Strategies for the use of Extracellular Vesicles for the Delivery of Therapeutics

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099

Extracellular vesicles: Exosomes, microvesicles, and friends

Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186

Biological properties of extracellular vesicles and their physiological functions

Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926

Exosomes: composition, biogenesis and function

Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature reviews. Immunology · doi:10.1038/nri855 · Cited by 5,478

Tumour exosome integrins determine organotropic metastasis

Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930

Membrane vesicles as conveyors of immune responses

Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,996

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715

Extracellular vesicles: biology and emerging therapeutic opportunities

EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,571

Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)

Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48095-7 · Cited by 2,931

Exosomes

Pegtel, D. M., & Gould, S. J. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111902 · Cited by 2,682

The Scientific World Journal

(2012) · The Scientific World JOURNAL · doi:10.1100/tswj · Cited by 2,600

Exosomes: Extracellular organelles important in intercellular communication

Mathivanan, S., Ji, H. L., & Simpson, R. J. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.06.006 · Cited by 2,581

Progress and challenges towards targeted delivery of cancer therapeutics

Rosenblum, D., Joshi, N., Tao, W., Karp, J. M., & Peer, D. (2018) · Nature Communications · doi:10.1038/s41467-018-03705-y · Cited by 2,220

Exosomes as drug delivery vehicles for Parkinson’s disease therapy

Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., Patel, T., Piroyan, A., Sokolsky, M., Kabanov, A. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.033 · Cited by 2,009

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

Becker, A., Thakur, B. K., Weiss, J. M., Kim, H. S., Peinado, H., & Lyden, D. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.009 · Cited by 2,003

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

Vlassov, A. V., Magdaleno, S. M., Setterquist, R. A., & Conrad, R. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.03.017 · Cited by 1,984

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

Tian, Y., Li, S., Song, J., Ji, T., Zhu, M., Anderson, G. J., Wei, J., & Nie, G. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.083 · Cited by 1,841

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Wiklander, O. P. B., Nordin, J. Z., O'Loughlin, A., Gustafsson, Y., Corso, G., Mäger, I., Vader, P., Lee, Y., Sork, H., Seow, Y., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26316 · Cited by 1,730

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

Ohno, S.-I., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A., Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2012.180 · Cited by 1,666

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W. E., Miller, D., & Zhang, H. (2010) · Molecular Therapy · doi:10.1038/mt.2010.105 · Cited by 1,579

Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper

Lener, T., Gimona, M., Aigner, L., Börger, V., Buzas, E., Camussi, G., Chaput, N., Chatterjee, D., Court, F. A., del Portillo, H. A., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.30087 · Cited by 1,491

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Kim, M. S., Haney, M. J., Zhao, Y., Mahajan, V., Deygen, I., Klyachko, N. L., Inskoe, E., Piroyan, A., Sokolsky, M., Okolie, O., et al. (2016) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2015.10.012 · Cited by 1,410

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R. C., Ju, S., Mu, J., Zhang, L., Steinman, L., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.164 · Cited by 1,356

Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

Zaborowski, M. P., Balaj, L., Breakefield, X. O., & Lai, C. P. (2015) · BioScience · doi:10.1093/biosci/biv084 · Cited by 1,336

Isolation of Extracellular Vesicles: General Methodologies and Latest Trends

Konoshenko, M. Y., Lekchnov, E. A., Vlassov, A. V., & Laktionov, P. P. (2018) · BioMed Research International · doi:10.1155/2018/8545347 · Cited by 1,302

Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

Escudier, B. J., Dorval, T., Chaput, N., André, F., Caby, M.-P., Novault, S., Flament, C., Leboulaire, C., Borg, C., Amigorena, S., et al. (2005) · Journal of Translational Medicine · doi:10.1186/1479-5876-3-10 · Cited by 1,285

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

Rani, S., Ryan, A. E., Griffin, M. D., & Ritter, T. (2015) · Molecular Therapy · doi:10.1038/mt.2015.44 · Cited by 1,251

Engineering exosomes as refined biological nanoplatforms for drug delivery

Luan, X., Sansanaphongpricha, K., Myers, I., Chen, H., Yuan, H., & Sun, D. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.12 · Cited by 1,196

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

Arslan, F., Lai, R. C., Smeets, M. B., Akeroyd, L., Choo, A. B. H., Aguor, E. N. E., Timmers, L., van Rijen, H. V. M., Doevendans, P. A., Pasterkamp, G., et al. (2013) · Stem Cell Research · doi:10.1016/j.scr.2013.01.002 · Cited by 1,137

A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

Morse, M. A., Garst, J. L., Osada, T., Khan, S., Hobeika, A. C., Clay, T. M., Valente, N., Shreeniwas, R., Sutton, M. A., Delcayre, A. X., et al. (2005) · Journal of Translational Medicine · doi:10.1186/1479-5876-3-9 · Cited by 1,123

Exosomes: proteomic insights and diagnostic potential

Simpson, R. J., Lim, J. W., Moritz, R. L., & Mathivanan, S. (2009) · Expert Review of Proteomics · doi:10.1586/epr.09.17 · Cited by 1,119

ExoCarta 2012: database of exosomal proteins, RNA and lipids

Mathivanan, S., Fahner, C. J., Reid, G. E., & Simpson, R. J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr828 · Cited by 1,096

Exfoliation of membrane ecto-enzymes in the form of micro-vesicles

Trams, E. G., Lauter, C. J., Salem, N., & Heine, U. (1981) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(81)90512-5 · Cited by 1,094

Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells

Morelli, A. E., Larregina, A. T., Shufesky, W. J., Sullivan, M. L. G., Stolz, D. B., Papworth, G. D., Zahorchak, A. F., Logar, A., Wang, Z., Watkins, S. C., et al. (2004) · Blood · doi:10.1182/blood-2004-03-0824 · Cited by 1,075

Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer

Zhang, M., Viennois, É., Prasad, M. A., Zhang, Y., Wang, L., Zhang, Z., Han, M. K., Xiao, B., Xu, C., Srinivasan, S., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.018 · Cited by 1,071

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

Jang, S. C., Kim, O. Y., Yoon, C. M., Choi, D., Roh, T., Park, J., Nilsson, J. A., Lötvall, J. O., Kim, Y., & Gho, Y. S. (2013) · ACS Nano · doi:10.1021/nn402232g · Cited by 1,037

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

Yang, T., Martin, P. B., Fogarty, B., Brown, A. H., Schurman, K., Phipps, R. J., Yin, V. P., Lockman, P. R., & Bai, S. (2015) · Pharmaceutical Research · doi:10.1007/s11095-014-1593-y · Cited by 980

Isolation of exosomes from whole blood by integrating acoustics and microfluidics

Wu, M., Ouyang, Y., Wang, Z., Zhang, R., Huang, P., Chen, C., Li, H., Li, P., Quinn, D., Dao, M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1709210114 · Cited by 974

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

Lai, C. P., Mardini, O., Ericsson, M., Prabhakar, S., Maguire, C. A., Chen, J. W., Tannous, B. A., & Breakefield, X. O. (2014) · ACS Nano · doi:10.1021/nn404945r · Cited by 915

Focus on Extracellular Vesicles: Introducing the Next Small Big Thing

Kalra, H., Drummen, G. P. C., & Mathivanan, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020170 · Cited by 906

Extracellular vesicle isolation and characterization: toward clinical application

Xu, R., Greening, D. W., Zhu, H., Takahashi, N., & Simpson, R. J. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81129 · Cited by 893

Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

Ju, S., Mu, J., Dokland, T., Zhuang, X., Wang, Q., Jiang, H., Xiang, X., Deng, Z., Wang, B., Zhang, L., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.64 · Cited by 889

Exosomes: endosomal-derived vesicles shipping extracellular messages

Février, B., & Raposo, G. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.06.003 · Cited by 881

As we wait: coping with an imperfect nomenclature for extracellular vesicles

Gould, S. J., & Raposo, G. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20389 · Cited by 864

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

Pascucci, L., Coccè, V., Bonomi, A., Ami, D., Ceccarelli, P., Ciusani, E., Viganò, L., Locatelli, A., Sisto, F., Doglia, S. M., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.07.042 · Cited by 846

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy

Ibrahim, A., Cheng, K., & Marbán, E. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.04.006 · Cited by 836

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

Dai, S., Wei, D., Wu, Z., Zhou, X., Wei, X., Huang, H., & Li, G. (2008) · Molecular Therapy · doi:10.1038/mt.2008.1 · Cited by 805

Molecular lipidomics of exosomes released by PC-3 prostate cancer cells

Llorente, A., Skotland, T., Sylvänne, T., Kauhanen, D., Róg, T., Orłowski, A., Vattulainen, I., Ekroos, K., & Sandvig, K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.04.011 · Cited by 804

Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension

Lee, C., Mitsialis, S. A., Aslam, M., Vitali, S. H., Vergadi, E., Konstantinou, G., Sdrimas, K., Fernandez‐Gonzalez, A., & Kourembanas, S. (2012) · Circulation · doi:10.1161/circulationaha.112.114173 · Cited by 795

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

Doeppner, T. R., Herz, J., Görgens, A., Schlechter, J., Ludwig, A., Radtke, S., de Miroschedji, K., Horn, P. A., Giebel, B., & Hermann, D. M. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0078 · Cited by 789

Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer

Janowska‐Wieczorek, A., Wysoczynski, M., Kijowski, J., Marquez‐Curtis, L. A., Machaliński, B., Ratajczak, J., & Ratajczak, M. Z. (2004) · International Journal of Cancer · doi:10.1002/ijc.20657 · Cited by 781

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

Fuhrmann, G., Serio, A., Mazo, M. M., Nair, R., & Stevens, M. M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.11.029 · Cited by 770

Exosome Function: From Tumor Immunology to Pathogen Biology

Schorey, J. S., & Bhatnagar, S. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00734.x · Cited by 766

Embryonic Stem Cell–Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction

Khan, M., Nickoloff, E., Abramova, T. V., Johnson, J. A., Verma, S. K., Krishnamurthy, P., Mackie, A. R., Vaughan, E. E., Garikipati, V. N. S., Benedict, C., et al. (2015) · Circulation Research · doi:10.1161/circresaha.117.305990 · Cited by 754

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

Besse, B., Charrier, M., Lapierre, V., Dansin, E., Lantz, O., Planchard, D., Le Chevalier, T., Livartoski, A., Barlesi, F., Laplanche, A., et al. (2016) · OncoImmunology · doi:10.1080/2162402x.2015.1071008 · Cited by 749

Engineering hybrid exosomes by membrane fusion with liposomes

Sato, Y. T., Umezaki, K., Sawada, S., Mukai, S.-A., Sasaki, Y., Harada, N., Shiku, H., & Akiyoshi, K. (2016) · Scientific Reports · doi:10.1038/srep21933 · Cited by 744

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

Takahashi, Y., Nishikawa, M., Shinotsuka, H., Matsui, Y., Ohara, S., Imai, T., & Takakura, Y. (2013) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2013.03.013 · Cited by 743

Biodistribution and delivery efficiency of unmodified tumor-derived exosomes

Smyth, T., Kullberg, M., Malik, N., Smith-Jones, P. M., Graner, M. W., & Anchordoquy, T. J. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.013 · Cited by 738

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

Wahlgren, J., Karlson, T. D. L., Brisslert, M., Sani, F. V., Telemo, E., Sunnerhagen, P., & Valadi, H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks463 · Cited by 727

A pathogenic picornavirus acquires an envelope by hijacking cellular membranes

Feng, Z., Hensley, L., McKnight, K. L., Hu, F., Madden, V. J., Ping, L., Jeong, S., Walker, C. M., Lanford, R. E., & Lemon, S. M. (2013) · Nature · doi:10.1038/nature12029 · Cited by 712

A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy

Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.005 · Cited by 704

Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts

Hu, L., Wang, J., Zhou, X., Xiong, Z., Zhao, J., Yu, R., Huang, F., Zhang, H., & Chen, L. (2016) · Scientific Reports · doi:10.1038/srep32993 · Cited by 693

Intercellular communication: diverse structures for exchange of genetic information

Mittelbrunn, M., & Sánchez‐Madrid, F. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3335 · Cited by 687

Extracellular Vesicles in Angiogenesis

Todorova, D., Simoncini, S., Lacroix, R., Sabatier, F., & Dignat‐George, F. (2017) · Circulation Research · doi:10.1161/circresaha.117.309681 · Cited by 667

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: In vitro and in vivo evaluations

Kim, M. S., Haney, M. J., Zhao, Y., Yuan, D., Deygen, I., Klyachko, N. L., Kabanov, A. V., & Batrakova, E. V. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.09.011 · Cited by 663

Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro

Zhou, Y., Xu, H., Xu, W., Wang, B., Wu, H., Tao, Y., Zhang, B., Wang, M., Mao, F., Yan, Y., et al. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt194 · Cited by 656

Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization

Laulagnier, K., Motta, C., Hamdi, S. M., Sébastien, R. O. Y., Fauvelle, F., Pageaux, J., Kobayashi, T., Salles, J., Perret, B., Bonnerot, C., et al. (2004) · Biochemical Journal · doi:10.1042/bj20031594 · Cited by 651

Isolation, cultivation, and characterization of human mesenchymal stem cells

Mushahary, D., Spittler, A., Kasper, C., Weber, V., & Charwat, V. (2017) · Cytometry Part A · doi:10.1002/cyto.a.23242 · Cited by 633

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

Antimisiaris, S. G., Mourtas, S., & Marazioti, A. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10040218 · Cited by 631

Ginger‐derived nanoparticles protect against alcohol‐induced liver damage

Zhuang, X., Deng, Z., Mu, J., Zhang, L., Yan, J., Miller, D. M., Feng, W., McClain, C. J., & Zhang, H. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.28713 · Cited by 628

Recent advancements in the use of exosomes as drug delivery systems

Bunggulawa, E. J., Wang, W., Yin, T., Wang, N., Durkan, C., Wang, Y., & Wang, G. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0403-9 · Cited by 608

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

Antimisiaris, S. G., Mourtas, S., & Marazioti, A. (2018) · doi:10.20944/preprints201810.0507.v1 · Cited by 605

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

Brites, D., & Fernandes, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00476 · Cited by 599 · cited 2×

Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery

Zhou, H., Yuen, P. S. T., Pisitkun, T., Gonzales, P. A., Yasuda, H., Dear, J. W., Gross, P., Knepper, M. A., & Star, R. A. (2006) · Kidney International · doi:10.1038/sj.ki.5000273 · Cited by 586

Exosomes: Novel Biomarkers for Clinical Diagnosis

Jin, L., Li, J., Huang, B., Liu, J., Chen, X., Chen, X., Xu, Y., Huang, L., & Wang, X. (2015) · The Scientific World JOURNAL · doi:10.1155/2015/657086 · Cited by 574

Surface Functionalization of Exosomes Using Click Chemistry

Smyth, T., Petrova, K., Payton, N. M., Persaud, I., Redzic, J. S., Graner, M. W., Smith-Jones, P., & Anchordoquy, T. J. (2014) · Bioconjugate Chemistry · doi:10.1021/bc500291r · Cited by 532

Exosome mimetics: a novel class of drug delivery systems

Schiffelers, R. M., Kooijmans, S. A. A., Vader, P., van Dommelen, & van Solinge, W. W. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s29661 · Cited by 531

Therapeutic Applications of Extracellular Vesicles: Clinical Promise and Open Questions

György, B., Hung, M. E., Breakefield, X. O., & Leonard, J. N. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124630 · Cited by 525

Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis

Cosenza, S., Toupet, K., Maumus, M., Luz‐Crawford, P., Blanc‐Brude, O., Jørgensen, C., & Noël, D. (2018) · Theranostics · doi:10.7150/thno.21072 · Cited by 506

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

Shtam, T. A., Kovalev, R. A., Varfolomeeva, E. Y., Makarov, E. M., Kil, Y. V., & Filatov, M. V. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-88 · Cited by 499

Electroporation: A general phenomenon for manipulating cells and tissues

Weaver, J. C. (1993) · Journal of Cellular Biochemistry · doi:10.1002/jcb.2400510407 · Cited by 491

Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase

Deng, Z., Rong, Y., Teng, Y., Mu, J., Zhuang, X., Tseng, M. T., Samykutty, A. K., Zhang, L., Yan, J., Miller, D. M., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.01.025 · Cited by 491

Exosome-mediated delivery of hydrophobically modified siRNA for huntingtin mRNA silencing

Didiot, M.-C., Hall, L. M., Coles, A. H., Haraszti, R. A., Godinho, B. M., Chase, K., Sapp, E., Ly, S., Alterman, J. F., Hassler, M. R., et al. (2016) · Molecular Therapy · doi:10.1038/mt.2016.126 · Cited by 483

Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

Fais, S., O’Driscoll, L., Borras, F. E., Buzas, E., Camussi, G., Cappello, F., Carvalho, J., Cordeiro da Silva, A., Del Portillo, H., El Andaloussi, S., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b08015 · Cited by 481

Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection

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Field-Free Isolation of Exosomes from Extracellular Vesicles by Microfluidic Viscoelastic Flows

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Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix

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Edible Ginger-derived Nano-lipids Loaded with Doxorubicin as a Novel Drug-delivery Approach for Colon Cancer Therapy

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Tissue-Engineered Bone Immobilized with Human Adipose Stem Cells-Derived Exosomes Promotes Bone Regeneration

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Exosomes: new molecular targets of diseases

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Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery

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Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

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Anticancer Drugs Cause Release of Exosomes with Heat Shock Proteins from Human Hepatocellular Carcinoma Cells That Elicit Effective Natural Killer Cell Antitumor Responses in Vitro

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Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus

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Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease

Huang‐Doran, I., Zhang, C., & Vidal‐Puig, A. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.10.003 · Cited by 387

Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice

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Efficient production and enhanced tumor delivery of engineered extracellular vesicles

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Exosomes Derived from IL-10-Treated Dendritic Cells Can Suppress Inflammation and Collagen-Induced Arthritis

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Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles

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Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

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Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging

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Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury

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Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles

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Dynamics of exosome internalization and trafficking

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Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication

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Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice

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Exosomes biological significance: A concise review

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Isolation and characterization of platelet-derived extracellular vesicles

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Maximizing exosome colloidal stability following electroporation

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Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses

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Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles

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Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten Pathways

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Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

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An integrated double-filtration microfluidic device for isolation, enrichment and quantification of urinary extracellular vesicles for detection of bladder cancer

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Permeabilization of Cell Membranes

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Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis

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Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats

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Exosomes derived from mature dendritic cells increase endothelial inflammation and atherosclerosis via membrane TNF ‐α mediated NF ‐κB pathway

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Exosomes from red blood cell units bind to monocytes and induce proinflammatory cytokines, boosting T-cell responses in vitro

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Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer’s disease

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Large-scale generation of cell-derived nanovesicles

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Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury

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Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis

Zhang, M., Xu, C., Liu, D., Han, M. K., Wang, L., & Merlin, D. (2017) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjx115 · Cited by 232

Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

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Exosomes Derived from Genetically Modified DC Expressing FasL Are Anti-inflammatory and Immunosuppressive

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RNAi delivery by exosome-mimetic nanovesicles – Implications for targeting c-Myc in cancer

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Exosomal formulation of anthocyanidins against multiple cancer types

Munagala, R., Aqil, F., Jeyabalan, J., Agrawal, A. K., Mudd, A. M., Kyakulaga, A. H., Singh, I. P., Vadhanam, M. V., & Gupta, R. C. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.02.004 · Cited by 224

BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis

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Evaluation of electroporation-induced adverse effects on adipose-derived stem cell exosomes

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Therapeutic Potential of Engineered Extracellular Vesicles

Mentkowski, K. I., Snitzer, J. D., Rusnak, S., & Lang, J. K. (2018) · The AAPS Journal · doi:10.1208/s12248-018-0211-z · Cited by 218

Extracellular vesicles from mesenchymal stem cells activates VEGF receptors and accelerates recovery of hindlimb ischemia

Gangadaran, P., Rajendran, R. L., Lee, H., Kalimuthu, S., Hong, C. M., Jeong, S. Y., Lee, S., Lee, J., & Ahn, B. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.08.022 · Cited by 216

Extracellular Microvesicles as New Industrial Therapeutic Frontiers

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Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity

Bryniarski, K., Ptak, W., Jayakumar, A., Püellmann, K., Caplan, M. J., Chairoungdua, A., Lü, J., Adams, B. D., Sikora, E., Nazimek, K., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.048 · Cited by 214

Exosomes Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells Stimulates Rejuvenation of Human Skin

Kim, Y.-J., Yoo, S. M., Park, H. H., Lim, H. J., Kim, Y.-L., Lee, S., Seo, K.-W., & Kang, K.-S. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.09.056 · Cited by 212

Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: a Cost-Effective Alternative

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Handling and storage of human body fluids for analysis of extracellular vesicles

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Release of Luminal Exosomes Contributes to TLR4-Mediated Epithelial Antimicrobial Defense

Hu, G., Gong, A.-Y., Roth, A. L., Huang, B. Q., Ward, H., Zhu, G., LaRusso, N. F., Hanson, N. D., & Chen, X. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003261 · Cited by 207

Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated Neuronal dysfunction

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Updated Technology to Produce Highly Immunogenic Dendritic Cell-derived Exosomes of Clinical Grade

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Magnetic resonance imaging of melanoma exosomes in lymph nodes

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Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity

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Nucleolin-targeted Extracellular Vesicles as a Versatile Platform for Biologics Delivery to Breast Cancer

Wang, Y., Chen, X., Tian, B., Liu, J., Yang, L., Zeng, L., Chen, T., Hong, A., & Wang, X. (2017) · Theranostics · doi:10.7150/thno.16532 · Cited by 198

TRAIL delivery by MSC‐derived extracellular vesicles is an effective anticancer therapy

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Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice

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Trigeminal Pathways Deliver a Low Molecular Weight Drug from the Nose to the Brain and Orofacial Structures

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Inflammation leads to distinct populations of extracellular vesicles from microglia

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Nanosomes carrying doxorubicin exhibit potent anticancer activity against human lung cancer cells

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Mesenchymal Stem Cell-Derived Exosomes Reduce A1 Astrocytes via Downregulation of Phosphorylated NFκB P65 Subunit in Spinal Cord Injury

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Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma

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Extracellular vesicles in diagnosis and therapy of kidney diseases

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Therapeutic biomaterials based on extracellular vesicles: classification of bio‐engineering and mimetic preparation routes

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Proteomic Analysis of C2C12 Myoblast and Myotube Exosome-Like Vesicles: A New Paradigm for Myoblast-Myotube Cross Talk?

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Asymmetric distribution of phospholipids in the membrane of vesicles released during in vitro maturation of guinea pig reticulocytes: Evidence precluding a role for “aminophospholipid translocase”

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Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice

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Toward characterizing extracellular vesicles at a single-particle level

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Integrating Protein Engineering and Bioorthogonal Click Conjugation for Extracellular Vesicle Modulation and Intracellular Delivery

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Exosomes carrying mycobacterial antigens can protect mice against M ycobacterium tuberculosis infection

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Biology and Role of Extracellular Vesicles (EVs) in the Pathogenesis of Thrombosis

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Cell-derived vesicles for drug therapy and diagnostics: Opportunities and challenges

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Elevated Cell-Specific Microparticles Are a Biological Marker for Cerebral Dysfunctions in Human Severe Malaria

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Cellular Engineering with Membrane Fusogenic Liposomes to Produce Functionalized Extracellular Vesicles

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Comparison of exosome-mimicking liposomes with conventional liposomes for intracellular delivery of siRNA

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Effect of MSCs and MSC-Derived Extracellular Vesicles on Human Blood Coagulation

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Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems

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MicroRNAs in extracellular vesicles: potential cancer biomarkers

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Magnetic resonance imaging of ultrasmall superparamagnetic iron oxide-labeled exosomes from stem cells: a new method to obtain labeled exosomes

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Membrane cell permeabilisation with saponin and multiparametric analysis by flow cytometry

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Horizontal transfer of RNA and proteins between cells by extracellular microvesicles: 14 years later

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Towards Therapeutic Delivery of Extracellular Vesicles: Strategies for In Vivo Tracking and Biodistribution Analysis

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Exosomal Expression of CXCR4 Targets Cardioprotective Vesicles to Myocardial Infarction and Improves Outcome after Systemic Administration

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Exploitation of Exosomes as Nanocarriers for Gene-, Chemo-, and Immune-Therapy of Cancer

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Suppression of inflammation reduces endothelial microparticles in active systemic lupus erythematosus

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Cell surface dynamics – how Rho GTPases orchestrate the interplay between the plasma membrane and the cortical cytoskeleton

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Exosomes secreted by hypoxic cardiosphere‐derived cells enhance tube formation and increase pro‐angiogenic miRNA

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