In utero programming of chronic disease
Abstract
1. Many human fetuses have to adapt to a limited supply of nutrients. In doing so they permanently change their structure and metabolism. 2. These 'programmed' changes may be the origins of a number of diseases in later life, including coronary heart disease and the related disorders stroke, diabetes and hypertension. 3. This review examines the evidence linking these diseases to fetal undernutrition and provides an overview of previous studies in this area.
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Reduced birth weight increases adult risk for chronic disorders, including hypertension, type 2 diabetes, and cardiovascular disease; one study associated fetal malnutrition with exposure to glucocorticoids.
“Reduced birth weight increases adult risk for chronic disorders, including hypertension, type 2 diabetes, and cardiovascular disease (118); one study associated fetal malnutrition with exposure to GCs (119).”
From Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society* Clinical Practice Guideline (2018) · cites this paper as [118]
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“Introduction There is growing recognition that the prenatal environment shapes health and disease across the lifespan (e.g., Barker, 1998).”
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- Authors
- BARKER, D. J. P.
- Affiliations
- Southampton General Hospital (GB)
- Corresponding author
- BARKER, D. J. P.
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 1998-08-01
- Volume
- 95
- Issue
- 2
- Pages
- 115-128
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W4254913758
- Cited by
- 1,765
- References
- 112
- Citations by year
- 2026: 39 · 2025: 58 · 2024: 56 · 2023: 72 · 2022: 67 · 2021: 106 · 2020: 85 · 2019: 69 · 2018: 101 · 2017: 87 · 2016: 77 · 2015: 79 · 2014: 74 · 2013: 83 · 2012: 89
- FWCI
- 23.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- in utero programming, fetal origins of disease, developmental origins of health and disease, chronic disease, fetal development, epigenetics
- MeSH terms
- Child, Child, Preschool, Chronic Disease, Coronary Disease, Diabetes Mellitus, Type 2, Female, Embryonic and Fetal Development, Fetal Growth Retardation, Humans, Hypertension, Infant, Newborn, Male, Middle Aged, Placental Insufficiency, Pregnancy, Prenatal Exposure Delayed Effects
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