Cited by 144Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyTactile and Sensory Interactions

The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.

Social touch-like tactile stimulation activates a tachykinin 1-oxytocin pathway to promote social interactions

Open access

Yu, Hang, Miao, Wanying, Ji, En, Huang, Shajin, Jin, Sen, Zhu, Xutao, Liu, Ming-Zhe, Sun, Yan-Gang, Xu, Fuqiang, Yu, Xiang·2022·Neuron

DOI 10.1016/j.neuron.2021.12.022

Open this paper in CoChat — free account

Abstract

It is well known that affective and pleasant touch promotes individual well-being and facilitates affiliative social communication, although the neural circuit that mediates this process is largely unknown. Here, we show that social-touch-like tactile stimulation (ST) enhances firing of oxytocin neurons in the mouse paraventricular hypothalamus (PVH) and promotes social interactions and positively reinforcing place preference. These results link pleasant somatosensory stimulation to increased social interactions and positive affective valence. We further show that tachykinin 1 (Tac1+) neurons in the lateral and ventrolateral periaqueductal gray (l/vlPAG) send monosynaptic excitatory projections to PVH oxytocin neurons. Functionally, activation of PVH-projecting Tac1+ neurons increases firing of oxytocin neurons, promotes social interactions, and increases preference for the social touch context, whereas reducing activity of Tac1+ neurons abolishes ST-induced oxytocin neuronal firing. Together, these results identify a dipeptidergic pathway from l/vlPAG Tac1+ neurons to PVH oxytocin neurons, through which pleasant sensory experience promotes social behavior.

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2021.12.022

Cites

125 of 125 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Cellular and Molecular Mechanisms of Pain
Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. (2009) · Cell · doi:10.1016/j.cell.2009.09.028 · Cited by 4,344
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations
Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
Zacharias, D. A., Violin, J. D., Newton, A. C., & Tsien, R. Y. (2002) · Science · doi:10.1126/science.1068539 · Cited by 2,270
A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsani, D., Fu, Y., Lu, J., Lin, Y., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.026 · Cited by 1,828
Shared and distinct transcriptomic cell types across neocortical areas
Tasic, B., Yao, Z., Graybuck, L. T., Smith, K. A., Nguyen, T. N., Bertagnolli, D., Goldy, J., Garren, E., Economo, M. N., Viswanathan, S., et al. (2018) · Nature · doi:10.1038/s41586-018-0654-5 · Cited by 1,746
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
The Sensory Neurons of Touch
Abraira, V. E., & Ginty, D. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.051 · Cited by 1,648
REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade
Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336
Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons
Vong, L., Ye, C., Yang, Z., Choi, B. J., Chua, S. C., & Lowell, B. B. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.028 · Cited by 1,237
A Comparison of the Social Postures of Some Common Laboratory Rodents
Grant, E. C., & Mackintosh, J. H. (1963) · Behaviour · doi:10.1163/156853963x00185 · Cited by 1,167
Coding of pleasant touch by unmyelinated afferents in humans
Löken, L. S., Wessberg, J., Morrison, I., McGlone, F., & Olausson, H. (2009) · Nature Neuroscience · doi:10.1038/nn.2312 · Cited by 1,120
Discriminative and affective touch: Sensing and feeling.
McGlone, F., Wessberg, J., & Olausson, H. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.001 · Cited by 1,112
Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049
The Challenge of Translation in Social Neuroscience: A Review of Oxytocin, Vasopressin, and Affiliative Behavior
Insel, T. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.005 · Cited by 1,044
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037
Variations in maternal care in the rat as a mediating influence for the effects of environment on development
Champagne, F. A., Francis, D. D., Mar, A., & Meaney, M. J. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00149-5 · Cited by 1,021
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
OXYTOCIN MAY MEDIATE THE BENEFITS OF POSITIVE SOCIAL INTERACTION AND EMOTIONS1The purpose of this paper is to describe the neuroendocrine mechanisms of positive social interactions.1
Uvnäs-Moberg, K. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00056-0 · Cited by 966
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945
The Neurobiology of Human Attachments
Feldman, R. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2016.11.007 · Cited by 839
Oxytocin enables maternal behaviour by balancing cortical inhibition
Marlin, B. J., Mitre, M., D’amour, J. A., Chao, M. V., & Froemke, R. C. (2015) · Nature · doi:10.1038/nature14402 · Cited by 744
Neurophysiological Correlates of Affiliative Behaviour between Humans and Dogs
Odendaal, J. S. J., & Meintjes, R. A. (2003) · The Veterinary Journal · doi:10.1016/s1090-0233(02)00237-x · Cited by 742
Sexually Dimorphic Neurons in the Ventromedial Hypothalamus Govern Mating in Both Sexes and Aggression in Males
Yang, C. F., Chiang, M. C., Gray, D. C., Prabhakaran, M., Alvarado, M., Juntti, S. A., Unger, E. K., Wells, J. A., & Shah, N. M. (2013) · Cell · doi:10.1016/j.cell.2013.04.017 · Cited by 694
Evolutionary optimization of fluorescent proteins for intracellular FRET
Nguyen, A. W., & Daugherty, P. S. (2005) · Nature Biotechnology · doi:10.1038/nbt1066 · Cited by 687
Genetic Causes and Modifiers of Autism Spectrum Disorder
Rylaarsdam, L. E., & Guemez‐Gamboa, A. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00385 · Cited by 618
The skin as a social organ
Morrison, I., Löken, L. S., & Olausson, H. (2009) · Experimental Brain Research · doi:10.1007/s00221-009-2007-y · Cited by 585
Social touch and human development
Cascio, C. J., Moore, D., & McGlone, F. P. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.04.009 · Cited by 554
Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation
Harris, J. A., Hirokawa, K. E., Sorensen, S. A., Gu, H., Mills, M., Ng, L. L., Bohn, P., Mortrud, M., Ouellette, B., Kidney, J., et al. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00076 · Cited by 485
The biology of mammalian parenting and its effect on offspring social development
Rilling, J. K., & Young, L. J. (2014) · Science · doi:10.1126/science.1252723 · Cited by 452
Adult restoration of Shank3 expression rescues selective autistic-like phenotypes
Mei, Y., Monteiro, P., Zhou, Y., Kim, J.-A., Gao, X., Fu, Z., & Feng, G. (2016) · Nature · doi:10.1038/nature16971 · Cited by 392
A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK?
Knapska, E., & Kaczmarek, L. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.007 · Cited by 390
Brain mechanisms for processing affective touch
Gordon, I., Voos, A. C., Bennett, R. H., Bolling, D. Z., Pelphrey, K. A., & Kaiser, M. D. (2011) · Human Brain Mapping · doi:10.1002/hbm.21480 · Cited by 374
Hypothalamic Oxytocin Mediates Social Buffering of the Stress Response
Smith, A. S., & Wang, Z. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.017 · Cited by 359
Oxytocin enhances social recognition by modulating cortical control of early olfactory processing
Oettl, L.-L., Ravi, N., Schneider, M., Scheller, M. F., Schneider, P., Mitre, M., da Silva Gouveia, M., Froemke, R. C., Chao, M. V., Young, W. S., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.033 · Cited by 359
The neural mechanisms and circuitry of the pair bond
Walum, H., & Young, L. J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0072-6 · Cited by 353
Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation
UvnÃ¤s-Moberg, K., Handlin, L., & Petersson, M. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01529 · Cited by 351
Localization of preproenkephalin mRNA in the rat brain and spinal cord by in situ hybridization
Harlan, R. E., Shivers, B. D., Romano, G. J., Pfaff, D. W., & Howells, R. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902580202 · Cited by 346
Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites
Ludwig, M., Sabatier, N., Bull, P. M., Landgraf, R., Dayanithi, G., & Leng, G. (2002) · Nature · doi:10.1038/nature00822 · Cited by 344
Quantitative assessment of pleasant touch
Essick, G. K., McGlone, F. P., Dancer, C., Fabricant, D., Ragin, Y., Phillips, N., Jones, T., & Guest, S. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.02.003 · Cited by 328
Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition
Young III, W. S., Shepard, E., Amico, J., Hennighausen, L., Wagner, K., LaMarca, M. E., McKinney, C., & Ginns, E. I. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.05266.x · Cited by 308
Early-life experience, epigenetics, and the developing brain
Kundakovic, M., & Champagne, F. A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.140 · Cited by 304
Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo
Vrontou, S., Wong, A. M., Rau, K. K., Koerber, H. R., & Anderson, D. J. (2013) · Nature · doi:10.1038/nature11810 · Cited by 298
Massage for promoting growth and development of preterm and/or low birth-weight infants
Vickers, A., Ohlsson, A., Lacy, J., & Horsley, A. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000390.pub2 · Cited by 293
Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain
He, M., Liu, Y., Wang, X., Zhang, M. Q., Hannon, G. J., & Huang, Z. J. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.010 · Cited by 277
Identifying the pathways required for coping behaviours associated with sustained pain
Huang, T., Lin, S.-H., Malewicz, N. M., Zhang, Y., Zhang, Y., Goulding, M., LaMotte, R. H., & Ma, Q. (2019) · Nature · doi:10.1038/s41586-018-0793-8 · Cited by 264
The cross-generation transmission of oxytocin in humans
Feldman, R., Gordon, I., & Zagoory-Sharon, O. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.005 · Cited by 256
Parallel ascending spinal pathways for affective touch and pain
Choi, S., Hachisuka, J., Brett, M. A., Magee, A. R., Omori, Y., Iqbal, N.-U.-A., Zhang, D., DeLisle, M. M., Wolfson, R. L., Bai, L., et al. (2020) · Nature · doi:10.1038/s41586-020-2860-1 · Cited by 255
Massage Accelerates Brain Development and the Maturation of Visual Function
Guzzetta, A., Baldini, S., Bancale, A., Baroncelli, L., Ciucci, F., Ghirri, P., Putignano, E., Sale, A., Viegi, A., Berardi, N., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5548-08.2009 · Cited by 251
Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons
Tang, Y., Benusiglio, D., Lefevre, A., Hilfiger, L., Althammer, F., Bludau, A., Hagiwara, D., Baudon, A., Darbon, P., Schimmer, J., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0674-y · Cited by 249
Breif Report: Sensory Abnormalities as Distinguishing Symptoms of Autism Spectrum Disorders in Young Children
Wiggins, L. D., Robins, D. L., Bakeman, R., & Adamson, L. B. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0711-x · Cited by 248
Social reward among juvenile mice
Panksepp, J. B., & Lahvis, G. P. (2007) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2006.00295.x · Cited by 248
Somatosensory projection to the mesencephalon: An anatomical study in the monkey
Wiberg, M., Westman, J., & Blomqvist, A. G. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902640108 · Cited by 231
Increased plasma levels of oxytocin in response to afferent electrical stimulation of the sciatic and vagal nerves and in response to touch and pinch in anaesthetized rats
STOCK, S., & UVNÄS‐MOBERG, K. (1988) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1988.tb08294.x · Cited by 230
Oxytocin treatment, circuitry and autism: a critical review of the literature placing oxytocin into the autism context
Guastella, A. J., & Hickie, I. B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.028 · Cited by 223
Periaqueductal gray
Benarroch, E. E. (2012) · Neurology · doi:10.1212/wnl.0b013e31823fcdee · Cited by 223
PDGFRβ Cells Rapidly Relay Inflammatory Signal from the Circulatory System to Neurons via Chemokine CCL2
Duan, L., Zhang, X., Miao, W., Sun, Y., Xiong, G., Wu, Q.-Z., Li, G., Yang, P., Yu, H., Li, H., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.030 · Cited by 219
Self-citation
Brain Mechanisms for Processing Affective (and Nonaffective) Touch Are Atypical in Autism
Kaiser, M. D., Yang, D. Y. ‐., Voos, A. C., Bennett, R. H., Gordon, I., Pretzsch, C. M., Beam, D. E., Keifer, C. M., Eilbott, J. A., McGlone, F. P., et al. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv125 · Cited by 216
Massage increases oxytocin and reduces adrenocorticotropin hormone in humans.
(2012) · PubMed · Cited by 215
Mapping the face in the somatosensory brainstem
Erzurumlu, R., Murakami, Y., & Rijli, F. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2804 · Cited by 213
Oxytocin mediates early experience-dependent cross-modal plasticity in the sensory cortices
Zheng, J.-J., Li, S.-J., Zhang, X.-D., Miao, W.-Y., Zhang, D., Yao, H., & Yu, X. (2014) · Nature Neuroscience · doi:10.1038/nn.3634 · Cited by 206
Self-citation
Autistic traits are associated with diminished neural response to affective touch
Voos, A. C., Pelphrey, K. A., & Kaiser, M. D. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss009 · Cited by 205
C-tactile afferents: Cutaneous mediators of oxytocin release during affiliative tactile interactions?
Walker, S. C., Trotter, P. D., Swaney, W. T., Marshall, A. G., & McGlone, F. P. (2017) · Neuropeptides · doi:10.1016/j.npep.2017.01.001 · Cited by 204
Oxytocin and early parent-infant interactions: A systematic review
Scatliffe, N., Casavant, S. G., Vittner, D. J., & Cong, X. S. (2019) · International Journal of Nursing Sciences · doi:10.1016/j.ijnss.2019.09.009 · Cited by 202
Massage therapy research
Field, T. M., Diego, M., & Hernandez‐Reif, M. (2006) · Developmental Review · doi:10.1016/j.dr.2005.12.002 · Cited by 197
An obligate role of oxytocin neurons in diet induced energy expenditure
Wu, Z., Xu, Y., Zhu, Y., Sutton, A. K., Zhao, R., Lowell, B. B., Olson, D. P., & Tong, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045167 · Cited by 181
Social transmission and buffering of synaptic changes after stress
Sterley, T.-L., Baimoukhametova, D., Füzesi, T., Zurek, A. A., Daviu, N., Rasiah, N. P., Rosenegger, D., & Bains, J. S. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0044-6 · Cited by 179
Artificially-reared female rats show reduced prepulse inhibition and deficits in the attentional set shifting task—reversal of effects with maternal-like licking stimulation
Lovic, V., & Fleming, A. S. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00206-7 · Cited by 170
The periaqueductal gray and primal emotional processing critical to influence complex defensive responses, fear learning and reward seeking
Motta, S. C., Carobrez, A. P., & Canteras, N. S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.012 · Cited by 167
Neuropsychopathology of Autism Spectrum Disorder: Complex Interplay of Genetic, Epigenetic, and Environmental Factors
Bhandari, R., Paliwal, J. K., & Kuhad, A. (2020) · Advances in neurobiology · doi:10.1007/978-3-030-30402-7_4 · Cited by 167
Are periaqueductal gray and dorsal raphe the foundation of appetitive and aversive control? A comprehensive review
Silva, C., & McNaughton, N. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.02.001 · Cited by 163
Uncovering the Cells and Circuits of Touch in Normal and Pathological Settings
Moehring, F., Halder, P., Seal, R. P., & Stucky, C. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.019 · Cited by 162
Spinal afferents to functionally distinct periaqueductal gray columns in the rat: An anterograde and retrograde tracing study
Keay, K. A., Feil, K., Gordon, B. D., Herbert, H., & Bandler, R. J. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970825)385:2 · Cited by 154
Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic
Nässel, D. R., Zandawala, M., Kawada, T., & Satake, H. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01262 · Cited by 153
Sensory Processing in Children with Autism Spectrum Disorders and Impact on Functioning
Suarez, M. A. (2012) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2011.10.012 · Cited by 152
Integrative Approaches Utilizing Oxytocin to Enhance Prosocial Behavior: From Animal and Human Social Behavior to Autistic Social Dysfunction
Yamasue, H., Yee, J. R., Hurlemann, R., Rilling, J. K., Chen, F. S., Meyer-Lindenberg, A., & Tost, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-12.2012 · Cited by 149
The efferent projections of the periaqueductal gray in the rat: A Phaseolus vulgaris‐leucoagglutinin study. I. Ascending projections
Cameron, A. A., Khan, I. A., Westlund, K. N., Cliffer, K. D., & Willis, W. D. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903510407 · Cited by 149
Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors
Grinevich, V., & Stoop, R. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.016 · Cited by 139
Tac1-Expressing Neurons in the Periaqueductal Gray Facilitate the Itch-Scratching Cycle via Descending Regulation
Gao, Z., Chen, W., Liu, M., Chen, X., Wan, L., Zhang, X., Yuan, L., Lin, J.-K., Wang, M., Zhou, L., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.010 · Cited by 136
Self-citation
Neural correlates of gentle skin stroking in early infancy
Tuulari, J. J., Scheinin, N. M., Lehtola, S. J., Merisaari, H., Saunavaara, J. P., Parkkola, R. K., Sehlstedt, I., Karlsson, L., Karlsson, H., & Björnsdotter, M. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.10.004 · Cited by 135
The ascending input to the midbrain periaqueductal gray of the primate
Mantyh, P. W. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902110106 · Cited by 134
The peptidergic organization of the cat periaqueductal gray. I. The distribution of immunoreactive enkephalin-containing neurons and terminals
Moss, M., Glazer, E. J., & Basbaum, A. I. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-03-00603.1983 · Cited by 132
Oxytocin modulation of neural circuits for social behavior
Marlin, B. J., & Froemke, R. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22452 · Cited by 130
Role of Massage Therapy in Cancer Care
Russell, N. C., Sumler, S.-S., Beinhorn, C. M., & Frenkel, M. A. (2008) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2007.7176 · Cited by 129
Autism and Oxytocin: New Developments in Translational Approaches to Therapeutics
Green, J. J., & Hollander, E. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.006 · Cited by 124
Oxytocin as an Indicator of Psychological and Social Well-Being in Domesticated Animals: A Critical Review
Rault, J., van den Munkhof, M. H., & Buisman‐Pijlman, F. T. A. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01521 · Cited by 122
Social and affective touch in primates and its role in the evolution of social cohesion
Jablonski, N. G. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.024 · Cited by 117
The oxytocin system promotes resilience to the effects of neonatal isolation on adult social attachment in female prairie voles
Barrett, C. E., Arambula, S. E., & Young, L. J. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.73 · Cited by 115
Interactions between the lateral hypothalamus and the periaqueductal gray
Behbehani, M. M., Park, M., & Clement, M. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02780.1988 · Cited by 115
Distribution of messenger RNAs encoding enkephalin, substance P, somatostatin, galanin, vasoactive intestinal polypeptide, neuropeptide Y, and calcitonin gene‐related peptide in the midbrain periaqueductal grey in the rat
Smith, G. S. J., Savery, D., Marden, C. M., Costa, J. J. L., Averill, S., Priestley, J. V., & Rattray, M. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903500103 · Cited by 114
Innate and plastic mechanisms for maternal behaviour in auditory cortex
Schiavo, J. K., Valtcheva, S., Bair-Marshall, C. J., Song, S. C., Martin, K. A., & Froemke, R. C. (2020) · Nature · doi:10.1038/s41586-020-2807-6 · Cited by 113
Periaqueductal Gray Sheds Light on Dark Areas of Psychopathology
George, D. T., Ameli, R., & Koob, G. F. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.03.004 · Cited by 108
The development of whisker control in rats in relation to locomotion
Grant, R. A., Mitchinson, B., & Prescott, T. J. (2011) · Developmental Psychobiology · doi:10.1002/dev.20591 · Cited by 106
Sexually dimorphic neuronal responses to social isolation
Senst, L., Baimoukhametova, D., Sterley, T.-L., & Bains, J. S. (2016) · eLife · doi:10.7554/elife.18726 · Cited by 101
Neonatal handling: An overview of the positive and negative effects
Raineki, C., Lucion, A. B., & Weinberg, J. (2014) · Developmental Psychobiology · doi:10.1002/dev.21241 · Cited by 96
Role of whiskers in sensorimotor development of C57BL/6 mice
Arakawa, H., & Erzurumlu, R. S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.03.040 · Cited by 91
Periaqueductal gray afferents synapse onto dopamine and GABA neurons in the rat ventral tegmental area
Omelchenko, N., & Sesack, S. R. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22265 · Cited by 90
The peptidergic organization of the cat periaqueductal gray. II. The distribution of immunoreactive substance P and vasoactive intestinal polypeptide
Moss, M., & Basbaum, A. I. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-07-01437.1983 · Cited by 87
Neonatal cardiac vagal tone and school-age developmental outcome in very low birth weight infants
Doussard-Roosevelt, J. A., McClenny, B. D., & Porges, S. W. (2000) · Developmental Psychobiology · doi:10.1002/1098-2302(2001)38:1 · Cited by 87
Activation of hypothalamic oxytocin neurons following tactile stimuli in rats
Okabe, S., Yoshida, M., Takayanagi, Y., & Onaka, T. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.05.055 · Cited by 82
Oxytocin and behavior: lessons from knockout mice
Caldwell, H. K., Aulino, E. A., Freeman, A. R., Miller, T. V., & Witchey, S. K. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22431 · Cited by 79
The Promise and Perils of Oxytocin
Miller, G. (2013) · Science · doi:10.1126/science.339.6117.267 · Cited by 76
Neuropathology and Animal Models of Autism: Genetic and Environmental Factors
Gadad, B. S., Hewitson, L. C., Young, K. A., & German, D. C. (2013) · Autism Research and Treatment · doi:10.1155/2013/731935 · Cited by 72
L-733,060, a novel tachykinin NK1 receptor antagonist; effects in [Ca2+]i mobilisation, cardiovascular and dural extravasation assays
Seabrook, G. R., Shepheard, S. L., Williamson, D. J., Tyrer, P. J., Rigby, M., Cascieri, M. A., Harrison, T., Hargreaves, R. J., & Hill, R. G. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00706-6 · Cited by 65
A Central Amygdala-Substantia Innominata Neural Circuitry Encodes Aversive Reinforcement Signals
Cui, Y., Lv, G., Jin, S., Peng, J., Yuan, J., He, X., Gong, H., Xu, F., Xu, T., & Li, H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.062 · Cited by 65
Self-citation
INFANT AVOIDANCE DURING A TACTILE TASK PREDICTS AUTISM SPECTRUM BEHAVIORS IN TODDLERHOOD
Mammen, M. A., Moore, G. A., Scaramella, L. V., Reiss, D., Ganiban, J. M., Shaw, D. S., Leve, L. D., & Neiderhiser, J. M. (2015) · Infant Mental Health Journal · doi:10.1002/imhj.21539 · Cited by 64
A Systematic Look at Environmental Modulation and Its Impact in Brain Development
Sale, A. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.10.004 · Cited by 63
Social touch during development: Long-term effects on brain and behavior
Bales, K. L., Witczak, L. R., Simmons, T. C., Savidge, L. E., Rothwell, E. S., Rogers, F. D., Manning, R., Heise, M. J., Englund, M., & Razo, R. A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.019 · Cited by 59
Tachykinin: recent developments and novel roles in health and disease
Onaga, T. (2014) · BioMolecular Concepts · doi:10.1515/bmc-2014-0008 · Cited by 53
Chemogenetic activation of oxytocin neurons: Temporal dynamics, hormonal release, and behavioral consequences
Grund, T., Tang, Y., Benusiglio, D., Althammer, F., Probst, S., Oppenländer, L., Neumann, I. D., & Grinevich, V. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.019 · Cited by 53
The periaqueductal gray as a critical site to mediate reward seeking during predatory hunting
Ortiz, S. R. M., Sukikara, M. H., Bittencourt, J. C., Baldo, M. V. C., Elias, C. F., Felício, L. F., & Canteras, N. S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.08.034 · Cited by 50
Substance P and neurotensin in the limbic system: Their roles in reinforcement and memory consolidation
Lénárd, L., László, K., Kertes, E., Ollmann, T., Péczely, L., Kovács, A., Kállai, V., Zagorácz, O., Gálosi, R., & Karádi, Z. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.003 · Cited by 49
Effects of Stroking on Salivary Oxytocin and Cortisol in Guide Dogs: Preliminary Results
Ogi, A., Mariti, C., Baragli, P., Sergi, V., & Gazzano, A. (2020) · Animals · doi:10.3390/ani10040708 · Cited by 49
Substance P decreases a potassium conductance of spinal cord neurons in cell culture
Nowak, L. M., & Macdonald, R. L. (1981) · Brain Research · doi:10.1016/0006-8993(81)91205-1 · Cited by 48
Periaqueductal efferents to dopamine and GABA neurons of the VTA
Ntamati, N. R., Creed, M. C., Achargui, R., & Lüscher, C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190297 · Cited by 40
Substance P Modulates Sensory Action Potentials in the Lamprey Via a Protein Kinase C‐Mediated Reduction of a 4‐Aminopyridine‐Sensitive Potassium Conductance
Parker, D., Svensson, E., & Grillner, S. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01374.x · Cited by 26
Three times as many lamina I neurons project to the periaqueductal gray than to the thalamus: a retrograde tracing study in the cat
Mouton, L. J., & Holstege, G. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00723-x · Cited by 26
An increased extrasynaptic NMDA tone inhibits A‐type K+ current and increases excitability of hypothalamic neurosecretory neurons in hypertensive rats
Zhang, M., Biancardi, V. C., & Stern, J. E. (2017) · The Journal of Physiology · doi:10.1113/jp274327 · Cited by 25
Experience Salience Gates Endocannabinoid Signaling at Hypothalamic Synapses
Cusulin, J. I. W., Senst, L., Teskey, G. C., & Bains, J. S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0163-14.2014 · Cited by 21
Periaqueductal gray and emotions: the complexity of the problem and the light at the end of the tunnel, the magnetic resonance imaging
Zelena, D., Menant, O., Andersson, F., & Chaillou, É. (2018) · Endocrine Regulations · doi:10.2478/enr-2018-0027 · Cited by 16
Post-weaning stroking stimuli induce affiliative behavior toward humans and influence brain activity in female rats
Okabe, S., Takayanagi, Y., Yoshida, M., & Onaka, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-83314-w · Cited by 16
Can Male Mice Develop Preference Towards Gentle Stroking by an Experimenter?
Cho, C., Chan, C., & Martin, L. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.12.017 · Cited by 13
Connections from the rat dorsal column nuclei (DCN) to the periaqueductal gray matter (PAG)
Barbaresi, P., & Mensa’, E. (2016) · Neuroscience Research · doi:10.1016/j.neures.2016.02.003 · Cited by 9
An Invitation to Neurobiology
Luo, L. (2020) · Garland Science eBooks · doi:10.1201/9781003053972-1 · Cited by 1

Sorted by citations

Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities
Rigney, N., de Vries, G. J., Petrulis, A., & Young, L. J. (2022) · Endocrinology · doi:10.1210/endocr/bqac111 · Cited by 191
The brain-body disconnect: A somatic sensory basis for trauma-related disorders
Kearney, B. E., & Lanius, R. A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1015749 · Cited by 154
“mediated social behaviors in mice (Yu et al., 2022).”
Background
A systematic review and multivariate meta-analysis of the physical and mental health benefits of touch interventions
Packheiser, J., Hartmann, H., Fredriksen, K., Gazzola, V., Keysers, C., & Michon, F. (2024) · Nature Human Behaviour · doi:10.1038/s41562-024-01841-8 · Cited by 166
Social isolation and the brain: effects and mechanisms
Xiong, Y., Hong, H., Liu, C., & Zhang, Y. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01835-w · Cited by 137
Detection, processing and reinforcement of social cues: regulation by the oxytocin system
Menon, R., & Neumann, I. D. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00759-w · Cited by 100

See all 144

Authors: Yu, H., Miao, W., Ji, E., Huang, S., Jin, S., Zhu, X., Liu, M.-Z., Sun, Y.-G., Xu, F., & Yu, X.
Affiliations: Chinese Academy of Sciences (CN)
Shenzhen Institutes of Advanced Technology (CN)
Corresponding author: Yu, Xiang
ORCID: Ji, En
Xu, Fuqiang
Yu, Xiang
Venue: Neuron
Publisher: Elsevier BV
Published: 2022-03
Volume: 110
Issue: 6
Pages: 1051-1067.e7
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2021.12.022
OpenAlex: W4205166062
Semantic Scholar: 8f383396e483b8ae6f8d9b1f571cccfeb4704641
Cited by: 144
References: 125
Citations by year: 2026: 25 · 2025: 42 · 2024: 29 · 2023: 26 · 2022: 22
FWCI: 28.09
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 380 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (31530030, 31771158)
Shanghai Municipal Government
Chinese Academy of Sciences (XDB32000000)
People's Government of Guangdong Province (2019B030335001)
Science and Technology Commission of Shanghai Municipality (2018SHZDZX05)
State Key Laboratory of Membrane Biology
Special Project for Research and Development in Key areas of Guangdong Province
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Keywords: social touch, tactile stimulation, oxytocin neurons, TAC1, paraventricular hypothalamus, periaqueductal gray, social interaction, positive reinforcement, place preference, social behavior, monosynaptic projection
MeSH terms: Social Interaction, Animals, Oxytocin, Touch, Tachykinins, Mice, Touch Perception

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Social touch-like tactile stimulation activates a tachykinin 1-oxytocin pathway to promote social interactions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks