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Cited by 1,507

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure

Open access
van Rooij, Eva, Sutherland, Lillian B., Liu, Ning, Williams, Andrew H., McAnally, John, Gerard, Robert D., Richardson, James A., Olson, Eric N.·2006·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0608791103
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Abstract

Diverse forms of injury and stress evoke a hypertrophic growth response in adult cardiac myocytes, which is characterized by an increase in cell size, enhanced protein synthesis, assembly of sarcomeres, and reactivation of fetal genes, often culminating in heart failure and sudden death. Given the emerging roles of microRNAs (miRNAs) in modulation of cellular phenotypes, we searched for miRNAs that were regulated during cardiac hypertrophy and heart failure. We describe >12 miRNAs that are up- or down-regulated in cardiac tissue from mice in response to transverse aortic constriction or expression of activated calcineurin, stimuli that induce pathological cardiac remodeling. Many of these miRNAs were similarly regulated in failing human hearts. Forced overexpression of stress-inducible miRNAs was sufficient to induce hypertrophy in cultured cardiomyocytes. Similarly, cardiac overexpression of miR-195, which was up-regulated during cardiac hypertrophy, resulted in pathological cardiac growth and heart failure in transgenic mice. These findings reveal an important role for specific miRNAs in the control of hypertrophic growth and chamber remodeling of the heart in response to pathological signaling and point to miRNAs as potential therapeutic targets in heart disease.

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Metadata

Authors
van Rooij, E., Sutherland, L. B., Liu, N., Williams, A. H., McAnally, J., Gerard, R. D., Richardson, J. A., & Olson, E. N.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2006-11-28
Volume
103
Issue
48
Pages
18255-18260
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0608791103
OpenAlex
W2051403674
Cited by
1,507
References
34
FWCI
45.27
Type
journal article
Language
en
Open access
green

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