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Skin immune sentinels in health and disease

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Nestle, Frank O., Di Meglio, Paola, Qin, Jian-Zhong, Nickoloff, Brian J.·2009·Nature Reviews Immunology
DOI 10.1038/nri2622
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Abstract

Human skin and its immune cells provide essential protection of the human body from injury and infection. Recent studies reinforce the importance of keratinocytes as sensors of danger through alert systems such as the inflammasome. In addition, newly identified CD103+ dendritic cells are strategically positioned for cross-presentation of skin-tropic pathogens and accumulating data highlight a key role of tissue-resident rather than circulating T cells in skin homeostasis and pathology. This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease.

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Metadata

Authors
Nestle, F. O., Di Meglio, P., Qin, J.-Z., & Nickoloff, B. J.
Venue
Nature Reviews Immunology
Publisher
Springer Science and Business Media LLC
Published
2009-09-18
Volume
9
Issue
10
Pages
679-691
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
DOI
10.1038/nri2622
OpenAlex
W2042194530
Cited by
1,420
References
16
FWCI
9.99
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Skin immune sentinels in health and disease. https://app.cochat.ai/papers/10.1038/nri2622
The paper
Nestle, F. O., Di Meglio, P., Qin, J.-Z., & Nickoloff, B. J. (2009). Skin immune sentinels in health and disease. Nature Reviews Immunology. https://doi.org/10.1038/nri2622

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.