Cited by 2,933Lipoproteins and Cardiovascular HealthAlzheimer's disease research and treatmentsGenetic Associations and Epidemiology

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Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

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Hixson, JE, Vernier, DT·1990·Journal of Lipid Research

DOI 10.1016/s0022-2275(20)43176-1

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Abstract

We have used restriction isotyping (restriction enzyme isoform genotyping) for rapid typing of common apolipoprotein E isoforms (E2, E3, E4). ApoE restriction isotyping used oligonucleotides to amplify apolipoprotein E gene sequences containing amino acid positions 112 and 158. The amplification products were digested with HhaI and subjected to electrophoresis on polyacrylamide gels. Each of the isoforms was distinguished by a unique combination of HhaI fragment sizes that enabled unambiguous typing of all homozygotic and heterozygotic combinations. HhaI cleaves at GCGC encoding 112arg (E4) and 158arg (E3, E4), but does not cut at GTGC encoding 112cys (E2, E3) and 158cys (E2).

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Authors: Hixson, J., & Vernier, D.
Affiliations: Texas Biomedical Research Institute (US)
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 1990-03
Volume: 31
Issue: 3
Pages: 545-548
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1016/s0022-2275(20)43176-1
OpenAlex: W2111774300
Cited by: 2,933
References: 3
Citations by year: 2026: 19 · 2025: 36 · 2024: 40 · 2023: 35 · 2022: 43 · 2021: 48 · 2020: 48 · 2019: 48 · 2018: 56 · 2017: 54 · 2016: 59 · 2015: 76 · 2014: 82 · 2013: 93 · 2012: 89
FWCI: 33.40
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 11194 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Heart, Lung, and Blood Institute (HL-28972, P01HL028972)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: apolipoprotein E, HhaI, gene amplification, apolipoprotein E isoforms
MeSH terms: Amino Acid Sequence, Apolipoproteins E, Base Sequence, DNA, Gene Amplification, Humans, Leukocytes, Molecular Sequence Data, Polymorphism, Genetic, Deoxyribonucleases, Type II Site-Specific, Polymerase Chain Reaction

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Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

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