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Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
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Cites
Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need
Muglia, L., Jacobson, L., Dikkes, P., & Majzoub, J. A. (1995) · Nature · doi:10.1038/373427a0 · Cited by 524
Cited by
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Central nervous system control of food intake and body weight
Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503
Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene
Farooqi, I. S., Keogh, J. M., Yeo, G. S. H., Lank, E. J., Cheetham, T., & O'Rahilly, S. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022050 · Cited by 1,778
Anatomy and regulation of the central melanocortin system
Cone, R. D. (2005) · Nature Neuroscience · doi:10.1038/nn1455 · Cited by 1,583
The genetics of obesity: From discovery to biology
Loos, R. J. F., & Yeo, G. S. H. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-021-00414-z · Cited by 1,291
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
Aponte, Y., Atasoy, D., & Sternson, S. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2739 · Cited by 1,157
Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120
The Human Obesity Gene Map: The 2005 Update
Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L., & Bouchard, C. (2006) · Obesity · doi:10.1038/oby.2006.71 · Cited by 1,119
Deconstruction of a neural circuit for hunger
Atasoy, D., Betley, J. N., Su, H. H., & Sternson, S. M. (2012) · Nature · doi:10.1038/nature11270 · Cited by 969
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935
Neuropeptide Transmission in Brain Circuits
van den Pol, A. N. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.014 · Cited by 810
Slominski, A., Wortsman, J., Luger, T., Paus, R., & Solomon, S. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.979 · Cited by 776
Exploring the opioid system by gene knockout
Kieffer, B. L., & Gavériaux-Ruff, C. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00008-4 · Cited by 620
Studies on the Physiological Functions of the Melanocortin System
Cone, R. D. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0034 · Cited by 615
The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology
Tao, Y.-X. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0037 · Cited by 531
Obesity and the skin: Skin physiology and skin manifestations of obesity
Yosipovitch, G., DeVore, A., & Dawn, A. (2007) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2006.12.004 · Cited by 524
Kleinridders, A., Schenten, D., Könner, A. C., Belgardt, B. F., Mauer, J., Okamura, T., Wunderlich, F. T., Medzhitov, R., & Brüning, J. C. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.013 · Cited by 483
Medicinal strategies in the treatment of obesity
Bray, G. A., & Tartaglia, L. A. (2000) · Nature · doi:10.1038/35007544 · Cited by 432
The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins
Benoit, S. C., Air, E. L., Coolen, L. M., Strauss, R., Jackman, A., Clegg, D. J., Seeley, R. J., & Woods, S. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09048.2002 · Cited by 417
Ishimoto, H., & Jaffe, R. B. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0001 · Cited by 379
Gao, Q., Wolfgang, M. J., Neschen, S., Morino, K., Horvath, T. L., Shulman, G. I., & Fu, X.-Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0303992101 · Cited by 385
Adaptive thermogenesis in humans
Rosenbaum, M., & Leibel, R. L. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.184 · Cited by 349
The role of proopiomelanocortin (POMC) neurones in feeding behaviour
Millington, G. W. (2007) · Nutrition & Metabolism · doi:10.1186/1743-7075-4-18 · Cited by 345
van de Wall, E., Leshan, R., Xu, A. W., Balthasar, N., Coppari, R., Liu, S. M., Jo, Y. H., MacKenzie, R. G., Allison, D. B., Dun, N. J., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1132 · Cited by 338
Münzberg, H., Huo, L., Nillni, E. A., Hollenberg, A. N., & Bjørbæk, C. (2003) · Endocrinology · doi:10.1210/en.2002-221037 · Cited by 328
Mandelblat-Cerf, Y., Ramesh, R. N., Burgess, C. R., Patella, P., Yang, Z., Lowell, B. B., & Andermann, M. L. (2015) · eLife · doi:10.7554/elife.07122 · Cited by 290
Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance.
Schneeberger, M., Gomis, R., & Claret, M. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0398 · Cited by 301
Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons
Wang, D., He, X., Zhao, Z., Feng, Q., Lin, R., Sun, Y., Ding, T., Xu, F., Luo, M., & Zhan, C. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00040 · Cited by 298
Liu, T., Kong, D., Shah, B. P., Ye, C., Koda, S., Saunders, A., Ding, J. B., Yang, Z., Sabatini, B. L., & Lowell, B. B. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.027 · Cited by 296
The Central Melanocortin System Can Directly Regulate Serum Insulin Levels*
Fan, W., Dinulescu, D. M., Butler, A. A., Zhou, J., Marks, D. L., & Cone, R. D. (2000) · Endocrinology · doi:10.1210/endo.141.9.7665 · Cited by 294
Differential expression of HPA axis homolog in the skin
Slominski, A., Wortsman, J., Tuckey, R. C., & Paus, R. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.012 · Cited by 279
Genetics and epigenetics of eating disorders
Bulik, C., Yilmaz, Z., & HArdaway, A. (2015) · Advances in Genomics and Genetics · doi:10.2147/agg.s55776 · Cited by 278
The role of mPer2 clock gene in glucocorticoid and feeding rhythms
Yang, S., Liu, A., Weidenhammer, A., Cooksey, R. C., McClain, D., Kim, M. K., Aguilera, G., Abel, E. D., & Chung, J. H. (2009) · Endocrinology · doi:10.1210/en.2008-0705 · Cited by 263
Masood, B., & Moorthy, M. (2023) · Clinical Medicine · doi:10.7861/clinmed.2023-0168 · Cited by 252
Hypothalamic-pituitary-adrenocortical axis regulation
Jacobson, L. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.01.003 · Cited by 248
Fu, L.-Y., & van den Pol, A. N. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2098-10.2010 · Cited by 243
A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH
Fenselau, H., Campbell, J. N., Verstegen, A. M. J., Madara, J. C., Xu, J., Shah, B. P., Resch, J. M., Yang, Z., Mandelblat-Cerf, Y., Livneh, Y., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4442 · Cited by 233
The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation
Bellinger, L. L., & Bernardis, L. L. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00756-4 · Cited by 228
Integrative neurocircuits that control metabolism and food intake
Brüning, J. C., & Fenselau, H. (2023) · Science · doi:10.1126/science.abl7398 · Cited by 214
Li, M. M., Madara, J. C., Steger, J. S., Krashes, M. J., Balthasar, N., Campbell, J. N., Resch, J. M., Conley, N. J., Garfield, A. S., & Lowell, B. B. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.028 · Cited by 195
Macia, L., Tsai, V. W.-W., Nguyen, A. D., Johnen, H., Kuffner, T., Shi, Y.-C., Lin, S., Herzog, H., Brown, D. A., Breit, S. N., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034868 · Cited by 211
Hypothalamic control of energy expenditure and thermogenesis
Tran, L. T., Park, S., Kim, S. K., Lee, J. S., Kim, K. W., & Kwon, O. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00741-z · Cited by 208
Neurotrophic factor control of satiety and body weight
Xu, B., & Xie, X. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.24 · Cited by 203
Ernst, M. B., Wunderlich, C. M., Hess, S., Paehler, M., Mesaros, A., Koralov, S. B., Kleinridders, A., Husch, A., Münzberg, H., Hampel, B., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5712-08.2009 · Cited by 185
Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood
Lee, S.-H., Zabolotny, J. M., Huang, H., Lee, H., & Kim, Y.-B. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.011 · Cited by 176
Manfredi-Lozano, M., Roa, J., & Tena-Sempere, M. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.008 · Cited by 162
Alcantara, I. C., Tapia, A. P. M., Aponte, Y., & Krashes, M. J. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00611-y · Cited by 155
Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice
Lloyd, D. J., Bohan, S., & Gekakis, N. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl111 · Cited by 142
Agouti-related protein-deficient mice display an age-related lean phenotype
Wortley, K. E., Anderson, K. D., Yasenchak, J., Murphy, A., Valenzuela, D., Diano, S., Yancopoulos, G. D., Wiegand, S. J., & Sleeman, M. W. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.11.004 · Cited by 128
Activation of Stat3 Signaling in AgRP Neurons Promotes Locomotor Activity
Mesaros, A., Koralov, S. B., Rother, E., Wunderlich, F. T., Ernst, M. B., Barsh, G. S., Rajewsky, K., & Brüning, J. C. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.01.007 · Cited by 128
Neural melanocortin receptors in obesity and related metabolic disorders
Girardet, C., & Butler, A. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.004 · Cited by 128
Identification of ALK in thinness
Orthofer, M., Valsesia, A., Mägi, R., Wang, Q.-P., Kaczanowska, J., Kozieradzki, I., Leopoldi, A., Cikes, D., Zopf, L. M., Tretiakov, E. O., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.034 · Cited by 117
Genetic approaches to hypothalamic-pituitary-adrenal axis regulation
Arnett, M. G., Muglia, L. M., Laryea, G., & Muglia, L. J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.215 · Cited by 105
Adage, T., Scheurink, A. J. W., de Boer, S. F., de Vries, K., Konsman, J. P., Kuipers, F., Adan, R. A. H., Baskin, D. G., Schwartz, M. W., & van Dijk, G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03639.2001 · Cited by 106
Ikenasio-Thorpe, B. A., Breier, B. H., Vickers, M. H., & Fraser, M. (2007) · Journal of Endocrinology · doi:10.1677/joe.1.07017 · Cited by 106
Melanocortin-5 receptor: A marker of human sebocyte differentiation
Zhang, L., Li, W.-H., Anthonavage, M., & Eisinger, M. (2006) · Peptides · doi:10.1016/j.peptides.2005.05.030 · Cited by 103
Inherited ACTH insensitivity illuminates the mechanisms of ACTH action
Clark, A. J. L., Metherell, L. A., Cheetham, M. E., & Huebner, A. (2005) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2005.10.006 · Cited by 82
Hypothalamic proopiomelanocortin (POMC) neurons have a cholinergic phenotype
Meister, B., Gömüç, B., Suarez, E., Ishii, Y., Dürr, K., & Gillberg, L. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05157.x · Cited by 75
Haskell‐Luevano, C., Schaub, J. W., Andreasen, A., Haskell, K. R., Moore, M. C., Koerper, L. M., Rouzaud, F., Baker, H. V., Millard, W. J., Walter, G., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-109686 · Cited by 72
The Neuroendocrine Circuitry Controlled by POMC, MSH, and AGRP
Biebermann, H., Kühnen, P., Kleinau, G., & Krude, H. (2012) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-24716-3_3 · Cited by 70
Proopiomelanocortin Peptides and Sebogenesis
ZHANG, L., ANTHONAVAGE, M., HUANG, Q., LI, W., & EISINGER, M. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03175.x · Cited by 68
Brain control of energy homeostasis: implications for anti-obesity pharmacotherapy
Johansen, V. B. I., Petersen, J., Lund, J., Mathiesen, C. V., Fenselau, H., & Clemmensen, C. (2025) · Cell · doi:10.1016/j.cell.2025.06.010 · Cited by 53
γ-MSH, sodium metabolism, and salt-sensitive hypertension
Humphreys, M. H. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00365.2003 · Cited by 51
Tennoune, N., Legrand, R., Ouelaa, W., Breton, J., Lucas, N., Bole-Feysot, C., Rego, J.-C. D., Déchelotte, P., & Fetissov, S. O. (2015) · Nutrition · doi:10.1016/j.nut.2014.11.003 · Cited by 31
Melanocortin agonists stimulate lipolysis in human adipose tissue explants but not in adipocytes
Møller, C. L., Pedersen, S. B., Richelsen, B., Conde-Frieboes, K. W., Raun, K., Grove, K. L., & Wulff, B. S. (2015) · BMC Research Notes · doi:10.1186/s13104-015-1539-4 · Cited by 22
Metadata
- Authors
- Yaswen, L., Diehl, N., Brennan, M. B., & Hochgeschwender, U.
- Venue
- Nature Medicine
- Published
- 1999-09
- Volume
- 5
- Issue
- 9
- Pages
- 1066-1070
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1539401343
- Cited by
- 1,012
- References
- 1
- FWCI
- 15.30
- Type
- journal article
- Language
- en
- Open access
- closed
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