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Diabetic neuropathy and oxidative stress

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Pop-Busui, Rodica, Sima, Anders, Stevens, Martin·2006·Diabetes/Metabolism Research and Reviews

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Abstract

This review will focus on the impact of hyperglycemia-induced oxidative stress in the development of diabetes-related neural dysfunction. Oxidative stress occurs when the balance between the production of reactive oxygen species (ROS) and the ability of cells or tissues to detoxify the free radicals produced during metabolic activity is tilted in the favor of the former. Although hyperglycemia plays a key role in inducing oxidative stress in the diabetic nerve, the contribution of other factors, such as endoneurial hypoxia, transition metal imbalances, and hyperlipidemia have been also suggested. The possible sources for the overproduction of ROS in diabetes are widespread and include enzymatic pathways, auto-oxidation of glucose, and mitochondrial superoxide production. Increase in oxidative stress has clearly been shown to contribute to the pathology of neural and vascular dysfunction in diabetes. Potential therapies for preventing increased oxidative stress in diabetic nerve dysfunction will be discussed.

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Dissection of Metabolic, Vascular, and Nerve Conduction Interrelationships in Experimental Diabetic Neuropathy by Cyclooxygenase Inhibition and Acetyl- l -Carnitine Administration
Pop‐Busui, R., Marinescu, V., Huysen, C. V., Li, F. Y., Sullivan, K., Greene, D. A., Larkin, D. D., & Stevens, M. J. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2619 · Cited by 107
Self-citation
Diabetes-induced endothelial dysfunction in streptozotocin-treated rats
Dai, F. X., Diederich, A., Skopec, J., & Diederich, D. A. (1993) · Journal of the American Society of Nephrology · doi:10.1681/asn.v461327 · Cited by 106
Neural Dysfunction and Metabolic Imbalances in Diabetic Rats: Prevention by Acetyl- L -Carnitine
Ido, Y., McHowat, J., Chang, K. C., et al. (1994) · Diabetes · doi:10.2337/diab.43.12.1469 · Cited by 103
Metabolism of Fructose-3-phosphate in the Diabetic Rat Lens
Lal, S., Szwergold, B. S., Taylor, A. H., Randall, W. C., Kappler, F. E., Wells‐Knecht, K. J., Baynes, J., & Brown, T. R. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1220 · Cited by 102
High glucose-induced activation of protein kinase signaling pathways in vascular smooth muscle cells: A potential role in the pathogenesis of vascular dysfunction in diabetes (Review)
Srivastava, A. K. (2002) · International Journal of Molecular Medicine · doi:10.3892/ijmm.9.1.85 · Cited by 101
Oxidative degradation of glucose adducts to protein. Formation of 3-(N epsilon-lysino)-lactic acid from model compounds and glycated proteins.
Ahmed, M., Dunn, J. A., Walla, M. D., Thorpe, S. R., & Baynes, J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68379-6 · Cited by 100
Neurotrophic Factors and Diabetic Peripheral Neuropathy
Apfel, S. C. (1999) · European Neurology · doi:10.1159/000052077 · Cited by 98
Osmoregulation by slow changes in aldose reductase and rapid changes in sorbitol flux
Bagnasco, S. M., Murphy, H. R., Bedford, J. J., & Burg, M. B. (1988) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1988.254.6.c788 · Cited by 98
Transgenic mice overexpressing aldose reductase in Schwann cells show more severe nerve conduction velocity deficit and oxidative stress under hyperglycemic stress
Song, Z. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00096-4 · Cited by 95
Role of oxygen derived radicals for vascular dysfunction in the diabetic heart: Prevention by α-tocopherol?
Rosen, P., Du, X., & Tschöpe, D. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006876607566 · Cited by 93
Timolol Treatment After Myocardial Infarction in Diabetic Patients
GUNDERSEN, T., & KJEKSHUS, J. K. (1983) · Diabetes Care · doi:10.2337/diacare.6.3.285 · Cited by 91
Insulin-Like Growth Factor (IGF) Gene Expression Is Reduced in Neural Tissues and Liver from Rats with Non-Insulin-Dependent Diabetes Mellitus, and IGF Treatment Ameliorates Diabetic Neuropathy
Zhuang, H.-X., Wuarin, L., Fei, Z., & Ishii, D. N. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37002-8 · Cited by 90
Depletion of Taurine in Experimental Diabetic Neuropathy: Implications for Nerve Metabolic, Vascular, and Functional Deficits
Pop‐Busui, R., Sullivan, K. A., Huysen, C. V., Bayer, L., Cao, X., Towns, R., & Stevens, M. J. (2001) · Experimental Neurology · doi:10.1006/exnr.2000.7591 · Cited by 89
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Mitochondrial Nitric Oxide Synthase, Oxidative Stress and Apoptosis
Ghafourifar, P., Bringold, U., Klein, S. D., & Richter, C. (2001) · Neurosignals · doi:10.1159/000046875 · Cited by 89
Mitochondrial dysfunction and death in motor neurons exposed to the glutathione-depleting agent ethacrynic acid
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Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy
Sloan, G., Selvarajah, D., & Tesfaye, S. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00496-z · Cited by 534
Mechanism of diabetic neuropathy: Where are we now and where to go?
Yagihashi, S., Mizukami, H., & Sugimoto, K. (2011) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2010.00070.x · Cited by 488
Glucose time in range and peripheral neuropathy in type 2 diabetes mellitus and chronic kidney disease
Mayeda, L., Katz, R., Ahmad, I., Bansal, N., Batacchi, Z., Hirsch, I. B., Robinson, N., Trence, D. L., Zelnick, L., & de Boer, I. H. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000991 · Cited by 162
Prevalence of diabetic peripheral neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohort
Pop‐Busui, R., Lu, J., Lopes, N., & Jones, T. L. Z. (2009) · Journal of the Peripheral Nervous System · doi:10.1111/j.1529-8027.2009.00200.x · Cited by 133
Self-citation
Peripheral Vascular Disease and Peripheral Neuropathy in Individuals With Cardiometabolic Clustering and Obesity
Ylitalo, K. R., Sowers, M., & Heeringa, S. (2011) · Diabetes Care · doi:10.2337/dc10-2150 · Cited by 85

See all 286

Authors: Pop-Busui, R., Sima, A., & Stevens, M.
Venue: Diabetes/Metabolism Research and Reviews
Publisher: Wiley
Published: 2006
Volume: 22
Issue: 4
Pages: 257-273
ISSN: 1520-7552 (ISSN-L)
1520-7560
DOI: 10.1002/dmrr.625
OpenAlex: W2091906768
Cited by: 286
References: 254
FWCI: 10.78
Type: journal article
Language: en
Open access: bronze

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Diabetic neuropathy and oxidative stress

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