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Cited by 1,281

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link

Hotamisligil, Gökhan S, Spiegelman, Bruce M·1994·Diabetes
DOI 10.2337/diab.43.11.1271
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Abstract

Recent data have suggested a key role for tumor necrosis factor (TNF)-α in the insulin resistance of obesity and non-insulin-dependent diabetes mellitus (NIDDM). TNF-α expression is elevated in the adipose tissue of multiple experimental models of obesity. Neutralization of TNF-α in one of these models improves insulin sensitivity by increasing the activity of the insulin receptor tyrosine kinase, specifically in muscle and fat tissues. On a cellular level, TNF-α is a potent inhibitor of the insulin-stimulated tyrosine phosphorylations on the β-chain of the insulin receptor and insulin receptor substrate-1, suggesting a defect at or near the tyrosine kinase activity of the insulin receptor. Given the clear link between obesity, insulin resistance, and diabetes, these results strongly suggest that TNF-α may play a crucial role in the systemic insulin resistance of NIDDM. This may allow for new treatments of disorders involving resistance to insulin.

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Metadata

Authors
Hotamisligil, G. S., & Spiegelman, B. M.
Venue
Diabetes
Publisher
American Diabetes Association
Published
1994-11-01
Volume
43
Issue
11
Pages
1271-1278
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diab.43.11.1271
OpenAlex
W2022801078
Cited by
1,281
References
1
FWCI
21.98
Type
journal article
Language
en
Open access
closed

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