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Leptin in human physiology and therapeutics

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Dardeno, Tina A., Chou, Sharon H., Moon, Hyun-Seuk, Chamberland, John P., Fiorenza, Christina G., Mantzoros, Christos S.·2010·Frontiers in Neuroendocrinology
DOI 10.1016/j.yfrne.2010.06.002
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Abstract

Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and metabolic functions. In this review, we describe the role of leptin in human physiology and review evidence from recent “proof of concept” clinical trials using recombinant human leptin in subjects with congenital leptin deficiency, hypoleptinemia associated with energy-deficient states, and hyperleptinemia associated with garden-variety obesity. Since most obese individuals are largely leptin-tolerant or -resistant, therapeutic uses of leptin are currently limited to patients with complete or partial leptin deficiency, including hypothalamic amenorrhea and lipoatrophy. Leptin administration in these energy-deficient states may help restore associated neuroendocrine, metabolic, and immune function and bone metabolism. Leptin treatment is currently available for individuals with congenital leptin deficiency and congenital lipoatrophy. The long-term efficacy and safety of leptin treatment in hypothalamic amenorrhea and acquired lipoatrophy are currently under investigation. Whether combination therapy with leptin and potential leptin sensitizers will prove effective in the treatment of garden-variety obesity and whether leptin may have a role in weight loss maintenance is being greatly anticipated.

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Cited by

Metadata

Authors
Dardeno, T. A., Chou, S. H., Moon, H.-S., Chamberland, J. P., Fiorenza, C. G., & Mantzoros, C. S.
Venue
Frontiers in Neuroendocrinology
Publisher
Elsevier BV
Published
2010-07
Volume
31
Issue
3
Pages
377-393
ISSN
0091-3022 (ISSN-L)
DOI
10.1016/j.yfrne.2010.06.002
OpenAlex
W2015130768
Cited by
286
References
60
FWCI
10.49
Type
journal article
Language
en
Open access
bronze
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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