Arzneimittelforschung: Erstanwendung am Menschen in der Phase I

Nitric oxide signalling and antidepressant action revisited

Joca, S. R. L., Sartim, A. G., Roncalho, A. L., Diniz, C. F. A., & Wegener, G. (2019) · Cell and Tissue Research · doi:10.1007/s00441-018-02987-4 · Cited by 63

Adverse Reactions and Interactions with H2-Receptor Antagonists

Pension, J., & Wormsley, K. G. (1986) · Medical Toxicology · doi:10.1007/bf03259837 · Cited by 63

Renin–angiotensin system research: from molecules to the whole body

Takimoto-Ohnishi, E., & Murakami, K. (2019) · The Journal of Physiological Sciences · doi:10.1007/s12576-019-00679-4 · Cited by 62

Bisphenol A exposure pathways in early childhood: Reviewing the need for improved risk assessment models

Healy, B. F., English, K. R., Jagals, P., & Sly, P. D. (2015) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2015.49 · Cited by 59

Pharmaco-radiology in barium examinations with special reference to glucagon

Kreel, L. (1975) · The British Journal of Radiology · doi:10.1259/0007-1285-48-573-691 · Cited by 57

Toxicology of dimethyl and monomethyl derivatives of acetamide and formamide: a second update

Kennedy, G. L. (2012) · Critical Reviews in Toxicology · doi:10.3109/10408444.2012.725028 · Cited by 56

Guidelines for the treatment of Alzheimer’s disease from the Italian Association of Psychogeriatrics

Caltagirone, C., Bianchetti, A., Luca, M. D., Mecocci, P., Padovani, A., Pirfo, E., Scapicchio, P., Senin, U., Trabucchi, M., & Musicco, M. (2005) · Drugs & Aging · doi:10.2165/00002512-200522001-00002 · Cited by 55

Insights into the clinical management of the syndrome of supine hypertension–orthostatic hypotension (SH-OH): the Irish Longitudinal Study on Ageing (TILDA)

Romero-Ortuno, R., O’Connell, M. D., Finucane, C., Soraghan, C., Fan, C. W., & Kenny, R. A. (2013) · BMC Geriatrics · doi:10.1186/1471-2318-13-73 · Cited by 54

Antioxidant and Anti-Inflammatory Properties of an Aqueous Cyanophyta Extract Derived from Arthrospira Platensis : Contribution to Bioactivities by the Non-Phycocyanin Aqueous Fraction

Jensen, G. S., Attridge, V. L., Beaman, J. L., Guthrie, J., Ehmann, A., & Benson, K. F. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.0083 · Cited by 53

Oral L-thyroxine liquid versus tablet in patients with hypothyroidism without malabsorption: a prospective study

Fallahi, P., Ferrari, S. M., & Antonelli, A. (2016) · Endocrine · doi:10.1007/s12020-015-0836-y · Cited by 53

Antihypertensive and antioxidant effects of a single daily dose of sodium nitrite in a model of renovascular hypertension

Montenegro, M. F., Pinheiro, L. C., Amaral, J. H., Marçal, D. M. O., Palei, A. C. T., Costa-Filho, A. J., & Tanus-Santos, J. E. (2012) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-011-0712-0 · Cited by 52

Pharmacological Management of Allergic Rhinitis in the Elderly

Bozek, A. (2017) · Drugs & Aging · doi:10.1007/s40266-016-0425-7 · Cited by 48

LDL-cholesterol-lowering effect of a dietary supplement with plant extracts in subjects with moderate hypercholesterolemia

Ogier, N., Amiot, M.-J., Georgé, S., Maillot, M., Mallmann, C., Maraninchi, M., Morange, S., Lescuyer, J.-F., Peltier, S. L., & Cardinault, N. (2013) · European Journal of Nutrition · doi:10.1007/s00394-012-0357-x · Cited by 49

Efficacy of berberine alone and in combination for the treatment of hyperlipidemia: A systematic review

Koppen, L. M., Whitaker, A., Rosene, A., & Beckett, R. D. (2017) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/2156587216687695 · Cited by 47

Anxiolytics targeting GABA A receptors: Insights on etifoxine

Poisbeau, P., Gazzo, G., & Calvel, L. (2018) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2018.1468030 · Cited by 47

Dermocosmetics: beneficial adjuncts in the treatment of acne vulgaris

Araviiskaia, E., Lopez Estebaranz, J. L., & Pincelli, C. (2021) · Journal of Dermatological Treatment · doi:10.1080/09546634.2019.1628173 · Cited by 47

Reversible normalisation of serum TSH levels in patients with autoimmune atrophic gastritis who received L-T4 in tablet form after switching to an oral liquid formulation: a case series

Fallahi, P., Ferrari, S. M., Ruffilli, I., & Antonelli, A. (2016) · BMC Gastroenterology · doi:10.1186/s12876-016-0439-y · Cited by 46

Effect of Curcumin on Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress in Rats

Kumar, A., Naidu, P. S., Seghal, N., & Padi, S. S. V. (2007) · Journal of Medicinal Food · doi:10.1089/jmf.2006.076 · Cited by 45

Interferon-β1bin multiple sclerosis

Buttmann, M., & Rieckmann, P. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.3.227 · Cited by 43

Nerve Protective Effect of Asiaticoside against Ischemia-Hypoxia in Cultured Rat Cortex Neurons

Sun, T., Liu, B., & Li, P. (2015) · Medical Science Monitor · doi:10.12659/msm.894024 · Cited by 42

The Pharmacokinetics and Analgesic Efficacy of Larger Dose Rectal Acetaminophen (40 mg/kg) in Adults: A Double-Blinded, Randomized Study

Beck, D. H., Schenk, M. R., Hagemann, K., Doepfmer, U. R., & Kox, W. J. (2000) · Anesthesia & Analgesia · doi:10.1213/00000539-200002000-00035 · Cited by 65

ROSSO-in-praxi-international: long-term effects of self-monitoring of blood glucose on glucometabolic control in patients with type 2 diabetes mellitus not treated with insulin

Kempf, K., Tankova, T., & Martin, S. (2013) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2012.0213 · Cited by 40

Sleep in a sitting position: effect of triazolam on sleep stages and EEG power spectra

Aeschbach, D., Cajochen, C., Tobler, I., Dijk, D.-J., & Borbély, A. A. (1994) · Psychopharmacology · doi:10.1007/bf02244838 · Cited by 40

Effects of streptozotocin-induced diabetes in domestic pigs with focus on the amino acid metabolism

Jensen-Waern, M., Andersson, M., Kruse, R., Nilsson, B., Larsson, R., Korsgren, O., & Essén-Gustavsson, B. (2009) · Laboratory Animals · doi:10.1258/la.2008.008069 · Cited by 39

Effects of Miglitol, Acarbose, and Sitagliptin on Plasma Insulin and Gut Peptides in Type 2 Diabetes Mellitus: A Crossover Study

Ueno, H., Tsuchimochi, W., Wang, H.-W., Yamashita, E., Tsubouchi, C., Nagamine, K., Sakoda, H., & Nakazato, M. (2015) · Diabetes Therapy · doi:10.1007/s13300-015-0113-3 · Cited by 38

HPLC Determination of Letrozole in Plasma Using Fluorescence Detection: Application to Pharmacokinetic Studies

Zarghi, A., Foroutan, S. M., Shafaati, A., & Khoddam, A. (2007) · Chromatographia · doi:10.1365/s10337-007-0381-9 · Cited by 38

Iron Chelators with Topoisomerase-Inhibitory Activity and Their Anticancer Applications

Rao, V. A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4877 · Cited by 37

The use of glutamine synthetase as a selection marker: recent advances in Chinese hamster ovary cell line generation processes

Fan, L., Frye, C. C., & Racher, A. J. (2013) · Pharmaceutical Bioprocessing · doi:10.4155/pbp.13.56 · Cited by 35

Effects of isradipine on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition

Johnson, B. A., Roache, J. D., Ait-Daoud, N., Wallace, C., Wells, L. T., & Wang, Y. (2005) · Psychopharmacology · doi:10.1007/s00213-004-1998-0 · Cited by 33

Quantitation of small intestinal permeability during normal human drug absorption

Levitt, D. G. (2013) · BMC Pharmacology and Toxicology · doi:10.1186/2050-6511-14-34 · Cited by 32

Effect on LDL-cholesterol of a large dose of a dietary supplement with plant extracts in subjects with untreated moderate hypercholesterolaemia: a randomised, double-blind, placebo-controlled study

Barrat, E., Zaïr, Y., Sirvent, P., Chauveau, P., Maudet, C., Housez, B., Derbord, E., Lescuyer, J.-F., Bard, J.-M., Cazaubiel, M., et al. (2013) · European Journal of Nutrition · doi:10.1007/s00394-012-0486-2 · Cited by 31

Anxiety Disorder-Specific Predictors of Treatment Outcome in the Coordinated Anxiety Learning and Management (CALM) Trial

Jakubovski, E., & Bloch, M. H. (2016) · Psychiatric Quarterly · doi:10.1007/s11126-015-9399-6 · Cited by 31

Effects of a single dose of orally administered gabapentin in dogs during a veterinary visit: a double-blinded, placebo-controlled study

Stollar, O. O., Moore, G. E., Mukhopadhyay, A., Gwin, W., & Ogata, N. (2022) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.21.03.0167 · Cited by 31

Effects of miglitol, an α-glucosidase inhibitor, on glycaemic status and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats

Goda, T., Suruga, K., Komori, A., Kuranuki, S., Mochizuki, K., Makita, Y., & Kumazawa, T. (2007) · British Journal of Nutrition · doi:10.1017/s0007114507742678 · Cited by 30

Efficacy, acceptability and cost effectiveness of four therapeutic agents for treatment of scabies.

Abdel-Raheem, T. A., Méabed, E. M. H., Nasef, G. A., Abdel Wahed, W. Y., & Rohaim, R. M. A. (2016) · Journal of Dermatological Treatment · doi:10.3109/09546634.2016.1151855 · Cited by 30

Novel pharmacotherapy for fibromyalgia

Wood, P. B., Holman, A. J., & Jones, K. D. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.6.829 · Cited by 30

Malfunction of Vascular Control in Lifestyle-Related Diseases: Formation of Systemic Hemoglobin-Nitric Oxide Complex (HbNO) From Dietary Nitrite

Tsuchiya, K., Takiguchi, Y., Okamoto, M., Izawa, Y., Kanematsu, Y., Yoshizumi, M., & Tamaki, T. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fmj04006x3 · Cited by 29

Rat Brain-Uptake Index for Phenylethylamine and Various Monomethylated Derivatives

Mosnaim, A. D., Callaghan, O. H., Hudzik, T., & Wolf, M. E. (2013) · Neurochemical Research · doi:10.1007/s11064-013-0988-1 · Cited by 24

CombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts

Huang, L., Wang, J., Fang, B., Meric-Bernstam, F., Roth, J. A., & Ha, M. J. (2022) · Scientific Reports · doi:10.1038/s41598-022-16933-6 · Cited by 21

In Vitro to in Vivo Extrapolation and Physiologically Based Modeling of Cytochrome P450 Mediated Metabolism in Beagle Dog Gut Wall and Liver

Heikkinen, A. T., Fowler, S., Gray, L., Li, J., Peng, Y., Yadava, P., Railkar, A., & Parrott, N. (2013) · Molecular Pharmaceutics · doi:10.1021/mp300692k · Cited by 20

An investigation into the influence of experimental conditions on in vitro drug release from immediate-release tablets of levothyroxine sodium and its relation to oral bioavailability

Kocic, I., Homsek, I., Dacevic, M., Parojcic, J., & Miljkovic, B. (2011) · AAPS PharmSciTech · doi:10.1208/s12249-011-9660-8 · Cited by 19

Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in Candida Albicans

Zhen, C., Wang, L., Feng, Y., Whiteway, M., Hang, S., Yu, J., Lu, H., & Jiang, Y. (2024) · Advanced Science · doi:10.1002/advs.202406473 · Cited by 16

Efficacy of mistletoe extract as a complement to standard treatment in advanced pancreatic cancer: study protocol for a multicentre, parallel group, double-blind, randomised, placebo-controlled clinical trial (MISTRAL)

Wode, K., Hök Nordberg, J., Kienle, G. S., Elander, N. O., Bernhardson, B.-M., Sunde, B., Sharp, L., Henriksson, R., & Fransson, P. (2020) · Trials · doi:10.1186/s13063-020-04581-y · Cited by 16

Proteomic studies of micronutrient deficiency and toxicity

Ali, A., Bhat, B. A., Rather, G. A., Malla, B. A., & Ganie, S. A. (2020) · Plant Micronutrients · doi:10.1007/978-3-030-49856-6_11 · Cited by 15

Energy Drink before Exercise Did Not Affect Autonomic Recovery Following Moderate Aerobic Exercise: A Crossover, Randomized and Controlled Trial

Porto, A. A., Valenti, V. E., Tonon do Amaral, J. A., Benjamim, C. J. R., Garner, D. M., & Ferreira, C. (2021) · Journal of the American College of Nutrition · doi:10.1080/07315724.2020.1768175 · Cited by 13

Immunological Effects of Probiotics and their Significance to Human Health

Gill, H. S., Grover, S., Batish, V. K., & Gill, P. (2009) · Prebiotics and Probiotics Science and Technology · doi:10.1007/978-0-387-79058-9_23 · Cited by 13

A current perspective into young female sex hormone replacement: a review

Giordano Imbroll, M., & Gruppetta, M. (2020) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2020.1816820 · Cited by 7

Are there links between Alzheimer’s disease and ADHD? The efficacy of acetylcholinesterase inhibitors and NMDA receptor antagonists in controlling ADHD symptoms: A systematic review

Abdi Dezfouli, R., Akbariforoud, S., & Esmaeilidezfouli, E. (2024) · Middle East Current Psychiatry · doi:10.1186/s43045-024-00405-w · Cited by 4

Pathophysiology of Obesity-Related Non-communicable Chronic Diseases and Advancements in Preventive Strategies

Badhwar, R., Kaur, G., Popli, H., Yadav, D., & Buttar, H. S. (2020) · Pathophysiology of Obesity-Induced Health Complications · doi:10.1007/978-3-030-35358-2_19 · Cited by 3

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Graham (1998) · doi:10.1002/(sici)1096-9926(199811)58:5<209::aid-tera8>3.0.co;2-q

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Nagano (1999) · doi:10.1002/(sici)1522-7243(199911/12)14:6<283::aid-bio572>3.0.co;2-g