Tumor angiogenesis: molecular pathways and therapeutic targets

The biology of VEGF and its receptors

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Isolation of Putative Progenitor Endothelial Cells for Angiogenesis

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Molecular mechanisms and clinical applications of angiogenesis

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Tumors: Wounds That Do Not Heal

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Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

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Modes of resistance to anti-angiogenic therapy

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Transplacental Carcinogenesis by Stilbestrol

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Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

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Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

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Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma

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Microenvironmental regulation of tumor progression and metastasis

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A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging

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Mesenchymal Stem Cells for Regenerative Medicine

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Non-small-cell lung cancer

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Metastatic heterogeneity of breast cancer: Molecular mechanism and potential therapeutic targets

Liang, Y., Zhang, H., Song, X., & Yang, Q. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.012 · Cited by 992

A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals

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Immunity, inflammation and cancer: a leading role for adenosine

Antonioli, L., Blandizzi, C., Pacher, P., & Haskó, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3613 · Cited by 765

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy

Schaaf, M. B., Garg, A. D., & Agostinis, P. (2018) · Cell Death & Disease · doi:10.1038/s41419-017-0061-0 · Cited by 629

Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment

Barkley, D., Moncada, R., Pour, M., Liberman, D. A., Dryg, I., Werba, G., Wang, W., Baron, M., Rao, A., Xia, B., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01141-9 · Cited by 532

Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis

Corliss, B. A., Azimi, M. S., Munson, J. M., Peirce, S. M., & Murfee, W. L. (2016) · Microcirculation · doi:10.1111/micc.12259 · Cited by 356

Breaking Down the Barriers to Precision Cancer Nanomedicine

von Roemeling, C., Jiang, W., Chan, C. K., Weissman, I. L., & Kim, B. Y. S. (2017) · Trends in Biotechnology · doi:10.1016/j.tibtech.2016.07.006 · Cited by 330

The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer

Berchtold, M. W., & Villalobo, A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.10.021 · Cited by 320

Optical Coherence Tomography Angiography Signs of Vascular Abnormalization With Antiangiogenic Therapy for Choroidal Neovascularization

Spaide, R. F. (2015) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2015.04.012 · Cited by 313

Mechanisms of Metastasis in Colorectal Cancer and Metastatic Organotropism: Hematogenous versus Peritoneal Spread

Pretzsch, E., Bösch, F., Neumann, J., Ganschow, P., Bazhin, A., Guba, M., Werner, J., & Angele, M. (2019) · Journal of Oncology · doi:10.1155/2019/7407190 · Cited by 298

Dynamic Optical Coherence Tomography in Dermatology

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Integrin β1 controls VE-cadherin localization and blood vessel stability

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MicroRNA-26a Regulates Pathological and Physiological Angiogenesis by Targeting BMP/SMAD1 Signaling

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PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells

Kim, S. M., Nguyen, T. T., Ravi, A., Kubiniok, P., Finicle, B. T., Jayashankar, V., Malacrida, L., Hou, J., Robertson, J., Gao, D., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1215 · Cited by 199

Normalization of the tumor microenvironment by harnessing vascular and immune modulation to achieve enhanced cancer therapy

Choi, Y., & Jung, K. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01114-w · Cited by 188

Endothelial Cells in the Tumor Microenvironment

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Wiring the Vascular Network with Neural Cues: A CNS Perspective

Wälchli, T., Wacker, A., Frei, K., Regli, L., Schwab, M. E., Hoerstrup, S. P., Gerhardt, H., & Engelhardt, B. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.038 · Cited by 178

The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance

Ahmed, S., Bradshaw, A.-D., Gera, S., Dewan, M., & Xu, R. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6010005 · Cited by 174

Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy

Jung, K., Heishi, T., Khan, O. F., Kowalski, P. S., Incio, J., Rahbari, N. N., Chung, E., Clark, J. W., Willett, C. G., Luster, A. D., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93182 · Cited by 164

Leveraging Physiology for Precision Drug Delivery

Sun, W., Hu, Q., Ji, W., Wright, G., & Gu, Z. (2017) · Physiological Reviews · doi:10.1152/physrev.00015.2016 · Cited by 169

Liposome imaging agents in personalized medicine

Petersen, A. L., Hansen, A. E., Gabizon, A., & Andresen, T. L. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.003 · Cited by 164

Hydrogels to model 3D in vitro microenvironment of tumor vascularization

Song, H.-H. G., Park, K. M., & Gerecht, S. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.06.002 · Cited by 153

Pathological neoangiogenesis depends on oxidative stress regulation by ATM

Okuno, Y., Nakamura-Ishizu, A., Otsu, K., Suda, T., & Kubota, Y. (2012) · Nature Medicine · doi:10.1038/nm.2846 · Cited by 152

Targeting PAK4 to reprogram the vascular microenvironment and improve CAR‐T immunotherapy for glioblastoma

Ma, W., Wang, Y., Zhang, R., Yang, F., Zhang, D., Huang, M., Zhang, L., Dorsey, J. F., Binder, Z. A., O’Rourke, D. M., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-00147-8 · Cited by 143

NIR‐II‐Excited Intravital Two‐Photon Microscopy Distinguishes Deep Cerebral and Tumor Vasculatures with an Ultrabright NIR‐I AIE Luminogen

Wang, S., Liu, J., Goh, C. C., Ng, L. G., & Liu, B. (2019) · Advanced Materials · doi:10.1002/adma.201904447 · Cited by 148

3D extracellular matrix interactions modulate tumour cell growth, invasion and angiogenesis in engineered tumour microenvironments

Taubenberger, A. V., Bray, L. J., Haller, B., Shaposhnykov, A., Binner, M., Freudenberg, U., Guck, J., & Werner, C. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.03.017 · Cited by 139

c-Met–mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma

Huang, M., Liu, T., Ma, P., Mitteer, R. A., Zhang, Z., Kim, H. J., Yeo, E., Zhang, D., Cai, P., Li, C., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84876 · Cited by 128

Biomimetic Model of Tumor Microenvironment on Microfluidic Platform

Chung, M., Ahn, J., Son, K., Kim, S., & Jeon, N. L. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700196 · Cited by 126

Microfluidic-Based 3D Engineered Microvascular Networks and Their Applications in Vascularized Microtumor Models

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Molecular alterations of cancer cell and tumour microenvironment in metastatic gastric cancer

Li, W., Ng, J. M.-K., Wong, C. C., Ng, E. K. W., & Yu, J. (2018) · Oncogene · doi:10.1038/s41388-018-0341-x · Cited by 87

Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature

Hooglugt, A., van der Stoel, M. M., Boon, R. A., & Huveneers, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.612802 · Cited by 82

Transforming Growth Factor β-regulated MicroRNA-29a Promotes Angiogenesis through Targeting the Phosphatase and Tensin Homolog in Endothelium

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Role of the tumor microenvironment in cancer hallmarks and targeted therapy (Review)

Naser, R., Fakhoury, I., El‑Fouani, A., Abi‑Habib, R., & El‑Sibai, M. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5471 · Cited by 61

The insulin-like growth factor system in multiple myeloma: diagnostic and therapeutic potential

Bieghs, L., Johnsen, H. E., Maes, K., Menu, E., Van Valckenborgh, E., Overgaard, M. T., Nyegaard, M., Conover, C. A., Vanderkerken, K., & De Bruyne, E. (2016) · Oncotarget · doi:10.18632/oncotarget.8982 · Cited by 61

Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology

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Activated hepatic stellate cells promote angiogenesis via interleukin-8 in hepatocellular carcinoma

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A collagen‐binding EGFR single‐chain Fv antibody fragment for the targeted cancer therapy

Liang, H., Li, X., Chen, B., Wang, B., Zhao, Y., Zhuang, Y., Shen, H., Zhang, Z., & Dai, J. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.04.029 · Cited by 54

The Anti-Angiogenic Effect of Atorvastatin in Glioblastoma Spheroids Tumor Cultured in Fibrin Gel: in 3D in Vitro Model

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Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition

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Leveraging microenvironmental synthetic lethalities to treat cancer

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A nanostructure of functional targeting epirubicin liposomes dually modified with aminophenyl glucose and cyclic pentapeptide used for brain glioblastoma treatment

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Homotypic and Heterotypic Activation of the Notch Pathway in Multiple Myeloma–Enhanced Angiogenesis: A Novel Therapeutic Target?

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Strategies for elevating hematopoietic stem cells expansion and engraftment capacity

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Treatment With a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy

Mathews Samuel, S., Satheesh, N. J., Ghosh, S., Büsselberg, D., Majeed, Y., Ding, H., & Triggle, C. R. (2019) · Cancers · doi:10.3390/cancers11111737 · Cited by 28

SALL4 promotes angiogenesis in gastric cancer by regulating VEGF expression and targeting SALL4/VEGF pathway inhibits cancer progression

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Glycosylation in cancer: mechanisms, diagnostic markers, and therapeutic applications

Qusairy, Z., & Rada, M. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05303-1 · Cited by 16

Therapeutic development in targeting protein–protein interactions with synthetic topological mimetics

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