The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

Larue, L., Ohsugi, M., Hirchenhain, J., & Kemler, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8263 · Cited by 930

Epithelial-Mesenchymal Transitions in Development and Disease

Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931

Molecular mechanisms of epithelial–mesenchymal transition

Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091

EMT: 2016

Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

Dongre, A., & Weinberg, R. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0080-4 · Cited by 3,876

Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?

Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121

Cancer stem cells revisited

Batlle, E., & Clevers, H. (2017) · Nature Medicine · doi:10.1038/nm.4409 · Cited by 2,769

TGF-β-induced epithelial to mesenchymal transition

Xu, J., Lamouille, S., & Derynck, R. (2009) · Cell Research · doi:10.1038/cr.2009.5 · Cited by 2,804

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

Ma, L., Teruya-Feldstein, J., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06174 · Cited by 2,605

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

Shibue, T., & Weinberg, R. A. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.44 · Cited by 2,539

Regulatory networks defining EMT during cancer initiation and progression

Craene, B. D., & Berx, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3447 · Cited by 2,487

Guidelines and definitions for research on epithelial-mesenchymal transition

Yang, J., Antin, P., Berx, G., Blanpain, C., Brabletz, T., Bronner, M., Campbell, K., Cano, A., Casanova, J., Christofori, G., et al. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0237-9 · Cited by 2,226

Signaling mechanisms of the epithelial-mesenchymal transition

Gonzalez, D. M., & Medici, D. (2014) · Science Signaling · doi:10.1126/scisignal.2005189 · Cited by 1,721

The snail superfamily of zinc-finger transcription factors

Nieto, M. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm757 · Cited by 1,719

Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition

Zhou, B. P., Deng, J., Xia, W., Xu, J., Li, Y. M., Gunduz, M., & Hung, M.-C. (2004) · Nature Cell Biology · doi:10.1038/ncb1173 · Cited by 1,581

Epithelial Mesenchymal Transition in Tumor Metastasis

Mittal, V. (2018) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-043854 · Cited by 1,528

Direct regulation of TWIST by HIF-1α promotes metastasis

Yang, M.-H., Wu, M.-Z., Chiou, S.-H., Chen, P.-M., Chang, S.-Y., Liu, C.-J., Teng, S.-C., & Wu, K.-J. (2008) · Nature Cell Biology · doi:10.1038/ncb1691 · Cited by 1,345

An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

Byers, L. A., Diao, L., Wang, J., Saintigny, P., Girard, L., Peyton, M., Shen, L., Fan, Y., Giri, U., Tumula, P. K., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1558 · Cited by 1,059

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

Li, R., Liang, J., Ni, S., Zhou, T., Qing, X., Li, H., He, W., Chen, J., Li, F., Zhuang, Q., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.04.014 · Cited by 1,072

Endometrial receptivity markers, the journey to successful embryo implantation.

Achache, H., & Revel, A. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml004 · Cited by 952

Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo

Arnold, S. J., & Robertson, E. J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2618 · Cited by 816

Regulation of tight junctions during the epithelium-mesenchyme transition:direct repression of the gene expression of claudins/occludin by Snail

Ikenouchi, J., Matsuda, M., Furuse, M., & Tsukita, S. (2003) · Journal of Cell Science · doi:10.1242/jcs.00389 · Cited by 678

Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells

Kurrey, N. K., Jalgaonkar, S. P., Joglekar, A. V., Ghanate, A. D., Chaskar, P. D., Doiphode, R. Y., & Bapat, S. A. (2009) · Stem Cells · doi:10.1002/stem.154 · Cited by 655

The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition

Carver, E. A., Jiang, R., Lan, Y., Oram, K. F., & Gridley, T. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.23.8184-8188.2001 · Cited by 624

Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis

Derksen, P. W. B., Liu, X., Saridin, F., van der Gulden, H., Zevenhoven, J., Evers, B., van Beijnum, J. R., Griffioen, A. W., Vink, J., Krimpenfort, P., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.09.013 · Cited by 591

Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders

Piera-Velazquez, S., Li, Z., & Jimenez, S. A. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.06.001 · Cited by 580

Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies

ten Berge, D., Koole, W., Fuerer, C., Fish, M., Eroglu, E., & Nusse, R. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.013 · Cited by 477

The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression

Berx, G., & Roy, F. V. (2001) · Breast Cancer Research · doi:10.1186/bcr309 · Cited by 463

The transcriptional control of trunk neural crest induction, survival, and delamination

Cheung, M., Chaboissier, M.-C., Mynett, A., Hirst, E., Schedl, A., & Briscoe, J. (2005) · Developmental Cell · doi:10.1016/j.devcel.2004.12.010 · Cited by 427

Hypoxia-Inducible Factor-1-Dependent Repression of E-cadherin in von Hippel-Lindau Tumor Suppressor–Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B

Krishnamachary, B., Zagzag, D., Nagasawa, H., Rainey, K., Okuyama, H., Baek, J. H., & Semenza, G. L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3719 · Cited by 415

Transforming growth factor‐β in stem cells and tissue homeostasis

Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414

Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells

Imai, T., Horiuchi, A., Wang, C., Oka, K., Ohira, S., Nikaido, T., & Konishi, I. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63501-8 · Cited by 377

β-Catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse

Liebner, S., Cattelino, A., Gallini, R., Rudini, N., Iurlaro, M., Piccolo, S., & Dejana, E. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403050 · Cited by 376

The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation

Ohkubo, T., & Ozawa, M. (2004) · Journal of Cell Science · doi:10.1242/jcs.01004 · Cited by 322

Role of the tumor microenvironment in tumor progression and the clinical applications (Review)

YUAN, Y., JIANG, Y.-C., SUN, C.-K., & CHEN, Q.-M. (2016) · Oncology Reports · doi:10.3892/or.2016.4660 · Cited by 320

Cranial neural crest cells on the move: Their roles in craniofacial development

Cordero, D. R., Brugmann, S., Chu, Y., Bajpai, R., Jame, M., & Helms, J. A. (2011) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33702 · Cited by 305

NF-kappaB Is Involved in the Regulation of EMT Genes in Breast Cancer Cells

Pires, B. R. B., Mencalha, A. L., Ferreira, G. M., de Souza, W. F., Morgado-Díaz, J. A., Maia, A. M., Corrêa, S., & Abdelhay, E. S. F. W. (2017) · PLOS ONE · doi:10.1371/journal.pone.0169622 · Cited by 296

Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol

Chen, Y.-F., Tseng, C.-Y., Wang, H.-W., Kuo, H.-C., Yang, V. W., & Lee, O. K. (2012) · Hepatology · doi:10.1002/hep.24790 · Cited by 291

Regulation of E-cadherin Expression by VHL and Hypoxia-Inducible Factor

Esteban, M. A., Tran, M. G. B., Harten, S. K., Hill, P., Castellanos, M. C., Chandra, A., Raval, R., O'Brien, T. S., & Maxwell, P. H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2670 · Cited by 262

Dual roles of myocardin-related transcription factors in epithelial–mesenchymal transition via slug induction and actin remodeling

Morita, T., Mayanagi, T., & Sobue, K. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200708174 · Cited by 262

Craniofacial Development

Depew, M. J., Tucker, A. S., & Sharpe, P. T. (2002) · Mouse Development · doi:10.1016/b978-012597951-1/50023-8 · Cited by 259

Role of cancer‐associated fibroblast subpopulations in immune infiltration, as a new means of treatment in cancer

Mhaidly, R., & Mechta‐Grigoriou, F. (2021) · Immunological Reviews · doi:10.1111/imr.12978 · Cited by 231

Hepatocyte nuclear factor 4α orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver

Battle, M. A., Konopka, G., Parviz, F., Gaggl, A. L., Yang, C., Sladek, F. M., & Duncan, S. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600246103 · Cited by 246

Epithelial-mesenchymal transition: From molecular mechanisms, redox regulation to implications in human health and disease

Cannito, S., Novo, E., di Bonzo, L. V., Busletta, C., Colombatto, S., & Parola, M. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2737 · Cited by 239

The morphological and molecular features of the epithelial-to-mesenchymal transition

Moreno-Bueno, G., Peinado, H., Molina, P., Olmeda, D., Cubillo, E., Santos, V., Palacios, J., Portillo, F., & Cano, A. (2009) · Nature Protocols · doi:10.1038/nprot.2009.152 · Cited by 221

Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance

Dudás, J., Ladányi, A., Ingruber, J., Steinbichler, T. B., & Riechelmann, H. (2020) · Cells · doi:10.3390/cells9020428 · Cited by 213

Signals and switches in mammalian neural crest cell differentiation

Bhatt, S., Diaz, R., & Trainor, P. A. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008326 · Cited by 200

Analysis of forkhead and snail expression reveals epithelial–mesenchymal transitions during embryonic and larval development of Nematostella vectensis

Fritzenwanker, J. H., Saina, M., & Technau, U. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.08.014 · Cited by 165

Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis

Celià-Terrassa, T., & Jolly, M. K. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036905 · Cited by 163

Toll-like receptor 4 signaling promotes epithelial-mesenchymal transition in human hepatocellular carcinoma induced by lipopolysaccharide

Jing, Y.-Y., Han, Z.-P., Sun, K., Zhang, S.-S., Hou, J., Liu, Y., Li, R., Gao, L., Zhao, X., Zhao, Q.-D., et al. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-98 · Cited by 162

Co-ordinating Notch, BMP, and TGF-β signaling during heart valve development

Garside, V. C., Chang, A. C., Karsan, A., & Hoodless, P. A. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1197-9 · Cited by 160

Epithelial–mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?

van Staalduinen, J., Baker, D., ten Dijke, P., & van Dam, H. (2018) · Oncogene · doi:10.1038/s41388-018-0378-x · Cited by 158

Tbx3 Represses E-Cadherin Expression and Enhances Melanoma Invasiveness

Rodriguez, M., Aladowicz, E., Lanfrancone, L., & Goding, C. R. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0301 · Cited by 157

Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025

Allgayer, H., Mahapatra, S., Mishra, B., Swain, B., Saha, S., Khanra, S., Kumari, K., Panda, V. K., Malhotra, D., Patil, N. S., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02338-2 · Cited by 127

The role of Pdcd4 in tumour suppression and protein translation

Wang, Q., & Yang, H. (2018) · Biology of the Cell · doi:10.1111/boc.201800014 · Cited by 113

Epigenetic regulation of miR-21 in colorectal cancer: ITGB4 as a novel miR-21 target and a three-gene network (miR-21-ITGΒ4-PDCD4) as predictor of metastatic tumor potential

Ferraro, A., Kontos, C. K., Boni, T., Bantounas, I., Siakouli, D., Kosmidou, V., Vlassi, M., Spyridakis, Y., Tsipras, I., Zografos, G., et al. (2014) · Epigenetics · doi:10.4161/epi.26842 · Cited by 111

Endothelial-to-mesenchymal transition (EndoMT): roles in tumorigenesis, metastatic extravasation and therapy resistance

Platel, V., Faure, S., Corre, I., & Clere, N. (2019) · Journal of Oncology · doi:10.1155/2019/8361945 · Cited by 101

Heart Valve Development, Maintenance, and Disease

Tao, G., Kotick, J. D., & Lincoln, J. (2012) · Current Topics in Developmental Biology · doi:10.1016/b978-0-12-387786-4.00006-3 · Cited by 89

Downregulation of E-cadherin is an essential event in activating β-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells

Wang, Q., Sun, Z. X., Allgayer, H., & Yang, H. S. (2010) · Oncogene · doi:10.1038/onc.2009.302 · Cited by 89

Transcriptional Repression of E-Cadherin by Human Papillomavirus Type 16 E6

D'Costa, Z. J., Jolly, C., Androphy, E. J., Mercer, A., Matthews, C. M., & Hibma, M. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048954 · Cited by 83

Glioblastoma Microenvironment and Cellular Interactions

Crivii, C.-B., Boșca, A. B., Melincovici, C. S., Constantin, A.-M., Mărginean, M., Dronca, E., Suflețel, R., Gonciar, D., Bungărdean, M., & Șovrea, A. (2022) · Cancers · doi:10.3390/cancers14041092 · Cited by 81

Epithelial-mesenchymal transition orchestrates tumor microenvironment: Current perceptions and challenges

Xie, Y., Wang, X., Wang, W., Pu, N., & Liu, L. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06422-5 · Cited by 80

Partially Evoked Epithelial-Mesenchymal Transition (EMT) Is Associated with Increased TGFβ Signaling within Lesional Scleroderma Skin

Nikitorowicz-Buniak, J., Denton, C. P., Abraham, D., & Stratton, R. (2015) · PLOS ONE · doi:10.1371/journal.pone.0134092 · Cited by 73

AhR protein trafficking and function in the skin

Ikuta, T., Namiki, T., Fujii-Kuriyama, Y., & Kawajiri, K. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.10.003 · Cited by 68

Study on the relationship between hepatic fibrosis and epithelial-mesenchymal transition in intrahepatic cells

Chen, Y., Fan, Y., Guo, D.-Y., Xu, B., Shi, X.-Y., Li, J.-T., & Duan, L.-F. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110413 · Cited by 63

Riding the crest of the wave: parallels between the neural crest and cancer in epithelial-to-mesenchymal transition and migration

Powell, D. R., Blasky, A. J., Britt, S. G., & Artinger, K. B. (2013) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1224 · Cited by 62

Insights From a Sea Lamprey Into the Evolution of Neural Crest Gene Regulatory Network

Sauka-Spengler, T., & Bronner-Fraser, M. (2008) · The Biological Bulletin · doi:10.2307/25470671 · Cited by 55

Oncogenic B-RAFV600E Signaling Induces the T-Box3 Transcriptional Repressor to Repress E-Cadherin and Enhance Melanoma Cell Invasion

Boyd, S. C., Mijatov, B., Pupo, G. M., Tran, S. L., Gowrishankar, K., Shaw, H. M., Goding, C. R., Scolyer, R. A., Mann, G. J., Kefford, R. F., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.421 · Cited by 53

A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells

Chou, C.-C., Chuang, H.-C., Salunke, S. B., Kulp, S. K., & Chen, C.-S. (2015) · Oncotarget · doi:10.18632/oncotarget.3186 · Cited by 50

The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion

Peres, J., & Prince, S. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-117 · Cited by 50

BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFβ receptor to promote invasion

Hill, C. R., Sanchez, N. S., Love, J. D., Arrieta, J. A., Hong, C. C., Brown, C. B., Austin, A. F., & Barnett, J. V. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2011.12.022 · Cited by 40

Regulation of Stem Cell Plasticity: Mechanisms and Relevance to Tissue Biology and Cancer

Strauss, R., Hamerlik, P., Lieber, A., & Bartek, J. (2012) · Molecular Therapy · doi:10.1038/mt.2012.2 · Cited by 41

Generation of a Snail1 (Snai1) conditional null allele

Murray, S. A., Carver, E. A., & Gridley, T. (2006) · genesis · doi:10.1002/gene.20178 · Cited by 35

Novel Compound 1, 3-bis (3, 5-dichlorophenyl) urea Inhibits Lung Cancer Progression

Singhal, S. S., Figarola, J., Singhal, J., Nagaprashantha, L., Berz, D., Rahbar, S., & Awasthi, S. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.09.022 · Cited by 14

Differentiation States of Phenotypic Transition of Melanoma Cells Are Revealed by 3D Cell Cultures

Fontana, F., Sommariva, M., Anselmi, M., Bianchi, F., Limonta, P., & Gagliano, N. (2024) · Cells · doi:10.3390/cells13020181 · Cited by 11

The mesenchymal transcription factor SNAI-1 instructs human liver specification

Goldman, O., Valdes, V. J., Ezhkova, E., & Gouon-Evans, V. (2016) · Stem Cell Research · doi:10.1016/j.scr.2016.05.007 · Cited by 8