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Cited by 122Functional Brain Connectivity StudiesSleep and Wakefulness ResearchNeural dynamics and brain function

Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep

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Mitra, Anish, Snyder, Abraham Z, Tagliazucchi, Enzo, Laufs, Helmut, Raichle, Marcus E·2015·eLife
DOI 10.7554/elife.10781PMC PMC4737658
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Abstract

Propagation of slow intrinsic brain activity has been widely observed in electrophysiogical studies of slow wave sleep (SWS). However, in human resting state fMRI (rs-fMRI), intrinsic activity has been understood predominantly in terms of zero-lag temporal synchrony (functional connectivity) within systems known as resting state networks (RSNs). Prior rs-fMRI studies have found that RSNs are generally preserved across wake and sleep. Here, we use a recently developed analysis technique to study propagation of infra-slow intrinsic blood oxygen level dependent (BOLD) signals in normal adults during wake and SWS. This analysis reveals marked changes in propagation patterns in SWS vs. wake. Broadly, ordered propagation is preserved within traditionally defined RSNs but lost between RSNs. Additionally, propagation between cerebral cortex and subcortical structures reverses directions, and intra-cortical propagation becomes reorganized, especially in visual and sensorimotor cortices. These findings show that propagated rs-fMRI activity informs theoretical accounts of the neural functions of sleep.

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Cited by

Sorted by citations

Authors
Mitra, A., Snyder, A. Z., Tagliazucchi, E., Laufs, H., & Raichle, M. E.
Affiliations
  • Washington University in St. Louis (US)
  • Goethe University Frankfurt (DE)
Corresponding author
Mitra, Anish
ORCID
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2015-11-09
Volume
4
ISSN
2050-084X (ISSN-L)
DOI
10.7554/elife.10781
PMC
PMC4737658
OpenAlex
W2129953207
Cited by
122
References
13
Citations by year
2026: 9 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 8 · 2021: 13 · 2020: 11 · 2019: 23 · 2018: 12 · 2017: 11 · 2016: 7
FWCI
4.92
Type
journal article
Language
en
Open access
Licence
Locations
  • eLife (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (NS080675, P30NS048056, F30MH106253)
  • Bundesministerium für Bildung und Forschung (01EV0703)
  • LOEWE Zentrum AdRIA
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
slow-wave sleep, resting-state networks, functional connectivity, sleep-wake differences, visual cortex, sensorimotor cortex, subcortical structures
MeSH terms
Brain, Electroencephalography, Humans, Magnetic Resonance Imaging, Sleep, Wakefulness, Brain Waves

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