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Flavonoid Intake and Long-term Risk of Coronary Heart Disease and Cancer in the Seven Countries Study
Open accessAbstract
OBJECTIVE: To determine whether flavonoid intake explains differences in mortality rates from chronic diseases between populations. DESIGN: Cross-cultural correlation study. SETTING/PARTICIPANTS: Sixteen cohorts of the Seven Countries Study in whom flavonoid intake at baseline around 1960 was estimated by flavonoid analysis of equivalent food composites that represented the average diet in the cohorts. MAIN OUTCOME MEASURES: Mortality from coronary heart disease, cancer (various sites), and all causes in the 16 cohorts after 25 years of follow-up. RESULTS: Average intake of antioxidant flavonoids was inversely associated with mortality from coronary heart disease and explained about 25% of the variance in coronary heart disease rates in the 16 cohorts. In multivariate analysis, intake of saturated fat (73%; P = 0.0001), flavonoid intake (8%, P = .01), and percentage of smokers per cohort (9%; P = .03) explained together, independent of intake of alcohol and antioxidant vitamins, 90% of the variance in coronary heart disease rates. Flavonoid intake was not independently associated with mortality from other causes. CONCLUSIONS: Average flavonoid intake may partly contribute to differences in coronary heart disease mortality across populations, but it does not seem to be an important determinant of cancer mortality.
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“Table 4: Bioactive compounds extracted from banana peel Bioactive compounds Sub-types References Flavan-3-ols Gallocatechin Glutathione Norepinephrine Naringin Salsolinol L-Dopa [67-69]”
From Functional, nutritional and medicinal potential of banana peel (2023) · cites this paper as [69]
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Functional, nutritional and medicinal potential of banana peel
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“Catechins show strong antioxidant effects against lipid peroxidation [84] and protective effects against diseases such as cancer and CVD [85] .”
Background
Metadata
- Authors
- Hertog, M. G. L.
- Affiliations
- National Institute for Public Health and the Environment (NL)
- Corresponding author
- Hertog, Michaël G. L.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1995-02-27
- Volume
- 155
- Issue
- 4
- Pages
- 381
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2074581135
- Cited by
- 1,853
- References
- 2
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 23 · 2023: 23 · 2022: 28 · 2021: 32 · 2020: 40 · 2019: 35 · 2018: 55 · 2017: 54 · 2016: 53 · 2015: 69 · 2014: 65 · 2013: 66 · 2012: 83
- FWCI
- 67.20
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (submittedVersion)
- Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- flavonoids, dietary flavonoid intake, coronary heart disease mortality, cancer mortality, all-cause mortality, saturated fat intake, smoking, antioxidant vitamins, alcohol consumption
- MeSH terms
- Adult, Cause of Death, Coronary Disease, Cross-Cultural Comparison, Diet, Europe, Flavonoids, Humans, Japan, Male, Middle Aged, Neoplasms, Risk Factors, Cohort Studies
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