Cited by 110Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges

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Castellani, Rudy J., Perry, George·2019·Journal of Alzheimer’s Disease

DOI 10.3233/jad-180721PMC PMC6398540

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Abstract

There is considerable interest in the pathobiology of tau protein, given its potential role in neurodegenerative diseases and aging. Tau is an important microtubule associated protein, required for the assembly of tubulin into microtubules and maintaining structural integrity of axons. Tau has other diverse cellular functions involving signal transduction, cellular proliferation, developmental neurobiology, neuroplasticity, and synaptic activity. Alternative splicing results in tau isoforms with differing microtubule binding affinity, differing representation in pathological inclusions in certain disease states, and differing roles in developmental biology and homeostasis. Tau haplotypes confer differing susceptibility to neurodegeneration. Tau phosphorylation is a normal metabolic process, critical in controlling tau’s binding to microtubules, and is ongoing within the brain at all times. Tau may be hyperphosphorylated, and may aggregate as detectable fibrillar deposits in tissues, in both aging and neurodegenerative disease. The hypothesis that p-tau is neurotoxic has prompted constructs related to isomers, low-n assembly intermediates or oligomers, and the “tau prion”. Human postmortem studies have elucidated broad patterns of tauopathy, with tendencies for those patterns to differ as a function of disease phenotype. However, there is extensive overlap, not only between genuine neurodegenerative diseases, but also between aging and disease. Recent studies highlight uniqueness to pathological patterns, including a pattern attributed to repetitive head trauma, although clinical correlations have been elusive. The diagnostic process for tauopathies and neurodegenerative diseases in general is challenging in many respects, and may be particularly problematic for postmortem evaluation of former athletes and military service members.

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See all 110

Authors: Castellani, R. J., & Perry, G.
Affiliations: West Virginia University (US)
The University of Texas at San Antonio (US)
Corresponding author: Castellani, Rudy J.
ORCID: Castellani, Rudy J.
Perry, George
Venue: Journal of Alzheimer’s Disease
Publisher: SAGE Publications
Published: 2018-12-18
Volume: 67
Issue: 2
Pages: 447-467
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-180721
PMC: PMC6398540
OpenAlex: W2906559084
Cited by: 110
References: 252
Citations by year: 2026: 10 · 2025: 16 · 2024: 9 · 2023: 18 · 2022: 13 · 2021: 23 · 2020: 17 · 2019: 4
FWCI: 1.44
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/4.0/ (unspecified)
Locations: Journal of Alzheimer s Disease (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: tau protein, tauopathy
MeSH terms: Brain Injuries, Traumatic, Animals, Humans, tau Proteins, Neurodegenerative Diseases, Tauopathies, Post-Concussion Syndrome

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Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges

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