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Cited by 1,283Posttraumatic Stress Disorder ResearchChild Abuse and TraumaStress Responses and Cortisol

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Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse—a preliminary report

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Bremner, J. Douglas, Randall, Penny, Vermetten, Eric, Staib, Lawrence, Bronen, Richard A., Mazure, Carolyn, Capelli, Sandi, McCarthy, Gregory, Innis, Robert B., Charney, Dennis S.·1997·Biological Psychiatry
DOI 10.1016/s0006-3223(96)00162-xPMC PMC3229101
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Abstract

We have previously reported smaller hippocampal volume and deficits in short-term memory in patients with combat-related posttraumatic stress disorder (PTSD) relative to comparison subjects. The purpose of this study was to compare hippocampal volume in adult survivors of childhood abuse to matched controls. Magnetic resonance imaging was used to measure volume of the hippocampus in adult survivors of childhood abuse (n = 17) and healthy subjects (n = 17) matched on a case-by-case basis for age, sex, race, handedness, years of education, body size, and years of alcohol abuse. All patients met criteria for PTSD secondary to childhood abuse. PTSD patients had a 12% smaller left hippocampal volume relative to the matched controls (p < .05), without smaller volumes of comparison regions (amygdala, caudate, and temporal lobe). The findings were significant after controlling for alcohol, age, and education, with multiple linear regression. These findings suggest that a decrease in left hippocampal volume is associated with abuse-related PTSD.

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Metadata

Authors
Bremner, J. D., Randall, P., Vermetten, E., Staib, L., Bronen, R. A., Mazure, C., Capelli, S., McCarthy, G., Innis, R. B., & Charney, D. S.
Affiliations
  • Yale University (US)
  • Maastricht University (NL)
Corresponding author
Bremner, J. Douglas
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1997-01
Volume
41
Issue
1
Pages
23-32
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(96)00162-x
PMC
PMC3229101
OpenAlex
W2064212981
Cited by
1,283
References
4
Citations by year
2026: 9 · 2025: 14 · 2024: 41 · 2023: 23 · 2022: 31 · 2021: 61 · 2020: 28 · 2019: 31 · 2018: 27 · 2017: 42 · 2016: 56 · 2015: 58 · 2014: 41 · 2013: 42 · 2012: 67
FWCI
54.28
Type
journal article
Language
en
Open access
Licence
Locations
  • Biological Psychiatry (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R01MH056120)
  • National Center for Research Resources (M01RR000125)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
post-traumatic stress disorder, child physical abuse, child sexual abuse, hippocampal volume, hippocampal atrophy, brain structure, alcohol abuse, short-term memory impairment, combat-related PTSD
MeSH terms
Adult, Alcoholism, Brain Mapping, Child, Child Abuse, Child Abuse, Sexual, Dominance, Cerebral, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Stress Disorders, Post-Traumatic, Comorbidity

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