Cited by 1,765Birth, Development, and HealthPregnancy and preeclampsia studiesPrenatal Substance Exposure Effects

In utero programming of chronic disease

BARKER, D. J. P.·1998·Clinical Science

Abstract

1. Many human fetuses have to adapt to a limited supply of nutrients. In doing so they permanently change their structure and metabolism. 2. These 'programmed' changes may be the origins of a number of diseases in later life, including coronary heart disease and the related disorders stroke, diabetes and hypertension. 3. This review examines the evidence linking these diseases to fetal undernutrition and provides an overview of previous studies in this area.

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Crossref · 10.1042/cs0950115

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112 of 112 references verified0 citation errors · 0 not checkable

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Authors
BARKER, D. J. P.
Affiliations
Southampton General Hospital (GB)
Corresponding author
BARKER, D. J. P.
Venue
Clinical Science
Published
1998-08-01
Volume
95
Issue
2
Pages
115-128
ISSN
  • 0143-5221 (ISSN-L)
  • 1470-8736
OpenAlex
W4254913758
Cited by
1,765
References
112
Citations by year
2026: 39 · 2025: 58 · 2024: 56 · 2023: 72 · 2022: 67 · 2021: 106 · 2020: 85 · 2019: 69 · 2018: 101 · 2017: 87 · 2016: 77 · 2015: 79 · 2014: 74 · 2013: 83 · 2012: 89
FWCI
23.05
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
in utero programming, fetal origins of disease, developmental origins of health and disease, chronic disease, fetal development, epigenetics
MeSH terms
Child, Child, Preschool, Chronic Disease, Coronary Disease, Diabetes Mellitus, Type 2, Female, Embryonic and Fetal Development, Fetal Growth Retardation, Humans, Hypertension, Infant, Newborn, Male, Middle Aged, Placental Insufficiency, Pregnancy, Prenatal Exposure Delayed Effects

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