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Cited by 1,311

The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.

Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects

Open access
Uddin, Tanvir Mahtab, Chakraborty, Arka Jyoti, Khusro, Ameer, Zidan, BM Redwan Matin, Mitra, Saikat, Emran, Talha Bin, Dhama, Kuldeep, Ripon, Md. Kamal Hossain, Gajdács, Márió, Sahibzada, Muhammad Umar Khayam, Hossain, Md. Jamal, Koirala, Niranjan·2021·Journal of Infection and Public Health
DOI 10.1016/j.jiph.2021.10.020
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Abstract

Antibiotics have been used to cure bacterial infections for more than 70 years, and these low-molecular-weight bioactive agents have also been used for a variety of other medicinal applications. In the battle against microbes, antibiotics have certainly been a blessing to human civilization by saving millions of lives. Globally, infections caused by multidrug-resistant (MDR) bacteria are on the rise. Antibiotics are being used to combat diversified bacterial infections. Synthetic biology techniques, in combination with molecular, functional genomic, and metagenomic studies of bacteria, plants, and even marine invertebrates are aimed at unlocking the world's natural products faster than previous methods of antibiotic discovery. There are currently only few viable remedies, potential preventive techniques, and a limited number of antibiotics, thereby necessitating the discovery of innovative medicinal approaches and antimicrobial therapies. MDR is also facilitated by biofilms, which makes infection control more complex. In this review, we have spotlighted comprehensively various aspects of antibiotics viz. overview of antibiotics era, mode of actions of antibiotics, development and mechanisms of antibiotic resistance in bacteria, and future strategies to fight the emerging antimicrobial resistant threat.

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Crossref · 10.1016/j.jiph.2021.10.020

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Metadata

Authors
Uddin, T. M., Chakraborty, A. J., Khusro, A., Zidan, B. R. M., Mitra, S., Emran, T. B., Dhama, K., Ripon, M. K. H., Gajdács, M., Sahibzada, M. U. K., Hossain, M. J., & Koirala, N.
Venue
Journal of Infection and Public Health
Publisher
Elsevier BV
Published
2021-12
Volume
14
Issue
12
Pages
1750-1766
ISSN
1876-0341 (ISSN-L)
DOI
10.1016/j.jiph.2021.10.020
OpenAlex
W3209603403
Cited by
1,311
References
166
FWCI
44.50
Type
journal article
Language
en
Open access
gold

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.