marked changes in numbers and functions of leukocytes in the eutopic endometrium, peritoneal fluid, and in endometriotic lesions.68”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Not checked yetcites [68] Berbic M, Fraser IS. Regulatory T cells and other leukocytes in the pathogenesis of endometriosis. J Reprod Immunol. 2011;88(2):149–155. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Endometriosis fulfills most of the classification criteria for autoimmune disease, including polyclonal B-cell activation, immunological abnormalities in T-and B-cell functions, increased apoptosis, tissue damage, and multiorgan involvement.59”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Not checked yetcites [59] Eisenberg VH, Zolti M, Soriano D. Is there an association between autoimmunity and endometriosis? Autoimmun Rev. 2012;11(11):806–814. source
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“Animal studies also show that endometriosis can be promoted by adult exposures to organochlorines, a class of chemicals that includes the dioxin, tetrachlorodibenzo-p-dioxin, the pesticides methoxychlor and dichlorodiphenyltrichloroethane, and polychlorinated biphenyls with dioxin-like effects.57”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Studies be undertaken to investigate the relationship between phenotypic variables, including BMI and endometriosis.
What the sources say
- Not checked yetcites [57] Crain DA, Janssen SJ, Edwards TM, et al. Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing. Fertil Steril. 2008;90(4):911–940. source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“This effect may be caused, at least in part, by reduced IL-6 and MCP-1 production and enhanced differentiation of peritoneal macrophages. 70”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Not checked yetcites [70] Wieser F, Wu J, Shen Z, Taylor RN, Sidell N. Retinoic acid suppresses growth of lesions, inhibits peritoneal cytokine secretion, and promotes macrophage differentiation in an immunocompetent mouse model of endometriosis. Fertil Steril. 2012;97(6):1430–1437. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
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None of the sources cited for this claim have been checked yet.
In the paper
“Interleukin (IL)-6, IL-10, interferon (IFN), and transforming growth factor (TGF-b) are implicated in the immune and inflammatory responses in the pathogenesis of endometriosis.61,64”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Not checked yetcites [61] Maybin JA, Critchley HO, Jabbour HN. Inflammatory pathways in endometrial disorders. Mol Cell Endocrinol. 2011;335(1):42–51. source
- Not checked yetcites [64] Sharpe-Timms KL, Nabli H, Zimmer RL, Birt JA, Davis JW. Inflammatory cytokines differentially up-regulate human endometrial haptoglobin production in women with endometriosis. Hum Reprod. 2010;25(5):1241–1250. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“In particular, prostaglandin biosynthetic enzyme expression is regulated by this transcription factor, and increased peritoneal prostaglandin concentrations have been demonstrated in endometriosis.74”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Oxidative Stress
What the sources say
- Not checked yetcites [74] Lousse JC, Defrere S, Gonzalez Ramos R, Van Langendonckt A, Colette S, Donnez J. Involvement of iron, nuclear factor-kappa B (NF-kB) and prostaglandins in the pathogenesis of peritoneal endometriosis-associated inflammation: a review. J Endometriosis. 2009;1(1):19–29. source
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“An equivocal literature exists regarding the relation between persistent organochlorine pollutants (POPs) and endometriosis in women, with differences attributed to methodologies.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Studies be undertaken to investigate the relationship between phenotypic variables, including BMI and endometriosis.
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“Conversely, it has been shown that lipoxin A4 and its receptor FPR2/ALX can regulate inflammatory events in the human endometrium and decidua of early pregnancy.66”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Not checked yetcites [66] Macdonald LJ, Boddy SC, Denison FC, Sales KJ, Jabbour HN. A role for lipoxin A(4) as an anti-inflammatory mediator in the human endometrium. Reproduction. 2011;142(2):345–352. source
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“in utero exposure to the xenoestrogen diethylstilbesterol (DES) increases a woman's risk of developing endometriosis as an adult by 80% (relative risk [RR] ¼ 1.8, confidence interval [CI]¼1.2-2.8).56”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Studies be undertaken to investigate the relationship between phenotypic variables, including BMI and endometriosis.
What the sources say
- Not checked yetcites [56] Missmer SA, Hankinson SE, Spiegelman D, Barbieri RL, Michels KB, Hunter DJ. In utero exposures and the incidence of endometriosis. Fertil Steril. 2004;82(6):1501–1508. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“There is strong evidence from nonhuman primate and rodent studies suggesting that environmental contaminants, specifically endocrine disrupting chemicals, may contribute to the pathogenesis of endometriosis.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Studies be undertaken to investigate the relationship between phenotypic variables, including BMI and endometriosis.
boostedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“The International ENDOGENE study in a European Caucasian sample from Australia (2270 cases and 1870 controls) and the Unites Kingdom (924 cases and 5190 controls) 8 identified significant association in an intergenic region on 7p15.2.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Epidemiology
What the sources say
- Not checked yetcites [8] Painter JN, Anderson CA, Nyholt DR, et al. Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nat Genet. 2011;43(1):51–54. source
plaincorrelationaln = 2,270- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“A recent study evaluated dietary risk factors for endometriosis in a population-based case-control study.53”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [53] Trabert B, Peters U, De Roos AJ, Scholes D, Holt VL. Diet and risk of endometriosis in a population-based case-control study. Br J Nutr. 2011;105(3):459–467. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“A second study has confirmed a lower BMI in patients with endometriosis than age-and smoking-statusmatched controls, independent of confounding variables.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The GWA studies have been successful in endometriosis despite modest sample sizes when compared to many other disease studies.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Epidemiology
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: unclear — It is unclear why the paper says it holds.
In the paper
“Human epithelial and stromal endometrial cells express nuclear factor-kappa B (NF-kB) proteins; NF-kB-mediated gene transcription promotes inflammation, invasion, angiogenesis, and cell proliferation and inhibits apoptosis of endometriotic cells.63”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Not checked yetcites [63] Gonzalez-Ramos R, Van Langendonckt A, Defrere S, et al. Involvement of the nuclear factor-kappaB pathway in the pathogenesis of endometriosis. Fertil Steril. 2010;94(6):1985–1994. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“However, evidence is mixed on the usefulness of anti-inflammatory agents to treat endometriosis symptoms, with a recent review concluding that there is no enough evidence to support the use of the antiinflammatory pentoxifylline in the management of subfertility and relief of pain from endometriosis.65”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Not checked yetcites [65] Lu D, Song H, Li Y, Clarke J, Shi G. Pentoxifylline for endometriosis. Cochrane Database Syst Rev. 2012;1: CD007677.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The best evidence exists for an association with inflammatory bowel diseases.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: unclear — It is unclear why the paper says it holds.
In the paper
“In particular, prostaglandin biosynthetic enzyme expression is regulated by this transcription factor, and increased peritoneal prostaglandin concentrations have been demonstrated in endometriosis.74”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Oxidative Stress
What the sources say
- Not checked yetcites [74] Lousse JC, Defrere S, Gonzalez Ramos R, Van Langendonckt A, Colette S, Donnez J. Involvement of iron, nuclear factor-kappa B (NF-kB) and prostaglandins in the pathogenesis of peritoneal endometriosis-associated inflammation: a review. J Endometriosis. 2009;1(1):19–29. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“There is also a link between endometriosis and increased risk of allergic autoimmune disorders.60”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Not checked yetcites [60] Matalliotakis I, Cakmak H, Matalliotakis M, Kappou D, Arici A. High rate of allergies among women with endometriosis. J Obstet Gynaecol. 2012;32(3):291–293. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“Local inflammation plays a role in pain and infertility associated with the disease, and may be extensively involved in molecular and cellular processes leading to development of endometriosis.62”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Not checked yetcites [62] Defrere S, Gonzalez-Ramos R, Lousse JC, et al. Insights into iron and nuclear factor-kappa B (NF-kappaB) involvement in chronic inflammatory processes in peritoneal endometriosis. Histol Histopathol. 2011;26(8):1083–1092.
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“However, dysregulation of this inflammatory response can lead to endometrial disorders, including endometriosis.61”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Not checked yetcites [61] Maybin JA, Critchley HO, Jabbour HN. Inflammatory pathways in endometrial disorders. Mol Cell Endocrinol. 2011;335(1):42–51. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“Using a matched cohort design, it was shown that cohort-specific and biological-medium-specific POPs were associated with endometriosis, underscoring the importance of methodological considerations when interpreting findings.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Studies be undertaken to investigate the relationship between phenotypic variables, including BMI and endometriosis.
What the sources say
- Not checked yetcites [58] Buck Louis GM, Chen Z, Peterson CM, et al. Persistent lipophilic environmental chemicals and endometriosis: the ENDO Study. Environ Health Perspect. 2012;120(6):811–816. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“There is increasing evidence that vasculogenesis plays a role in blood vessel formation during growth of endometriotic lesions.91,92”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Angiogenesis and Lymphangiogenesis
What the sources say
- Not checked yetcites [91] Laschke MW, Giebels C, Menger MD. Vasculogenesis: a new piece of the endometriosis puzzle. Hum Reprod Update. 2011;17(5):628–636. source
- Not checked yetcites [92] Becker CM, Beaudry P, Funakoshi T, et al. Circulating endothelial progenitor cells are up-regulated in a mouse model of endometriosis. Am J Pathol. 2011;178(4):1782–1791. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“In a systematic review of oxidative stress biomarkers measured in patients with endometriosis, a total of 36 were identified.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Oxidative Stress
What the sources say
- Not checked yetcites [77] Carvalho LF, Samadder AN, Agarwal A, Fernandes LF, Abrao MS. Oxidative stress biomarkers in patients with endometriosis: systematic review. Arch Gynecol Obstet. 2012;286(4):1033–1040. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“This is the first model to record in vivo electrophysiological recordings from sensory neurons innervating the lesions which revealed a significantly increased response to sustained mechanical stimulation.89”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [89] Alvarez P, Chen X, Hendrich J, et al. Ectopic uterine tissue as a chronic pain generator. Neuroscience. 2012;225:269–282. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“Of those 36 oxidative stress biomarkers, 23 were found to be significantly higher in patients with endometriosis compared to controls.77”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Oxidative Stress
What the sources say
- Not checked yetcites [77] Carvalho LF, Samadder AN, Agarwal A, Fernandes LF, Abrao MS. Oxidative stress biomarkers in patients with endometriosis: systematic review. Arch Gynecol Obstet. 2012;286(4):1033–1040. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“These phenomena were abrogated by the antioxidant molecule N-acetyl-cysteine both in vitro and in a mouse model of endometriosis.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Oxidative Stress
What the sources say
- Not checked yetcites [75] Ngo C, Chereau C, Nicco C, Weill B, Chapron C, Batteux F. Reactive oxygen species controls endometriosis progression. Am J Pathol. 2009;175(1):225–234. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“Oxidative stress is implicated as a key factor in the pathogenesis of endometriosis.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Oxidative Stress
What the sources say
- Not checked yetcites [77] Carvalho LF, Samadder AN, Agarwal A, Fernandes LF, Abrao MS. Oxidative stress biomarkers in patients with endometriosis: systematic review. Arch Gynecol Obstet. 2012;286(4):1033–1040. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“These findings suggest that painful endometriosis can be classified as a mixed inflammatory/neuropathic pain condition that opens new avenues for pain relief.81”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [81] McAllister SL, Dmitrieva N, Berkley KJ. Sprouted innervation into uterine transplants contributes to the development of hyperalgesia in a rat model of endometriosis. PLoS One. 2012;7(2):e31758. source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“The lymphatic metastasis theory of endometriosis is supported by observations of the presence of endometriosis in pelvic lymph nodes and associations between deepinfiltrating endometriosis and lymph node involvement.[96][97][98]”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Angiogenesis and Lymphangiogenesis
What the sources say
- Not checked yetcites [96] Keichel S, Barcena de Arellano ML, Reichelt U, et al. Lymphangiogenesis in deep infiltrating endometriosis. Hum Reprod. 2011;26(10):2713–2720. source
- Not checked yetcites [97] Riedlinger WFJ, Weichbrodt M, Gericke J, et al. Sentinel Lymph node labeling of patients with deep infiltrating rectovaginal endometriosis: Does this make sense? J Endometriosis. 2010;2(1):33–40. source
- Not checked yetcites [98] Mechsner S, Weichbrodt M, Riedlinger WF, Kaufmann AM, Schneider A, Kohler C. Immunohistochemical evaluation of endometriotic lesions and disseminated endometriosis-like cells in incidental lymph nodes of patients with endometriosis. Fertil Steril. 2010;94(2):457–463. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“These results suggest that antioxidant molecules could potentially be used as a treatment option for endometriosis.75”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Oxidative Stress
What the sources say
- Not checked yetcites [75] Ngo C, Chereau C, Nicco C, Weill B, Chapron C, Batteux F. Reactive oxygen species controls endometriosis progression. Am J Pathol. 2009;175(1):225–234. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“Based on these results, it is suggested that protein kinase inhibitors could be considered as new candidates to treat endometriosis; however, further studies are needed to evaluate their effects and tolerability in humans.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Oxidative Stress
What the sources say
- Not checked yetcites [76] Ngo C, Nicco C, Leconte M, et al. Protein kinase inhibitors can control the progression of endometriosis in vitro and in vivo. J Pathol. 2010;222(2):148–157. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“Patients with endometriosis who have painful symptoms had more nerve fibers in peritoneal endometriotic lesions than patients with endometriosis who had no pain, and there is a correlation between pain score and the density of nerve fibers in peritoneal endometriotic lesions.10,87”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [10] Wang G, Tokushige N, Fraser IS. Nerve fibers and menstrual cycle in peritoneal endometriosis. Fertil Steril. 2011;95(8):2772–2774. source
- Not checked yetcites [87] Wang G, Tokushige N, Markham R, Fraser IS. Rich innervation of deep infiltrating endometriosis. Hum Reprod. 2009;24(4):827–834. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“Furthermore, significantly increased lymphatic microvessel density in women with endometriosis has been described in the endometrium during the proliferative phase, 94”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Angiogenesis and Lymphangiogenesis
What the sources say
- Not checked yetcites [94] Hey-Cunningham AJ, Ng FW, Busard MPH, et al. Uterine lymphatic and blood micro-vessels in women with endometriosis through the menstrual cycle. J Endometriosis. 2010;2(4):197–204. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“In vivo A771726, leflunomide, PD98059, and U0126 modulated the growth of endometriotic implants in a mouse model of endometriosis.76”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Oxidative Stress
What the sources say
- Not checked yetcites [76] Ngo C, Nicco C, Leconte M, et al. Protein kinase inhibitors can control the progression of endometriosis in vitro and in vivo. J Pathol. 2010;222(2):148–157. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“and the presence of lymphatic vessels in and around peritoneal endometriotic lesions 95”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Angiogenesis and Lymphangiogenesis
What the sources say
- Not checked yetcites [95] Hey-Cunningham AJ, Berbic M, Ng CHM, Markham R, Fraser IS. Lymphatic vessels in peritoneal endometriotic lesions. J Endometriosis. 2011;2(3):59–66. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“and lymphangiogenesis in deep-infiltrating endometriotic lesions has been reported.96”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Angiogenesis and Lymphangiogenesis
What the sources say
- Not checked yetcites [96] Keichel S, Barcena de Arellano ML, Reichelt U, et al. Lymphangiogenesis in deep infiltrating endometriosis. Hum Reprod. 2011;26(10):2713–2720. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“This increase in endogenous ROS correlated with increased cellular proliferation and activation of ERK1/2.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Oxidative Stress
What the sources say
- Not checked yetcites [75] Ngo C, Chereau C, Nicco C, Weill B, Chapron C, Batteux F. Reactive oxygen species controls endometriosis progression. Am J Pathol. 2009;175(1):225–234. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“Patients with endometriosis who have painful symptoms had more nerve fibers in peritoneal endometriotic lesions than patients with endometriosis who had no pain, and there is a correlation between pain score and the density of nerve fibers in peritoneal endometriotic lesions.10,87”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [10] Wang G, Tokushige N, Fraser IS. Nerve fibers and menstrual cycle in peritoneal endometriosis. Fertil Steril. 2011;95(8):2772–2774. source
- Not checked yetcites [87] Wang G, Tokushige N, Markham R, Fraser IS. Rich innervation of deep infiltrating endometriosis. Hum Reprod. 2009;24(4):827–834. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“There is good evidence that adult progenitor stem cells contribute to the remarkable regenerative capacity of the endometrium.103,104”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Stem Cells
What the sources say
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“A 70-kDa SRC-1 proteolytic isoform is highly elevated both in the endometriotic tissue of mice with surgically induced endometriosis and in endometriotic stromal cells biopsied from patients with endometriosis compared to normal endometrium.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Apoptosis
What the sources say
- Not checked yetcites [111] Han SJ, Hawkins SM, Begum K, et al. A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med. 2012;18(7):1102–1111. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“Clinical assessment of women with pelvic pain can be a poor indicator of disease seen at laparoscopy.119”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Role of the Microbiome in Endometriosis
What the sources say
- Not checked yetcites [119] Taylor-Robinson D, Jensen JS, Svenstrup H, Stacey CM. Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. Int J STD AIDS. 2012;23(1):18–24. source
plainn = 109- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“Efficacy studies had been conducted in a wide range of different models with no clear consensus on which model or end point had the most translational value.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Animal and Other Preclinical Models
What the sources say
- Not checked yetcites [115] Pullen N, Birch CL, Douglas GJ, Hussain Q, Pruimboom-Brees I, Walley RJ. The translational challenge in the development of new and effective therapies for endometriosis: a review of confidence from published preclinical efficacy studies. Hum Reprod Update. 2011;17(6):791–802. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“It is thought that the decreased susceptibility of endometrial tissue to apoptosis may contribute to the pathogenesis of endometriosis.109,110”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Apoptosis
What the sources say
- Not checked yetcites [109] Taniguchi F, Kaponis A, Izawa M, et al. Apoptosis and endometriosis. Front Biosci (Elite Ed). 2011;3(2):648–662. source
- Not checked yetcites [110] Nasu K, Nishida M, Kawano Y, et al. Aberrant expression of apoptosis-related molecules in endometriosis: a possible mechanism underlying the pathogenesis of endometriosis. Reprod Sci. 2011;18(3):206–218. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“In a systematic review of preclinical efficacy data from rodent and nonhuman primates between 2000 and 2010, 94 publications were identified which met the criteria for review.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Animal and Other Preclinical Models
What the sources say
- Not checked yetcites [115] Pullen N, Birch CL, Douglas GJ, Hussain Q, Pruimboom-Brees I, Walley RJ. The translational challenge in the development of new and effective therapies for endometriosis: a review of confidence from published preclinical efficacy studies. Hum Reprod Update. 2011;17(6):791–802. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“Within the main body of recommendations, some areas of research appear to have progressed more rapidly than others since the last research directions workshop in 2008. 1”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Discussion
What the sources say
- Not checked yetcites [1] Rogers PA, D’Hooghe TM, Fazleabas A, et al. Priorities for endometriosis research: recommendations from an international consensus workshop. Reprod Sci. 2009;16(4):335–346. source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“Most recently, in a study of 13 226 controls and 7911 women with invasive ovarian cancer, self-reported endometriosis was associated with a significantly increased risk of clear-cell, low-grade serous, and endometrioid invasive ovarian cancers.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Role of the Ovary as a Target of Endometriosis
What the sources say
- Not checked yetcites [118] Pearce CL, Templeman C, Rossing MA, et al. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet Oncol. 2012;13(4):385–394. source
plaincorrelationaln = 7,911- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“Although progenitor stem cells reside in the uterus, mesenchymal stem cells may also travel from other tissues such as bone marrow to repopulate the progenitor population.105,106”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Stem Cells
What the sources say
- Not checked yetcites [105] Figueira PG, Abrao MS, Krikun G, Taylor HS. Stem cells in endometrium and their role in the pathogenesis of endometriosis. Ann N Y Acad Sci. 2011;1221(1):10–17. source
- Not checked yetcites [106] Maruyama T, Yoshimura Y. Stem cell theory for the pathogenesis of endometriosis. Front Biosci (Elite Ed). 2012;4(8):2754–2763. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“It is becoming increasingly evident that altered expression of genes in a pathological context contributes to many of the biological processes that are dysregulated in endometriosis, including cell proliferation, inhibition of apoptosis, and altered hormonal sensitivity.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Use of Targeted Transgenic Models
What the sources say
- Not checked yetcites [116] Jeong JW, Lee HS, Lee KY, et al. Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc Natl Acad Sci U S A. 2009;106(21):8677–8682. source
- Not checked yetcites [117] Jeong JW, Lee HS, Franco HL, et al. beta-catenin mediates glandular formation and dysregulation of beta-catenin induces hyperplasia formation in the murine uterus. Oncogene. 2009;28(1):31–40. source
- Not checked yetcites [111] Han SJ, Hawkins SM, Begum K, et al. A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med. 2012;18(7):1102–1111. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“A steroid receptor coactivator-1 (SRC-1)-null mouse model reveals that the mouse SRC-1 gene has an essential role in endometriosis progression.111”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Apoptosis
What the sources say
- Not checked yetcites [111] Han SJ, Hawkins SM, Begum K, et al. A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med. 2012;18(7):1102–1111. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“Ectopic endometriotic implants recruit their own neural and vascular supplies through neuroangiogenesis.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Angiogenesis and Lymphangiogenesis
What the sources say
- Not checked yetcites [100] Asante A, Taylor RN. Endometriosis: the role of neuroangiogenesis. Annu Rev Physiol. 2011;73:163–182. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“Endometriosis and ovarian cancer have been linked by a number of studies.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Role of the Ovary as a Target of Endometriosis
What the sources say
- Not checked yetcites [118] Pearce CL, Templeman C, Rossing MA, et al. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet Oncol. 2012;13(4):385–394. source
plaincorrelationaln = 7,911- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“The cornerstone of developing new therapies for endometriosis is the confidence and translational value placed in the preclinical models used to assess efficacy of emerging approaches.115”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Animal and Other Preclinical Models
What the sources say
- Not checked yetcites [115] Pullen N, Birch CL, Douglas GJ, Hussain Q, Pruimboom-Brees I, Walley RJ. The translational challenge in the development of new and effective therapies for endometriosis: a review of confidence from published preclinical efficacy studies. Hum Reprod Update. 2011;17(6):791–802. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“No association was noted between endometriosis and risk of mucinous or high-grade serous invasive ovarian cancer or borderline tumors of either subtype.118”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Role of the Ovary as a Target of Endometriosis
What the sources say
- Not checked yetcites [118] Pearce CL, Templeman C, Rossing MA, et al. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet Oncol. 2012;13(4):385–394. source
plainn = 7,911- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“In the normal endometrium, BCL-2, acting as a cell death repressor, is reported to inhibit apoptosis during the proliferative phase of the cycle.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Apoptosis
What the sources say
- Not checked yetcites [109] Taniguchi F, Kaponis A, Izawa M, et al. Apoptosis and endometriosis. Front Biosci (Elite Ed). 2011;3(2):648–662. source
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“In particular, some of the advances in genetics and associated technologies have moved the field forward significantly over the past 3 years.8,9”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Discussion
What the sources say
- Not checked yetcites [8] Painter JN, Anderson CA, Nyholt DR, et al. Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nat Genet. 2011;43(1):51–54. source
- Not checked yetcites [9] Uno S, Zembutsu H, Hirasawa A, et al. A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese. Nat Genet. 2010;42(8):707–710. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- It may state two separate claims as one. 39
- Probably not a substantial claim. 21
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Not surprisingly, ectopic and eutopic endometrium produce neurotrophic factors, 83 some of which are differentially expressed in cases of endometrioisis 84 and could serve as minimally invasive endometriosis biomarkers.85”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [83] Borghese B, Vaiman D, Mondon F, et al. [Neurotrophins and pain in endometriosis]. Gynecol Obstet Fertil. 2010;38(7–8):442–446. source
- Supportedcites [84] Browne AS, Yu J, Huang RP, Francisco AM, Sidell N, Taylor RN. Proteomic identification of neurotrophins in the eutopic endometrium of women with endometriosis. Fertil Steril. 2012;98(3):713–719. source
Citation 85 is attached to the biomarker clause. The Discussion (page not provided) proposes that measuring differentially expressed neurotrophins in endometrial biopsies could provide biomarkers and describes minimally invasive diagnostic use. (LLM, conf=0.92)
- Not checked yetcites [85] Giannini A, Bucci F, Luisi S, Cela V, Pluchino N, Merlini S. Brain-derived neurotrophic factor in plasma of women with endometriosis. J Endometriosis. 2010;2(3):144–145. source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
Every source the paper cites for this claim was checked and supports it.
In the paper
“Significantly increased presence of endometrial cells and altered immune environment has also been demonstrated in uterine-draining lymph nodes in the baboon model of induced endometriosis.99”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Angiogenesis and Lymphangiogenesis
What the sources say
- Supportedcites [99] Hey-Cunningham AJ, Fazleabas AT, Braundmeier AG, Markham R, Fraser IS, Berbic M. Endometrial stromal cells and immune cell populations within lymph nodes in a nonhuman primate model of endometriosis. Reprod Sci. 2011;18(8):747–754. source
The Discussion reports significantly increased CD10-positive endometrial stromal cells in femoral lymph nodes of baboons with induced endometriosis compared with controls. It also reports changes in immune-cell populations and antigen expression. These femoral nodes drain both the uterus and the peritoneal cavity. (LLM, conf=0.90)
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Thus, studies focused on gene regulation using transgenic models will provide valuable insights into mechanisms that may contribute to endometriosis.116,117,111”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Use of Targeted Transgenic Models
What the sources say
- Partly supportedcites [116] Jeong JW, Lee HS, Lee KY, et al. Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc Natl Acad Sci U S A. 2009;106(21):8677–8682. sourceExperimental — accuracy not yet measured
The Results describe a conditional Mig-6 mouse model used to study uterine hormone responses, and the Discussion notes that progesterone-regulated genes, including MIG-6, are dysregulated in endometrium from women with endometriosis. The model’s demonstrated disease findings concern endometrial hyperplasia and cancer, however; the paper does not show that this model reveals mechanisms of endometriosis. (LLM, conf=0.82)
- Partly supportedcites [117] Jeong JW, Lee HS, Franco HL, et al. beta-catenin mediates glandular formation and dysregulation of beta-catenin induces hyperplasia formation in the murine uterus. Oncogene. 2009;28(1):31–40. sourceExperimental — accuracy not yet measured
The Discussion (page unavailable) says that β-catenin mouse models provide insights into uterine dysfunction and that further study of Wnt signaling could reveal how hormone regulation is altered. This supports the value of gene-regulation studies using transgenic models, but the paper connects those insights to endometrial cancer, not endometriosis. (LLM, conf=0.86)
- Supportedcites [111] Han SJ, Hawkins SM, Begum K, et al. A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med. 2012;18(7):1102–1111. source
The Results section, “SRC-1 gene modulates progression of ectopic lesion” (page unavailable), uses SRC-1 knockout and GFP-transgenic mice to investigate how SRC-1 affects endometriotic lesion growth. This directly exemplifies the claim that studying gene regulation with transgenic models can provide insight into mechanisms contributing to endometriosis. (LLM, conf=0.90)
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence.
- Partly supported
In the paper
“Endometriosis affects an estimated 6% to 10% of women in the reproductive age group.3”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
What the sources say
- Not checked yetcites [3] Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North Am. 1997;24(2):235–258. source
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“estimated annual costs of US $12 419 per woman (approximately €9579), comprising one-third of the direct health care costs with two-thirds attributed to loss of productivity.6”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
What the sources say
- Not checked yetcites [6] Simoens S, Dunselman G, Dirksen C, et al. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Hum Reprod. 2012;27(5):1292–1299. source
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“However, this classification system does not appear to be widely used.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Classification and Prognosis
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. The paper may give no reason why it holds.
In the paper
“Oral CHM may have a better overall treatment effect than danazol; it may be more effective in relieving dysmenorrhea and shrinking adnexal masses when used in conjunction with a CHM enema.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [37] Flower A, Liu JP, Lewith G, Little P, Li Q. Chinese herbal medicine for endometriosis. Cochrane Database Syst Rev. 2012;5:CD006568.
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Endometriosis occurs in adolescents, and presenting symptoms may vary from those seen in adult women with the disease.38”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [38] Laufer MR, Sanfilippo J, Rose G. Adolescent endometriosis: diagnosis and treatment approaches. J Pediatr Adolesc Gynecol. 2003;16(suppl 3):S3–S11. source
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Different techniques for diagnostic and preoperative imaging of endometriosis are being explored, including ultrasound, computed tomography, and magnetic resonance imaging.21”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [21] Chamie LP, Blasbalg R, Pereira RM, Warmbrand G, Serafini PC. Findings of pelvic endometriosis at transvaginal us, mr imaging, and laparoscopy. Radiographics. 2011;31(4):E77–E100. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“A refinement of the rAFS/rASRM criteria is the ENZIAN classification system, developed to describe more severe disease.25”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Classification and Prognosis
What the sources say
- Not checked yetcites [25] Tuttlies F, Keckstein J, Ulrich U, et al. [ENZIAN-score, a classification of deep infiltrating endometriosis]. Zentralbl Gynakol. 2005;127(5):275–281. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Loss of work productivity translated into significant costs, ranging from US $208 in Nigeria to US $23 712 in Italy per woman per year.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
What the sources say
- Not checked yetcites [7] Nnoaham KE, Hummelshoj L, Webster P, et al. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril. 2011;96(2):366–373 e368. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Based on a review of best available evidence, pain recurrence and reoperation rates after conservative surgery for symptomatic endometriosis are high and probably underestimated.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Clinical Trials, Treatment, and Outcomes
What the sources say
- Not checked yetcites [33] Vercellini P, Crosignani PG, Abbiati A, Somigliana E, Vigano P, Fedele L. The effect of surgery for symptomatic endometriosis: the other side of the story. Hum Reprod Update. 2009;15(2):177–188. source
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“The state of advancement and the results of novel treatments studied in registered trials (www.ClinicalTrials.gov)have recently been reviewed.36”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [36] Streuli I, de Ziegler D, Borghese B, Santulli P, Batteux F, Chapron C. New treatment strategies and emerging drugs in endometriosis[published online march 23, 2012]. Expert Opin Emerg Drugs. 2012. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“The EFI is a simple, robust, and validated clinical tool that provides reassurance to those patients with good prognoses and avoids wasting time and treatment for those with poor prognoses.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Classification and Prognosis
What the sources say
- Not checked yetcites [27] Adamson GD, Pasta DJ. Endometriosis fertility index: the new, validated endometriosis staging system. Fertil Steril. 2010;94(5):1609–1615. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“In China, treatment of endometriosis using Chinese herbal medicine (CHM) is routine, and considerable research into the role of CHM in alleviating pain, promoting fertility, and preventing relapse has taken place.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“Genetic and environmental factors contribute to endometriosis risk and the disease is inherited as a complex trait.[41][42][43][44][45]”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Epidemiology
What the sources say
- Not checked yetcites [41][42][43][44][45]
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Methodological drawbacks limit considerably the validity of observational, noncomparative studies on the effect of laparoscopy, identifying the need for prospective, multicenter randomized controlled trials.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Clinical Trials, Treatment, and Outcomes
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“However, these classifications are restricted to a limited number of criteria and are not particularly valuable for predicting many of the parameters needed for clinical management, including pain or fertility outcomes.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Classification and Prognosis
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“However, the authors concluded that larger studies in well-defined populations are required to determine their true usefulness.18”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Diagnosis
What the sources say
- Not checked yetcites [18] May KE, Villar J, Kirtley S, Kennedy SH, Becker CM. Endometrial alterations in endometriosis: a systematic review of putative biomarkers. Hum Reprod Update. 2011;17(5):637–653. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“The authors concluded that post-surgical administration of CHM may have comparable benefits to gestrinone but with fewer side effects.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [37] Flower A, Liu JP, Lewith G, Little P, Li Q. Chinese herbal medicine for endometriosis. Cochrane Database Syst Rev. 2012;5:CD006568.
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Furthermore, there is a paucity of data on longterm outcomes and little data on cost-effectiveness and QoL.16”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Diagnosis
What the sources say
- Not checked yetcites [16] Hori Y. Diagnostic laparoscopy guidelines: This guideline was prepared by the SAGES Guidelines Committee and reviewed and approved by the Board of Governors of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), November 2007. Surg Endosc. 2008;22(5):1353–1383. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Currently, The American Association of Gynecologic Laparoscopists is developing a categorization system that will be more focused on pain.26”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Classification and Prognosis
What the sources say
- Not checked yetcites [26] Adamson GD. Endometriosis classification: an update. Curr Opin Obstet Gynecol. 2011;23(4):213–220. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Current treatment options for women with endometriosisassociated pain and/or infertility include surgery, medical treatment, alternative therapies, and assisted reproduction.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Clinical Trials, Treatment, and Outcomes
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Each affected woman lost on average 10.8 hours of work weekly, mainly owing to reduced effectiveness while working.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Background
What the sources say
- Not checked yetcites [7] Nnoaham KE, Hummelshoj L, Webster P, et al. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril. 2011;96(2):366–373 e368. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“However, studies in Australian twins, 45 in the Icelandic population, 43 and in rhesus macaques 49 provide strong evidence for a genetic contribution to the disease with the heritability of endometriosis estimated to be around 50%. 45”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Epidemiology
What the sources say
- Not checked yetcites [45] Treloar SA, O’Connor DT, O’Connor VM, Martin NG. Genetic influences on endometriosis in an Australian twin sample. sueT@qimr.edu.au. Fertil Steril. 1999;71(4):701–710. source
- Not checked yetcites [43] Stefansson H, Geirsson RT, Steinthorsdottir V, et al. Genetic factors contribute to the risk of developing endometriosis. Hum Reprod. 2002;17(3):555–559. source
- Not checked yetcites [49] Zondervan KT, Weeks DE, Colman R, et al. Familial aggregation of endometriosis in a large pedigree of rhesus macaques. Hum Reprod. 2004;19(2):448–455. source
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Increased total fat consumption was associated with decreased endometriosis risk and increased b-carotene consumption and servings of fruit were associated with increased risk.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [53] Trabert B, Peters U, De Roos AJ, Scholes D, Holt VL. Diet and risk of endometriosis in a population-based case-control study. Br J Nutr. 2011;105(3):459–467. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Diet plausibly has a role in the etiology of endometriosis through effects at various levels including on steroid hormones; however, few published studies have examined diet and endometriosis risk, 52 resulting in no clear consensus recommendations.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [52] Fjerbaek A, Knudsen UB. Endometriosis, dysmenorrhea and diet–what is the evidence? Eur J Obstet Gynecol Reprod Biol. 2007;132(2): 140–147. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Autoimmune diseases that may be associated with endometriosis include systemic lupus erythematosus (SLE), hypothyroidism, rheumatoid arthritis, Sjo ¨gren syndrome, and multiple sclerosis.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Human epithelial and stromal endometrial cells express nuclear factor-kappa B (NF-kB) proteins; NF-kB-mediated gene transcription promotes inflammation, invasion, angiogenesis, and cell proliferation and inhibits apoptosis of endometriotic cells.63”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Not checked yetcites [63] Gonzalez-Ramos R, Van Langendonckt A, Defrere S, et al. Involvement of the nuclear factor-kappaB pathway in the pathogenesis of endometriosis. Fertil Steril. 2010;94(6):1985–1994. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“However, evidence is mixed on the usefulness of anti-inflammatory agents to treat endometriosis symptoms, with a recent review concluding that there is no enough evidence to support the use of the antiinflammatory pentoxifylline in the management of subfertility and relief of pain from endometriosis.65”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Inflammation and Immunology
What the sources say
- Not checked yetcites [65] Lu D, Song H, Li Y, Clarke J, Shi G. Pentoxifylline for endometriosis. Cochrane Database Syst Rev. 2012;1: CD007677.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“The dysregulation of ROS production in endometriotic cells correlates with a proproliferative phenotype and may be implicated in the spreading of the disease.75”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Oxidative Stress
What the sources say
- Not checked yetcites [75] Ngo C, Chereau C, Nicco C, Weill B, Chapron C, Batteux F. Reactive oxygen species controls endometriosis progression. Am J Pathol. 2009;175(1):225–234. source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“There was also a suggestion of decreased endometriosis risk associated with the consumption of dairy products.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Recommendation
What the sources say
- Not checked yetcites [53] Trabert B, Peters U, De Roos AJ, Scholes D, Holt VL. Diet and risk of endometriosis in a population-based case-control study. Br J Nutr. 2011;105(3):459–467. source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Taken together, these reports show that endometriotic lesions can develop their own nerve supply, thereby creating a direct and 2-way interaction between lesions and the CNS.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“These results are consistent with clinical and pathological findings observed in patients with endometriosis, compatible with the ectopic endometrium as a source of pain.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [89] Alvarez P, Chen X, Hendrich J, et al. Ectopic uterine tissue as a chronic pain generator. Neuroscience. 2012;225:269–282. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In a rat model of autotransplantation of endometrium to the gastrocnemius muscle, cystic lesions developed within 2 weeks with stromal invasion of the muscle, nociceptor nerve fibers, and neuronal sprouting, and persistent mechanical hyperalgesia at the site of the lesions.89”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [89] Alvarez P, Chen X, Hendrich J, et al. Ectopic uterine tissue as a chronic pain generator. Neuroscience. 2012;225:269–282. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“It has been reported that endometrial biopsy, with detection of nerve fibres, provides a reliability of diagnosis of endometriosis which is close to the accuracy of laparoscopic assessment by experienced gynecological laparoscopists.86”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [86] Al-Jefout M, Dezarnaulds G, Cooper M, et al. Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study. Hum Reprod. 2009;24(12):3019–3024. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Endometriotic cells display higher endogenous oxidative stress with an increase in ROS production, alterations in ROS detoxification pathways, and a drop in catalase levels.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Oxidative Stress
What the sources say
- Not checked yetcites [75] Ngo C, Chereau C, Nicco C, Weill B, Chapron C, Batteux F. Reactive oxygen species controls endometriosis progression. Am J Pathol. 2009;175(1):225–234. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Yet causality remains an enigma, because pain symptoms attributed to endometriosis occur in women without endometriosis and because pain symptoms and severity correlate poorly with lesion characteristics.34”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [34] Stratton P, Berkley KJ. Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Hum Reprod Update. 2011;17(3):327–346. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In a rat autotransplantation model of endometrium to the mesentery, vascularized endometriotic cysts become innervated with sensory and sympathetic fibers, and rats subsequently exhibit vaginal hyperalgesia.81”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [81] McAllister SL, Dmitrieva N, Berkley KJ. Sprouted innervation into uterine transplants contributes to the development of hyperalgesia in a rat model of endometriosis. PLoS One. 2012;7(2):e31758. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Intralesional, but not contralateral, injection of progesterone was dose-dependently antihyperalgesic as was systemic administration of leuprolide.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [89] Alvarez P, Chen X, Hendrich J, et al. Ectopic uterine tissue as a chronic pain generator. Neuroscience. 2012;225:269–282. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Corticotropin-releasing hormone and urocortin are expressed by endometriotic tissue and their deranged expression in endometrium of patients with endometriosis suggests that these neuropeptides may also participate in the pathogenesis of endometriosis.88”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [88] Novembri R, Borges LE, Carrarelli P, et al. Impaired CRH and urocortin expression and function in eutopic endometrium of women with endometriosis. J Clin Endocrinol Metab. 2011;96(4):1145–1150. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Removing cysts before they acquired functional innervation prevented vaginal hyperalgesia from developing, whereas sham cyst removal did not.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [81] McAllister SL, Dmitrieva N, Berkley KJ. Sprouted innervation into uterine transplants contributes to the development of hyperalgesia in a rat model of endometriosis. PLoS One. 2012;7(2):e31758. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In human studies, it has been reported that there is an imbalance between sympathetic and sensory nerve fibres in peritoneal endometriosis as well as an altered modulation of peritoneal fluids from patients with endometriosis on sympathetic and sensory innervation, which might directly be involved in the maintenance of inflammation and pain.82”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Nerves, Neuropeptides, and Pain
What the sources say
- Not checked yetcites [82] Arnold J, Barcena de Arellano ML, Ruster C, et al. Imbalance between sympathetic and sensory innervation in peritoneal endometriosis. Brain Behav Immun. 2012;26(1):132–141. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In a study of pelvic inflammatory disease in 109 women, 22 at laparoscopy had salpingitis, 19 had adhesions without salpingitis, 20 had endometriosis or ovarian pathology, and 48 no observable abnormality.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Role of the Microbiome in Endometriosis
What the sources say
- Not checked yetcites [119] Taylor-Robinson D, Jensen JS, Svenstrup H, Stacey CM. Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. Int J STD AIDS. 2012;23(1):18–24. source
plainn = 109- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In contrast to full-length SRC-1, the endometriotic 70-kDa SRC-1 C-terminal fragment prevents TNF-a-mediated apoptosis in human endometrial epithelial cells and causes the epithelial-mesenchymal transition and the invasion of human endometrial cells that are hallmarks of progressive endometriosis.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Apoptosis
What the sources say
- Not checked yetcites [111] Han SJ, Hawkins SM, Begum K, et al. A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med. 2012;18(7):1102–1111. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“They conclude that this could influence the expression of angiogenic factors and play a role in the pathogenesis of endometriosis.114”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Endometriosis-Related MicroRNAs Work
What the sources say
- Not checked yetcites [114] Ramon LA, Braza-Boils A, Gilabert-Estelles J, et al. micro-RNAs expression in endometriosis and their relation to angiogenic factors. Hum Reprod. 2011;26(5):1082–1090. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
In the paper
“The results reported for the whole group of women with pain highlight the difficulties in making a precise microbial diagnosis and highlight the need for further investigation into the links between the microbiome, pain, and endometriosis.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Role of the Microbiome in Endometriosis
What the sources say
- Not checked yetcites [119] Taylor-Robinson D, Jensen JS, Svenstrup H, Stacey CM. Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. Int J STD AIDS. 2012;23(1):18–24. source
plaincorrelationaln = 109- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Endometrial BCL-2 expression may be stimulated by estrogen and downregulated by progesterone.110”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Apoptosis
What the sources say
- Not checked yetcites [110] Nasu K, Nishida M, Kawano Y, et al. Aberrant expression of apoptosis-related molecules in endometriosis: a possible mechanism underlying the pathogenesis of endometriosis. Reprod Sci. 2011;18(3):206–218. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“The authors concluded that greater scrutiny of the preclinical efficacy of models, end points, and experimental designs are needed if the desire of translating novel treatment approaches is to be realized in women with endometriosis.115”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Animal and Other Preclinical Models
What the sources say
- Not checked yetcites [115] Pullen N, Birch CL, Douglas GJ, Hussain Q, Pruimboom-Brees I, Walley RJ. The translational challenge in the development of new and effective therapies for endometriosis: a review of confidence from published preclinical efficacy studies. Hum Reprod Update. 2011;17(6):791–802. source
plainconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
None of the sources cited for this claim have been checked yet.
In the paper
“Clonogenic cells and side populations have been identified in human endometrium; these cells are few in number and have the ability to give rise to a variety of differentiated cell types.101,102”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Stem Cells
What the sources say
- Not checked yetcites [101] Chan RW, Schwab KE, Gargett CE. Clonogenicity of human endometrial epithelial and stromal cells. Biol Reprod. 2004;70(6): 1738–1750. source
- Not checked yetcites [102] Kato K, Yoshimoto M, Kato K, et al. Characterization of side-population cells in human normal endometrium. Human Reproduction. 2007;22(5):1214–1223. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Women with endometriosis are reported to have reduced endometrial apoptosis with increased expression of antiapoptotic and decreased expression of proapoptotic factors.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Apoptosis
What the sources say
- Not checked yetcites [109] Taniguchi F, Kaponis A, Izawa M, et al. Apoptosis and endometriosis. Front Biosci (Elite Ed). 2011;3(2):648–662. source
- Not checked yetcites [110] Nasu K, Nishida M, Kawano Y, et al. Aberrant expression of apoptosis-related molecules in endometriosis: a possible mechanism underlying the pathogenesis of endometriosis. Reprod Sci. 2011;18(3):206–218. source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In endometriosis, there is altered expression of BCL-2 in the eutopic endometrium and thereby fewer apoptotic cells and abnormal survival in ectopic sites.109”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Apoptosis
What the sources say
- Not checked yetcites [109] Taniguchi F, Kaponis A, Izawa M, et al. Apoptosis and endometriosis. Front Biosci (Elite Ed). 2011;3(2):648–662. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Currently, there are no definitive markers to allow isolation and characterization of endometrial progenitor or stem cells, and it is unknown what drives the recruitment and homing of these cells to eutopic endometrium or ectopic sites.107,108”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Stem Cells
What the sources say
- Not checked yetcites [107] Du H, Taylor HS. Contribution of bone marrow-derived stem cells to endometrium and endometriosis. Stem Cells. 2007;25(8):2082–2086. source
- Not checked yetcites [108] Sasson IE, Taylor HS. Stem cells and the pathogenesis of endometriosis. Ann N Y Acad Sci. 2008;1127(1):106–115. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Other workers have shown that expression levels of miRNAs related to angiogenesis were different in eutopic endometrium from that observed in ovarian endometrioma.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Endometriosis-Related MicroRNAs Work
What the sources say
- Not checked yetcites [114] Ramon LA, Braza-Boils A, Gilabert-Estelles J, et al. micro-RNAs expression in endometriosis and their relation to angiogenic factors. Hum Reprod. 2011;26(5):1082–1090. source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“The authors conclude that miRNAs may play an important role in endometriotic lesion development, including regulatory functions associated with hypoxia, inflammation, tissue repair, TGF-b-regulated pathways, cell growth, cell proliferation, apoptosis, extracellular matrix remodeling, and angiogenesis.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Endometriosis-Related MicroRNAs Work
What the sources say
- Not checked yetcites [112] Teague EM, Print CG, Hull ML. The role of microRNAs in endometriosis and associated reproductive conditions. Hum Reprod Update. 2010;16(2):142–165. source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“In all laparoscopic categories, Ureaplasma spp and Mycoplasma hominis, but not Mycoplasma genitalium, were at least as common in the cervix/vagina as Chlamydia trachomatis and equally frequent in the endometrium.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Role of the Microbiome in Endometriosis
What the sources say
- Not checked yetcites [119] Taylor-Robinson D, Jensen JS, Svenstrup H, Stacey CM. Difficulties experienced in defining the microbial cause of pelvic inflammatory disease. Int J STD AIDS. 2012;23(1):18–24. source
plainn = 109- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“The meeting recognized the impact that pain has on many women with endometriosis and attached significant priority to the need for research on all aspects of pain, including basic mechanisms, classification, and treatment.”
§ Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France > Discussion
What the sources say
- Not checked yetcites [34] Stratton P, Berkley KJ. Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Hum Reprod Update. 2011;17(3):327–346. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
Peritoneal oxidative stress is one of the major constituents of the endometriosis-associated inflammatory response.
“Peritoneal oxidative stress is thought to be one of the major constituent of the endometriosis-associated inflammatory response.”
The paper relies on this without support.
Excessive production of ROS, secondary to peritoneal influx of prooxidants such as heme and iron, may induce cellular damage and increased proinflammatory gene expression through NF-kB activation.
“Excessive production of reactive oxygen species (ROS), secondary to peritoneal influx of prooxidants such as heme and iron, may induce cellular damage and increased proinflammatory gene expression through NF-kB activation.”
The paper relies on this without support.
ROS are proinflammatory mediators that modulate cell proliferation.
“The ROS are proinflammatory mediators that modulate cell proliferation.”
The paper relies on this without support.
The presence of unmyelinated sensory nerve fibers in the functional layer of endometrium and increased nerve fiber density in endometrium and myometrium in women with endometriosis suggests a possible role in pain perception.
“The presence of unmyelinated sensory nerve fibers in the functional layer of endometrium and a significantly increased nerve fiber density in endometrium and myometrium in women with endometriosis suggests a possible role in pain perception.”
The paper relies on this without support.
Angiogenesis and lymphangiogenesis are critical processes in the pathogenesis of endometriosis.
“Angiogenesis and lymphangiogenesis, or the development of new blood and lymphatic vessels from preexisting ones, are critical processes in the pathogenesis of endometriosis.”
The paper relies on this without support.
Clinical evidence for the efficacy of antiangiogenic endometriosis therapy is still lacking.
“However, clinical evidence for their efficacy in antiangiogenic endometriosis therapy is still lacking.”
The paper relies on this without support.
Progenitor stem cells have the capacity to generate endometriosis if shed in a retrograde fashion.
“It is also likely that these same progenitor stem cells have the capacity to generate endometriosis if shed in a retrograde fashion.”
The paper relies on this without support.
Stem cells not of uterine origin may migrate to and cause or contribute to endometriotic lesions.
“It is also possible that stem cells that are not of uterine origin may migrate to and cause or contribute to endometriotic lesions, both in the peritoneal cavity and in the rarer instances where endometriosis occurs outside of the peritoneal cavity.”
The paper relies on this without support.
Progestins have overall anti-inflammatory activity.
“Progestins have overall anti-inflammatory activity, and there appears to be progesterone resistance in endometriotic lesions and eutopic endometrium of women with endometriosis.”
The paper relies on this without support.
There is progesterone resistance in endometriotic lesions and eutopic endometrium of women with endometriosis.
“Progestins have overall anti-inflammatory activity, and there appears to be progesterone resistance in endometriotic lesions and eutopic endometrium of women with endometriosis.”
The paper relies on this without support.
Different progestins have different glucocorticoid and androgenic activity.
“Given that different progestins have different glucocorticoid and androgenic activity there may be opportunities for modifying treatments to improve outcomes.”
The paper relies on this without support.
Selective progesterone receptor modulators (SPRMs) may have a role in treating endometriosis.
“Selective progesterone receptor modulators (SPRMs) may also have a role in treating endometriosis, although evidence to support this is lacking to date.”
The paper relies on this without support.
Expression of VEGF-C and VEGF-D and their receptors neuropilin 2 is dysregulated in the endometrium from women with endometriosis.
“It has recently been demonstrated that expression of the potent lymphangiogenic growth factors VEGF-C and VEGF-D and their receptors neuropilin 2 is dysregulated in the endometrium from women with endometriosis.”
The paper relies on this without support.
Endometriosis organizations, often led by women with endometriosis, have greater credibility with politicians and the general public than scientists or physicians, giving them greater access to media and better effectiveness for educational campaigns.
“Endometriosis Organizations, which are often led by women with endometriosis, have the ability to raise public awareness about the challenges posed by endometriosis more effectively than scientists or physicians, not the least because they are seen by politicians and the general public to have greater credibility.This gives greater access to media and better effectiveness for educational campaigns”
The paper relies on this without support.
Different endometriosis organizations have been responsible for multimillion dollar outreach campaigns, public service announcement campaigns, numerous outreach mailings, e-mail blitzes, educational outreach videos, books, and brochures.
“Different endometriosis organizations have been responsible for multimillion dollar outreach campaigns, public service announcement campaigns, numerous outreach mailings, and e-mail blitzes to key stakeholders, educational outreach videos, books, and brochures”
The paper relies on this without support.
These activities have contributed significantly to raising the profile of endometriosis as a disease.
“This has contributed significantly to raising the profile of endometriosis as a disease”
The paper relies on this without support.
Women with endometriosis often have more persuasive power with government bodies, politicians, and institutions than others.
“Women with endometriosis often have more persuasive power with government bodies, politicians, and institutions”
The paper relies on this without support.
Personal stories and sharing experience and impact of a disease are more powerful than simply asking for research funds.
“Personal stories and sharing experience and impact of a disease are more powerful than simply asking for research funds, and women with endometriosis have more political capital as they can represent a significant block of votes”
The paper relies on this without support.
Women with endometriosis have more political capital because they can represent a significant block of votes.
“Personal stories and sharing experience and impact of a disease are more powerful than simply asking for research funds, and women with endometriosis have more political capital as they can represent a significant block of votes”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“the invasive nature of surgery, coupled with the lack of a laboratory biomarker for the disease, results in a mean latency of 7–11 years from onset of symptoms to definitive diagnosis.”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [11]
In the citing paper
“Although there is consensus in the World Endometriosis Society that the development of a reliable noninvasive test is one of the top research priorities in endometriosis [11, 21]”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [11]
In the citing paper
“It also is a direct answer to the key priority of phenome data collection and SOP harmonization identified in Endometriosis Research Directions workshops held in 2008 (12) and 2011 (2)”
In the citing paper
“it may be that the inclusion of different patient populations in studies, which cannot be adequately defined or recognized as they have been poorly characterized, has led to conflicting results between studies of different populations (2).”
Citations
Cites
Revised American Society for Reproductive Medicine classification of endometriosis: 1996
American Society for Reproductive Medicine (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81391-x · Cited by 3,018
Visscher, P. M., Brown, M. A., McCarthy, M. I., & Yang, J. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.11.029 · Cited by 2,425
Giudice, L. C. (2010) · New England Journal of Medicine · doi:10.1056/nejmcp1000274 · Cited by 1,924
Self-citationRevised American Fertility Society Classification of Endometriosis: 1985
(1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48430-x · Cited by 1,803
Eskenazi, B., & Warner, M. L. (1997) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(05)70302-8 · Cited by 1,617
Nnoaham, K. E., Hummelshoj, L., Webster, P., d’Hooghe, T., de Cicco Nardone, F., de Cicco Nardone, C., Jenkinson, C., Kennedy, S. H., & Zondervan, K. T. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.05.090 · Cited by 1,584
Self-citationSimoens, S., Dunselman, G., Dirksen, C., Hummelshoj, L., Bokor, A., Brandes, I., Brodszky, V., Canis, M., Colombo, G. L., DeLeire, T., et al. (2012) · Human Reproduction · doi:10.1093/humrep/des073 · Cited by 1,070
Self-citationPearce, C. L., Templeman, C., Rossing, M. A., Lee, A., Near, A. M., Webb, P. M., Nagle, C. M., Doherty, J. A., Cushing-Haugen, K. L., Wicklund, K. G., et al. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70404-1 · Cited by 939
Clonogenicity of Human Endometrial Epithelial and Stromal Cells1
Chan, R. W. S., Schwab, K. E., & Gargett, C. E. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.024109 · Cited by 653
Endometriosis and infertility: a committee opinion
(2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.05.031 · Cited by 633
Research works printed but not linked: 1
- Cakmak H, Guzeloglu-Kayisli O, Kayisli UA, Arici A. Immuneendocrine interactions in endometriosis. Front Biosci (Elite Ed). 2009;1(2):429–443.
Cited by
Sorted by citations
Theories on the pathogenesis of endometriosis
Sourial, S., Tempest, N., & Hapangama, D. K. (2014) · International Journal of Reproductive Medicine · doi:10.1155/2014/179515 · Cited by 418
“Endometriosis has estimated annual costs of US $12 419 per woman (approximately C9579), comprising one-third of the direct health care costs with two-thirds attributed to loss of productivity [11].”
BackgroundVitonis, A. F., Vincent, K., Rahmioglu, N., Fassbender, A., Buck Louis, G. M., Hummelshoj, L., Giudice, L. C., Stratton, P., Adamson, G. D., Becker, C. M., et al. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.07.1244 · Cited by 236
“Intervention(s): Development of a self-administered endometriosis patient questionnaire (EPQ), based on [1] systematic comparison of questionnaires from eight centers that collect data from endometriosis cases (and controls/comparison women) on a medium to large scale (publication on >100 cases); [2] literature eviden…”
BackgroundInfluentialSelf-citationRahmioglu, N., Fassbender, A., Vitonis, A. F., Tworoger, S. S., Hummelshoj, L., D'Hooghe, T. M., Adamson, G. D., Giudice, L. C., Becker, C. M., Zondervan, K. T., et al. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.07.1208 · Cited by 227
Self-citationBecker, C. M., Laufer, M. R., Stratton, P., Hummelshoj, L., Missmer, S. A., Zondervan, K. T., Adamson, G. D., Adamson, G. D., Allaire, C., Anchan, R., et al. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.07.709 · Cited by 206
Self-citationUpdate on biomarkers for the detection of endometriosis
Fassbender, A., Burney, R. O., F. O, D., D’Hooghe, T., & Giudice, L. (2015) · BioMed Research International · doi:10.1155/2015/130854 · Cited by 195
“This theory holds that endometriosis originates from the implantation of sloughed endometrial tissue refluxed into the pelvis via the fallopian tube(s) during menstruation.”
BackgroundSelf-citation
Metadata
- Authors
- Rogers, P. A. W., D’Hooghe, T. M., Fazleabas, A., Giudice, L. C., Montgomery, G. W., Petraglia, F., & Taylor, R. N.
- Affiliations
- Royal Women's Hospital (AU)
- Universitair Ziekenhuis Leuven (BE)
- Michigan State University (US)
- University of California, San Francisco (US)
- QIMR Berghofer Medical Research Institute (AU)
- University of Siena (IT)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Rogers, Peter A. W.
- ORCID
- Venue
- Reproductive Sciences
- Published
- 2013-05
- Volume
- 20
- Issue
- 5
- Pages
- 483-499
- ISSN
- 1933-7191 (ISSN-L)
- 1933-7205
- PMC
- PMC3635070
- OpenAlex
- W2103672022
- Semantic Scholar
- 63a4d6c6f314f869bfec6ec5c5d35efc1db55094
- Cited by
- 154
- References
- 130
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 9 · 2022: 7 · 2021: 16 · 2020: 15 · 2019: 6 · 2018: 5 · 2017: 16 · 2016: 23 · 2015: 19 · 2014: 28 · 2013: 1
- FWCI
- 28.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Reproductive Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD055764, U54HD040093, 1U54HD40093, 1U54HD05576, U54HD055787)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, research priorities, consensus statement, endometriosis diagnosis, endometriosis classification, prognosis, clinical trials, treatment outcomes, pathophysiology, science policy, quality of life, economic burden, delayed diagnosis
- MeSH terms
- Animals, Endometriosis, Female, Forecasting, Humans, Prognosis, Consensus, Biomedical Research
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