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TNF/iNOS-Producing Dendritic Cells Mediate Innate Immune Defense against Bacterial Infection

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Serbina, Natalya V, Salazar-Mather, Thais P, Biron, Christine A, Kuziel, William A, Pamer, Eric G·2003·Immunity

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Abstract

Dendritic cells (DCs) present microbial antigens to T cells and provide inflammatory signals that modulate T cell differentiation. While the role of DCs in adaptive immunity is well established, their involvement in innate immune defenses is less well defined. We have identified a TNF/iNOS-producing (Tip)-DC subset in spleens of Listeria monocytogenes-infected mice that is absent from CCR2-deficient mice. The absence of Tip-DCs results in profound TNF and iNOS deficiencies and an inability to clear primary bacterial infection. CD8 and CD4 T cell responses to L. monocytogenes antigens are preserved in CCR2-deficient mice, indicating that Tip-DCs are not essential for T cell priming. Tip-DCs, as the predominant source of TNF and iNOS during L. monocytogenes infection, orchestrate and mediate innate immune defense against this intracellular bacterial pathogen.

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Authors: Serbina, N. V., Salazar-Mather, T. P., Biron, C. A., Kuziel, W. A., & Pamer, E. G.
Venue: Immunity
Publisher: Elsevier BV
Published: 2003-07
Volume: 19
Issue: 1
Pages: 59-70
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/s1074-7613(03)00171-7
OpenAlex: W1990083653
Cited by: 1,175
References: 3
FWCI: 9.05
Type: journal article
Language: en
Open access: bronze

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TNF/iNOS-Producing Dendritic Cells Mediate Innate Immune Defense against Bacterial Infection

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