The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
microPrimer: the biogenesis and function of microRNA
Open accessAbstract
Discovered in nematodes in 1993, microRNAs (miRNAs) are non-coding RNAs that are related to small interfering RNAs (siRNAs), the small RNAs that guide RNA interference (RNAi). miRNAs sculpt gene expression profiles during plant and animal development. In fact, miRNAs may regulate as many as one-third of human genes. miRNAs are found only in plants and animals, and in the viruses that infect them. miRNAs function very much like siRNAs, but these two types of small RNAs can be distinguished by their distinct pathways for maturation and by the logic by which they regulate gene expression.
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Citations
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292
Processing of primary microRNAs by the Microprocessor complex
Denli, A. M., Tops, B. B. J., Plasterk, R. H. A., Ketting, R. F., & Hannon, G. J. (2004) · Nature · doi:10.1038/nature03049 · Cited by 2,784
A pancreatic islet-specific microRNA regulates insulin secretion
Poy, M. N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., MacDonald, P. E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., et al. (2004) · Nature · doi:10.1038/nature03076 · Cited by 2,102
Xie, X., Lu, J., Kulbokas, E. J., Golub, T. R., Mootha, V., Lindblad-Toh, K., Lander, E. S., & Kellis, M. (2005) · Nature · doi:10.1038/nature03441 · Cited by 1,872
Ketting, R. F., Fischer, S. E. J., Bernstein, E., Sijen, T., Hannon, G. J., & Plasterk, R. H. A. (2001) · Genes & Development · doi:10.1101/gad.927801 · Cited by 1,852
BASKERVILLE, S., & BARTEL, D. P. (2005) · RNA · doi:10.1261/rna.7240905 · Cited by 1,508
MicroRNAs Regulate Brain Morphogenesis in Zebrafish
Giraldez, A. J., Cinalli, R. M., Glasner, M. E., Enright, A. J., Thomson, J. M., Baskerville, S., Hammond, S. M., Bartel, D. P., & Schier, A. F. (2005) · Science · doi:10.1126/science.1109020 · Cited by 1,315
Cited by
(2008) · doi:10.1038/nrg2290 · Cited by 5,199
Bushati, N., & Cohen, S. M. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123406 · Cited by 2,750
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
Esau, C., Davis, S., Murray, S. F., Yu, X. X., Pandey, S. K., Pear, M., Watts, L., Booten, S. L., Graham, M., McKay, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.005 · Cited by 2,082
MicroRNA: Biogenesis, Function and Role in Cancer
MacFarlane, L.-A., & R. Murphy, P. (2010) · Current Genomics · doi:10.2174/138920210793175895 · Cited by 1,584
Functions and Regulation of RNA Editing by ADAR Deaminases
Nishikura, K. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060208-105251 · Cited by 1,242
Zhang, L., Hou, D., Chen, X., Li, D., Zhu, L., Zhang, Y., Li, J., Bian, Z., Liang, X., Cai, X., et al. (2012) · Cell Research · doi:10.1038/cr.2011.158 · Cited by 1,216
A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)
Lee, Y. S., Shibata, Y., Malhotra, A., & Dutta, A. (2009) · Genes & Development · doi:10.1101/gad.1837609 · Cited by 1,173
Characterization of microRNA expression profiles in normal human tissues.
Liang, Y., Ridzon, D., Wong, L., & Chen, C. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-166 · Cited by 881
Redirection of Silencing Targets by Adenosine-to-Inosine Editing of miRNAs
Kawahara, Y., Zinshteyn, B., Sethupathy, P., Iizasa, H., Hatzigeorgiou, A. G., & Nishikura, K. (2007) · Science · doi:10.1126/science.1138050 · Cited by 712
Cell-type-specific signatures of microRNAs on target mRNA expression
Sood, P., Krek, A., Zavolan, M., Macino, G., & Rajewsky, N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511045103 · Cited by 650
RETRACTED: Downregulation of miR‐122 in the rodent and human hepatocellular carcinomas
Kutay, H., Bai, S., Datta, J., Motiwala, T., Pogribny, I., Frankel, W., Jacob, S. T., & Ghoshal, K. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20982 · Cited by 608
RetractedAn activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP
Wayman, G. A., Davare, M., Ando, H., Fortin, D., Varlamova, O., Cheng, H.-Y. M., Marks, D., Obrietan, K., Soderling, T. R., Goodman, R. H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803072105 · Cited by 559
Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus
Lukiw, W. J. (2007) · NeuroReport · doi:10.1097/wnr.0b013e3280148e8b · Cited by 530
Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability
Miska, E. A., Alvarez-Saavedra, E., Abbott, A. L., Lau, N. C., Hellman, A. B., McGonagle, S. M., Bartel, D. P., Ambros, V. R., & Horvitz, H. R. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030215 · Cited by 484
“Pre-miRNAs are exported from the nucleus by Exportin-5 [28], processed by the RNase III enzyme Dicer, and incorporated into an Argonaute-containing RNA-induced silencing complex (RISC) [29].”
BackgroundMicroRNA expression in the adult mouse central nervous system
Bak, M., Silahtaroglu, A., Møller, M., Christensen, M., Rath, M. F., Skryabin, B., Tommerup, N., & Kauppinen, S. (2008) · RNA · doi:10.1261/rna.783108 · Cited by 463
Epigenetic Regulation in Plants
Pikaard, C. S., & Mittelsten Scheid, O. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019315 · Cited by 440
The cartilage specific microRNA‐140 targets histone deacetylase 4 in mouse cells
Tuddenham, L., Wheeler, G., Ntounia-Fousara, S., Waters, J., Hajihosseini, M. K., Clark, I., & Dalmay, T. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.06.080 · Cited by 422
Improved targeting of miRNA with antisense oligonucleotides
Davis, S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl183 · Cited by 422
Sethi, P., & Lukiw, W. J. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.04.052 · Cited by 409
RNA editing of the microRNA‐151 precursor blocks cleavage by the Dicer–TRBP complex
Kawahara, Y., Zinshteyn, B., Chendrimada, T. P., Shiekhattar, R., & Nishikura, K. (2007) · The EMBO Reports · doi:10.1038/sj.embor.7401011 · Cited by 348
Frequency and fate of microRNA editing in human brain
Kawahara, Y., Megraw, M., Kreider, E., Iizasa, H., Valente, L., Hatzigeorgiou, A. G., & Nishikura, K. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn479 · Cited by 325
Differential Regulation of Germline mRNAs in Soma and Germ Cells by Zebrafish miR-430
Mishima, Y., Giraldez, A. J., Takeda, Y., Fujiwara, T., Sakamoto, H., Schier, A. F., & Inoue, K. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.086 · Cited by 321
Isolation of microRNA targets by miRNP immunopurification
Easow, G., Teleman, A. A., & Cohen, S. M. (2007) · RNA · doi:10.1261/rna.563707 · Cited by 301
MicroRNAs shape the neuronal landscape
McNeill, E., & Van Vactor, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.005 · Cited by 274
An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling
Impey, S., Davare, M., Lasiek, A., Fortin, D., Ando, H., Varlamova, O., Obrietan, K., Soderling, T. R., Goodman, R. H., & Wayman, G. A. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.10.005 · Cited by 270
Principles of micro-RNA production and maturation
Zeng, Y. (2006) · Oncogene · doi:10.1038/sj.onc.1209908 · Cited by 267
Functional MicroRNA Involved in Endometriosis
Hawkins, S. M., Creighton, C. J., Han, D. Y., Zariff, A., Anderson, M. L., Gunaratne, P. H., & Matzuk, M. M. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0371 · Cited by 264
miR-195 and miR-483-5p Identified as Predictors of Poor Prognosis in Adrenocortical Cancer
Soon, P. S. H., Tacon, L. J., Gill, A. J., Bambach, C. P., Sywak, M. S., Campbell, P. R., Yeh, M. W., Wong, S. G., Clifton-Bligh, R. J., Robinson, B. G., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1587 · Cited by 262
Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma
Pierson, J., Hostager, B., Fan, R., & Vibhakar, R. (2008) · Journal of Neuro-Oncology · doi:10.1007/s11060-008-9624-3 · Cited by 233
miR-34/449 miRNAs are required for motile ciliogenesis by repressing CP110
Song, R., Walentek, P., Sponer, N., Klimke, A., Lee, J. S., Dixon, G., Harland, R., Wan, Y., Lishko, P., Lize, M., et al. (2014) · Nature · doi:10.1038/nature13413 · Cited by 228
Argonaute Loading Improves the 5′ Precision of Both MicroRNAs and Their miRNA∗ Strands in Flies
Seitz, H., Ghildiyal, M., & Zamore, P. D. (2008) · Current Biology · doi:10.1016/j.cub.2007.12.049 · Cited by 172
Self-citationVenkataraman, S., Alimova, I., Fan, R., Harris, P., Foreman, N., & Vibhakar, R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010748 · Cited by 156
MicroRNA-520g Confers Drug Resistance by Regulating p21 Expression in Colorectal Cancer
Zhang, Y., Geng, L., Talmon, G., & Wang, J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.620252 · Cited by 100
Joshi, N. R., Miyadahira, E. H., Afshar, Y., Jeong, J.-W., Young, S. L., Lessey, B. A., Serafini, P. C., & Fazleabas, A. T. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2076 · Cited by 87
Signatures of Purifying and Local Positive Selection in Human miRNAs
Quach, H., Barreiro, L. B., Laval, G., Zidane, N., Patin, E., Kidd, K. K., Kidd, J. R., Bouchier, C., Veuille, M., Antoniewski, C., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.01.022 · Cited by 85
Analysis of miRNA expression profiles in breast cancer using biclustering
Fiannaca, A., La Rosa, M., La Paglia, L., Rizzo, R., & Urso, A. (2015) · BMC Bioinformatics · doi:10.1186/1471-2105-16-s4-s7 · Cited by 45
MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease
Li, W., & Zheng, Y. (2023) · Cells · doi:10.3390/cells12101378 · Cited by 43
Identification of MicroRNAs as Potential Biomarkers in Ovarian Endometriosis
Gu, C.-L., Zhang, Z., Fan, W.-S., Li, L.-A., Ye, M.-X., Zhang, Q., Zhang, N.-N., Li, Z., & Meng, Y.-G. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00148-z · Cited by 31
Dysregulation and Diagnostic Potential of microRNA in Alzheimer’s Disease
Pan, Y., Liu, R., Terpstra, E., Wang, Y., Qiao, F., Wang, J., Tong, Y., & Pan, B. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-150451 · Cited by 29
Su, L., & Liu, M. (2018) · Oncology Letters · doi:10.3892/ol.2018.8669 · Cited by 27
MiR-137–3p rescue motoneuron death by targeting calpain-2
Tang, Y., Fu, R., Ling, Z.-M., Liu, L.-L., Yu, G.-Y., Li, W., Fang, X.-Y., Zhu, Z., Wu, W.-T., & Zhou, L.-H. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.01.008 · Cited by 18
Metadata
- Authors
- Du, T., & Zamore, P. D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-11-01
- Volume
- 132
- Issue
- 21
- Pages
- 4645-4652
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2113869362
- Cited by
- 813
- References
- 17
- FWCI
- 22.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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