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The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods
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The Netherlands Study of Depression and Anxiety (NESDA) is a multi‐site naturalistic cohort study to: (1) describe the long‐term course and consequences of depressive and anxiety disorders, and (2) to integrate biological and psychosocial research paradigms within an epidemiological approach in order to examine (interaction between) predictors of the long‐term course and consequences. Its design is an eight‐year longitudinal cohort study among 2981 participants aged 18 through 65 years. The sample consists of 1701 persons with a current (six‐month recency) diagnosis of depression and/or anxiety disorder, 907 persons with life‐time diagnoses or at risk because of a family history or subthreshold depressive or anxiety symptoms, and 373 healthy controls. Recruitment took place in the general population, in general practices (through a three‐stage screening procedure), and in mental health organizations in order to recruit persons reflecting various settings and developmental stages of psychopathology. During a four‐hour baseline assessment including written questionnaires, interviews, a medical examination, a cognitive computer task and collection of blood and saliva samples, extensive information was gathered about key (mental) health outcomes and demographic, psychosocial, clinical, biological and genetic determinants. Detailed assessments will be repeated after one, two, four and eight years of follow‐up. The findings of NESDA are expected to provide more detailed insight into (predictors of) the long‐term course of depressive and anxiety disorders in adults. Besides its scientific relevance, this may contribute to more effective prevention and treatment of depressive and anxiety disorders. Copyright © 2008 John Wiley & Sons, Ltd.
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Self-citationMuntingh, A. D., van der Feltz-Cornelis, C. M., van Marwijk, H. W., Spinhoven, P., Penninx, B. W., & van Balkom, A. J. (2011) · BMC Family Practice · doi:10.1186/1471-2296-12-66 · Cited by 147
Recurrence of anxiety disorders and its predictors
Scholten, W. D., Batelaan, N. M., van Balkom, A. J., WJH. Penninx, B., Smit, J. H., & van Oppen, P. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.10.031 · Cited by 146
Self-citationReasons and determinants for not receiving treatment for common mental disorders
van Beljouw, I., Verhaak, P., Prins, M., Cuijpers, P., Penninx, B., & Bensing, J. (2010) · Psychiatric Services · doi:10.1176/ps.2010.61.3.250 · Cited by 143
Self-citationConditional eQTL analysis reveals allelic heterogeneity of gene expression
Jansen, R., Hottenga, J.-J., Nivard, M. G., Abdellaoui, A., Laport, B., de Geus, E. J., Wright, F. A., Penninx, B. W. J. H., & Boomsma, D. I. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx043 · Cited by 141
van Beljouw, I. M., Verhaak, P. F., Cuijpers, P., van Marwijk, H. W., & Penninx, B. W. (2010) · BMC Psychiatry · doi:10.1186/1471-244x-10-86 · Cited by 128
Self-citationVogelzangs, N., Beekman, A. T., van Reedt Dortland, A. K., Schoevers, R. A., Giltay, E. J., de Jonge, P., & Penninx, B. W. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.9 · Cited by 133
Self-citationBus, B. A. A., Molendijk, M. L., Tendolkar, I., Penninx, B. W. J. H., Prickaerts, J., Elzinga, B. M., & Voshaar, R. C. O. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.83 · Cited by 133
Self-citationChildhood abuse in late-life depression
Comijs, H. C., van Exel, E., van der Mast, R. C., Paauw, A., Oude Voshaar, R., & Stek, M. L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.11.010 · Cited by 123
An integrative study of five biological clocks in somatic and mental health
Jansen, R., Han, L. K., Verhoeven, J. E., Aberg, K. A., van den Oord, E. C., Milaneschi, Y., & Penninx, B. W. (2021) · eLife · doi:10.7554/elife.59479 · Cited by 127
Self-citationDinga, R., Marquand, A. F., Veltman, D. J., Beekman, A. T. F., Schoevers, R. A., van Hemert, A. M., Penninx, B. W. J. H., & Schmaal, L. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0289-1 · Cited by 125
Self-citationScholten, W. D., Batelaan, N. M., Penninx, B. W. J. H., Balkom, A. J. L. M. V., Smit, J. H., Schoevers, R. A., & Oppen, P. V. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.02.025 · Cited by 125
Self-citationVerduijn, J., Verhoeven, J. E., Milaneschi, Y., Schoevers, R. A., van Hemert, A. M., Beekman, A. T. F., & Penninx, B. W. J. H. (2017) · BMC Medicine · doi:10.1186/s12916-017-0972-8 · Cited by 122
Self-citationSalivary cortisol levels and the 2-year course of depressive and anxiety disorders
Vreeburg, S. A., Hoogendijk, W. J. G., DeRijk, R. H., van Dyck, R., Smit, J. H., Zitman, F. G., & Penninx, B. W. J. H. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.12.017 · Cited by 121
Self-citationHovenkamp-Hermelink, J. H. M., Jeronimus, B. F., van der Veen, D. C., Spinhoven, P., Penninx, B. W. J. H., Schoevers, R. A., & Riese, H. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.04.005 · Cited by 116
Self-citationDrost, J., van der Does, W., van Hemert, A. M., Penninx, B. W. J. H., & Spinhoven, P. (2014) · Behaviour Research and Therapy · doi:10.1016/j.brat.2014.06.004 · Cited by 115
The 7-year course of depression and anxiety in the general population
Rhebergen, D., Batelaan, N. M., de Graaf, R., Nolen, W. A., Spijker, J., Beekman, A. T. F., & Penninx, B. W. J. H. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01677.x · Cited by 116
Self-citationPain, not chronic disease, is associated with the recurrence of depressive and anxiety disorders
Gerrits, M. M., van Oppen, P., Leone, S. S., van Marwijk, H. W., van der Horst, H. E., & Penninx, B. W. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-187 · Cited by 106
Self-citationVinkers, C. H., Kuzminskaite, E., Lamers, F., Giltay, E. J., & Penninx, B. W. J. H. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.01.051 · Cited by 113
Self-citationGlashouwer, K. A., & de Jong, P. J. (2010) · Psychological Medicine · doi:10.1017/s0033291709991371 · Cited by 111
van Tol, M.-J., Demenescu, L. R., van der Wee, N. J. A., Kortekaas, R., Marjan M.A., N., Boer, J. A. D., Renken, R. J., van Buchem, M. A., Zitman, F. G., Aleman, A., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.016 · Cited by 105
Self-citationten Have, M., de Graaf, R., van Dorsselaer, S., Tuithof, M., Kleinjan, M., & Penninx, B. W. J. H. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12874 · Cited by 106
Self-citationDepression, anxiety, and arterial stiffness
Seldenrijk, A., van Hout, H. P. J., van Marwijk, H. W. J., de Groot, E., Gort, J., Rustemeijer, C., Diamant, M., & Penninx, B. W. J. H. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.034 · Cited by 101
Self-citationQuak, J., Doornbos, B., Roest, A. M., Duivis, H. E., Vogelzangs, N., Nolen, W. A., Penninx, B. W. J. H., Kema, I. P., & de Jonge, P. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.03.013 · Cited by 98
Self-citationHardeveld, F., Spijker, J., De Graaf, R., Hendriks, S. M., Licht, C. M. M., Nolen, W. A., Penninx, B. W. J. H., & Beekman, A. T. F. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.11.008 · Cited by 95
Self-citationBekhuis, E., Schoevers, R. A., van Borkulo, C. D., Rosmalen, J. G. M., & Boschloo, L. (2016) · Psychological Medicine · doi:10.1017/s0033291716001550 · Cited by 89
Gaspersz, R., Lamers, F., Kent, J. M., Beekman, A. T. F., Smit, J. H., van Hemert, A. M., Schoevers, R. A., & Penninx, B. W. J. H. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.09.018 · Cited by 88
Self-citationvan Veen, T., Wardenaar, K. J., Carlier, I. V. E., Spinhoven, P., Penninx, B. W. J. H., & Zitman, F. G. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.09.011 · Cited by 88
Self-citationPeyrot, W. J., Lee, S. H., Milaneschi, Y., Abdellaoui, A., Byrne, E. M., Esko, T., de Geus, E. J. C., Hemani, G., Hottenga, J. J., Kloiber, S., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.50 · Cited by 84
Self-citationSpinhoven, P., Penninx, B. W., Krempeniou, A., van Hemert, A. M., & Elzinga, B. (2015) · Behaviour Research and Therapy · doi:10.1016/j.brat.2015.06.004 · Cited by 84
Self-citationDemenescu, L. R., Kortekaas, R., Cremers, H. R., Renken, R. J., van Tol, M. J., van der Wee, N. J. A., Veltman, D. J., den Boer, J. A., Roelofs, K., & Aleman, A. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.03.020 · Cited by 79
Metadata
- Authors
- Penninx, B. W. J. H., Beekman, A. T. F., Smit, J. H., Zitman, F. G., Nolen, W. A., Spinhoven, P., Cuijpers, P., De Jong, P. J., Van Marwijk, H. W. J., Assendelft, W. J. J., Van Der Meer, K., Verhaak, P., Wensing, M., De Graaf, R., Hoogendijk, W. J., Ormel, J., & Van Dyck, R.
- Venue
- International Journal of Methods in Psychiatric Research
- Publisher
- Wiley
- Published
- 2008-09
- Volume
- 17
- Issue
- 3
- Pages
- 121-140
- ISSN
- 1049-8931 (ISSN-L)
- 1557-0657
- OpenAlex
- W2124084192
- Cited by
- 927
- References
- 132
- FWCI
- 62.55
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
